Fabrication of a new tubular fibrous PLCL scaffold for vascular tissue engineering
Abstract
Biodegradable macroporous scaffolds have been developed for tissue-engineering applications. We fabricated and characterized a new tubular, macroporous, fibrous scaffold using a very elastic biodegradable co-polymer, poly(L-lactide-co-caprolactone) (PLCL, 5:5) in a gel-spinning process. A viscous PLCL solution was spun as a gel-phase under swirl-flow conditions and was subsequently fabricated to produce a tubular fibrous scaffold on a rotating cylindrical shaft in a methanol solution. The porosity and median pore size of the fibrous PLCL scaffolds were 55-75% and 120-150 microm, respectively, using a 5-10% PLCL solution. The use of a 7.5% (w/v) solution resulted in scaffolds with tensile strength and elastic modulus of 3.39 MPa and 1.22 MPa, respectively. The scaffolds exhibited 500-600% elongation-at-break. The tensile strength and modulus of fibrous PLCL scaffolds were proven to decrease on lowering the concentration of the PLCL spinning solution; however, the tensile strength and modulus of fibrous PLCL scaffolds, produced from 5% solutions, are approximately 4- and 5-times higher than those of extruded PLCL scaffolds. These properties indicated that the fibrous PLCL scaffolds were very elastic and mechanically strong. The scaffolds appeared to be well inter-connected between the pores as determined by SEM imaging analysis. In addition, the cell-seeding efficiency was 2-fold higher using gel-spun scaffolds than using extruded scaffolds. These results suggest that the gel-spun fibrous PLCL scaffold is an excellent matrix for vascular tissue-engineering applications.
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The elastic modulus of PLCL generally ranges from 400 to 600 MPa, depending on its molecular weight, polymer structure, and composition ratio.
“The elastic modulus of PLCL generally ranges from 400 to 600 MPa, and this depends on its molecular weight, polymer structure and composition ratio [55].”
From Application of PLCL as a biodegradable polymer in biomedical engineering (2026) · cites this paper as [55]
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- Authors
- Kim, S.-H., Kwon, J. H., Chung, M. S., Chung, E., Jung, Y., Kim, S. H., & Kim, Y. H.
- Affiliations
- Korea Institute of Science and Technology (KR)
- Korean Association Of Science and Technology Studies (KR)
- Gwangju Institute of Science and Technology (KR)
- Venue
- Journal of Biomaterials Science, Polymer Edition
- Publisher
- Informa UK Limited
- Published
- 2006-01
- Volume
- 17
- Issue
- 12
- Pages
- 1359-1374
- ISSN
- 0920-5063 (ISSN-L)
- 1568-5624
- OpenAlex
- W2042812961
- Cited by
- 55
- References
- 24
- Citations by year
- 2026: 1 · 2024: 5 · 2023: 4 · 2022: 1 · 2021: 1 · 2019: 3 · 2018: 2 · 2017: 3 · 2016: 4 · 2015: 2 · 2014: 2 · 2013: 5 · 2012: 5
- FWCI
- 1.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Biomaterials Science Polymer Edition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
- Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Keywords
- poly(L-lactide-co-ε-caprolactone), PLCL, gel spinning, vascular tissue engineering, macroporous scaffolds, biodegradable polymers, porosity, pore size, tensile strength, elastic modulus, cell seeding
- MeSH terms
- Biocompatible Materials, Biomechanical Phenomena, Endothelium, Vascular, Gels, Humans, Polyesters, Porosity, Tissue Engineering, Cell Proliferation
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