Cited by 69Transcranial Magnetic Stimulation StudiesExercise and Physiological ResponsesCardiovascular and exercise physiology

A Single Bout of High-intensity Interval Exercise Increases Corticospinal Excitability, Brain-derived Neurotrophic Factor, and Uncarboxylated Osteolcalcin in Sedentary, Healthy Males

Nicolini, Chiara, Michalski, Bernadeta, Toepp, Stephen L., Turco, Claudia V., D'Hoine, Tarra, Harasym, Diana, Gibala, Martin J., Fahnestock, Margaret +1 more·2020·Neuroscience

Abstract

Exercise induces neuroplasticity in descending motor pathways facilitating motor learning, and as such it could be utilized as an intervention in neurorehabilitation, for example when re-learning motor skills after stroke. To date, however, the neurophysiological and molecular mechanisms underlying exercise-induced neuroplasticity remain largely unknown impeding the potential utilization of exercise protocols as 'motor learning boosters' in clinical and non-clinical settings. Here, we assessed corticospinal excitability, intracortical facilitation (ICF) and short-interval intracortical inhibition (SICI) using transcranial magnetic stimulation (TMS) and serum biochemical markers including brain-derived neurotrophic factor (BDNF), total and precursor cathepsin B (tCTSB, proCTSB), uncarboxylated and carboxylated osteocalcin (unOCN, cOCN) and irisin using ELISA. Measurements were carried out in sedentary, healthy males before and after a single session of high-intensity interval exercise (HIIE) or in individuals who rested and did not perform exercise (No Exercise). We found that HIIE increased corticospinal excitability, BDNF and unOCN, and decreased cOCN. We also determined that greater increases in BDNF were associated with increases in unOCN and irisin and decreases in cOCN only in participants who underwent HIIE, suggesting that unOCN and irisin may contribute to exercise-induced BDNF increases. Conversely, no changes other than a decrease in serum unOCN/tOCN were found in N…

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Crossref · 10.1016/j.neuroscience.2020.03.042

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  • In humans, acute exercise does not clearly increase plasma cathepsin B.

    “Studies in humans have shown that acute exercise does not clearly increase plasma levels of cathepsin B7, although chronic exercise does increase plasma levels of cathepsin B145,157.”

    From Exerkines in health, resilience and disease (2022) · cites this paper as [7]

  • In humans, acute exercise increases plasma BDNF.

    “In humans, acute exercise increases plasma levels of brain-derived neurotrophic factor (BDNF)7, whereas chronic exercise training has been shown to not alter140, increase or even decrease plasma levels of BDNF140,145.”

    From Exerkines in health, resilience and disease (2022) · cites this paper as [7]

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Authors
Nicolini, C., Michalski, B., Toepp, S. L., Turco, C. V., D'Hoine, T., Harasym, D., Gibala, M. J., Fahnestock, M., & Nelson, A. J.
Affiliations
McMaster University (CA)
Corresponding author
Nelson, Aimee J.
Venue
Neuroscience
Publisher
Elsevier BV
Published
2020-06
Volume
437
Pages
242-255
ISSN
0306-4522 (ISSN-L)
OpenAlex
W3031608662
Cited by
69
References
104
Citations by year
2026: 3 · 2025: 16 · 2024: 14 · 2023: 13 · 2022: 13 · 2021: 8 · 2020: 2
FWCI
3.48
Type
journal article
Language
en
Open access
closed
Locations
  • Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Canadian Institutes of Health Research
  • Natural Sciences and Engineering Research Council of Canada
Topics
  • Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
  • Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
Keywords
high-intensity interval exercise, corticospinal excitability, brain-derived neurotrophic factor, uncarboxylated osteocalcin, carboxylated osteocalcin, irisin, cathepsin B, intracortical inhibition, intracortical facilitation, exercise-induced neuroplasticity, motor learning, stroke rehabilitation, sedentary men
MeSH terms
Cathepsin B, Humans, Male, Motor Cortex, Exercise, Evoked Potentials, Motor, Brain-Derived Neurotrophic Factor, Transcranial Magnetic Stimulation

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