A Single Bout of High-intensity Interval Exercise Increases Corticospinal Excitability, Brain-derived Neurotrophic Factor, and Uncarboxylated Osteolcalcin in Sedentary, Healthy Males
Abstract
Exercise induces neuroplasticity in descending motor pathways facilitating motor learning, and as such it could be utilized as an intervention in neurorehabilitation, for example when re-learning motor skills after stroke. To date, however, the neurophysiological and molecular mechanisms underlying exercise-induced neuroplasticity remain largely unknown impeding the potential utilization of exercise protocols as 'motor learning boosters' in clinical and non-clinical settings. Here, we assessed corticospinal excitability, intracortical facilitation (ICF) and short-interval intracortical inhibition (SICI) using transcranial magnetic stimulation (TMS) and serum biochemical markers including brain-derived neurotrophic factor (BDNF), total and precursor cathepsin B (tCTSB, proCTSB), uncarboxylated and carboxylated osteocalcin (unOCN, cOCN) and irisin using ELISA. Measurements were carried out in sedentary, healthy males before and after a single session of high-intensity interval exercise (HIIE) or in individuals who rested and did not perform exercise (No Exercise). We found that HIIE increased corticospinal excitability, BDNF and unOCN, and decreased cOCN. We also determined that greater increases in BDNF were associated with increases in unOCN and irisin and decreases in cOCN only in participants who underwent HIIE, suggesting that unOCN and irisin may contribute to exercise-induced BDNF increases. Conversely, no changes other than a decrease in serum unOCN/tOCN were found in N…
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In humans, acute exercise does not clearly increase plasma cathepsin B.
“Studies in humans have shown that acute exercise does not clearly increase plasma levels of cathepsin B7, although chronic exercise does increase plasma levels of cathepsin B145,157.”
From Exerkines in health, resilience and disease (2022) · cites this paper as [7]
In humans, acute exercise increases plasma BDNF.
“In humans, acute exercise increases plasma levels of brain-derived neurotrophic factor (BDNF)7, whereas chronic exercise training has been shown to not alter140, increase or even decrease plasma levels of BDNF140,145.”
From Exerkines in health, resilience and disease (2022) · cites this paper as [7]
Cites
The assessment and analysis of handedness: The Edinburgh inventory
Oldfield, R. C. (1971) · Neuropsychologia · doi:10.1016/0028-3932(71)90067-4 · Cited by 35,900 · see citing works
Exercise training increases size of hippocampus and improves memory
Erickson, K. I., Voss, M. W., Prakash, R. S., Basak, C., Szabo, A., Chaddock, L., Kim, J. S., Heo, S., Alves, H., White, S. M., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1015950108 · Cited by 4,855 · see citing works
A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis
Boström, P., Wu, J., Jedrychowski, M. P., Korde, A., Ye, L., Lo, J. C., Rasbach, K. A., Boström, E. A., Choi, J. H., Long, J. Z., et al. (2012) · Nature · doi:10.1038/nature10777 · Cited by 4,810 · see citing works
Neurotrophins: Roles in Neuronal Development and Function
Huang, E. J., & Reichardt, L. F. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.677 · Cited by 4,394 · see citing works
Be smart, exercise your heart: Exercise effects on brain and cognition
Hillman, C. H., Erickson, K. I., & Kramer, A. F. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2298 · Cited by 3,563 · see citing works
Muscles, exercise and obesity: skeletal muscle as a secretory organ
Pedersen, B. K., & Febbraio, M. A. (2012) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2012.49 · Cited by 2,909 · see citing works
Exercise: a behavioral intervention to enhance brain health and plasticity
Cotman, C. (2002) · Trends in Neurosciences · doi:10.1016/s0166-2236(02)02143-4 · Cited by 2,739 · see citing works
Exercise builds brain health: key roles of growth factor cascades and inflammation
Cotman, C. W., Berchtold, N. C., & Christie, L.-A. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.06.011 · Cited by 2,268 · see citing works
Neurotrophin regulation of neural circuit development and function
Park, H., & Poo, M.-M. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3379 · Cited by 2,060 · see citing works
Motulsky, H. J., & Brown, R. E. (2006) · BMC Bioinformatics · doi:10.1186/1471-2105-7-123 · Cited by 1,616 · see citing works
Exercise induces hippocampal BDNF through a PGC-1α/FNDC5 pathway
Wrann, C. D., White, J. P., Salogiannnis, J., Laznik-Bogoslavski, D., Wu, J., Ma, D., Lin, J. D., Greenberg, M. E., & Spiegelman, B. M. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.09.008 · Cited by 1,440 · see citing works
BDNF function in adult synaptic plasticity: The synaptic consolidation hypothesis
Bramham, C. R., & Messaoudi, E. (2005) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2005.06.003 · Cited by 1,193 · see citing works
Ziemann, U., Lönnecker, S., Steinhoff, B. J., & Paulus, W. (1996) · Annals of Neurology · doi:10.1002/ana.410400306 · Cited by 1,136 · see citing works
Insulin signaling in osteoblasts integrates bone remodeling and energy metabolism
Ferron, M., Wei, J., Yoshizawa, T., Del Fattore, A., DePinho, R. A., Teti, A., Ducy, P., & Karsenty, G. (2010) · Cell · doi:10.1016/j.cell.2010.06.003 · Cited by 1,123 · see citing works
Autophosphorylation at Thr <sup>286</sup> of the α Calcium-Calmodulin Kinase II in LTP and Learning
Giese, K. P., Fedorov, N. B., Filipkowski, R. K., & Silva, A. J. (1998) · Science · doi:10.1126/science.279.5352.870 · Cited by 1,055 · see citing works
Trejo, J. L., Carro, E., & Torres-Alemán, I. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-05-01628.2001 · Cited by 1,017 · see citing works
Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models
Lourenco, M. V., Frozza, R. L., de Freitas, G. B., Zhang, H., Kincheski, G. C., Ribeiro, F. C., Gonçalves, R. A., Clarke, J. R., Beckman, D., Staniszewski, A., et al. (2019) · Nature Medicine · doi:10.1038/s41591-018-0275-4 · Cited by 935 · see citing works
Bherer, L., Erickson, K. I., & Liu-Ambrose, T. (2013) · Journal of Aging Research · doi:10.1155/2013/657508 · Cited by 899 · see citing works
Differential effects on motorcortical inhibition induced by blockade of GABA uptake in humans
Werhahn, K. J., Kunesch, E., Noachtar, S., Benecke, R., & Classen, J. (1999) · The Journal of Physiology · doi:10.1111/j.1469-7793.1999.0591t.x · Cited by 887 · see citing works
FERRIS, L. T., WILLIAMS, J. S., & SHEN, C.-L. (2007) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e31802f04c7 · Cited by 849 · see citing works
Little, J. P., Gillen, J. B., Percival, M. E., Safdar, A., Tarnopolsky, M. A., Punthakee, Z., Jung, M. E., & Gibala, M. J. (2011) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00921.2011 · Cited by 787 · see citing works
Self-citationRunning-induced systemic cathepsin B secretion is associated with memory function
Moon, H. Y., Becke, A., Berron, D., Becker, B., Sah, N., Benoni, G., Janke, E., Lubejko, S. T., Greig, N. H., Mattison, J. A., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.05.025 · Cited by 628 · see citing works
New insights into the biology of osteocalcin
Zoch, M. L., Clemens, T. L., & Riddle, R. C. (2015) · Bone · doi:10.1016/j.bone.2015.05.046 · Cited by 612 · see citing works
Ludyga, S., Gerber, M., Brand, S., Holsboer‐Trachsler, E., & Pühse, U. (2016) · Psychophysiology · doi:10.1111/psyp.12736 · Cited by 589 · see citing works
Norheim, F., Langleite, T. M., Hjorth, M., Holen, T., Kielland, A., Stadheim, H. K., Gulseth, H. L., Birkeland, K. I., Jensen, J., & Drevon, C. A. (2014) · The FEBS Journal · doi:10.1111/febs.12619 · Cited by 563 · see citing works
The role of GABAB receptors in intracortical inhibition in the human motor cortex
McDonnell, M. N., Orekhov, Y., & Ziemann, U. (2006) · Experimental Brain Research · doi:10.1007/s00221-006-0365-2 · Cited by 558 · see citing works
Ding, Q., Vaynman, S., Akhavan, M., Ying, Z., & Gomez-Pinilla, F. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.02.084 · Cited by 555 · see citing works
Aerobic exercise improves hippocampal function and increases BDNF in the serum of young adult males
Griffin, É. W., Mullally, S. L., Foley, C., Warmington, S. A., O’Mara, S. M., & Kelly, A. M. (2011) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.06.005 · Cited by 543 · see citing works
Maternal and Offspring Pools of Osteocalcin Influence Brain Development and Functions
Oury, F., Khrimian, L., Denny, C. A., Gardin, A., Chamouni, A., Goeden, N., Huang, Y.-Y., Lee, H., Srinivas, P., Gao, X.-B., et al. (2013) · Cell · doi:10.1016/j.cell.2013.08.042 · Cited by 484 · see citing works
MC4R-dependent suppression of appetite by bone-derived lipocalin 2
Mosialou, I., Shikhel, S., Liu, J., Maurizi, A., Luo, N., He, Z., Huang, Y., Zong, H., Friedman, R. A., Barasch, J. M., et al. (2017) · Nature · doi:10.1038/nature21697 · Cited by 457 · see citing works
Osteocalcin Signaling in Myofibers Is Necessary and Sufficient for Optimum Adaptation to Exercise
Mera, P., Laue, K., Ferron, M., Confavreux, C. B., Wei, J., Galán-Díez, M., Lacampagne, A., Mitchell, S. J., Mattison, J. A., Chen, Y., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.05.004 · Cited by 429 · see citing works
Heyman, E., Gamelin, F.-X., Goekint, M., Piscitelli, F., Roelands, B., Leclair, E., Di Marzo, V., & Meeusen, R. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.09.017 · Cited by 427 · see citing works
Huh, J. Y., Mougios, V., Kabasakalis, A., Fatouros, I., Siopi, A., Douroudos, I. I., Filippaios, A., Panagiotou, G., Park, K. H., & Mantzoros, C. S. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-1437 · Cited by 363 · see citing works
Mang, C. S., Campbell, K. L., Ross, C. J., & Boyd, L. A. (2013) · Physical Therapy · doi:10.2522/ptj.20130053 · Cited by 352 · see citing works
A Necessity for MAP Kinase Activation in Mammalian Spatial Learning
Selcher, J. C., Atkins, C. M., Trzaskos, J. M., Paylor, R., & Sweatt, J. D. (1999) · Learning & Memory · doi:10.1101/lm.6.5.478 · Cited by 341 · see citing works
Acute exercise improves motor memory: exploring potential biomarkers.
Skriver, K., Roig, M., Lundbye-Jensen, J., Pingel, J., Helge, J. W., Kiens, B., & Nielsen, J. B. (2014) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2014.08.004 · Cited by 326 · see citing works
Aerobic Exercise Improves Cognition and Motor Function Poststroke
Quaney, B. M., Boyd, L. A., McDowd, J. M., Zahner, L. H., He, J., Mayo, M. S., & Macko, R. F. (2009) · Neurorehabilitation and neural repair · doi:10.1177/1545968309338193 · Cited by 324 · see citing works
Gpr158 mediates osteocalcin’s regulation of cognition
Khrimian, L., Obri, A., Ramos-Brossier, M., Rousseaud, A., Moriceau, S., Nicot, A.-S., Mera, P., Kosmidis, S., Karnavas, T., Saudou, F., et al. (2017) · Journal of Experimental Medicine · doi:10.1084/jem.20171320 · Cited by 308 · see citing works
Gold, S. M., Schulz, K., Hartmann, S., Mladek, M., Lang, U. E., Hellweg, R., Reer, R., Braumann, K.-M., & Heesen, C. (2003) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(03)00121-8 · Cited by 300 · see citing works
Pekkala, S., Wiklund, P. K., Hulmi, J. J., Ahtiainen, J. P., Horttanainen, M., Pöllänen, E., Mäkelä, K. A., Kainulainen, H., Häkkinen, K., Nyman, K., et al. (2013) · The Journal of Physiology · doi:10.1113/jphysiol.2013.263707 · Cited by 292 · see citing works
Exercise counteracts declining hippocampal function in aging and Alzheimer's disease
Intlekofer, K. A., & Cotman, C. W. (2012) · Neurobiology of Disease · doi:10.1016/j.nbd.2012.06.011 · Cited by 286 · see citing works
Schwarz, A. J., Brasel, J. A., Hintz, R. L., Mohan, S., & Cooper, D. M. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.10.8855791 · Cited by 284 · see citing works
Bone and Muscle Endocrine Functions: Unexpected Paradigms of Inter-organ Communication
Karsenty, G., & Olson, E. N. (2016) · Cell · doi:10.1016/j.cell.2016.02.043 · Cited by 274 · see citing works
Tang, S. W., Chu, E., Hui, T. C. K., Helmeste, D. M., & Law, C. (2007) · Neuroscience Letters · doi:10.1016/j.neulet.2007.11.019 · Cited by 247 · see citing works
Marquez, C. M. S., Vanaudenaerde, B. M., Troosters, T., & Wenderoth, N. (2015) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00126.2015 · Cited by 243 · see citing works
Di Lazzaro, V., Pilato, F., Dileone, M., Profice, P., Ranieri, F., Ricci, V., Bria, P., Tonali, P. A., & Ziemann, U. (2007) · Clinical Neurophysiology · doi:10.1016/j.clinph.2007.07.005 · Cited by 240 · see citing works
Osteocalcin—A Versatile Bone-Derived Hormone
Moser, S. C., & van der Eerden, B. C. J. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00794 · Cited by 234 · see citing works
Müller‐Dahlhaus, J. F. M., Liu, Y., & Ziemann, U. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.142059 · Cited by 230 · see citing works
Mang, C. S., Snow, N. J., Campbell, K. L., Ross, C. J., & Boyd, L. A. (2014) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00498.2014 · Cited by 224 · see citing works
Daskalopoulou, S. S., Cooke, A. B., Sandoval, Y.-H. G., Mutter, A. F., Filippaios, A., Mesfum, E. T., & Mantzoros, C. S. (2014) · European Journal of Endocrinology · doi:10.1530/eje-14-0204 · Cited by 216 · see citing works
Serum Irisin Levels Are Regulated by Acute Strenuous Exercise
Löffler, D., Müller, U., Scheuermann, K., Friebe, D., Gesing, J. K., Bielitz, J., Erbs, S., Landgraf, K., Wagner, I. V., Kieß, W., et al. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-2932 · Cited by 213 · see citing works
Irisin in response to exercise in humans with and without metabolic syndrome
Huh, J. Y., Siopi, A., Mougios, V., Park, K. H., & Mantzoros, C. S. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-2416 · Cited by 210 · see citing works
Kuipers, S. D., & Bramham, C. R. (2006) · PubMed · Cited by 209 · see citing works
Resistance exercise induces a greater irisin response than endurance exercise
Tsuchiya, Y., Ando, D., Takamatsu, K., & Goto, K. (2015) · Metabolism · doi:10.1016/j.metabol.2015.05.010 · Cited by 207 · see citing works
Cirillo, J., Lavender, A. P., Ridding, M. C., & Semmler, J. G. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2009.181834 · Cited by 199 · see citing works
Effect of brief exercise on circulating insulin-like growth factor I
Cappon, J. P., Brasel, J. A., Mohan, S., & Cooper, D. M. (1994) · Journal of Applied Physiology · doi:10.1152/jappl.1994.76.6.2490 · Cited by 190 · see citing works
Anastasilakis, A. D., Pοlyzos, S. A., Saridakis, Z. G., Kynigopoulos, G., Skouvaklidou, E. C., Molyvas, D., Vasiloglou, M. F., Apostolou, A., Karagiozoglou‐Lampoudi, Τ., Siopi, A., et al. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-1367 · Cited by 186 · see citing works
Kraemer, R. R., Shockett, P. E., Webb, N., Shah, U. R., & Castracane, V. D. (2013) · Hormone and Metabolic Research · doi:10.1055/s-0033-1355381 · Cited by 181 · see citing works
Tsuchiya, Y., Ando, D., Goto, K., Kiuchi, M., Yamakita, M., & Koyama, K. (2014) · The Tohoku Journal of Experimental Medicine · doi:10.1620/tjem.233.135 · Cited by 176 · see citing works
A single bout of aerobic exercise promotes motor cortical neuroplasticity
McDonnell, M. N., Buckley, J. D., Opie, G. M., Ridding, M. C., & Semmler, J. G. (2013) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01378.2012 · Cited by 170 · see citing works
Davis, S., & Laroche, S. (2006) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2006.00230.x · Cited by 164 · see citing works
On the Run for Hippocampal PlasticityPreprint
Cooper, C. P., Moon, H. Y., & van Praag, H. (2017) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a029736 · Cited by 160 · see citing works
The influence of exercise on brain aging and dementia
Lautenschlager, N. T., Cox, K. L., & Cyarto, E. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.07.010 · Cited by 157 · see citing works
Guntur, A. R., & Rosen, C. J. (2012) · Endocrine Practice · doi:10.4158/ep12141.ra · Cited by 150 · see citing works
The influence of a single bout of aerobic exercise on short-interval intracortical excitability
Smith, A. E., Goldsworthy, M. R., Garside, T., Wood, F. M., & Ridding, M. C. (2014) · Experimental Brain Research · doi:10.1007/s00221-014-3879-z · Cited by 147 · see citing works
Singh, A. M., Duncan, R. E., Neva, J. L., & Staines, R. W. (2014) · BMC Sports Science Medicine and Rehabilitation · doi:10.1186/2052-1847-6-23 · Cited by 145 · see citing works
Chang, Y., Tsai, C., Huang, C., Wang, C., & Chu, I. (2013) · Journal of science and medicine in sport · doi:10.1016/j.jsams.2013.02.007 · Cited by 145 · see citing works
Nygaard, H., Slettaløkken, G., Vegge, G., Hollan, I., Whist, J. E., Strand, T. A., Rønnestad, B. R., & Ellefsen, S. (2015) · PLoS ONE · doi:10.1371/journal.pone.0121367 · Cited by 141 · see citing works
Young, M. F., Valaris, S., & Wrann, C. D. (2019) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2019.02.007 · Cited by 136 · see citing works
Bechara, R. G., & Kelly, A. M. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.02.018 · Cited by 132 · see citing works
Hyun-Chul, C., Kim, J., Kim, S.-Y., Son, Y. H., Lee, N., & Jung, S. H. (2012) · Neuroscience Letters · doi:10.1016/j.neulet.2012.05.025 · Cited by 128 · see citing works
Stavrinos, E. L., & Coxon, J. P. (2016) · Journal of Cognitive Neuroscience · doi:10.1162/jocn_a_01078 · Cited by 125 · see citing works
No exercise-induced increase in serum BDNF after cycling near a major traffic road
Bos, I., Jacobs, L., Nawrot, T. S., de Geus, B., Torfs, R., Panis, L. I., Degraeuwe, B., & MEEUSEN, R. R. (2011) · Neuroscience Letters · doi:10.1016/j.neulet.2011.06.019 · Cited by 124 · see citing works
Molecular bases of the crosstalk between bone and muscle
Karsenty, G., & Mera, P. (2017) · Bone · doi:10.1016/j.bone.2017.04.006 · Cited by 116 · see citing works
Irisin in response to acute and chronic whole-body vibration exercise in humans
Huh, J. Y., Mougios, V., Skraparlis, A. N., Kabasakalis, A., & Mantzoros, C. S. (2014) · Metabolism · doi:10.1016/j.metabol.2014.04.001 · Cited by 112 · see citing works
Singh, A. M., Neva, J. L., & Staines, R. W. (2014) · Experimental Brain Research · doi:10.1007/s00221-014-4049-z · Cited by 112 · see citing works
Andrews, S. C., Curtin, D., Hawi, Z., Wongtrakun, J., Stout, J. C., & Coxon, J. P. (2019) · Cerebral Cortex · doi:10.1093/cercor/bhz075 · Cited by 109 · see citing works
Active and resting motor threshold are efficiently obtained with adaptive threshold hunting
Sen, C. B. A., Fassett, H. J., El‐Sayes, J., Turco, C. V., Hameer, M. M., & Nelson, A. J. (2017) · PLoS ONE · doi:10.1371/journal.pone.0186007 · Cited by 107 · see citing works
Self-citationLocal Effects of BDNF on Dendritic Growth
Horch, H. W. (2004) · Reviews in the Neurosciences · doi:10.1515/revneuro.2004.15.2.117 · Cited by 103 · see citing works
The effect of acute exercise on undercarboxylated osteocalcin and insulin sensitivity in obese men
Levinger, I., Jerums, G., Stepto, N. K., Parker, L., Serpiello, F. R., McConell, G. K., Anderson, M., Hare, D. L., Byrnes, E., Ebeling, P. R., et al. (2014) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2285 · Cited by 101 · see citing works
Phillips, B. E., Kelly, B. M., Lilja, M. R., Ponce‐González, J. G., Brogan, R. J., Morris, D. L., Gustafsson, T. P., Kraus, W. E., Atherton, P. J., Vollaard, N. B. J., et al. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00229 · Cited by 98 · see citing works
Physical activity levels determine exercise-induced changes in brain excitability
Lulic-Kuryllo, T., El‐Sayes, J., Fassett, H. J., & Nelson, A. J. (2017) · PLoS ONE · doi:10.1371/journal.pone.0173672 · Cited by 97 · see citing works
Self-citationNovel insights into CaMKII function and regulation during memory formation
Lucchesi, W., Mizuno, K., & Giese, K.-P. (2010) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2010.10.009 · Cited by 95 · see citing works
Yeap, B. B., Alfonso, H. S., Chubb, S. A. P., Gauci, R., Byrnes, E., Beilby, J. P., Ebeling, P. R., Handelsman, D. J., Allan, C. A., Grossmann, M., et al. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-3019 · Cited by 94 · see citing works
The effect of perspiration on the sEMG amplitude and power spectrum
Abdoli-Eramaki, M., Damecour, C., Christenson, J., & Stevenson, J. M. (2012) · Journal of Electromyography and Kinesiology · doi:10.1016/j.jelekin.2012.04.009 · Cited by 87 · see citing works
The effect of acute exercise on undercarboxylated osteocalcin in obese men
Levinger, I., Zebaze, R., Jerums, G., Hare, D. L., Selig, S. E., & Seeman, E. (2010) · Osteoporosis International · doi:10.1007/s00198-010-1370-7 · Cited by 79 · see citing works
Belviranlı, M., Okudan, N., Kabak, B., Erdoğan, M., & Karanfılcı, M. (2016) · The Physician and Sportsmedicine · doi:10.1080/00913847.2016.1196125 · Cited by 76 · see citing works
Takahashi, K., Maruyama, A., Hirakoba, K., Maeda, M., Etoh, S., Kawahira, K., & Rothwell, J. C. (2010) · Brain stimulation · doi:10.1016/j.brs.2010.07.001 · Cited by 71 · see citing works
Acute aerobic exercise modulates primary motor cortex inhibition
Mooney, R. A., Coxon, J. P., Cirillo, J., Glenny, H., Gant, N., & Byblow, W. D. (2016) · Experimental Brain Research · doi:10.1007/s00221-016-4767-5 · Cited by 69 · see citing works
Goekint, M., Heyman, E., Roelands, B., Njemini, R., Bautmans, I., Mets, T. F., & MEEUSEN, R. R. (2008) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e31817eee85 · Cited by 62 · see citing works
Chubb, S. A. P., Byrnes, E., Manning, L. A., Beilby, J. P., Ebeling, P. R., Vasikaran, S. D., Golledge, J., Flicker, L. A., & Yeap, B. B. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-2646 · Cited by 57 · see citing works
Brain-Derived Neurotrophic Factor: the Link Between Amyloid-β and Memory Loss
Fahnestock, M. L. (2011) · Future Neurology · doi:10.2217/fnl.11.44 · Cited by 55 · see citing works
Self-citationPercival, M. E., Martin, B. J., Gillen, J. B., Skelly, L. E., MacInnis, M. J., Green, A. E., Tarnopolsky, M. A., & Gibala, M. J. (2015) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00048.2015 · Cited by 50 · see citing works
Self-citationOpie, G. M., & Semmler, J. G. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2019.05.049 · Cited by 48 · see citing works
The Effect of Aerobic Exercise on Neuroplasticity within the Motor Cortex following Stroke
Murdoch, K., Buckley, J. D., & McDonnell, M. N. (2016) · PLoS ONE · doi:10.1371/journal.pone.0152377 · Cited by 45 · see citing works
Fibroblast growth factor 23 as a phosphotropic hormone and beyond
Fukumoto, S., & Shimizu, Y. (2011) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-011-0298-0 · Cited by 44 · see citing works
Nicolini, C., Toepp, S. L., Harasym, D., Michalski, B., Fahnestock, M. L., Gibala, M. J., & Nelson, A. J. (2019) · Physiological Reports · doi:10.14814/phy2.14140 · Cited by 42 · see citing works
Self-citationThe Effects of Biological Sex and Ovarian Hormones on Exercise-Induced Neuroplasticity
El‐Sayes, J., Turco, C. V., Skelly, L. E., Nicolini, C., Fahnestock, M. L., Gibala, M. J., & Nelson, A. J. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2019.04.054 · Cited by 40 · see citing works
Self-citationYeap, B. B., Alfonso, H. S., Chubb, S. A. P., Byrnes, E., Beilby, J. P., Ebeling, P. R., Allan, C. A., Schultz, C. J., Hankey, G. J., Golledge, J., et al. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2015-1899 · Cited by 31 · see citing works
Forman, D. A., Baarbé, J. K., Daligadu, J., Murphy, B. A., & Holmes, M. W. R. (2016) · Journal of Electromyography and Kinesiology · doi:10.1016/j.jelekin.2016.02.005 · Cited by 29 · see citing works
Rahman, N. Z. A., Greenwood, S. M., Brett, R. R., Tossell, K., Ungless, M. A., Plevin, R. J., & Bushell, T. J. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.3825-15.2016 · Cited by 28 · see citing works
Intensity of acute aerobic exercise but not aerobic fitness impacts on corticospinal excitability
MacDonald, M., Khan, H., Kraeutner, S. N., Usai, F., Rogers, E. A., Kimmerly, D. S., Dechman, G., & Boe, S. G. (2019) · Applied Physiology Nutrition and Metabolism · doi:10.1139/apnm-2018-0643 · Cited by 24 · see citing works
El‐Sayes, J., Turco, C. V., Skelly, L. E., Locke, M. B., Gibala, M. J., & Nelson, A. J. (2020) · PLoS ONE · doi:10.1371/journal.pone.0227581 · Cited by 21 · see citing works
Self-citation
Flagged first, then by citations
1 of the 104 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Exerkines in health, resilience and disease
Chow, L. S., Gerszten, R. E., Taylor, J. M., Pedersen, B. K., van Praag, H., Trappe, S., Febbraio, M. A., Galis, Z. S., Gao, Y., Haus, J. M., et al. (2022) · Nature Reviews Endocrinology · doi:10.1038/s41574-022-00641-2 · Cited by 927 · see citing works
Gaitán, J. M., Moon, H. Y., Stremlau, M., Dubal, D. B., Cook, D. B., Okonkwo, O. C., & van Praag, H. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.660181 · Cited by 160 · see citing works
Exerkines and long-term synaptic potentiation: Mechanisms of exercise-induced neuroplasticity
Vints, W. A. J., Levin, O., Fujiyama, H., Verbunt, J., & Masiulis, N. (2022) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2022.100993 · Cited by 114 · see citing works
Fernández‐Rodríguez, R., Álvarez‐Bueno, C., Martínez-Ortega, I. A., Martínez‐Vizcaíno, V., Mesas, A. E., & Notario‐Pacheco, B. (2021) · Journal of sport and health science/Journal of Sport and Health Science · doi:10.1016/j.jshs.2021.08.004 · Cited by 102 · see citing works
The Combined Influences of Exercise, Diet and Sleep on Neuroplasticity
Pickersgill, J. W., Turco, C. V., Ramdeo, K. R., Rehsi, R. S., Foglia, S. D., & Nelson, A. J. (2022) · Frontiers in Psychology · doi:10.3389/fpsyg.2022.831819 · Cited by 88 · see citing works
Self-citationJaberi, S., & Fahnestock, M. L. (2023) · Biomolecules · doi:10.3390/biom13111577 · Cited by 74 · see citing works
Self-citationNicolini, C., Fahnestock, M. L., Gibala, M. J., & Nelson, A. J. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.12.013 · Cited by 50 · see citing works
Self-citationKazeminasab, F., Sadeghi, E., & Afshari-Safavi, A. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/8235809 · Cited by 43 · see citing works
Cellular and Molecular Regulation of Exercise—A Neuronal Perspective
Reddy, I., Yadav, Y., & Dey, C. S. (2022) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-022-01272-x · Cited by 41 · see citing works
Exercise, exerkines, and cardiometabolic health: from individual players to a team sport
Robbins, J., & Gerszten, R. E. (2023) · Journal of Clinical Investigation · doi:10.1172/jci168121 · Cited by 41 · see citing works
Sui, S. X., Balanta‐Melo, J., Pasco, J. A., & Plotkin, L. I. (2022) · Current Osteoporosis Reports · doi:10.1007/s11914-022-00736-9 · Cited by 34 · see citing works
Mazo, C. E., Miranda, E. R., Shadiow, J., Vesia, M., & Haus, J. M. (2022) · Brain Plasticity · doi:10.3233/bpl-220137 · Cited by 29 · see citing works
Exercise and Dietary Factors Mediate Neural Plasticity Through Modulation of BDNF Signaling
Fakhoury, M., Eid, F., Ahmad, P. E., Khoury, R. E., Mezher, A., Masri, D. E., Haddad, Z. L., Zoghby, Y. E., Ghayad, L. M., Sleiman, S. F., et al. (2022) · Brain Plasticity · doi:10.3233/bpl-220140 · Cited by 29 · see citing works
Hugues, N., Pin-Barre, C., Pellegrino, C., Rivera, C., Berton, É., & Laurin, J. (2021) · Cerebral Cortex · doi:10.1093/cercor/bhab451 · Cited by 28 · see citing works
Exercise, Neuroprotective Exerkines, and Parkinson’s Disease: A Narrative Review
Mitchell, A. K., Bliss, R. R., & Church, F. (2024) · Biomolecules · doi:10.3390/biom14101241 · Cited by 32 · see citing works
Chbeir, S., & Carrión, V. (2023) · World Journal of Psychiatry · doi:10.5498/wjp.v13.i5.144 · Cited by 25 · see citing works
Zhang, S., Gu, B., Zhen, K., Du, L., Lv, Y., & Yu, L. (2024) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2024.105538 · Cited by 25 · see citing works
Hola, V., Polanská, H., Jandova, T., Dytrtová, J. J., Weinerová, J., Šteffl, M., Kramperová, V., Daďová, K., Durkalec‐Michalski, K., & Bartoš, A. (2024) · Clinical Interventions in Aging · doi:10.2147/cia.s482479 · Cited by 27 · see citing works
Stephan, J. S., & Sleiman, S. F. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.600365 · Cited by 23 · see citing works
Transcranial Magnetic Stimulation to Assess Exercise-Induced Neuroplasticity
Turco, C. V., & Nelson, A. J. (2021) · Frontiers in Neuroergonomics · doi:10.3389/fnrgo.2021.679033 · Cited by 23 · see citing works
Self-citationKhoury, R., & Nagy, C. (2023) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2023.1154872 · Cited by 18 · see citing works
Acute Exercise Modulates the Excitability of Specific Interneurons in Human Motor Cortex
Neva, J. L., Brown, K. E., Peters, S., Feldman, S. J., Mahendran, N., Boisgontier, M. P., & Boyd, L. A. (2021) · Neuroscience · doi:10.1016/j.neuroscience.2021.08.032 · Cited by 18 · see citing works
Youssef, L., Harroum, N., Francisco, B. A., Johnson, L. G., Arvisais, D., Pageaux, B., Romain, A. J., Hayward, K. S., & Neva, J. L. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105811 · Cited by 17 · see citing works
Ren, J., & Xiao, H. (2023) · Life · doi:10.3390/life13122285 · Cited by 16 · see citing works
Abdulghani, A., Poghosyan, M., Mehren, A., Philipsen, A., & Anderzhanova, E. A. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.997054 · Cited by 15 · see citing works
Investigation of Brain Function-Related Myokine Secretion by Using Contractile 3D-Engineered Muscle
Sugimoto, T., Nakamura, T., YOKOYAMA, S., Fujisato, T., Konishi, S., & Hashimoto, T. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23105723 · Cited by 14 · see citing works
Bogard, A. T., Hemmerle, M. R., Smith, A. C., & Tan, A. Q. (2023) · The Journal of Physiology · doi:10.1113/jp285425 · Cited by 13 · see citing works
Katz, D. H., Lindholm, M. E., & Ashley, E. A. (2024) · Physiology · doi:10.1152/physiol.00024.2024 · Cited by 12 · see citing works
Gao, S., Li, N., Qi, L., Li, X., Zhang, J., Zhang, Z., Xu, Z., Liang, S., Zhu, W., & Liu, W. (2025) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2025.09.001 · Cited by 12 · see citing works
Cathepsin B and Muscular Strength are Independently Associated with Cognitive Control
Kim, J., McKenna, C. F., Salvador, A. F., Scaroni, S. E., Askow, A. T., Cerna, J., Cannavale, C. N., Paluska, S. A., Lisio, M. D., Petruzzello, S. J., et al. (2022) · Brain Plasticity · doi:10.3233/bpl-210136 · Cited by 11 · see citing works
Nicolini, C., & Nelson, A. J. (2021) · Frontiers in Neuroergonomics · doi:10.3389/fnrgo.2021.678541 · Cited by 8 · see citing works
Self-citationGökçe, E., Adıgüzel, E., Koçak, Ö. K., Kılınç, H., Langeard, A., Boran, H. E., & Çengiz, B. (2024) · Neuroscience · doi:10.1016/j.neuroscience.2024.05.032 · Cited by 7 · see citing works
Rodrigues, L., Moncion, K., Heras, B. D. L., Cristini, J., Khalili, R., Eng, J. J., Fung, J., MacKay-Lyons, M. J., Thiel, A., Tang, A., et al. (2025) · Neurorehabilitation and neural repair · doi:10.1177/15459683251351883 · Cited by 7 · see citing works
Proessl, F., Canino, M. C., Beckner, M. E., Conkright, W. R., LaGoy, A. D., Sinnott, A. M., Eagle, S. R., Martin, B. J., Sterczala, A. J., Roma, P. G., et al. (2021) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00628.2021 · Cited by 6 · see citing works
Shah, Z., Ahmad, F., Zahra, M., Zulfiqar, F., Aziz, S., & Mahmood, A. (2022) · Brain Plasticity · doi:10.3233/bpl-210130 · Cited by 6 · see citing works
The Effects of Electrical Stimulation on a 3D Osteoblast Cell Model
Mahadeo, C., Shahin‐Shamsabadi, A., Khodamoradi, M., Fahnestock, M. L., & Selvaganapathy, P. R. (2025) · Cells · doi:10.3390/cells14060396 · Cited by 5 · see citing works
Self-citationVints, W. A. J., Gökçe, E., Langeard, A., Павлова, Ю., Çevik, Ö. S., Ziaaldini, M. M., Todri, J., Lena, O., Shalom, S. B., Jak, S., et al. (2025) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2025.106381 · Cited by 5 · see citing works
Bone-brain crosstalk: emerging roles of osteocalcin in central nervous system disorders
Chen, H., Zhang, Z., Yi, W., Wang, N., Dong, X., Xing, Y., Liu, Q., Wu, Y., & Ma, X. (2025) · Neuroscience · doi:10.1016/j.neuroscience.2025.12.028 · Cited by 6 · see citing works
Ramdeo, K. R., Fahnestock, M. L., Gibala, M. J., Selvaganapathy, P. R., Lee, J., & Nelson, A. J. (2023) · JMIR Research Protocols · doi:10.2196/50030 · Cited by 5 · see citing works
Self-citationReducing motor evoked potential amplitude variability through normalization
Viana, F. F., Cotovio, G., da Silva, D. R., Seybert, C., Pereira, P., Silva, A., Carvalho, F., & Oliveira-Maia, A. J. (2024) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2024.1279072 · Cited by 4 · see citing works
Li, Q., Li, C., & Zhang, X. (2024) · Cellular and molecular neurobiology · doi:10.1007/s10571-024-01497-y · Cited by 5 · see citing works
Wang, J., Fan, S., & Wang, J. (2025) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-025-05357-1 · Cited by 3 · see citing works
Harroum, N., O’Farrell, A., Youssef, L., Bohbot, L., Maati, H., Joubert, M., Pageaux, B., & Neva, J. L. (2025) · Cerebral Cortex · doi:10.1093/cercor/bhaf230 · Cited by 6 · see citing works
Saez-Berlanga, Á., Gené‐Morales, J., Teixeira, A. M., Castuera, R. J., Gené‐Sampedro, A., Juesas, Á., Gargallo, P., Caballero, O., Garrido, J. F., Alix‐Fages, C., et al. (2025) · Healthcare · doi:10.3390/healthcare13233129 · Cited by 3 · see citing works
Motor cortex plasticity is greater in endurance-trained cyclists following acute exercise
Hand, B. J., Opie, G. M., Sidhu, S. K., & Semmler, J. G. (2022) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00213.2022 · Cited by 3 · see citing works
Sezer, T., Okudan, N., & Belviranlı, M. (2024) · Neuroscience Letters · doi:10.1016/j.neulet.2024.137993 · Cited by 3 · see citing works
High-intensity training and irisin response: A possible molecular cross-talk for irisin response
Li, P., Tong, L., & Bi, X. (2025) · Current Research in Physiology · doi:10.1016/j.crphys.2025.100163 · Cited by 4 · see citing works
Exercise-induced neuroplasticity
Neva, J. L. (2024) · Elsevier eBooks · doi:10.1016/b978-0-12-820480-1.00218-7 · Cited by 3 · see citing works
Global multi-omics analysis of exerkines in progressive treadmill-exercised rodentsPreprint
Taha, H. B. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.12.08.627439 · Cited by 3 · see citing works
Bjørndal, J. R., Jespersen, L., Wiedemann, R. D., Therkildsen, E. R., Karabanov, A. N., & Lundbye‐Jensen, J. (2025) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2025.108107 · Cited by 2 · see citing works
Irisin at the Croasroad of Autophagy and BNDF Signaling for Neuroplasticity Regulation
Anderzhanova, E. A., & Воронина, Т. А. (2023) · Neurochemical Journal · doi:10.1134/s1819712423020034 · Cited by 2 · see citing works
Michou, V., Tsamos, G., Vasdeki, D., Deligiannis, A. P., & Kouidi, E. J. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13195698 · Cited by 2 · see citing works
García-Salazar, L. F., Pereira, N. D., da Silva, E. S. M., Ribeiro, J. A. M., Ocamoto, G. N., Zambetta, R. M., Oliveira, S. G., Catai, A. M., Borstad, A. L., & Russo, T. L. (2024) · Physiotherapy Theory and Practice · doi:10.1080/09593985.2024.2411311 · Cited by 2 · see citing works
Motor cortical circuits are uniquely impacted by different exercise intensitiesPreprint
Harroum, N., O’Farrell, A., Youssef, L., Bohbot, L., Maati, H., Joubert, M., Pageaux, B., & Neva, J. L. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.01.24.634315 · Cited by 2 · see citing works
High intensity interval exercise maintains irisin level and reduces body fat in overweight women
Karimullah, A., Wibowo, N. F., Devi, A. I., Ilmi, S. Z., Yosnengsih, Azmy, U., Irwadi, I., Mohamed, M. N. A., Kusnanik, N. W., Purwanto, B., et al. (2023) · Comparative Exercise Physiology · doi:10.1163/17552559-20230030 · Cited by 1 · see citing works
Chan, A. S., Zare, N., Blank, M. A., Broatch, J. R., Bishop, D. J., Sims, N. A., Lynch, G. S., & Levinger, I. (2025) · Bone · doi:10.1016/j.bone.2025.117615 · Cited by 1 · see citing works
Cross-Platform Transcriptomic Analysis of 40 Human and Rodent Skeletal Muscle Exerkines
Taha, H. B., Robbins, N., Zoha, F.-S., Zhu, S., Vivek, N., & Bogoniewski, A. (2026) · Muscles · doi:10.3390/muscles5010015 · Cited by 1 · see citing works
Irwin, G., Rogatzki, M. J., Wiltshire, H., Williams, G., Gu, Y., Ash, G. I., Tao, D., & Baker, J. S. (2023) · Biology · doi:10.3390/biology12081089 · Cited by 1 · see citing works
Irisin at the Crossroad of Autophagy and BNDF Signaling for Neuroplasticity Regulation
Андяржанова, Э. А., & Воронина, Т. А. (2023) · Нейрохимия · doi:10.31857/s1027813323020036 · Cited by 1 · see citing works
Effects of Physical Activity-Induced Myocytokines on Alzheimer's Disease
He, Q. (2022) · Journal of Quality in Health Care & Economics · doi:10.23880/jqhe-16000255
High intensity exercise may be needed to change Levels of Biomarkers related to Neuroplasticity
Murphy, B. A. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.04.012 · Cited by 1 · see citing works
Morales, V. J., Ledesma-Amaya, L. I., Vázquez-Moreno, A., Delgado‐Olivares, L., Lerma, A., & Bosques-Brugada, L. E. (2024) · Revista Argentina de Ciencias del Comportamiento ( RACC ) · doi:10.32348/1852.4206.v16.n4.45118
Eccentric cycling enhances primary motor cortex excitabilityPreprint
Youssef, L., O’Farrell, A., Harroum, N., Bakhta, Y., Cohen, L., Pageaux, B., & Neva, J. L. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.07.04.663236
Yamazaki, Y., Sato, D., & Yamashiro, K. (2025) · Advances in neurobiology · doi:10.1007/978-981-95-0066-6_22
Li, C., Che, X., Yu, J., Yan, F., Yu, F., Zhao, P., Zhang, J., Zhao, L., & Xia, X. (2025) · BMC Psychology · doi:10.1186/s40359-025-03413-5
Aerobic Exercise Intensity: A Dose-Response Effect on Motor Adaptation and LearningPreprint
Harroum, N., Mahrez, Y., Pageaux, B., & Neva, J. L. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.10.28.680122
Hugues, N. (2023) · theses.fr (ABES) · doi:10.70675/3c52cc4bze9dfz499cza28az42945d38cbd6
Motor cortical excitability is differentially modulated by HIIT and strength exercise
Rostami, M., Lee, A., Frazer, A. K., Akalu, Y., Siddique, U., Walker, S., Tallent, J., & Kidgell, D. J. (2026) · Journal of Sports Sciences · doi:10.1080/02640414.2026.2705072
Turčić, M., & Vurušić, K. (2026) · Galician Medical Journal · doi:10.21802/e-gmj2026-a24
- Authors
- Nicolini, C., Michalski, B., Toepp, S. L., Turco, C. V., D'Hoine, T., Harasym, D., Gibala, M. J., Fahnestock, M., & Nelson, A. J.
- Affiliations
- McMaster University (CA)
- Corresponding author
- Nelson, Aimee J.
- ORCID
- Venue
- Neuroscience
- Publisher
- Elsevier BV
- Published
- 2020-06
- Volume
- 437
- Pages
- 242-255
- ISSN
- 0306-4522 (ISSN-L)
- OpenAlex
- W3031608662
- Cited by
- 69
- References
- 104
- Citations by year
- 2026: 3 · 2025: 16 · 2024: 14 · 2023: 13 · 2022: 13 · 2021: 8 · 2020: 2
- FWCI
- 3.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Canadian Institutes of Health Research
- Natural Sciences and Engineering Research Council of Canada
- Topics
- Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Keywords
- high-intensity interval exercise, corticospinal excitability, brain-derived neurotrophic factor, uncarboxylated osteocalcin, carboxylated osteocalcin, irisin, cathepsin B, intracortical inhibition, intracortical facilitation, exercise-induced neuroplasticity, motor learning, stroke rehabilitation, sedentary men
- MeSH terms
- Cathepsin B, Humans, Male, Motor Cortex, Exercise, Evoked Potentials, Motor, Brain-Derived Neurotrophic Factor, Transcranial Magnetic Stimulation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review