Wnt signaling and cellular metabolism in osteoblasts

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

Vander Heiden, M. G., Cantley, L. C., & Thompson, C. B. (2009) · Science · doi:10.1126/science.1160809 · Cited by 16,197 · see citing works

Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1

Tahiliani, M., Koh, K. P., Shen, Y., Pastor, W. A., Bandukwala, H., Brudno, Y., Agarwal, S., Iyer, L. M., Liu, D. R., Aravind, L., et al. (2009) · Science · doi:10.1126/science.1170116 · Cited by 5,836 · see citing works

The Wnt Signaling Pathway in Development and Disease

Logan, C. Y., & Nusse, R. (2004) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.20.010403.113126 · Cited by 5,325 · see citing works

Osf2/Cbfa1: A Transcriptional Activator of Osteoblast Differentiation

Ducy, P., Zhang, R., Geoffroy, V., Ridall, A. L., & Karsenty, G. (1997) · Cell · doi:10.1016/s0092-8674(00)80257-3 · Cited by 4,246 · see citing works

Targeted Disruption of Results in a Complete Lack of Bone Formation owing to Maturational Arrest of Osteoblasts

Komori, T., Yagi, H., Nomura, S., Yamaguchi, A., Sasaki, K., Deguchi, K., Shimizu, Y., Bronson, R. T., Gao, Y.-H., Inada, M., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80258-5 · Cited by 4,244 · see citing works

The Novel Zinc Finger-Containing Transcription Factor Osterix Is Required for Osteoblast Differentiation and Bone Formation

Nakashima, K., Zhou, X., Kunkel, G., Zhang, Z., Deng, J. M., Behringer, R. R., & de Crombrugghe, B. (2002) · Cell · doi:10.1016/s0092-8674(01)00622-5 · Cited by 3,608 · see citing works

Regulated Translation Initiation Controls Stress-Induced Gene Expression in Mammalian Cells

Harding, H. P., Novoa, I., Zhang, Y., Zeng, H., Wek, R. C., Schapira, M., & Ron, D. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)00108-8 · Cited by 3,281 · see citing works

Functional interaction of β-catenin with the transcription factor LEF-1

Behrens, J., von Kries, J. P., Kühl, M., Bruhn, L., Wedlich, D., Grosschedl, R., & Birchmeier, W. (1996) · Nature · doi:10.1038/382638a0 · Cited by 2,912 · see citing works

Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis

DeBerardinis, R. J., Mancuso, A., Daikhin, E., Nissim, I., Yudkoff, M., Wehrli, S., & Thompson, C. B. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709747104 · Cited by 2,622 · see citing works

ATP-citrate lyase links cellular metabolism to histone acetylation

Wellen, K. E., Hatzivassiliou, G., Sachdeva, U. M., Bui, T. V., Cross, J. R., & Thompson, C. B. (2009) · Science · doi:10.1126/science.1164097 · Cited by 2,298 · see citing works

LDL Receptor-Related Protein 5 (LRP5) Affects Bone Accrual and Eye Development

Gong, Y., Slee, R. B., Fukai, N., Rawadi, G., Roman-Roman, S., Reginato, A. M., Wang, H., Cundy, T., Glorieux, F. H., Lev, D., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00571-2 · Cited by 2,235 · see citing works

Histone demethylation by a family of JmjC domain-containing proteins

Tsukada, Y.-I., Fang, J., Erdjument‐Bromage, H., Warren, M., Borchers, C. H., Tempst, P., & Zhang, Y. (2005) · Nature · doi:10.1038/nature04433 · Cited by 2,171 · see citing works

Bidirectional Transport of Amino Acids Regulates mTOR and Autophagy

Nicklin, P., Bergman, P., Zhang, B., Triantafellow, E., Wang, H., Nyfeler, B., Yang, H., Hild, M., Kung, C., Wilson, C., et al. (2009) · Cell · doi:10.1016/j.cell.2008.11.044 · Cited by 1,798 · see citing works

ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death

Han, J., Back, S. H., Hur, J., Lin, Y.-H., Gildersleeve, R., Shan, J., Yuan, C. L., Krokowski, D., Wang, S., Hatzoglou, M., et al. (2013) · Nature Cell Biology · doi:10.1038/ncb2738 · Cited by 1,691 · see citing works

Wnt/β-Catenin/Tcf Signaling Induces the Transcription of Axin2, a Negative Regulator of the Signaling Pathway

Jho, E., Zhang, T., Domon–Dell, C., Joo, C., Freund, J., & Costantini, F. D. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.4.1172-1183.2002 · Cited by 1,683 · see citing works

mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H ⁺ -ATPase

Zoncu, R., Bar-Peled, L., Efeyan, A., Wang, S., Sancak, Y., & Sabatini, D. M. (2011) · Science · doi:10.1126/science.1207056 · Cited by 1,673 · see citing works

Wnt/β-Catenin Signaling in Mesenchymal Progenitors Controls Osteoblast and Chondrocyte Differentiation during Vertebrate Skeletogenesis

Day, T. F., Guo, X., Garrett-Beal, L., & Yang, Y. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.03.016 · Cited by 1,616 · see citing works

High Bone Density Due to a Mutation in LDL-Receptor–Related Protein 5

Boyden, L. M., Mao, J., Belsky, J., Mitzner, L., Farhi, A., Mitnick, M. A., Wu, D., Insogna, K., & Lifton, R. P. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa013444 · Cited by 1,591 · see citing works

Canonical wnt signaling in differentiated osteoblasts controls osteoclast differentiation.

Glass, D. A., Bialek, P., Ahn, J. D., Starbuck, M., Patel, M. S., Clevers, H., Taketo, M. M., Long, F., McMahon, A. P., Lang, R. A., et al. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.02.017 · Cited by 1,558 · see citing works

TSC2 Integrates Wnt and Energy Signals via a Coordinated Phosphorylation by AMPK and GSK3 to Regulate Cell Growth

Inoki, K., Ouyang, H., Zhu, T., Lindvall, C., Wang, Y., Zhang, X., Yang, Q., Bennett, C., Harada, Y., Stankunas, K., et al. (2006) · Cell · doi:10.1016/j.cell.2006.06.055 · Cited by 1,377 · see citing works

A Mutation in the LDL Receptor–Related Protein 5 Gene Results in the Autosomal Dominant High–Bone-Mass Trait

Little, R. D., Folz, C., Manning, S. P., Swain, P. M., Zhao, S.-C., Eustace, B., Lappe, M. M., Spitzer, L., Zweier, S., Braunschweiger, K., et al. (2002) · The American Journal of Human Genetics · doi:10.1086/338450 · Cited by 1,282 · see citing works

Purified Wnt5a Protein Activates or Inhibits β-Catenin–TCF Signaling Depending on Receptor Context

Mikels, A. J., & Nusse, R. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0040115 · Cited by 1,244 · see citing works

Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture

Estrada, K., Styrkársdóttir, U., Εvangelou, Ε., Hsu, Y., Duncan, E. L., Ntzani, E., Oei, L., Albagha, O., Amin, N., Kemp, J. P., et al. (2012) · Nature Genetics · doi:10.1038/ng.2249 · Cited by 1,177 · see citing works

Canonical WNT Signaling Promotes Osteogenesis by Directly Stimulating Runx2 Gene Expression

Gaur, T., Lengner, C. J., Hovhannisyan, H., Bhat, R. A., Bodine, P. V. N., Komm, B. S., Javed, A., van Wijnen, A. J., Stein, J. L., Stein, G. S., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m500608200 · Cited by 1,170 · see citing works

Building strong bones: molecular regulation of the osteoblast lineage

Long, F. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3254 · Cited by 1,149 · see citing works

Mechanisms of diabetes mellitus-induced bone fragility

On behalf of the IOF Bone and Diabetes Working Group, Napoli, N., Chandran, M., Pierroz, D. D., Abrahamsen, B., Schwartz, A. V., & Ferrari, S. L. (2017) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.153 · Cited by 1,107 · see citing works

Facilitative glucose transporters

Mueckler, M. M. (1994) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1994.tb18550.x · Cited by 1,092 · see citing works

Canonical Wnt/β-Catenin Signaling Prevents Osteoblasts from Differentiating into Chondrocytes

Hill, T. P., Später, D., Taketo, M. M., Birchmeier, W., & Hartmann, C. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.02.013 · Cited by 1,086 · see citing works

<i>Cbfa1</i>-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor

Kato, M., Patel, M. S., Levasseur, R., Lobov, I., Chang, B. H.-J., Glass, D. A., Hartmann, C., Li, L., Hwang, T.-H., Brayton, C. F., et al. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200201089 · Cited by 1,086 · see citing works

LDL receptor-related proteins 5 and 6 in Wnt/β-catenin signaling:Arrows point the way

He, X., Semenov, M., Tamai, K., & Zeng, X. (2004) · Development · doi:10.1242/dev.01117 · Cited by 1,044 · see citing works

LDL-receptor-related protein 6 is a receptor for Dickkopf proteins

Mao, B., Wu, W., Li, Y., Hoppe, D., Stannek, P., Glinka, A., & Niehrs, C. (2001) · Nature · doi:10.1038/35077108 · Cited by 1,042 · see citing works

Distinct roles for Hedgehog and canonical Wnt signaling in specification,differentiation and maintenance of osteoblast progenitors

Rodda, S. J., & McMahon, A. P. (2006) · Development · doi:10.1242/dev.02480 · Cited by 1,011 · see citing works

Bone Dysplasia Sclerosteosis Results from Loss of the SOST Gene Product, a Novel Cystine Knot–Containing Protein

Brunkow, M. E., Gardner, J. C., Van Ness, J., Paeper, B. W., Kovacevich, B. R., Proll, S., Skonier, J. E., Zhao, L., Sabo, P. J., Fu, Y.-H., et al. (2001) · The American Journal of Human Genetics · doi:10.1086/318811 · Cited by 1,011 · see citing works

Targeted Deletion of the Sclerostin Gene in Mice Results in Increased Bone Formation and Bone Strength

Li, X., Ominsky, M. S., Niu, Q., Sun, N., Daugherty, B., D’Agostin, D. M., Kurahara, C., Gao, Y., Cao, J., Gong, J., et al. (2008) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.080216 · Cited by 938 · see citing works

A hierarchy of ATP-consuming processes in mammalian cells

Buttgereit, F., & Brand, M. D. (1995) · Biochemical Journal · doi:10.1042/bj3120163 · Cited by 929 · see citing works

Sclerostin Is an Osteocyte-expressed Negative Regulator of Bone Formation, But Not a Classical BMP Antagonist

van Bezooijen, R. L., Roelen, B. A. J., Visser, A., van der Wee-Pals, L. J. A., de Wilt, E., Karperien, M., Hamersma, H. A., Papapoulos, S. E., ten Dijke, P., & Löwik, C. W. G. M. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20031454 · Cited by 893 · see citing works

Regulation of osteoblastogenesis and bone mass by Wnt10b

Bennett, C. N., Longo, K. A., Hahn, W. S., Suva, L. J., Lane, T. F., Hankenson, K. D., & MacDougald, O. A. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408742102 · Cited by 882 · see citing works

ATF4 Is a Substrate of RSK2 and an Essential Regulator of Osteoblast Biology

Yang, X., Matsuda, K., Bialek, P., Jacquot, S., Masuoka, H. C., Schinke, T., Li, L., Brancorsini, S., Sassone‐Corsi, P., Townes, T. M., et al. (2004) · Cell · doi:10.1016/s0092-8674(04)00344-7 · Cited by 822 · see citing works

SOST Is a Ligand for LRP5/LRP6 and a Wnt Signaling Inhibitor

Semënov, M., Tamai, K., & He, X. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m504308200 · Cited by 771 · see citing works

Inversin, the gene product mutated in nephronophthisis type II, functions as a molecular switch between Wnt signaling pathways

Simons, M., Gloy, J., Ganner, A., Bullerkotte, A., Bashkurov, M., Krönig, C., Schermer, B., Benzing, T., Cabello, O. A., Jenny, A., et al. (2005) · Nature Genetics · doi:10.1038/ng1552 · Cited by 767 · see citing works

Differential regulation of mTORC1 by leucine and glutamine

Jewell, J. L., Kim, Y. C., Russell, R. C., Yu, F.-X., Park, H. W., Plouffe, S. W., Tagliabracci, V. S., & Guan, K.-L. (2015) · Science · doi:10.1126/science.1259472 · Cited by 757 · see citing works

Frzb-1 Is a Secreted Antagonist of Wnt Signaling Expressed in the Spemann Organizer

Leyns, L., Bouwmeester, T., Kim, S., Piccolo, S., & Robertis, E. M. D. (1997) · Cell · doi:10.1016/s0092-8674(00)81921-2 · Cited by 736 · see citing works

Glutaminolysis Activates Rag-mTORC1 Signaling

Durán, R. V., Oppliger, W., Robitaille, A. M., Heiserich, L., Skendaj, R., Gottlieb, E., & Hall, M. N. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.05.043 · Cited by 723 · see citing works

Wnt Signaling Requires Sequestration of Glycogen Synthase Kinase 3 inside Multivesicular Endosomes

Taelman, V. F., Dobrowolski, R., Plouhinec, J.-L., Fuentealba, L. C., Vorwald, P. P., Gumper, I., Sabatini, D. D., & Robertis, E. M. D. (2010) · Cell · doi:10.1016/j.cell.2010.11.034 · Cited by 715 · see citing works

Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies

Rivadeneira, F., Estrada, K., Zillikens, M. C., van Meurs, J. B. J., Pols, H. A. P., Uitterlinden, A. G., Amin, N., Aulchenko, Y. S., Albert Hofman, D., van Duijn, C. M., et al. (2009) · Nature Genetics · doi:10.1038/ng.446 · Cited by 706 · see citing works

Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6

Semënov, M. V., Tamai, K., Brott, B. K., Kühl, M., Sokol, S. Y., & He, X. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00290-1 · Cited by 700 · see citing works

Identification of a 52 kb deletion downstream of the <i>SOST</i> gene in patients with van Buchem disease

Balemans, W., Patel, N., Ebeling, M., Van Hul, E., Wuyts, W., Lacza, C., Dioszegi, M., Dikkers, F. G., Hildering, P., Willems, P. J., et al. (2002) · Journal of Medical Genetics · doi:10.1136/jmg.39.2.91 · Cited by 698 · see citing works

Sequential roles of Hedgehog and Wnt signaling in osteoblast development

Hu, H., Hilton, M. J., Tu, X., Yu, K., Ornitz, D. M., & Long, F. (2005) · Development · doi:10.1242/dev.01564 · Cited by 682 · see citing works

Bone mineral density, osteoporosis, and osteoporotic fractures: a genome-wide association study

Richards, J. B., Rivadeneira, F., Inouye, M., Pastinen, T., Soranzo, N., Wilson, S. G., Andrew, T., Falchi, M., Gwilliam, R., Ahmadi, K. R., et al. (2008) · The Lancet · doi:10.1016/s0140-6736(08)60599-1 · Cited by 680 · see citing works

Genetic Control of Bone Formation

Karsenty, G., Kronenberg, H. M., & Settembre, C. (2009) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.042308.113308 · Cited by 667 · see citing works

Matrix IGF-1 maintains bone mass by activation of mTOR in mesenchymal stem cells

Xian, L., Wu, X., Pang, L., Lou, M., Rosen, C. J., Qiu, T., Crane, J., Frassica, F., Zhang, L., Rodriguez, J. P., et al. (2012) · Nature Medicine · doi:10.1038/nm.2793 · Cited by 631 · see citing works

β-Catenin destruction complex: insights and questions from a structural perspective

Kimelman, D., & Xu, W. (2006) · Oncogene · doi:10.1038/sj.onc.1210055 · Cited by 628 · cited 1× · see citing works

The PERK Eukaryotic Initiation Factor 2α Kinase Is Required for the Development of the Skeletal System, Postnatal Growth, and the Function and Viability of the Pancreas

Zhang, P., McGrath, B. C., Li, S., Frank, A. T., Zambito, F., Reinert, J., GANNON, M. A., Ma, K., McNaughton, K., & Cavener, D. R. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.11.3864-3874.2002 · Cited by 604 · see citing works

Coactivation of Rac and Rho by Wnt/Frizzled signaling is required for vertebrate gastrulation

Habas, R., Dawid, I. B., & He, X. (2003) · Genes &amp; Development · doi:10.1101/gad.1022203 · Cited by 603 · see citing works

Essential role of β-catenin in postnatal bone acquisition.

Holmen, S. L., Zylstra, C. R., Mukherjee, A., Sigler, R. E., Faugere, M.-C., Bouxsein, M. L., Deng, L., Clemens, T. L., & Williams, B. O. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m501900200 · Cited by 584 · see citing works

A family of secreted proteins contains homology to the cysteine-rich ligand-binding domain of frizzled receptors

Rattner, A., Hsieh, J.-C., Smallwood, P. M., Gilbert, D. J., Copeland, N. G., Jenkins, N. A., & Nathans, J. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.7.2859 · Cited by 574 · see citing works

Missense mutations abolishing DNA binding of the osteoblast-specific transcription factor OSF2/CBFA1 in cleidocranial dysplasia

Lee, B., Thirunavukkarasu, K., Zhou, L., Pastore, L., Baldini, A., Hecht, J. T., Geoffrey, V., Ducy, P. F., & Karsenty, G. (1997) · Nature Genetics · doi:10.1038/ng0797-307 · Cited by 567 · see citing works

Deletion of a Single Allele of the Dkk1 Gene Leads to an Increase in Bone Formation and Bone Mass

Morvan, F., Boulukos, K. E., Clément-Lacroix, P., Roman‐Roman, S., Suc-Royer, I., Vayssière, B., Ammann, P., Martin, P., Pinho, S., Pognonec, P., et al. (2006) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.060311 · Cited by 521 · see citing works

Methionine Metabolism Regulates Maintenance and Differentiation of Human Pluripotent Stem Cells

Shiraki, N., Shiraki, Y., Tsuyama, T., Obata, F., Miura, M., Nagae, G., Aburatani, H., Kume, K., Endo, F., & Kume, S. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.03.017 · Cited by 514 · see citing works

High Bone Mass in Mice Expressing a Mutant LRP5 Gene

Babij, P., Zhao, W., Small, C. G., Kharode, Y. P., Yaworsky, P. J., Bouxsein, M., Reddy, P. S., Bodine, P. V. N., Robinson, J. A., Bhat, B. M., et al. (2003) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2003.18.6.960 · Cited by 497 · see citing works

BCAT1 promotes cell proliferation through amino acid catabolism in gliomas carrying wild-type IDH1

Tönjes, M., Barbus, S., Park, Y. J., Wang, W., Schlotter, M., Lindroth, A. M., Pleier, S. V., Bai, A. H. C., Karra, D., Piro, R. M., et al. (2013) · Nature Medicine · doi:10.1038/nm.3217 · Cited by 486 · see citing works

Rac1 Activation Controls Nuclear Localization of β-catenin during Canonical Wnt Signaling

Wu, X., Tu, X., Joeng, K. S., Hilton, M. J., Williams, D. A., & Long, F. (2008) · Cell · doi:10.1016/j.cell.2008.01.052 · Cited by 481 · see citing works

Protein kinase C is differentially stimulated by Wnt and Frizzled homologs in aG-protein-dependent manner

Sheldahl, L. C., Park, M., Malbon, C. C., & Moon, R. T. (1999) · Current Biology · doi:10.1016/s0960-9822(99)80310-8 · Cited by 475 · see citing works

Branched-chain amino acid catabolism fuels adipocyte differentiation and lipogenesis

Green, C. R., Wallace, M., Divakaruni, A. S., Phillips, S. A., Murphy, A. N., Ciaraldi, T. P., & Metallo, C. M. (2016) · Nature Chemical Biology · doi:10.1038/nchembio.1961 · Cited by 471 · see citing works

Structure and function of mammalian facilitative sugar transporters.

Bell, G. I., Burant, C., Takeda, J., & Gould, G. W. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)36489-0 · Cited by 466 · see citing works

Mammalian Ryk Is a Wnt Coreceptor Required for Stimulation of Neurite Outgrowth

Lu, W., Yamamoto, V. N., Ortega, B., & Baltimore, D. (2004) · Cell · doi:10.1016/j.cell.2004.09.019 · Cited by 466 · see citing works

Wnt signaling directs a metabolic program of glycolysis and angiogenesis in colon cancer

Pate, K. T., Stringari, C., Sprowl‐Tanio, S., Wang, K., TeSlaa, T., Hoverter, N. P., McQuade, M. M., Garner, C., Digman, M. A., Teitell, M. A., et al. (2014) · The EMBO Journal · doi:10.15252/embj.201488598 · Cited by 459 · see citing works

β-catenin–sensitive isoforms of lymphoid enhancer factor-1 are selectively expressed in colon cancer

Hovanes, K., Li, T. W. H., Munguia, J. E., Truong, T., Milovanović, T., Marsh, J., Holcombe, R. F., & Waterman, M. L. (2001) · Nature Genetics · doi:10.1038/ng0501-53 · Cited by 458 · see citing works

Synergy Between Tumor Suppressor APC and the β-Catenin-Tcf4 Target Tcf1

Roose, J. P., Huls, G. A., van Beest, M., Moerer, P., van der Horn, K., Goldschmeding, R., Logtenberg, T., & Clevers, H. C. (1999) · Science · doi:10.1126/science.285.5435.1923 · Cited by 456 · see citing works

Glucose Uptake and Runx2 Synergize to Orchestrate Osteoblast Differentiation and Bone Formation

Wei, J., Shimazu, J., Makinistoglu, M. P., Maurizi, A., Kajimura, D., Zong, H., Takarada, T., Iezaki, T., Pessin, J. E., Hinoi, E., et al. (2015) · Cell · doi:10.1016/j.cell.2015.05.029 · Cited by 455 · see citing works

JNK functions in the non‐canonical Wnt pathway to regulate convergent extension movements in vertebrates

Yamanaka, H., Moriguchi, T., Masuyama, N., Kusakabe, M., Hanafusa, H., Takada, R., Takada, S., & Nishida, E. (2002) · EMBO Reports · doi:10.1093/embo-reports/kvf008 · Cited by 454 · see citing works

Lrp5 functions in bone to regulate bone mass

Cui, Y., Niziolek, P., MacDonald, B. T., Diegel, C. R., Alenina, N. V., Robinson, D. R., Zhong, Z. A., Matthes, S., Jacobsen, C. M., Conlon, R. A., et al. (2011) · Nature Medicine · doi:10.1038/nm.2388 · Cited by 454 · see citing works

The Wnt Antagonist Secreted Frizzled-Related Protein-1 Is a Negative Regulator of Trabecular Bone Formation in Adult Mice

Bodine, P. V. N., Zhao, W., Kharode, Y. P., Bex, F. J., Lambert, A.-J., Goad, M. B., Gaur, T., Stein, G. S., Lian, J. B., & Komm, B. S. (2004) · Molecular Endocrinology · doi:10.1210/me.2003-0498 · Cited by 450 · see citing works

Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action

Finch, P. W., He, X., Kelley, M. J., Üren, A., Schaudies, R. P., Popescu, N. C., Rudikoff, S., Aaronson, S. A., VARMUS, H. E., & Rubin, J. S. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.13.6770 · Cited by 417 · see citing works

WNT1 Mutations in Early-Onset Osteoporosis and Osteogenesis Imperfecta

Laine, C. M., Joeng, K. S., Campeau, P. M., Kiviranta, R., Tarkkonen, K. M., Grover, M., Lu, J. T., Pekkinen, M., Wessman, M., Heino, T. J., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1215458 · Cited by 369 · see citing works

WNT-LRP5 Signaling Induces Warburg Effect through mTORC2 Activation during Osteoblast Differentiation

Esen, E., Chen, J., Karner, C. M., Okunade, A. L., Patterson, B. W., & Long, F. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.03.017 · Cited by 367 · see citing works

Dependence of Mouse Embryonic Stem Cells on Threonine Catabolism

Wang, J., Alexander, P. B., Wu, L. C., Hammer, R. E., Cleaver, O. B., & McKnight, S. L. (2009) · Science · doi:10.1126/science.1173288 · Cited by 365 · see citing works

Dishevelled activates Ca2+ flux, PKC, and CamKII in vertebrate embryos

Sheldahl, L. C., Slusarski, D. C., Pandur, P., Miller, J. R., Kühl, M., & Moon, R. T. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200211094 · Cited by 350 · see citing works

Noncanonical Wnt Signaling through G Protein-Linked PKCδ Activation Promotes Bone Formation

Tu, X., Joeng, K. S., Nakayama, K., Nakayama, K., Rajagopal, J., Carroll, T. J., McMahon, A. P., & Long, F. (2007) · Developmental Cell · doi:10.1016/j.devcel.2006.11.003 · Cited by 314 · see citing works

Protein kinase A signalling via CREB controls myogenesis induced by Wnt proteins

Chen, A. E., Ginty, D. D., & Fan, C.-M. (2005) · Nature · doi:10.1038/nature03126 · Cited by 309 · see citing works

WNT16 Influences Bone Mineral Density, Cortical Bone Thickness, Bone Strength, and Osteoporotic Fracture Risk

Zheng, H., Tobias, J. H., Duncan, E. L., Evans, D. M., Eriksson, J., Paternoster, L., Yerges-Armstrong, L. M., Lehtimäki, T. J., Bergström, U., Kähönen, M. A. P., et al. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002745 · Cited by 293 · see citing works

Endoplasmic Reticulum Stress Response Mediated by the PERK-eIF2α-ATF4 Pathway Is Involved in Osteoblast Differentiation Induced by BMP2

Saito, A., Ochiai, K., Kondo, S., Tsumagari, K., Murakami, T., Cavener, D. R., & Imaizumi, K. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.152900 · Cited by 282 · see citing works

Large-Scale Analysis of Association Between LRP5 and LRP6 Variants and Osteoporosis

van Meurs, J. B. J. (2008) · JAMA · doi:10.1001/jama.299.11.1277 · Cited by 264 · see citing works

naked cuticle encodes an inducible antagonist of Wnt signalling

Zeng, W., Wharton, K. A., Mack, J. A., Wang, K., Gadbaw, M., Suyama, K. L., Klein, P. S., & Scott, M. P. (2000) · Nature · doi:10.1038/35001615 · Cited by 241 · see citing works

ATF4 mediation of NF1 functions in osteoblast reveals a nutritional basis for congenital skeletal dysplasiae

Elefteriou, F., Benson, M. D., Sowa, H., Starbuck, M. W., Liu, X., Ron, D., Parada, L. F., & Karsenty, G. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.10.010 · Cited by 234 · see citing works

Loss of wnt/β-catenin signaling causes cell fate shift of preosteoblasts from osteoblasts to adipocytes

Song, L., Liu, M., Ono, N., Bringhurst, F. R., Kronenberg, H. M., & Guo, J. (2012) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.1694 · Cited by 234 · see citing works

Wnt5a can both activate and repress Wnt/β-catenin signaling during mouse embryonic development

van Amerongen, R., Fuerer, C., Mizutani, M., & Nusse, R. (2012) · Developmental Biology · doi:10.1016/j.ydbio.2012.06.020 · Cited by 224 · see citing works

Bioenergetics and mitochondrial transmembrane potential during differentiation of cultured osteoblasts

Komarova, S. V., Ataullakhanov, F. I., & Globus, R. K. (2000) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2000.279.4.c1220 · Cited by 205 · see citing works

Comprehensive expression analysis of all Wnt genes and their major secreted antagonists during mouse limb development and cartilage differentiation

Witte, F., Dokas, J., Neuendorf, F., Mundlos, S., & Stricker, S. (2009) · Gene Expression Patterns · doi:10.1016/j.gep.2008.12.009 · Cited by 199 · see citing works

Mutations in WNT1 are a cause of osteogenesis imperfecta

Fahiminiya, S., Majewski, J., Mort, J. S., Moffatt, P., Glorieux, F. H., & Rauch, F. (2013) · Journal of Medical Genetics · doi:10.1136/jmedgenet-2013-101567 · Cited by 198 · see citing works

CELL POPULATION KINETICS OF AN OSTEOGENIC TISSUE · I

Owen, M. E. (1963) · The Journal of Cell Biology · doi:10.1083/jcb.19.1.19 · Cited by 191 · see citing works

HIF-1α Promotes Glutamine-Mediated Redox Homeostasis and Glycogen-Dependent Bioenergetics to Support Postimplantation Bone Cell Survival

Stegen, S., van Gastel, N., Eelen, G., Ghesquière, B., D’Anna, F., Thienpont, B., Goveia, J., Torrekens, S., Looveren, R. V., Luyten, F. P., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.01.002 · Cited by 187 · see citing works

Canonical Wnt signaling inhibits osteoclastogenesis independent of osteoprotegerin

Albers, J., Keller, J., Baranowsky, A., Beil, F. T., Catalá-Lehnen, P., Schulze, J., Amling, M., & Schinke, T. (2013) · The Journal of Cell Biology · doi:10.1083/jcb.201207142 · Cited by 186 · see citing works

Up-regulation of glycolytic metabolism is required for HIF1α-driven bone formation

Regan, J. N., Lim, J., Shi, Y., Joeng, K. S., Arbeit, J. M., Shohet, R. V., & Long, F. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1324290111 · Cited by 182 · see citing works

Metabolic Studies of Bone in Vitro

Borle, A. B., Nichols, N., & Nichols, G. (1960) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)69506-7 · Cited by 181 · see citing works

Wntless functions in mature osteoblasts to regulate bone mass

Zhong, Z. A., Diegel, C. R., Schumacher, C. A., Baker, J. J., Carpenter, A. C., Rao, S., Yao, W., Guan, M., Helms, J. A., Lane, N. E., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1120407109 · Cited by 178 · see citing works

Wnt Antagonists Bind through a Short Peptide to the First β-Propeller Domain of LRP5/6

Bourhis, E., Wang, W., Tam, C., Hwang, J., Zhang, Y., Spittler, D., Huang, O. W., Gong, Y., Estevez, A., Zilberleyb, I., et al. (2011) · Structure · doi:10.1016/j.str.2011.07.005 · Cited by 169 · see citing works

Wnt-Lrp5 Signaling Regulates Fatty Acid Metabolism in the Osteoblast

Frey, J. L., Li, Z., Ellis, J. M., Zhang, Q., Farber, C. R., Aja, S. M., Wolfgang, M. J., Clemens, T. L., & Riddle, R. C. (2015) · Molecular and Cellular Biology · doi:10.1128/mcb.01343-14 · Cited by 164 · see citing works

Bioenergetics During Calvarial Osteoblast Differentiation Reflect Strain Differences in Bone Mass

Guntur, A. R., Le, P. T., Farber, C. R., & Rosen, C. J. (2014) · Endocrinology · doi:10.1210/en.2013-1974 · Cited by 163 · see citing works

Increased glutamine catabolism mediates bone anabolism in response to WNT signaling

Karner, C. M., Esen, E., Okunade, A. L., Patterson, B. W., & Long, F. (2014) · Journal of Clinical Investigation · doi:10.1172/jci78470 · Cited by 153 · see citing works

PTH Promotes Bone Anabolism by Stimulating Aerobic Glycolysis via IGF Signaling

Esen, E., Lee, S.-Y., Wice, B. M., & Long, F. (2015) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2556 · Cited by 149 · see citing works

WNT7B Promotes Bone Formation in part through mTORC1

Chen, J., Tu, X., Esen, E., Joeng, K. S., Lin, C., Arbeit, J. M., Rüegg, M. A., Hall, M. N., Ma, L., & Long, F. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004145 · Cited by 142 · see citing works

A Comprehensive Overview of Skeletal Phenotypes Associated with Alterations in Wnt/β-catenin Signaling in Humans and Mice

Maupin, K. A., Droscha, C. J., & Williams, B. O. (2013) · Bone Research · doi:10.4248/br201301004 · Cited by 133 · see citing works

Mice Lacking Brain/Kidney Phosphate-Activated Glutaminase Have Impaired Glutamatergic Synaptic Transmission, Altered Breathing, Disorganized Goal-Directed Behavior and Die Shortly after Birth

Masson, J., Darmon, M. C., Conjard‐Duplany, A., Chuhma, N., Ropert, N., Thoby‐Brisson, M., Foutz, A. S., Parrot, S., Miller, G. M., Jorisch, R., et al. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.4241-05.2006 · Cited by 131 · see citing works

β-catenin promotes bone formation and suppresses bone resorption in postnatal growing mice

Chen, J., & Long, F. (2012) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.1834 · Cited by 129 · see citing works

PTH Promotes Bone Anabolism by Stimulating Aerobic Glycolysis via IGF Signaling

Esen, E., Lee, S.-Y., Wice, B. M., & Long, F. (2015) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2714 · Cited by 128 · see citing works

Inhibition of the Wnt Signaling Pathway by Idax, a Novel Dvl-Binding Protein

Hino, S.-I., Kishida, S., Michiue, T., Fukui, A., Sakamoto, I., Takada, S., Asashima, M., & Kikuchi, A. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.1.330-342.2001 · Cited by 127 · see citing works

WNT signaling in bone development and homeostasis

Zhong, Z. A., Ethen, N. J., & Williams, B. O. (2014) · Wiley Interdisciplinary Reviews Developmental Biology · doi:10.1002/wdev.159 · Cited by 125 · see citing works

Lrp5 and Lrp6 Exert Overlapping Functions in Osteoblasts during Postnatal Bone Acquisition

Riddle, R. C., Diegel, C. R., Leslie, J. M., van Koevering, K., Monier‐Faugere, M., Clemens, T. L., & Williams, B. O. (2013) · PLoS ONE · doi:10.1371/journal.pone.0063323 · Cited by 115 · see citing works

Control of bone formation by the serpentine receptor Frizzled-9

Albers, J., Schulze, J., Beil, F. T., Gebauer, M., Baranowsky, A., Keller, J., Marshall, R. P., Wintges, K., Friedrich, F. W., Priemel, M., et al. (2011) · The Journal of Cell Biology · doi:10.1083/jcb.201008012 · Cited by 113 · see citing works

Aerobic Glycolysis in Osteoblasts

Esen, E., & Long, F. (2014) · Current Osteoporosis Reports · doi:10.1007/s11914-014-0235-y · Cited by 109 · see citing works

mTORC1 Prevents Preosteoblast Differentiation through the Notch Signaling Pathway

Huang, B., Wang, Y., Wang, W., Chen, J., Lai, P., Liu, Z., Yan, B., Xu, S., Zhang, Z., Zeng, C., et al. (2015) · PLoS Genetics · doi:10.1371/journal.pgen.1005426 · Cited by 98 · see citing works

Uptake of postprandial lipoproteins into bone in vivo: Impact on osteoblast function

Niemeier, A., Niedzielska, D., Seçer, R., Schilling, A. F., Merkel, M., Enrich, C., Rensen, P. C. N., & Heeren, J. (2008) · Bone · doi:10.1016/j.bone.2008.03.022 · Cited by 96 · see citing works

mTORC2 Signaling Promotes Skeletal Growth and Bone Formation in Mice

Chen, J., Holguin, N., Shi, Y., Silva, M. J., & Long, F. (2014) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2348 · Cited by 94 · see citing works

mTORC1 Signaling Promotes Osteoblast Differentiation from Preosteoblasts

Chen, J., & Long, F. (2015) · PLoS ONE · doi:10.1371/journal.pone.0130627 · Cited by 86 · see citing works

The swaying mouse as a model of osteogenesis imperfecta caused by WNT1 mutations

Joeng, K. S., Lee, Y., Jiang, M., Bertin, T., Chen, Y., Abraham, A. M., Ding, H., Bi, X., Ambrose, C. G., & Lee, B. (2014) · Human Molecular Genetics · doi:10.1093/hmg/ddu117 · Cited by 86 · see citing works

CELL POPULATION KINETICS OF AN OSTEOGENIC TISSUE · II

Owen, M. E., & MacPherson, S. (1963) · The Journal of Cell Biology · doi:10.1083/jcb.19.1.33 · Cited by 84 · see citing works

Fatty acid oxidation in bone tissue and bone cells in culture. Characterization and hormonal influences

Adamek, G., Felix, R., Guenther, H. L., & Fleisch, H. A. (1987) · Biochemical Journal · doi:10.1042/bj2480129 · Cited by 72 · see citing works

Aerobic Metabolism of Glucose by Bone

Cohn, D. V., & Forscher, B. K. (1962) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)60342-4 · Cited by 69 · see citing works

Aging Reduces an ERRalpha-Directed Mitochondrial Glutaminase Expression Suppressing Glutamine Anaplerosis and Osteogenic Differentiation of Mesenchymal Stem Cells

Huang, T., Liu, R., Fu, X., Yao, D., Yang, M., Liu, Q., Lu, W. W., Wu, C., & Guan, M. (2016) · Stem Cells · doi:10.1002/stem.2470 · Cited by 69 · see citing works

Stimulation of glucose transport in osteoblastic cells by parathyroid hormone and insulin-like growth factor I

Zoidis, E., Ghirlanda-Keller, C., & Schmid, C. (2010) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-010-0634-z · Cited by 66 · see citing works

Aerobic glycolysis in bone: lactate production and gradients in calvaria

Neuman, W. F., Neuman, M. W., & Brommage, R. (1978) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1978.234.1.c41 · Cited by 65 · see citing works

Amino Acid Transport in Bone

Finerman, G. A. M., & Rosenberg, L. E. (1966) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)96738-4 · Cited by 63 · see citing works

Insulin effect on amino acid transport in bone: dependence on protein synthesis and Na+

Hahn, T., Downing, S., & Phang, J. (1971) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1971.220.6.1717 · Cited by 59 · see citing works

Tsc2 Is a Molecular Checkpoint Controlling Osteoblast Development and Glucose Homeostasis

Riddle, R. C., Frey, J. L., Tomlinson, R. E., Ferron, M., Li, Y., DiGirolamo, D. J., Monier‐Faugere, M., Hussain, M. A., Karsenty, G., & Clemens, T. L. (2014) · Molecular and Cellular Biology · doi:10.1128/mcb.00075-14 · Cited by 57 · see citing works

Selective Alteration by Triiodothyronine of Amino Acid Transport in Embryonic Bone

Adamson, L. F., & Ingbar, S. H. (1967) · Endocrinology · doi:10.1210/endo-81-6-1362 · Cited by 51 · see citing works

Wnt Protein Signaling Reduces Nuclear Acetyl-CoA Levels to Suppress Gene Expression during Osteoblast Differentiation

Karner, C. M., Esen, E., Chen, J., Hsu, F., TURK, J. W., & Long, F. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.708578 · Cited by 49 · see citing works

Energy Excess, Glucose Utilization, and Skeletal Remodeling: New Insights

Lecka‐Czernik, B., & Rosen, C. J. (2015) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2574 · Cited by 48 · see citing works

Some Properties of the Stimulatory Effect of Thyroid Hormones on Amino Acid Transport by Embryonic Chick Bone

Adamson, L. F., & Ingbar, S. H. (1967) · Endocrinology · doi:10.1210/endo-81-6-1372 · Cited by 45 · see citing works

Gpr177, a novel locus for bone mineral density and osteoporosis, regulates osteogenesis and chondrogenesis in skeletal development

Maruyama, T., Jiang, M., & Hsu, W. (2012) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.1830 · Cited by 41 · see citing works

Amino acid transport in bone: stimulation by cyclic AMP

Phang, J., & Downing, S. (1973) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1973.224.1.191 · Cited by 39 · see citing works

Absence of Glutamine Supplementation Prevents Differentiation of Murine Calvarial Osteoblasts to a Mineralizing Phenotype

Brown, P. M., Hutchison, J. D., & Crockett, J. C. (2011) · Calcified Tissue International · doi:10.1007/s00223-011-9537-6 · Cited by 37 · see citing works

Carnitine and Dehydroepiandrosterone Sulfate Induce Protein Synthesis in Porcine Primary Osteoblast-Like Cells

Chiu, K. M., Keller, E. T., Crenshaw, T. D., & Gravenstein, S. (1999) · Calcified Tissue International · doi:10.1007/s002239900644 · Cited by 36 · see citing works

Aerobic glycolysis in bone: lactic acid production by rat calvaria cells in culture

Felix, R., Neuman, W. F., & Fleisch, H. (1978) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1978.234.1.c51 · Cited by 34 · see citing works

Further Studies of Amino Acid Transport by Embryonic Chick Bone

Adamson, L. F., & Ingbar, S. H. (1967) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)99619-5 · Cited by 32 · see citing works

Glutamate preferentially suppresses osteoblastogenesis than adipogenesis through the cystine/glutamate antiporter in mesenchymal stem cells

Takarada‐Iemata, M., Takarada, T., Nakamura, Y., Nakatani, E., Hori, O., & Yoneda, Y. (2010) · Journal of Cellular Physiology · doi:10.1002/jcp.22390 · Cited by 29 · see citing works

Differential expression and functional characterization of system L amino acid transporters in human normal osteoblast cells and osteogenic sarcoma cells.

Kim, S.-G., Kim, H., Kim, H.-K., Kim, C., Chun, H. S., Kanai, Y., Endou, H., & Kim, D. K. (2006) · PubMed · Cited by 27 · see citing works

Rictor is required for optimal bone accrual in response to anti-sclerostin therapy in the mouse

Sun, W., Shi, Y., Lee, W., Lee, S.-Y., & Long, F. (2016) · Bone · doi:10.1016/j.bone.2016.01.013 · Cited by 27 · see citing works

Glutamine metabolism in bone.

BILTZ, R. M., Letteri, J. M., Pellegrino, E. D., Palekar, A. G., & Pinkus, L. M. (1983) · PubMed · Cited by 26 · see citing works

Induction of osteoprogenitor cell differentiation in rat marrow stroma increases mitochondrial retention of rhodamine 123 in stromal cells

Klein, B., Gal, I., Hartshtark, Z., & Segal, D. (1993) · Journal of Cellular Biochemistry · doi:10.1002/jcb.240530303 · Cited by 25 · see citing works

Effect of parathyroid extract on the oxidation in vitro of glucose and the production of 14CO2 by bone and kidney

Cohn, D. V., & Forscher, B. K. (1962) · Biochimica et Biophysica Acta · doi:10.1016/0006-3002(62)90145-2 · Cited by 21 · see citing works

Mechanism of mobilization of bone mineral by 1,25-dihydroxyvitamin D3.

Brommage, R., & Neuman, W. F. (1979) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1979.237.2.e113 · Cited by 20 · see citing works

Insulin effect on amino acid transport in bone

Hahn, T. J., Downing, S. J., & Phang, J. M. (1969) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(69)90292-x · Cited by 19 · see citing works

Growth of rat osteoblast-like cells in a lipid-enriched culture medium and regulation of function by parathyroid hormone and 1,25-dihydroxyvitamin D

Catherwood, B. D., Addison, J., Chapman, G. D., Contreras, S., & Lorang, M. T. (1988) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650030410 · Cited by 18 · see citing works

A Negative Correlation Between Expression Profiles of Runt-Related Transcription Factor-2 and Cystine/Glutamate Antiporter xCT Subunit in Ovariectomized Mouse Bone

Uno, K., Takarada, T., Nakamura, Y., Fujita, H., Hinoi, E., & Yoneda, Y. (2011) · Journal of Pharmacological Sciences · doi:10.1254/jphs.10310fp · Cited by 17 · see citing works

Effect of parathyroid hormone on amino acid transport by cultured neonatal mouse calvarial bone cells

Yee, J. A. (1988) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650030214 · Cited by 17 · see citing works

Ontogenesis of ultrastructural features during osteogenic differentiation in diffusion chamber cultures of marrow cells

Passi-Even, L., Gazit, D., & Bab, I. (1993) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650080510 · Cited by 16 · see citing works

Parathormone promotes glycogen formation from [14C]glucose in cultured osteoblast‐like cells

Schmid, C., Steiner, T., & Froesch, E. R. (1982) · FEBS Letters · doi:10.1016/0014-5793(82)81236-2 · Cited by 14 · see citing works

Amino acid transport in adult diaphyseal bone contrast with amino acid transport mechanisms in fetal membranous bone

Hahn, T. J., Downing, S. J., & Phang, J. M. (1969) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(69)90143-6 · Cited by 12 · see citing works

Negative regulation of osteoblastogenesis through downregulation of runt‐related transcription factor‐2 in osteoblastic MC3T3‐E1 cells with stable overexpression of the cystine/glutamate antiporter xCT subunit

Uno, K., Takarada, T., Takarada‐Iemata, M., Nakamura, Y., Fujita, H., Hinoi, E., & Yoneda, Y. (2011) · Journal of Cellular Physiology · doi:10.1002/jcp.22642 · Cited by 11 · see citing works

Characteristics of a neutral amino acid transport system (system A) in osteoblastic rat osteosarcoma cells

Baum, B. J., & Shteyer, A. (1987) · Experimental Cell Research · doi:10.1016/0014-4827(87)90205-9 · Cited by 6 · see citing works

Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities

Liu, J., Xiao, Q., Xiao, J., Niu, C., Li, Y., Zhang, X., Zhou, Z., Shu, G., & Yin, G. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00762-6 · Cited by 2,519 · see citing works

Bone remodeling: an operational process ensuring survival and bone mechanical competence

Bolamperti, S., Villa, I., & Rubinacci, A. (2022) · Bone Research · doi:10.1038/s41413-022-00219-8 · Cited by 482 · see citing works

Wnt/β-catenin signaling components and mechanisms in bone formation, homeostasis, and disease

Hu, L., Chen, W., Qian, A., & Li, Y.-P. (2024) · Bone Research · doi:10.1038/s41413-024-00342-8 · Cited by 359 · see citing works

The Regulation of Bone Metabolism and Disorders by Wnt Signaling

Maeda, K., Kobayashi, Y., Koide, M., Uehara, S., Okamoto, M., Ishihara, A., Kayama, T., Saito, M., & Marumo, K. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20225525 · Cited by 353 · see citing works

Osteoporosis pathogenesis and treatment: existing and emerging avenues

Liang, B., Burley, G., Lin, S., & Shi, Y. (2022) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-022-00371-3 · Cited by 250 · see citing works

Regulatory Effects and Interactions of the Wnt and OPG-RANKL-RANK Signaling at the Bone-Cartilage Interface in Osteoarthritis

Kovács, B., Vajda, E., & Nagy, E. E. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20184653 · Cited by 224 · see citing works

Self-powered implantable electrical stimulator for osteoblasts’ proliferation and differentiation

Tian, J., Shi, R., Liu, Z., Ouyang, H., Yu, M., Zhao, C., Zou, Y., Jiang, D., Zhang, J., & Li, Z. (2019) · Nano Energy · doi:10.1016/j.nanoen.2019.02.073 · Cited by 196 · see citing works

ROS signaling cascades: dual regulations for osteoclast and osteoblast

Tao, H., Ge, G., Liang, X., Zhang, W., Sun, H., Li, M., & Geng, D. (2020) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmaa098 · Cited by 182 · see citing works

Glucose metabolism in bone

Karner, C. M., & Long, F. (2017) · Bone · doi:10.1016/j.bone.2017.08.008 · Cited by 163 · see citing works

Targeting strategies for bone diseases: signaling pathways and clinical studies

Xu, H., Wang, W., Liu, X., Huang, W. H., Chen, Z., Xu, Y., Yang, H., Bai, J., & Geng, D. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01467-8 · Cited by 173 · see citing works

Interferon-Gamma-Mediated Osteoimmunology

Tang, M., Tian, L., Luo, G., & Yu, X. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01508 · Cited by 159 · see citing works

Insights into Oxidative Stress in Bone Tissue and Novel Challenges for Biomaterials

Cerqueni, G., Scalzone, A., Licini, C., Gentile, P., & Mattioli‐Belmonte, M. (2020) · Materials Science and Engineering C · doi:10.1016/j.msec.2021.112433 · Cited by 128 · see citing works

Biocompatibility pathways and mechanisms for bioactive materials: The bioactivity zone

Williams, D. F. (2021) · Bioactive Materials · doi:10.1016/j.bioactmat.2021.08.014 · Cited by 128 · see citing works

The Mechanosensory Role of Osteocytes and Implications for Bone Health and Disease States

Choi, J. U. A., Kijas, A. W., Lauko, J., & Rowan, A. E. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.770143 · Cited by 127 · see citing works

The Development of Molecular Biology of Osteoporosis

Gao, Y., Patil, S., & Jia, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22158182 · Cited by 116 · see citing works

Emerging insights into the comparative effectiveness of anabolic therapies for osteoporosis

Estell, E. G., & Rosen, C. J. (2020) · Nature Reviews Endocrinology · doi:10.1038/s41574-020-00426-5 · Cited by 114 · see citing works

Gut microbiota and bone metabolism

Lu, L., Chen, X., Liu, Y., & Yu, X. (2021) · The FASEB Journal · doi:10.1096/fj.202100451r · Cited by 120 · see citing works

The role of Wnt signaling pathway in tumor metabolic reprogramming

Mo, Y., Wang, Y., Zhang, L., Yang, L., Zhou, M., Li, X., Li, Y., Li, G., Zeng, Z., Xiong, W., et al. (2019) · Journal of Cancer · doi:10.7150/jca.31166 · Cited by 106 · see citing works

Mechanical Properties of Compact Bone Defined by the Stress-Strain Curve Measured Using Uniaxial Tensile Test: A Concise Review and Practical Guide

Lin, C.-Y., & Kang, J. (2021) · Materials · doi:10.3390/ma14154224 · Cited by 105 · see citing works

The role of lipid metabolism in osteoporosis: Clinical implication and cellular mechanism

Zhang, J., Hu, W., Zou, Z., Li, Y., Kang, F., Li, J.-M., & Dong, S. (2023) · Genes and Diseases · doi:10.1016/j.gendis.2023.101122 · Cited by 111 · see citing works

Wnt target genes and where to find them

Ramakrishnan, A., & Cadigan, K. M. (2017) · F1000Research · doi:10.12688/f1000research.11034.1 · Cited by 94 · see citing works

Therapeutic targeting of the oncogenic Wnt signaling pathway for treating colorectal cancer and other colonic disorders

Caspi, M., Wittenstein, A., Kazelnik, M., Shor-Nareznoy, Y., & Rosin‐Arbesfeld, R. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.12.010 · Cited by 90 · see citing works

Bone Regeneration, Reconstruction and Use of Osteogenic Cells; from Basic Knowledge, Animal Models to Clinical Trials

Hutchings, G., Moncrieff, L., Dompé, C., Janowicz, K., Sibiak, R., Bryja, A., Jankowski, M., Mozdziak, P. E., Bukowska, D., Antosik, P., et al. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9010139 · Cited by 88 · see citing works

Recent Progresses in the Treatment of Osteoporosis

Li, S., He, S., Xie, P.-Y., Li, W., Zhang, X., Li, T.-F., & Li, D. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.717065 · Cited by 89 · see citing works

Small molecules from natural products targeting the Wnt/β-catenin pathway as a therapeutic strategy

Liu, D., Chen, L., Zhao, H., Vaziri, N. D., Ma, S., & Zhao, Y. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.108990 · Cited by 84 · see citing works

Enhancing effects of myricetin on the osteogenic differentiation of human periodontal ligament stem cells via BMP-2/Smad and ERK/JNK/p38 mitogen-activated protein kinase signaling pathway

Kim, H.-Y., Park, S., & Choung, S. (2018) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2018.07.012 · Cited by 83 · see citing works

MicroRNA-181a/b-1 over-expression enhances osteogenesis by modulating PTEN/PI3K/AKT signaling and mitochondrial metabolism

Zheng, H., Liu, J., Tycksen, E., Nunley, R. M., & McAlinden, A. (2019) · Bone · doi:10.1016/j.bone.2019.03.020 · Cited by 76 · see citing works

An In Vitro and In Vivo Comparison of Osteogenic Differentiation of Human Mesenchymal Stromal/Stem Cells

Mollentze, J., Durandt, C., & Pepper, M. S. (2021) · Stem Cells International · doi:10.1155/2021/9919361 · Cited by 77 · see citing works

Mechanical, hormonal and metabolic influences on blood vessels, blood flow and bone

Prisby, R. D. (2017) · Journal of Endocrinology · doi:10.1530/joe-16-0666 · Cited by 75 · see citing works

7,8-Dihydroxyflavone modulates bone formation and resorption and ameliorates ovariectomy-induced osteoporosis

Fan, X., Zhao, Z., Gu, Y., Han, J., Ye, K., & Zhang, Y. (2021) · eLife · doi:10.7554/elife.64872 · Cited by 74 · see citing works

Metabolic reprogramming in skeletal cell differentiation

Bertels, J., He, G., & Long, F. (2024) · Bone Research · doi:10.1038/s41413-024-00374-0 · Cited by 78 · see citing works

Energy metabolism: A newly emerging target of BMP signaling in bone homeostasis

Yang, J., Ueharu, H., & Mishina, Y. M. (2020) · Bone · doi:10.1016/j.bone.2020.115467 · Cited by 74 · see citing works

lncRNA NEAT1 ameliorates LPS‑induced inflammation in MG63 cells by activating autophagy and suppressing the NLRP3 inflammasome

Dai, W., Wang, M., Wang, P., Wen, J., Wang, J., Cha, S., Xiao, X., He, Y., Shu, R., & Bai, D. (2020) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2020.4827 · Cited by 73 · see citing works

Glutamine Metabolism Is Essential for Stemness of Bone Marrow Mesenchymal Stem Cells and Bone Homeostasis

Zhou, T., Yang, Y., Chen, Q., & Xie, L. (2019) · Stem Cells International · doi:10.1155/2019/8928934 · Cited by 73 · see citing works

A novel approach for the prevention of ionizing radiation-induced bone loss using a designer multifunctional cerium oxide nanozyme

Wei, F., Neal, C. J., Sakthivel, T. S., Fu, Y., Omer, M., Adhikary, A., Ward, S., Ta, K. M., Moxon, S., Molinari, M., et al. (2022) · Bioactive Materials · doi:10.1016/j.bioactmat.2022.09.011 · Cited by 72 · see citing works

Osteometabolism: Metabolic Alterations in Bone Pathologies

Srivastava, R. K., Sapra, L., & Mishra, P. K. (2022) · Cells · doi:10.3390/cells11233943 · Cited by 72 · see citing works

Increased glycolysis mediates Wnt7b‐induced bone formation

Chen, H., Ji, X., Lee, W., Shi, Y., Li, B., Abel, E. D., Jiang, D., Huang, W., & Long, F. (2019) · The FASEB Journal · doi:10.1096/fj.201900201rr · Cited by 72 · see citing works

Lactate induces osteoblast differentiation by stabilization of HIF1α

Wu, Y., Wang, M., Feng, H., Peng, Y., Sun, J., Qu, X., & Li, C. (2017) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2017.05.017 · Cited by 71 · see citing works

Targeting the Wnt/β-catenin pathway in human osteosarcoma cells

Fang, F., VanCleave, A. M., Helmuth, R., de Oliveira, H. T., Rickel, K., Wollenzien, H., Sun, H., Zeng, E., Zhao, J., & Tao, J. (2018) · Oncotarget · doi:10.18632/oncotarget.26377 · Cited by 71 · see citing works

Circadian rhythms affect bone reconstruction by regulating bone energy metabolism

Luo, B., Zhou, X., Tang, Q., Yin, Y., Feng, G., Li, S., & Chen, L. (2021) · Journal of Translational Medicine · doi:10.1186/s12967-021-03068-x · Cited by 69 · see citing works

Biphasic regulation of osteoblast development via the ERK MAPK–mTOR pathway

Kim, J., Yang, Y.-S., Hong, J., Chaugule, S. R., Chun, H., van der Meulen, M. C. H., Xu, R., Greenblatt, M. B., & Shim, J. (2022) · eLife · doi:10.7554/elife.78069 · Cited by 69 · see citing works

Phase 1 study of CWP232291 in patients with relapsed or refractory acute myeloid leukemia and myelodysplastic syndrome

Lee, J., Faderl, S. H., Pagel, J. M., Jung, C. W., Yoon, S., Pardanani, A. D., Becker, P. S., Lee, H., Choi, J., Lee, K.-J., et al. (2020) · Blood Advances · doi:10.1182/bloodadvances.2019000757 · Cited by 66 · see citing works

Corylin, a flavonoid derived from Psoralea Fructus, induces osteoblastic differentiation via estrogen and Wnt/β‐catenin signaling pathways

Yu, A. X., Xu, M. L., Yao, P., Kwan, K. K., Liu, Y., Duan, R., Dong, T. T.-X., Ko, K., & Tsim, K. W. K. (2020) · The FASEB Journal · doi:10.1096/fj.201902319rrr · Cited by 64 · see citing works

Influence of HIV Infection and Antiretroviral Therapy on Bone Homeostasis

Delpino, M. V., & Quarleri, J. F. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00502 · Cited by 63 · see citing works

Glutamine Metabolism in Osteoprogenitors Is Required for Bone Mass Accrual and PTH-Induced Bone Anabolism in Male Mice

Stegen, S., Devignes, C.-S., Torrekens, S., Looveren, R. V., Carmeliet, P., & Carmeliet, G. (2020) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.4219 · Cited by 64 · see citing works

The Mental Health Nursing Clinical Confidence Scale: a tool for measuring undergraduate learning on mental health clinical placements.

Bell, A., Horsfall, J. M., & Goodin, W. (1998) · PubMed · Cited by 63 · see citing works

Biphasic regulation of glutamine consumption by WNT during osteoblast differentiation

Shen, L., Sharma, D., Yu, Y., Long, F., & Karner, C. (2020) · Journal of Cell Science · doi:10.1242/jcs.251645 · Cited by 61 · see citing works

Role of Wnt signaling in synaptic plasticity and memory

Narvaes, R. F., & Furini, C. R. G. (2021) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2021.107558 · Cited by 61 · see citing works

Progress of Signaling Pathways, Stress Pathways and Epigenetics in the Pathogenesis of Skeletal Fluorosis

Qiao, L., Liu, X., He, Y., Zhang, J., Huang, H., Bian, W., Chilufya, M. M., Zhao, Y., & Han, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111932 · Cited by 62 · see citing works

The plasticity of biocompatibility

Williams, D. F. (2023) · Biomaterials · doi:10.1016/j.biomaterials.2023.122077 · Cited by 62 · see citing works

Effect of the Wnt signal-RANKL/OPG axis on the enhanced osteogenic integration of a lithium incorporated surface

Huang, T., Li, Y., Ke, Y., Zhou, Y., Wang, Y., Jiang, Z., Wang, H., & Yang, G. (2018) · Biomaterials Science · doi:10.1039/c8bm01411f · Cited by 59 · see citing works

Krüppel-like factor 3 inhibition by mutated lncRNA Reg1cp results in human high bone mass syndrome

Yang, M., Guo, Q., Peng, H., Xiao, Y., Xiao, Y., Huang, Y. H., Li, C., Su, T., Zhang, Y.-L., Lei, M., et al. (2019) · The Journal of Experimental Medicine · doi:10.1084/jem.20181554 · Cited by 59 · see citing works

Genome-Wide Association Study of Body Weight Traits in Chinese Fine-Wool Sheep

Lu, Z., Yue, Y., Yuan, C., Liu, J., Chen, Z., Niu, C., Sun, X., Zhu, S., Zhao, H., Guo, T., et al. (2020) · Animals · doi:10.3390/ani10010170 · Cited by 59 · see citing works

Single-cell RNA sequencing of human femoral head in vivo

Qiu, X., Liu, Y., Shen, H., Wang, Z., Gong, Y., Yang, J., Li, X., Zhang, H., Chen, Y., Zhou, C., et al. (2021) · Aging · doi:10.18632/aging.203124 · Cited by 58 · see citing works

Human cells with osteogenic potential in bone tissue research

Dvorakova, J., Wiesnerova, L., Chocholata, P., Kulda, V., Landsmann, L., Cedikova, M., Kripnerova, M., Eberlova, L., & Babuska, V. (2023) · BioMedical Engineering OnLine · doi:10.1186/s12938-023-01096-w · Cited by 58 · see citing works

Wnt7b-induced Sox11 functions enhance self-renewal and osteogenic commitment of bone marrow mesenchymal stem cells

Yu, F., Wu, F., Li, F., Liao, X., Wang, Y., Li, X., Wang, C., Shi, Y., & Ye, L. (2020) · Stem Cells · doi:10.1002/stem.3192 · Cited by 57 · see citing works

Positive association of high-density lipoprotein cholesterol with lumbar and femoral neck bone mineral density in postmenopausal women

Zolfaroli, I., Murillo, E. O., García‐Pérez, M. Á., Hidalgo‐Mora, J. J., Tarín, J. J., & Cano, A. (2021) · Maturitas · doi:10.1016/j.maturitas.2021.03.001 · Cited by 57 · see citing works

Cardiovascular Outcomes of Romosozumab and Protective Role of Alendronate

Asadipooya, K., & Weinstock, A. (2019) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.119.312371 · Cited by 56 · see citing works

Osteoblast role in the pathogenesis of rheumatoid arthritis

Berardi, S., Corrado, A., Maruotti, N., Cici, D., & Cantatore, F. P. (2021) · Molecular Biology Reports · doi:10.1007/s11033-021-06288-y · Cited by 56 · see citing works

Phytochemical Compounds Involved in the Bone Regeneration Process and Their Innovative Administration: A Systematic Review

Hanga-Fărcaș, A., Miere, F. G., Filip, G. A., Clichici, S. V., Fritea, L., Vicaș, L. G., Marian, E., Pallag, A., Jurca, T., Filip, S. M., et al. (2023) · Plants · doi:10.3390/plants12102055 · Cited by 55 · see citing works

Bone turnover markers and novel biomarkers in lung cancer bone metastases

Lang, J., Zhao, Q., He, Y., & Yu, X. (2018) · Biomarkers · doi:10.1080/1354750x.2018.1463566 · Cited by 54 · see citing works

Duck Egg White–Derived Peptide VSEE (Val‐Ser‐Glu‐Glu) Regulates Bone and Lipid Metabolisms by Wnt/β‐Catenin Signaling Pathway and Intestinal Microbiota

Guo, D., Liu, W., Zhang, X., Zhao, M., Zhu, B., Hou, T., & He, H. (2019) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201900525 · Cited by 54 · see citing works

How zoledronic acid improves osteoporosis by acting on osteoclasts

Wang, B., Zhan, Y., Yan, L. W., & Hao, D. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.961941 · Cited by 52 · see citing works

Protective effects of curcumin against osteoporosis and its molecular mechanisms: a recent review in preclinical trials

Yang, S., Sun, Y., Капилевич, Л. В., Zhang, X., & Huang, Y. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1249418 · Cited by 52 · see citing works

Emerging role and function of Hippo-YAP/TAZ signaling pathway in musculoskeletal disorders

Han, J., Zhang, J., Zhang, X.-Y., Luo, W., Liu, L.-F., Zhu, Y.-Q., Liu, Q.-F., & Zhang, X.-A. (2024) · Stem cell research & therapeutics · doi:10.1186/s13287-024-04011-9 · Cited by 57 · see citing works

SLC1A5 provides glutamine and asparagine necessary for bone development in mice

Sharma, D., Yu, Y., Shen, L., Zhang, G., & Karner, C. M. (2021) · eLife · doi:10.7554/elife.71595 · Cited by 51 · see citing works

Wnt Signaling Inhibitors and Their Promising Role in Tumor Treatment

Pećina‐Šlaus, N., Aničić, S., Bukovac, A., & Kafka, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076733 · Cited by 51 · see citing works

Wnt signaling: An attractive target for periodontitis treatment

Bao, J., Yang, Y., Xia, M., Sun, W., & Chen, L. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110935 · Cited by 50 · see citing works

Lactate-mediated lactylation in human health and diseases: Progress and remaining challenges

Hu, X., Wu, X., Xu, J., & Xu, X. M. (2024) · Journal of Advanced Research · doi:10.1016/j.jare.2024.11.010 · Cited by 49 · see citing works

Osteoblast as a target of anti-osteoporotic treatment

Corrado, A., Sanpaolo, E. R., Bello, S. D., & Cantatore, F. P. (2017) · Postgraduate Medicine · doi:10.1080/00325481.2017.1362312 · Cited by 50 · see citing works

Global MicroRNA Profiling in Human Bone Marrow Skeletal—Stromal or Mesenchymal–Stem Cells Identified Candidates for Bone Regeneration

Chang, C.-C., Venø, M. T., Chen, L., Ditzel, N., Le, D. Q. S., Dillschneider, P., Kassem, M. S., & Kjems, J. (2017) · Molecular Therapy · doi:10.1016/j.ymthe.2017.11.018 · Cited by 52 · see citing works

Consequences of Aging on Bone

Zhang, L., Guan, Q., Wang, Z., Feng, J., Zou, J., & Gao, B. (2023) · Aging and Disease · doi:10.14336/ad.2023.1115 · Cited by 55 · see citing works

Bioinspired fabrication of carbonated hydroxyapatite/chitosan nanohybrid scaffolds loaded with TWS119 for bone regeneration

Chen, Y., Yu, J. J., Ke, Q., Gao, Y., Zhang, C., & Guo, Y. (2018) · Chemical Engineering Journal · doi:10.1016/j.cej.2018.02.010 · Cited by 48 · see citing works

An update on the problem of osteoporosis in people with epilepsy taking antiepileptic drugs

Miziak, B., Chrościńska–Krawczyk, M., & Czuczwar, S. J. (2019) · Expert Opinion on Drug Safety · doi:10.1080/14740338.2019.1625887 · Cited by 48 · see citing works

Fermented Oyster Extract Promotes Osteoblast Differentiation by Activating the Wnt/β-Catenin Signaling Pathway, Leading to Bone Formation

Molagoda, I. M. N., Karunarathne, W. A. H. M., Choi, Y. H., Park, E. K., Jeon, Y., Lee, B.-J., Kang, C., & Kim, G. (2019) · Biomolecules · doi:10.3390/biom9110711 · Cited by 48 · see citing works

Inducible expression of Wnt7b promotes bone formation in aged mice and enhances fracture healing

Song, D., He, G., Song, F., Wang, Z., Liu, X., Liao, L., Ni, J., Silva, M. J., & Long, F. (2020) · Bone Research · doi:10.1038/s41413-019-0081-8 · Cited by 48 · see citing works

Biomechanical Interfaces of Corticotomies on Periodontal Tissue Remodeling during Orthodontic Tooth Movement

Liu, R., Huang, L., Xiao, X., Guan, Y., Jiang, Y., Yin, X., Zou, S., & Ye, Q. (2020) · Coatings · doi:10.3390/coatings11010001 · Cited by 48 · see citing works

Lactate enhanced the effect of parathyroid hormone on osteoblast differentiation via GPR81-PKC-Akt signaling

Wu, Y., Wang, M., Zhang, K., Li, Y., Xu, M., Tang, S., Qu, X., & Li, C. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.06.069 · Cited by 46 · see citing works

Cellular and molecular mechanisms underlying obesity in degenerative spine and joint diseases

Xiang, Q., Wu, Z., Zhao, Y., Tian, S., Lin, J., Wang, L., Jiang, S., Sun, Z., & Li, W. (2024) · Bone Research · doi:10.1038/s41413-024-00388-8 · Cited by 46 · see citing works

Dorsal root ganglion neurons regulate the transcriptional and translational programs of osteoblast differentiation in a microfluidic platform

Silva, D. I., dos Santos, B. P., Leng, J., Oliveira, H., & Amédée, J. (2017) · Cell Death and Disease · doi:10.1038/s41419-017-0034-3 · Cited by 46 · see citing works

Impact of aging on bone, marrow and their interactions

Hoffman, C. M., Han, J., & Calvi, L. M. (2018) · Bone · doi:10.1016/j.bone.2018.07.012 · Cited by 46 · see citing works

Wnt3a involved in the mechanical loading on improvement of bone remodeling and angiogenesis in a postmenopausal osteoporosis mouse model

Li, X., Liu, D., Li, J., Yang, S., Xu, J., Yokota, H., & Zhang, P. (2019) · The FASEB Journal · doi:10.1096/fj.201802711r · Cited by 46 · see citing works

Extracellular vesicles in bone: “dogrobbers” in the “eternal battle field”

Tao, S., & Guo, S. (2019) · Cell Communication and Signaling · doi:10.1186/s12964-019-0319-5 · Cited by 45 · see citing works

Cytoprotective effect of Fufang Lurong Jiangu capsule against hydrogen peroxide-induced oxidative stress in bone marrow stromal cell-derived osteoblasts through the Nrf2/HO-1 signaling pathway

Jin, W., Zhu, X., Yao, F., Xu, X., Chen, X., Luo, Z.-J., Zhao, D., Li, X., Leng, X., & Sun, L. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.109676 · Cited by 44 · see citing works

Development of selective bispecific Wnt mimetics for bone loss and repair

Fowler, T. W., Mitchell, T. L., Janda, C. Y., Xie, L., Tu, S., Chen, H., Zhang, H., Ye, J., Ouyang, B., Yuan, T. Z., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-23374-8 · Cited by 44 · see citing works

Spatial transcriptomics reveals metabolic changes underly age-dependent declines in digit regeneration

Tower, R. J., Busse, E., Jaramillo, J., Lacey, M., Hoffseth, K., Guntur, A. R., Simkin, J., & Sammarco, M. C. (2022) · eLife · doi:10.7554/elife.71542 · Cited by 43 · see citing works

Regulation of bone mass in inflammatory diseases

Adami, G. (2022) · Best Practice &amp; Research Clinical Endocrinology &amp; Metabolism · doi:10.1016/j.beem.2021.101611 · Cited by 41 · see citing works

A lithium-containing nanoporous coating on entangled titanium scaffold can enhance osseointegration through Wnt/β-catenin pathway

Liu, W. X., Chen, D., Jiang, G., Li, Q., Wang, Q., Cheng, M., He, G., & Zhang, X. (2017) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2017.09.006 · Cited by 41 · see citing works

The Delivery of RNA-Interference Therapies Based on Engineered Hydrogels for Bone Tissue Regeneration

Yu, T., Wang, H., Zhang, Y., Wang, X., & Han, B. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.00445 · Cited by 40 · see citing works

Injectable Bacteria-Sensitive Hydrogel Promotes Repair of Infected Fractures via Sustained Release of miRNA Antagonist

Yu, C., Chen, L., Zhou, W., Hu, L., Xie, X., Lin, Z., Panayi, A. C., Zhan, X., Tao, R., Mi, B., et al. (2022) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.2c08491 · Cited by 39 · see citing works

RhoA/Rock activation represents a new mechanism for inactivating Wnt/β-catenin signaling in the aging-associated bone loss

Shi, W., Xu, C., Gong, Y., Wang, J., Ren, Q., Yan, Z., Mei, L., Tang, C., Ji, X., Hu, X., et al. (2021) · Cell Regeneration · doi:10.1186/s13619-020-00071-3 · Cited by 38 · see citing works

Osteoporosis and vascular calcification: A shared scenario

Gómez, M. C. G., & Vilahur, G. (2020) · Clínica e Investigación en Arteriosclerosis (English Edition) · doi:10.1016/j.artere.2019.03.008 · Cited by 37 · see citing works

ROS Dependent Wnt/β-Catenin Pathway and Its Regulation on Defined Micro-Pillars—A Combined In Vitro and In Silico Study

Staehlke, S., Haack, F., Waldner, A.-C., Koczan, D., Moerke, C., Mueller, P., Uhrmacher, A. M., & Nebe, J. B. (2020) · Cells · doi:10.3390/cells9081784 · Cited by 36 · see citing works

Nr4a1 enhances Wnt4 transcription to promote mesenchymal stem cell osteogenesis and alleviates inflammation-inhibited bone regeneration

Gao, Y., Zou, Y., Sokolowskei, D., Xing, X., Tower, R. J., Lai, Z., Shi, J., Zhu, L., Zheng, Q., James, A. W., et al. (2024) · Molecular Therapy · doi:10.1016/j.ymthe.2024.02.034 · Cited by 36 · see citing works

Cerium Oxide Nanoparticles Promote Osteoplastic Precursor Differentiation by Activating the Wnt Pathway

Luo, J., Zhu, S., Yu, T., Zhang, Y., Li, Y., Cao, L., Kong, M., Luo, M., Bi, Q., & Zhang, Q. (2022) · Biological Trace Element Research · doi:10.1007/s12011-022-03168-9 · Cited by 36 · see citing works

Capturing cerium ions via hydrogel microspheres promotes vascularization for bone regeneration

Liu, J., Zhou, Z., Hou, M., Xia, X., Liu, Y., Zhao, Z., Wu, Y., Deng, Y., Zhang, Y., He, F., et al. (2024) · Materials Today Bio · doi:10.1016/j.mtbio.2024.100956 · Cited by 35 · see citing works

Vitamin E-stabilized UHMWPE: Biological response on human osteoblasts to wear debris

Galliera, E., Ragone, V., Marazzi, M. G., Selmin, F., Banci, L., & Romanelli, M. M. C. (2018) · Clinica Chimica Acta · doi:10.1016/j.cca.2018.07.012 · Cited by 35 · see citing works

Desalted duck egg white peptides promoted osteogenesis via wnt/β‐catenin signal pathway

Guo, D., He, H., Zhao, M., Zhang, G., & Hou, T. (2020) · Journal of Food Science · doi:10.1111/1750-3841.15067 · Cited by 35 · see citing works

FOXO1 differentially regulates bone formation in young and aged mice

Xiong, Y., Zhang, Y., Zhou, F., Liu, Y., Yi, Z., Gong, P., & Wu, Y. (2022) · Cellular Signalling · doi:10.1016/j.cellsig.2022.110438 · Cited by 35 · see citing works

Ultrasound‐Responsive Piezoelectric Membrane Promotes Osteoporotic Bone Regeneration via the “Two‐Way Regulation” Bone Homeostasis Strategy

Wu, X., Wang, T., Zhao, J., Zhang, L., Liu, Z., Chen, Y., Luo, Y., Liu, Y., Chen, Y., Jiang, H., et al. (2025) · Advanced Science · doi:10.1002/advs.202504293 · Cited by 34 · see citing works

Regulation of Osteoblast Metabolism by Wnt Signaling

Moorer, M. C., & Riddle, R. C. (2018) · Endocrinology and Metabolism · doi:10.3803/enm.2018.33.3.318 · Cited by 58 · see citing works

The Regulation of Glucose Metabolism during Osteoblast Differentiation

Esen, E. (2014) · Open Scholarship Institutional Repository (Washington University in St. Louis) · doi:10.7936/k7348hcq

Wnt signaling: Essential roles in osteoblast differentiation, bone metabolism and therapeutic implications for bone and skeletal disorders

Vlashi, R., Zhang, X., Wu, M., & Chen, G. (2023) · Genes &amp; Diseases · doi:10.1016/j.gendis.2022.07.011 · Cited by 165 · see citing works

Energy Metabolism of the Osteoblast: Implications for Osteoporosis

Lee, W.-C., Guntur, A. R., Long, F., & Rosen, C. J. (2017) · Endocrine Reviews · doi:10.1210/er.2017-00064 · Cited by 443 · see citing works

Glycolysis in bone remodeling: from energy supply to signaling regulation

Song, H., Cheng, S., Ma, S., Wang, Z., Liu, B., Dan, Y., Li, J., Wei, B., Yuan, R., Wu, S., et al. (2026) · Molecular Biology Reports · doi:10.1007/s11033-026-12832-5