The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Dysregulation of apoptotic signaling in cancer: Molecular mechanisms and therapeutic opportunities
Open accessAbstract
Apoptosis is a tightly regulated cell suicide program that plays an essential role in the maintenance of tissue homeostasis by eliminating unnecessary or harmful cells. Defects in this native defense mechanism promote malignant transformation and frequently confer chemoresistance to transformed cells. Indeed, the evasion of apoptosis has been recognized as a hallmark of cancer. Given that multiple mechanisms function at many levels to orchestrate the regulation of apoptosis, a multitude of opportunities for apoptotic dysregulation are present within the intricate signaling network of cell. Several of the molecular mechanisms by which cancer cells are protected from apoptosis have been elucidated. These advances have facilitated the development of novel apoptosis‐inducing agents that have demonstrated single‐agent activity against various types of cancers cells and/or sensitized resistant cancer cells to conventional cytotoxic therapies. Herein, we will highlight several of the central modes of apoptotic dysregulation found in cancer. We will also discuss several therapeutic strategies that aim to reestablish the apoptotic response, and thereby eradicate cancer cells, including those that demonstrate resistance to traditional therapies. J. Cell. Biochem. 104: 1124–1149, 2008. © 2008 Wiley‐Liss, Inc.
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Mutations of the BRAF gene in human cancer
Davies, H., Bignell, G. R., Cox, C., Stephens, P., Edkins, S., Clegg, S., Teague, J., Woffendin, H., Garnett, M. J., Bottomley, W., et al. (2002) · Nature · doi:10.1038/nature00766 · Cited by 10,674
Vogelstein, B., Lane, D., & Levine, A. J. (2000) · Nature · doi:10.1038/35042675 · Cited by 6,607 · cited 2×
“In particular, the tumor suppressor p53 plays a key role in the prevention of aberrant cellular proliferation and the preservation of genomic integrity by inducing either DNA repair or apoptosis in response to several stress stimuli, including DNA damage and oncogene overexpression [Vogelstein et al., 2000; Fuster et…”
BackgroundDeath Receptors: Signaling and Modulation
Ashkenazi, A., & Dixit, V. M. (1998) · Science · doi:10.1126/science.281.5381.1305 · Cited by 5,866
Danial, N. N., & Korsmeyer, S. J. (2004) · Cell · doi:10.1016/s0092-8674(04)00046-7 · Cited by 4,651
ROWLEY, J. D. (1973) · Nature · doi:10.1038/243290a0 · Cited by 4,291
Moore, M. J., Goldstein, D., Hamm, J., Figer, A., Hecht, J. R., Gallinger, S., Au, H. J., Murawa, P., Walde, D., Wolff, R. A., et al. (2007) · Journal of Clinical Oncology · doi:10.1200/jco.2006.07.9525 · Cited by 3,848
Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer
Roberts, P. J., & Der, C. J. (2007) · Oncogene · doi:10.1038/sj.onc.1210422 · Cited by 2,788
NF-κB at the crossroads of life and death
Karin, M., & Lin, A. (2002) · Nature Immunology · doi:10.1038/ni0302-221 · Cited by 2,709
Fridman, J. S., & Lowe, S. W. (2003) · Oncogene · doi:10.1038/sj.onc.1207116 · Cited by 1,401
Activation of Apoptosis in Vivo by a Hydrocarbon-Stapled BH3 Helix
Walensky, L. D., Kung, A. L., Escher, I., Malia, T. J., Barbuto, S., Wright, R. D., Wagner, G., Verdine, G. L., & Korsmeyer, S. J. (2004) · Science · doi:10.1126/science.1099191 · Cited by 1,349
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Apoptosis and Molecular Targeting Therapy in Cancer
Hassan, M., Watari, H., AbuAlmaaty, A., Ohba, Y., & Sakuragi, N. (2014) · BioMed Research International · doi:10.1155/2014/150845 · Cited by 1,121
RetractedBetulin and betulinic acid: triterpenoids derivatives with a powerful biological potential
Hordyjewska, A., Ostapiuk, A., Horecka, A., & Kurzepa, J. (2019) · Phytochemistry Reviews · doi:10.1007/s11101-019-09623-1 · Cited by 298
The Story of Human Cytomegalovirus and Cancer: Increasing Evidence and Open Questions
Michaelis, M., Doerr, H. W., & Cinatl, J. (2009) · Neoplasia · doi:10.1593/neo.81178 · Cited by 293
Interferon regulatory factor 1 regulates PANoptosis to prevent colorectal cancer
Karki, R., Sharma, B. R., Lee, E., Banoth, B., Malireddi, R. K. S., Samir, P., Tuladhar, S., Mummareddy, H., Burton, A. R., Vogel, P., et al. (2020) · JCI Insight · doi:10.1172/jci.insight.136720 · Cited by 282
MicroRNA regulation of core apoptosis pathways in cancer
Lima, R. T., Busacca, S., Almeida, G. M., Gaudino, G., Fennell, D. A., & Vasconcelos, M. H. (2011) · European Journal of Cancer · doi:10.1016/j.ejca.2010.11.005 · Cited by 260
Metadata
- Authors
- Plati, J., Bucur, O., & Khosravi‐Far, R.
- Venue
- Journal of Cellular Biochemistry
- Publisher
- Wiley
- Published
- 2008-05-05
- Volume
- 104
- Issue
- 4
- Pages
- 1124-1149
- ISSN
- 0730-2312 (ISSN-L)
- 1097-4644
- OpenAlex
- W2075637276
- Cited by
- 293
- References
- 17
- FWCI
- 2.98
- Type
- journal article
- Language
- en
- Open access
- green
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