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Cited by 101Physical Activity and HealthCardiovascular and exercise physiologyDiabetes, Cardiovascular Risks, and Lipoproteins

The effect of acute exercise on undercarboxylated osteocalcin and insulin sensitivity in obese men

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Levinger, Itamar, Jerums, George, Stepto, Nigel K, Parker, Lewan, Serpiello, Fabio R, McConell, Glenn K, Anderson, Mitchell, Hare, David L +3 more·2014·Journal of Bone and Mineral Research
DOI 10.1002/jbmr.2285
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Abstract

Acute exercise improves insulin sensitivity for hours after the exercise is ceased. The skeleton contributes to glucose metabolism and insulin sensitivity via osteocalcin (OC) in its undercarboxylated (ucOC) form in mice. We tested the hypothesis that insulin sensitivity over the hours after exercise is associated with circulating levels of ucOC. Eleven middle-aged (58.1 ± 2.2 years mean ± SEM), obese (body mass index [BMI] = 33.1 ± 1.4 kg/m(2) ) nondiabetic men completed a euglycemic-hyperinsulinemic clamp at rest (rest-control) and at 60 minutes after exercise (4 × 4 minutes of cycling at 95% of HRpeak ). Insulin sensitivity was determined by glucose infusion rate relative to body mass (GIR, mL/kg/min) as well as GIR per unit of insulin (M-value). Blood samples and five muscle biopsies were obtained; two at the resting-control session, one before and one after clamping, and three in the exercise session, at rest, 60 minutes after exercise, and after the clamp. Exercise increased serum ucOC (6.4 ± 2.1%, p = 0.013) but not total OC (p > 0.05). Blood glucose was ∼6% lower and insulin sensitivity was ∼35% higher after exercise compared with control (both p < 0.05). Phosphorylated (P)-AKT (Ak thymoma) was higher after exercise and insulin compared with exercise alone (no insulin) and insulin alone (no exercise, all p < 0.05). In a multiple-linear regression including BMI, age, and aerobic fitness, ucOC was associated with whole-body insulin sensitivity at rest (β = 0.59, p = 0.023) and after exercise (β = 0.66, p = 0.005). Insulin sensitivity, after acute exercise, is associated with circulating levels of ucOC in obese men. Whether ucOC has a direct effect on skeletal muscle insulin sensitivity after exercise is yet to be determined.

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Authors
Levinger, I., Jerums, G., Stepto, N. K., Parker, L., Serpiello, F. R., McConell, G. K., Anderson, M., Hare, D. L., Byrnes, E., Ebeling, P. R., & Seeman, E.
Affiliations
  • The University of Melbourne (AU)
  • Victoria University (AU)
  • Queen Elizabeth II Medical Centre (AU)
ORCID
Venue
Journal of Bone and Mineral Research
Publisher
Oxford University Press (OUP)
Published
2014-05-24
Volume
29
Issue
12
Pages
2571-2576
ISSN
  • 0884-0431 (ISSN-L)
  • 1523-4681
DOI
10.1002/jbmr.2285
OpenAlex
W1802503633
Cited by
101
References
35
Citations by year
2026: 3 · 2025: 7 · 2024: 7 · 2023: 4 · 2022: 7 · 2021: 8 · 2020: 10 · 2019: 10 · 2018: 8 · 2017: 12 · 2016: 8 · 2015: 14 · 2014: 3
FWCI
8.20
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Bone and Mineral Research (publishedVersion)
  • PubMed (publishedVersion)
  • Victoria University Research Repository (Victoria University) (submittedVersion)
  • Figshare (submittedVersion, cc-by)
  • Minerva Access (University of Melbourne) (submittedVersion)
Funders
  • National Heart Foundation of Australia (100040)
  • Victoria University
Topics
  • Health Sciences › Medicine › Physiology › Physical Activity and Health
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords
undercarboxylated osteocalcin, acute exercise, insulin sensitivity, obesity, skeletal muscle insulin sensitivity, Akt phosphorylation, hyperinsulinemic-euglycemic clamp, glucose infusion rate, skeletal muscle, cardiorespiratory fitness, middle-aged men
MeSH terms
Animals, Humans, Insulin Resistance, Male, Middle Aged, Obesity, Phosphorylation, Glucose Clamp Technique, Exercise, Osteocalcin, Body Mass Index, Muscle, Skeletal, Proto-Oncogene Proteins c-akt, Mice

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