The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Loss of wnt/β-catenin signaling causes cell fate shift of preosteoblasts from osteoblasts to adipocytes
Open accessAbstract
Wnt signaling is essential for osteogenesis and also functions as an adipogenic switch, but it is not known if interrupting wnt signaling via knockout of β-catenin from osteoblasts would cause bone marrow adiposity. Here, we determined whether postnatal deletion of β-catenin in preosteoblasts, through conditional cre expression driven by the osterix promoter, causes bone marrow adiposity. Postnatal disruption of β-catenin in the preosteoblasts led to extensive bone marrow adiposity and low bone mass in adult mice. In cultured bone marrow–derived cells isolated from the knockout mice, adipogenic differentiation was dramatically increased, whereas osteogenic differentiation was significantly decreased. As myoblasts, in the absence of wnt/β-catenin signaling, can be reprogrammed into the adipocyte lineage, we sought to determine whether the increased adipogenesis we observed partly resulted from a cell-fate shift of preosteoblasts that had to express osterix (lineage-committed early osteoblasts), from the osteoblastic to the adipocyte lineage. Using lineage tracing both in vivo and in vitro we showed that the loss of β-catenin from preosteoblasts caused a cell-fate shift of these cells from osteoblasts to adipocytes, a shift that may at least partly contribute to the bone marrow adiposity and low bone mass in the knockout mice. These novel findings indicate that wnt/β-catenin signaling exerts control over the fate of lineage-committed early osteoblasts, with respect to their differentiation into osteoblastic versus adipocytic populations in bone, and thus offers potential insight into the origin of bone marrow adiposity. © 2012 American Society for Bone and Mineral Research.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Many studies have demonstrated that β-catenin is required for bone formation and is activated during multiple stages of osteoblast differentiation to regulate both osteoblast and osteoclast.40–43”
From Bone remodeling: an operational process ensuring survival and bone mechanical competence (2022) · cites this paper as [42]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Nakashima, K., Zhou, X., Kunkel, G., Zhang, Z., Deng, J. M., Behringer, R. R., & de Crombrugghe, B. (2002) · Cell · doi:10.1016/s0092-8674(01)00622-5 · Cited by 3,608
A global double-fluorescent Cre reporter mouse
Muzumdar, M. D., Tasic, B., Miyamichi, K., Li, L., & Luo, L. (2007) · genesis · doi:10.1002/dvg.20335 · Cited by 3,491
Mesenchymal and haematopoietic stem cells form a unique bone marrow niche
Méndez‐Ferrer, S., Michurina, T. V., Ferraro, F., Mazloom, A. R., MacArthur, B. D., Lira, S. A., Scadden, D. T., Ma’ayan, A., Enikolopov, G., & Frenette, P. S. (2010) · Nature · doi:10.1038/nature09262 · Cited by 3,381
Transcriptional regulation of adipogenesisPreprint
Rosen, E. D., Walkey, C. J., Puigserver, P., & Spiegelman, B. M. (2000) · Genes & Development · doi:10.1101/gad.14.11.1293 · Cited by 1,908
Inhibition of Adipogenesis by Wnt Signaling
Ross, S. E., Hemati, N., Longo, K. A., Bennett, C. N., Lucas, P. C., Erickson, R. L., & MacDougald, O. A. (2000) · Science · doi:10.1126/science.289.5481.950 · Cited by 1,876
Day, T. F., Guo, X., Garrett-Beal, L., & Yang, Y. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.03.016 · Cited by 1,616
Canonical wnt signaling in differentiated osteoblasts controls osteoclast differentiation.
Glass, D. A., Bialek, P., Ahn, J. D., Starbuck, M., Patel, M. S., Clevers, H., Taketo, M. M., Long, F., McMahon, A. P., Lang, R. A., et al. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.02.017 · Cited by 1,558
Regulation of bone mass by Wnt signaling
Krishnan, V. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28551 · Cited by 1,407
Molecular Regulation of Adipogenesis
Rosen, E. D., & Spiegelman, B. M. (2000) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.16.1.145 · Cited by 1,310
Canonical Wnt/β-Catenin Signaling Prevents Osteoblasts from Differentiating into Chondrocytes
Hill, T. P., Später, D., Taketo, M. M., Birchmeier, W., & Hartmann, C. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.02.013 · Cited by 1,086
Cited by
Sorted by citations
Bone remodeling: an operational process ensuring survival and bone mechanical competence
Bolamperti, S., Villa, I., & Rubinacci, A. (2022) · Bone Research · doi:10.1038/s41413-022-00219-8 · Cited by 482
Mizoguchi, T., Pinho, S., Ahmed, J. U., Kunisaki, Y., Hanoun, M., Mendelson, A., Ono, N., Kronenberg, H. M., & Frenette, P. S. (2014) · Developmental Cell · doi:10.1016/j.devcel.2014.03.013 · Cited by 451
Self-citationWnt/β-catenin signaling components and mechanisms in bone formation, homeostasis, and disease
Hu, L., Chen, W., Qian, A., & Li, Y.-P. (2024) · Bone Research · doi:10.1038/s41413-024-00342-8 · Cited by 359
Gli1 identifies osteogenic progenitors for bone formation and fracture repair
Shi, Y., He, G., Lee, W., McKenzie, J. A., Silva, M. J., & Long, F. (2017) · Nature Communications · doi:10.1038/s41467-017-02171-2 · Cited by 345
Matsushita, Y., Nagata, M., Kozloff, K. M., Welch, J. D., Mizuhashi, K., Tokavanich, N., Hallett, S. A., Link, D. C., Nagasawa, T., Ono, W., et al. (2020) · Nature Communications · doi:10.1038/s41467-019-14029-w · Cited by 305
Self-citationWnt signaling and cellular metabolism in osteoblasts
Karner, C. M., & Long, F. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2425-5 · Cited by 295
Regulation and Role of Transcription Factors in Osteogenesis
Chan, W. C. W., Tan, Z., To, M. K.-T., & Chan, D. T.-M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115445 · Cited by 276
Estrogen receptor-α signaling in osteoblast progenitors stimulates cortical bone accrual
Almeida, M., Iyer, S. V., Martín-Millán, M., Bartell, S. M., Han, L., Ambrogini, E., Onal, M., Xiong, J., Weinstein, R. S., Jilka, R. L., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci65910 · Cited by 260
Wnt and the Wnt signaling pathway in bone development and disease
Wang, Y. (2014) · Frontiers in bioscience · doi:10.2741/4214 · Cited by 255
FOXOs attenuate bone formation by suppressing Wnt signaling
Iyer, S. V., Ambrogini, E., Bartell, S. M., Li, H., Roberson, P. K., de Cabo, R., Jilka, R. L., Weinstein, R. S., O’Brien, C. A., Manolagas, S. C., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci68049 · Cited by 233
SOX2 Regulates YAP1 to Maintain Stemness and Determine Cell Fate in the Osteo-Adipo Lineage
Seo, E., Basu-Roy, U., Gunaratne, P. H., Coarfa, C., Lim, D.-S., Basilico, C., & Mansukhani, A. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.05.029 · Cited by 216
Basic Biology of Skeletal Aging: Role of Stress Response Pathways
Almeida, M., & O’Brien, C. A. (2013) · The Journals of Gerontology Series A · doi:10.1093/gerona/glt079 · Cited by 207
Dirckx, N., Hul, M. V., & Maes, C. (2013) · Birth Defects Research Part C Embryo Today Reviews · doi:10.1002/bdrc.21047 · Cited by 201
Update on the impact of type 2 diabetes mellitus on bone metabolism and material properties
Picke, A., Campbell, G. M., Napoli, N., Hofbauer, L. C., & Rauner, M. (2019) · Endocrine Connections · doi:10.1530/ec-18-0456 · Cited by 207
Wnt-Lrp5 Signaling Regulates Fatty Acid Metabolism in the Osteoblast
Frey, J. L., Li, Z., Ellis, J. M., Zhang, Q., Farber, C. R., Aja, S. M., Wolfgang, M. J., Clemens, T. L., & Riddle, R. C. (2015) · Molecular and Cellular Biology · doi:10.1128/mcb.01343-14 · Cited by 168
Jing, H., Liao, L., An, Y., Su, X., Liu, S., Shuai, Y., Zhang, X., & Jin, Y. J. (2015) · Molecular Therapy · doi:10.1038/mt.2015.152 · Cited by 165
Liu, W., Zhou, L., Zhou, C., Zhang, S., Jing, J., Xie, L., Sun, N., Duan, X., Jing, W., Liang, X., et al. (2016) · Nature Communications · doi:10.1038/ncomms12794 · Cited by 159
Bone marrow fat accumulation accelerated by high fat diet is suppressed by exercise
Styner, M., Thompson, W. R., Galior, K. D., Uzer, G., Wu, X., Kadari, S., Case, N. D., Xie, Z., Sen, B., Romaine, A., et al. (2014) · Bone · doi:10.1016/j.bone.2014.03.044 · Cited by 155
Increased glutamine catabolism mediates bone anabolism in response to WNT signaling
Karner, C. M., Esen, E., Okunade, A. L., Patterson, B. W., & Long, F. (2014) · Journal of Clinical Investigation · doi:10.1172/jci78470 · Cited by 154
Multipotent stromal cells: One name, multiple identities
Soliman, H., Theret, M., Scott, W., Hill, L., Underhill, T. M., Hinz, B., & Rossi, F. M. V. (2021) · Cell Stem Cell · doi:10.1016/j.stem.2021.09.001 · Cited by 147
The diverse origin of bone-forming osteoblasts
Mizoguchi, T., & Ono, N. (2020) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.4410 · Cited by 151
Self-citationWNT7B Promotes Bone Formation in part through mTORC1
Chen, J., Tu, X., Esen, E., Joeng, K. S., Lin, C., Arbeit, J. M., Rüegg, M. A., Hall, M. N., Ma, L., & Long, F. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004145 · Cited by 141
Maupin, K. A., Droscha, C. J., & Williams, B. O. (2013) · Bone Research · doi:10.4248/br201301004 · Cited by 133
β-catenin promotes bone formation and suppresses bone resorption in postnatal growing mice
Chen, J., & Long, F. (2012) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.1834 · Cited by 132
Parathyroid hormone regulates fates of murine osteoblast precursors in vivo
Balani, D., Ono, N., & Kronenberg, H. M. (2017) · Journal of Clinical Investigation · doi:10.1172/jci91699 · Cited by 129
Self-citationChen, Z., Xue, J., Shen, T., MU, S., & Fu, Q. (2015) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2015.2432 · Cited by 130
Signaling network regulating osteogenesis in mesenchymal stem cells
Thomas, S., & Jaganathan, B. G. (2021) · Journal of Cell Communication and Signaling · doi:10.1007/s12079-021-00635-1 · Cited by 134
Targeting sphingosine-1-phosphate lyase as an anabolic therapy for bone loss
Weske, S., Vaidya, M., Reese, A., Lipinski, K. V. W., Keul, P., Bayer, J. K., Fischer, J. W., Flögel, U., Nelsen, J., Epple, M., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0005-y · Cited by 121
Extracellular matrix dynamics during mesenchymal stem cells differentiation
Assis-Ribas, T., Forni, M. F., Winnischofer, S. M. B., Sogayar, M. C., & Trombetta-Lima, M. (2018) · Developmental Biology · doi:10.1016/j.ydbio.2018.03.002 · Cited by 116
Yu, M. S., Qin, K. H., Fan, J., Zhao, G., Zhao, P., Zeng, W., Chen, C., Wang, A., Wang, Y., Zhong, J., et al. (2023) · Genes & Diseases · doi:10.1016/j.gendis.2023.04.042 · Cited by 125
Li, L., Rao, S., Cheng, Y., Zhuo, X., Deng, C., Xu, N., Zhang, H., & Yang, L. (2019) · MicrobiologyOpen · doi:10.1002/mbo3.810 · Cited by 109
“Osteoblast function was regulated by Wnt/β‐catenin signaling in almost all aspects from infancy to matu‐ rity (Hill, Später, Taketo, Birchmeier, & Hartmann, 2005; Song et al., 2012).”
BackgroundThe Role of Bone Marrow Fat in Skeletal Health: Usefulness and Perspectives for Clinicians
Paccou, J., Hardouin, P., Cotten, A., Penel, G., & Cortet, B. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2015-2338 · Cited by 107
Zhang, R., Yang, G., Wu, X., Xie, J., Yang, X. Y., & Li, T. (2013) · International Journal of Biological Sciences · doi:10.7150/ijbs.5476 · Cited by 107
Huang, L., Wang, X., Cao, H., Li, L., Chow, D. H. K., Tian, L., Wu, H., Zhang, J., Wang, N., Zheng, L., et al. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.07.046 · Cited by 101
Bone Marrow Adipose Tissue and Skeletal Health
Muruganandan, S., Govindarajan, R., & Sinal, C. J. (2018) · Current Osteoporosis Reports · doi:10.1007/s11914-018-0451-y · Cited by 95
mTOR inhibition rescues osteopenia in mice with systemic sclerosis
Chen, C., Akiyama, K., Wang, D., Xu, X., Li, B., Moshaverinia, A., Brombacher, F., Sun, L., & Shi, S. (2014) · The Journal of Experimental Medicine · doi:10.1084/jem.20140643 · Cited by 89
Li, Y., Lu, L., Xie, Y., Chen, X., Tian, L., Liang, Y., Li, H., Zhang, J., Liu, Y., & Yu, X. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.622950 · Cited by 87
Understanding and managing corticosteroid-induced osteoporosis
Kobza, A. O., Herman, D., Papaioannou, A., Lau, A. N., & Adachi, J. D. (2021) · Open Access Rheumatology Research and Reviews · doi:10.2147/oarrr.s282606 · Cited by 84
Guo, Y., Wang, M., Zhang, S., Wu, Y., Zhou, C., Zheng, R., Shao, B., Wang, Y., Xie, L., Liu, W., et al. (2018) · The EMBO Journal · doi:10.15252/embj.201899398 · Cited by 84
The Wnt pathway: An important control mechanism in bone's response to mechanical loading
Choi, R. B., & Robling, A. G. (2021) · Bone · doi:10.1016/j.bone.2021.116087 · Cited by 86
Bone Cell Senescence: Mechanisms and Perspectives
Marie, P. J. (2014) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2190 · Cited by 87
Stem and progenitor cells in skeletal development
Ono, N., Balani, D., & Kronenberg, H. M. (2019) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2019.01.006 · Cited by 80
Self-citationCarbonare, L. D., Cominacini, M., Trabetti, E., Bombieri, C., Pessoa, J., Romanelli, M. G., & Valenti, M. T. (2025) · Stem Cell Research & Therapy · doi:10.1186/s13287-025-04288-4 · Cited by 91
Osterix-Cre Transgene Causes Craniofacial Bone Development Defect
Wang, L., Mishina, Y. M., & Liu, F. (2014) · Calcified Tissue International · doi:10.1007/s00223-014-9945-5 · Cited by 80
Houben, A., Kostanova‐Poliakova, D., Weißenböck, M., Graf, J., Teufel, S., von der Mark, K., & Hartmann, C. (2016) · Development · doi:10.1242/dev.137489 · Cited by 83
Insights into skeletal stem cells
Li, Q., Xu, R., Lei, K., & Yuan, Q. (2022) · Bone Research · doi:10.1038/s41413-022-00235-8 · Cited by 79
Skeletal stem and progenitor cells in bone physiology, ageing and disease
Melis, S., Trompet, D., Chagin, A. S., & Maes, C. (2024) · Nature Reviews Endocrinology · doi:10.1038/s41574-024-01039-y · Cited by 88
FAK Promotes Osteoblast Progenitor Cell Proliferation and Differentiation by Enhancing Wnt Signaling
Sun, C., Yuan, H., Wang, L., Wei, X., Williams, L., Krebsbach, P. H., Guan, J., & Liu, F. (2016) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2908 · Cited by 79
Niches for Skeletal Stem Cells of Mesenchymal Origin
Kurenkova, A. D., Medvedeva, E. V., Newton, P. T., & Chagin, A. S. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00592 · Cited by 74
Sclerostin Antibody Treatment Improves Fracture Outcomes in a Type I Diabetic Mouse Model
Yee, C. S., Xie, L.-Q., Hatsell, S., Hum, N., Murugesh, D., Economides, A., Loots, G., & Collette, N. (2015) · Bone · doi:10.1016/j.bone.2015.04.048 · Cited by 74
Dietary nutraceuticals as backbone for bone health
Pandey, M. K., Gupta, S. C., Karelia, D. N., Gilhooley, P. J., Shakibaei, M., & Aggarwal, B. B. (2018) · Biotechnology Advances · doi:10.1016/j.biotechadv.2018.03.014 · Cited by 71
Increased glycolysis mediates Wnt7b‐induced bone formation
Chen, H., Ji, X., Lee, W., Shi, Y., Li, B., Abel, E. D., Jiang, D., Huang, W., & Long, F. (2019) · The FASEB Journal · doi:10.1096/fj.201900201rr · Cited by 72
Wnt-signaling in skeletal development
Teufel, S., & Hartmann, C. (2018) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2018.11.010 · Cited by 70
miR-142-3p promotes osteoblast differentiation by modulating Wnt signaling
Hu, W., Ye, Y., Zhang, W., Jiang, W., Chen, A., & Guo, F. (2012) · Molecular Medicine Reports · doi:10.3892/mmr.2012.1207 · Cited by 70
Ko, J., Chuang, P.-C., Ke, H.-J., Chen, Y., Sun, Y., & Wang, F. (2015) · Bone · doi:10.1016/j.bone.2015.06.022 · Cited by 68
McGee‐Lawrence, M. E., Shull, L. C., Schulze, R. J., Pierce, J. L., McNiven, M. A., Farr, J. N., Khosla, S., Oursler, M. J., & Westendorf, J. J. (2015) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2602 · Cited by 70
Hang, K., Ye, C., Xu, J., Chen, E., Wang, C., Zhang, W., Ni, L., Kuang, Z., Li, Y., Xue, D., et al. (2019) · Stem Cell Research & Therapy · doi:10.1186/s13287-019-1286-x · Cited by 68
Wu, M., Wang, Y., Shao, J., Wang, J., Chen, W., & Li, Y. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1619294114 · Cited by 65
From Stem Cells to Bone-Forming Cells
Donsante, S., Palmisano, B., Serafini, M., Robey, P. G., Corsi, A., & Riminucci, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22083989 · Cited by 66
Exercise Regulation of Marrow Fat in the Setting of PPARγ Agonist Treatment in Female C57BL/6 Mice
Styner, M., Pagnotti, G. M., Galior, K., Wu, X., Thompson, W. R., Uzer, G., Sen, B., Xie, Z., Horowitz, M. C., Styner, M. A., et al. (2015) · Endocrinology · doi:10.1210/en.2015-1213 · Cited by 60
Ko, J., Chuang, P.-C., Chen, M.-W., Ke, H.-C., Wu, S.-L., Chang, Y., Chen, Y., & Wang, F. (2013) · Bone · doi:10.1016/j.bone.2013.09.019 · Cited by 62
Muruganandan, S., Govindarajan, R., McMullen, N. M., & Sinal, C. J. (2016) · Stem Cells · doi:10.1002/stem.2520 · Cited by 62
Tan, Z., Kong, M., Wen, S., Tsang, K. Y., Niu, B., Hartmann, C., Chan, D., Hui, C.-C., & Cheah, K. S. E. (2020) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.4132 · Cited by 52
Liu, Y., Kou, X., Chen, C., Yu, W., Su, Y., Kim, Y., Shi, S., & Liu, Y. (2016) · Stem Cells · doi:10.1002/stem.2392 · Cited by 61
Tratwal, J., Rojas‐Sutterlin, S., Bataclan, C., Blum, S., & Naveiras, O. (2021) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2021.101564 · Cited by 62
The regulation of osteoclast differentiation by Wnt signals
Kobayashi, Y., Uehara, S., Koide, M., & Takahashi, N. (2015) · BoneKEy Reports · doi:10.1038/bonekey.2015.82 · Cited by 63
Signaling pathways effecting crosstalk between cartilage and adjacent tissues
Maes, C. (2016) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2016.05.007 · Cited by 61
Park, J., Hanawa, T., & Chung, J. (2019) · International Journal of Nanomedicine · doi:10.2147/ijn.s214363 · Cited by 60
Oncogenic role of SFRP2 in p53-mutant osteosarcoma development via autocrine and paracrine mechanism
Kim, H., Yoo, S., Zhou, R., Xu, A., Bernitz, J. M., Yuan, Y., Gomes, A., Daniel, M. G., Su, J., Demicco, E. G., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1814044115 · Cited by 59
Similarities Between Disuse and Age-Induced Bone Loss
Buettmann, E. G., Goldscheitter, G., Hoppock, G. A., Friedman, M. A., Suva, L. J., & Donahue, H. J. (2020) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.4643 · Cited by 61
Zhang, W., Xue, D., Yin, H., Wang, S., Li, C., Chen, E., Hu, D., Tao, Y., Yu, J., Zheng, Q., et al. (2016) · Scientific Reports · doi:10.1038/srep27622 · Cited by 54
Wnt/β-catenin signaling in osteoblasts regulates global energy metabolism
Yao, Q., Yu, C., Zhang, X., Zhang, K., Guo, J., & Song, L. (2017) · Bone · doi:10.1016/j.bone.2017.01.028 · Cited by 55
Self-citationChoi, H. K., Yuan, H., Fang, F., Wei, X., Liu, L., Li, Q., Guan, J., & Liu, F. (2018) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.3530 · Cited by 54
Kruppel-like factor 4 attenuates osteoblast formation, function, and cross talk with osteoclasts
Kim, J. H., Kim, K., Youn, B. U., Lee, J., Kim, I., Shin, H., Akiyama, H., Choi, Y., & Kim, N. (2014) · The Journal of Cell Biology · doi:10.1083/jcb.201308102 · Cited by 53
Yang, S., Sun, Y., Капилевич, Л. В., Zhang, X., & Huang, Y. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1249418 · Cited by 52
Surface Engineering of Nanostructured Titanium Implants with Bioactive Ions
Kim, H.-S., Kim, Y.-J., Jang, J., & Park, J. (2016) · Journal of Dental Research · doi:10.1177/0022034516638026 · Cited by 52
Mesenchymal Progenitors and the Osteoblast Lineage in Bone Marrow Hematopoietic Niches
Panaroni, C., Tzeng, Y.-S., Saeed, H., & Wu, J. Y. (2014) · Current Osteoporosis Reports · doi:10.1007/s11914-014-0190-7 · Cited by 54
Low bone turnover and reduced angiogenesis in streptozotocin-induced osteoporotic mice
Peng, J., Kang, H., Chen, H., Zhao, P., Gao, Q., Jin, Q., Lei, G., Min, J., Zhou, Q., Chen, B., et al. (2016) · Connective Tissue Research · doi:10.3109/03008207.2016.1171858 · Cited by 51
AFF1 and AFF4 differentially regulate the osteogenic differentiation of human MSCs
Zhou, C., Xiong, Q., Zhu, X., Du, W., Deng, P., Li, X., Jiang, Y., Zou, S., Wang, C., & Yuan, Q. (2017) · Bone Research · doi:10.1038/boneres.2017.44 · Cited by 51
Nie, F., Zhang, W., Cui, Q., Fu, Y., Li, H., & Zhang, J. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118143 · Cited by 51
Yang, M., Arai, A., Udagawa, N., Hiraga, T., Zhao, L., Ito, S., Komori, T., Moriishi, T., Matsuo, K., Shimoda, K., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-05401-1 · Cited by 50
Louvet, L., Leterme, D., Delplace, S., Miellot, F., Marchandise, P., Gauthier, V., Hardouin, P., Chauveau, C., & Mhenni, O. G. (2020) · Bone · doi:10.1016/j.bone.2020.115361 · Cited by 51
Osteoblast as a target of anti-osteoporotic treatment
Corrado, A., Sanpaolo, E. R., Bello, S. D., & Cantatore, F. P. (2017) · Postgraduate Medicine · doi:10.1080/00325481.2017.1362312 · Cited by 51
Sclerostin expression in the subchondral bone of patients with knee osteoarthritis
Wu, L., Guo, H., Sun, K., Zhao, X. S., Ma, T., & Jin, Q. (2016) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2016.2741 · Cited by 49
Amirhosseini, M., Madsen, R. V., Escott, K. J., Bostrom, M. P., Ross, F. P., & Fahlgren, A. (2017) · Journal of Cellular Physiology · doi:10.1002/jcp.26111 · Cited by 48
Wnt co-receptors Lrp5 and Lrp6 differentially mediate Wnt3a signaling in osteoblasts
Sebastian, A., Hum, N. R., Murugesh, D. K., Hatsell, S. J., Economides, A. N., & Loots, G. G. (2017) · PLoS ONE · doi:10.1371/journal.pone.0188264 · Cited by 52
Rendina-Ruedy, E., & Rosen, C. (2016) · Endocrinology and metabolism clinics of North America (Print) · doi:10.1016/j.ecl.2016.09.004 · Cited by 43
Lin, W., Xu, L., Pan, Q., Lin, S., Lu, F., Wang, B., Chen, S., Li, Y., Wang, H., Li, Y., et al. (2019) · The FASEB Journal · doi:10.1096/fj.201900082rr · Cited by 45
Choi, S., & Park, J. (2018) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.36490 · Cited by 45
Sinha, P. S., Aarnisalo, P., Chubb, R., Poulton, I. J., Guo, J., Nachtrab, G. T., Kimura, T., Swami, S., Saeed, H., Chen, M., et al. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.679753 · Cited by 44
Self-citationSinha, P. S., Aarnisalo, P., Chubb, R., Ono, N., Fulzele, K. S., Selig, M. K., Saeed, H., Chen, M., Weinstein, L. S., Pajevic, P. D., et al. (2014) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2270 · Cited by 43
Self-citationInteractions Between B Lymphocytes and the Osteoblast Lineage in Bone Marrow
Panaroni, C., & Wu, J. Y. (2013) · Calcified Tissue International · doi:10.1007/s00223-013-9753-3 · Cited by 41
Tzeng, Y.-S., Chung, N., Chen, Y.-R., Huang, H., Chuang, W., & Lai, D. (2018) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.3340 · Cited by 35
microRNA‐146a controls age‐related bone loss
Saferding, V., Hofmann, M., Brunner, J. S., Niederreiter, B., Timmen, M., Magilnick, N., Hayer, S., Heller, G., Steiner, G. E., Stange, R., et al. (2020) · Aging Cell · doi:10.1111/acel.13244 · Cited by 38
Almeida, M., Kim, H., Li, H., Zhou, D., Thostenson, J., Porter, R. M., Ambrogini, E., Manolagas, S. C., & Jilka, R. L. (2020) · Aging Cell · doi:10.1111/acel.13247 · Cited by 35
Pathophysiological role of enhanced bone marrow adipogenesis in diabetic complications
Piccinin, M. A., & Khan, Z. A. (2014) · Adipocyte · doi:10.4161/adip.32215 · Cited by 39
Huang, J., & Chen, L. (2017) · genesis · doi:10.1002/dvg.23040 · Cited by 34
Shu, B., Zhao, Y., Zhao, S., Pan, H., Xie, R., Yi, D., Lu, K., Yang, J., Xue, C., Huang, J. H., et al. (2020) · Bone Research · doi:10.1038/s41413-020-0104-5 · Cited by 31
Wu, X., Li, J., Zhang, H., Wang, H., Yin, G., & Miao, D. (2017) · PubMed Central · Cited by 31
Matsushita, Y., Chu, A. K. Y., Ono, W., Welch, J. D., & Ono, N. (2020) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.4282 · Cited by 29
Self-citation
Metadata
- Authors
- Song, L., Liu, M., Ono, N., Bringhurst, F. R., Kronenberg, H. M., & Guo, J.
- Affiliations
- Harvard University (US)
- Corresponding author
- Guo, Jun
- Venue
- Journal of Bone and Mineral Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2012-06-22
- Volume
- 27
- Issue
- 11
- Pages
- 2344-2358
- ISSN
- 0884-0431 (ISSN-L)
- 1523-4681
- PMC
- PMC3474875
- OpenAlex
- W2045808113
- Cited by
- 234
- References
- 41
- Citations by year
- 2026: 3 · 2025: 14 · 2024: 15 · 2023: 13 · 2022: 15 · 2021: 17 · 2020: 23 · 2019: 21 · 2018: 23 · 2017: 20 · 2016: 20 · 2015: 16 · 2014: 17 · 2013: 12 · 2012: 4
- FWCI
- 6.29
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- Journal of Bone and Mineral Research (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (P01DK11794, P01DK011794)
- National Institute of Dental and Craniofacial Research (K99DE022564)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Keywords
- Wnt/β-catenin signaling, preosteoblasts, bone marrow adiposity, Osterix, osteogenic differentiation, adipogenesis, osteopenia, lineage tracing
- MeSH terms
- Sp7 Transcription Factor, Animals, Bone Marrow Cells, Cell Separation, Cells, Cultured, Gene Expression Regulation, Mice, Inbred C57BL, Osteoblasts, Osteogenesis, Transcription Factors, Transcription, Genetic, Gene Deletion, Adipocytes, Mice, Knockout, Cell Lineage, Integrases, Green Fluorescent Proteins, Adiposity, Adipogenesis, beta Catenin, Mice, Wnt Signaling Pathway
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
