Adipogenesis

Obesity is associated with macrophage accumulation in adipose tissue

Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041 · see citing works

Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance

Hotamisligil, G. S., Shargill, N. S., & Spiegelman, B. M. (1993) · Science · doi:10.1126/science.7678183 · Cited by 7,518 · see citing works

The hormone resistin links obesity to diabetes

Steppan, C. M., Bailey, S. T., Bhat, S., Brown, E. J., Banerjee, R. R., Wright, C. M., Patel, H. R., Ahima, R. S., & Lazar, M. A. (2001) · Nature · doi:10.1038/35053000 · Cited by 4,755 · see citing works

Identification and Importance of Brown Adipose Tissue in Adult Humans

Cypess, A. M., Lehman, S., Williams, G., Tal, I., Rodman, D., Goldfine, A. B., Kuo, F. C., Palmer, E. L., Tseng, Y.-H., Doria, A., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0810780 · Cited by 4,399 · see citing works

Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase

Yamauchi, T., Kamon, J., Minokoshi, Y., Ito, Y., Waki, H., Uchida, S., Yamashita, S., Noda, M., Kita, S., Ueki, K., et al. (2002) · Nature Medicine · doi:10.1038/nm788 · Cited by 4,238 · see citing works

STATs and Gene Regulation

Darnell, J. E. (1997) · Science · doi:10.1126/science.277.5332.1630 · Cited by 3,979 · see citing works

An Antidiabetic Thiazolidinedione Is a High Affinity Ligand for Peroxisome Proliferator-activated Receptor γ (PPARγ)

Lehmann, J. M., Moore, L. B., Smith-Oliver, T. A., Wilkison, W. O., Willson, T. M., & Kliewer, S. A. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.22.12953 · Cited by 3,626 · see citing works

Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor

Tontonoz, P., Hu, E., & Spiegelman, B. M. (1994) · Cell · doi:10.1016/0092-8674(94)90006-x · Cited by 3,533 · see citing works

Principles of interleukin (IL)-6-type cytokine signalling and its regulation

HEINRICH, P. C., BEHRMANN, I., HAAN, S., HERMANNS, H. M., MÜLLER-NEWEN, G., & SCHAPER, F. (2003) · Biochemical Journal · doi:10.1042/bj20030407 · Cited by 3,272 · see citing works

A Novel Serum Protein Similar to C1q, Produced Exclusively in Adipocytes

Scherer, P. E., Williams, S. P., Fogliano, M., Baldini, G., & Lodish, H. F. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.45.26746 · Cited by 3,238 · see citing works

Wnt signaling: a common theme in animal development

Cadigan, K. M., & Nusse, R. (1997) · Genes & Development · doi:10.1101/gad.11.24.3286 · Cited by 2,567 · see citing works

The adipocyte-secreted protein Acrp30 enhances hepatic insulin action

Berg, A. H., Combs, T. P., Du, X., Brownlee, M., & Scherer, P. E. (2001) · Nature Medicine · doi:10.1038/90992 · Cited by 2,526 · see citing works

PRDM16 controls a brown fat/skeletal muscle switch

Seale, P., Bjork, B., Yang, W., Kajimura, S., Chin, S., Kuang, S., Scimè, A., Devarakonda, S., Conroe, H. M., Erdjument-Bromage, H., et al. (2008) · Nature · doi:10.1038/nature07182 · Cited by 2,347 · see citing works

AdipoQ Is a Novel Adipose-specific Gene Dysregulated in Obesity

Hu, E., Liang, P., & Spiegelman, B. M. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.18.10697 · Cited by 2,239 · see citing works

cDNA Cloning and Expression of a Novel Adipose Specific Collagen-like Factor, apM1 (AdiposeMost Abundant Gene Transcript 1)

Maeda, K., Okubo, K., Shimomura, I., Funahashi, T., Matsuzawa, Y., & Matsubara, K. (1996) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1996.0587 · Cited by 2,081 · see citing works

PPARγ Is Required for the Differentiation of Adipose Tissue In Vivo and In Vitro

Rosen, E. D., Sarraf, P., Troy, A. E., Bradwin, G., Moore, K. J., Milstone, D. S., Spiegelman, B. M., & Mortensen, R. M. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80211-7 · Cited by 2,081 · see citing works

PPARγ Is Required for Placental, Cardiac, and Adipose Tissue Development

Barak, Y., Nelson, M. C., Ong, E. S., Jones, Y., Ruiz‐Lozano, P., Chien, K. R., Koder, A., & Evans, R. M. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80209-9 · Cited by 1,960 · see citing works

Inhibition of Adipogenesis by Wnt Signaling

Ross, S. E., Hemati, N., Longo, K. A., Bennett, C. N., Lucas, P. C., Erickson, R. L., & MacDougald, O. A. (2000) · Science · doi:10.1126/science.289.5481.950 · Cited by 1,876 · see citing works

Unexpected evidence for active brown adipose tissue in adult humans

Nedergaard, J., Bengtsson, T., & Cannon, B. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00691.2006 · Cited by 1,824 · see citing works

Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells.

Cao, Z., Umek, R. M., & McKnight, S. L. (1991) · Genes & Development · doi:10.1101/gad.5.9.1538 · Cited by 1,663 · see citing works

Targeted Disruption of the Stat1 Gene in Mice Reveals Unexpected Physiologic Specificity in the JAK–STAT Signaling Pathway

Meraz, M. A., White, J. M., Sheehan, K. C. F., Bach, E. A., Rodig, S. J., Dighe, A. S., Kaplan, D. H., Riley, J. K., Greenlund, A. C., Campbell, D., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81288-x · Cited by 1,656 · see citing works

Dominant negative mutations in human PPARγ associated with severe insulin resistance, diabetes mellitus and hypertension

Barroso, I., Gurnell, M., Crowley, V. E. F., Agostini, M., Schwabe, J. W., Soos, M. A., Maslen, G. L., Williams, T. D. M., Lewis, H., Schafer, A. J., et al. (1999) · Nature · doi:10.1038/47254 · Cited by 1,368 · see citing works

Obesity-associated improvements in metabolic profile through expansion of adipose tissue

Kim, J.-Y., van de Wall, E., Laplante, M., Azzara, A., Trujillo, M. E., Hofmann, S. M., Schraw, T., Durand, J. L., Li, H., Li, G., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31021 · Cited by 1,310 · see citing works

Increased adipose tissue in male and female estrogen receptor-α knockout mice

Heine, P. A., Taylor, J. A., Iwamoto, G. A., Lubahn, D. B., & Cooke, P. S. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.23.12729 · Cited by 1,282 · see citing works

Stat5a and Stat5b Proteins Have Essential and Nonessential, or Redundant, Roles in Cytokine Responses

Teglund, S., McKay, C., Schuetz, E. G., van Deursen, J. M., Stravopodis, D. J., Wang, D., Brown, M. P., Bodner, S. M., Grosveld, G. C., & Ihle, J. N. (1998) · Cell · doi:10.1016/s0092-8674(00)81444-0 · Cited by 1,266 · see citing works

Chronic Peroxisome Proliferator-activated Receptor γ (PPARγ) Activation of Epididymally Derived White Adipocyte Cultures Reveals a Population of Thermogenically Competent, UCP1-containing Adipocytes Molecularly Distinct from Classic Brown Adipocytes

Petrovic, N., Walden, T. B., Shabalina, I. G., Timmons, J. A., Cannon, B., & Nedergaard, J. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.053942 · Cited by 1,263 · see citing works

A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-γ

Pascual, G., Fong, A. L., Ogawa, S., Gamliel, A., Li, A. C., Perissi, V., Rose, D. W., Willson, T. M., Rosenfeld, M. G., & Glass, C. K. (2005) · Nature · doi:10.1038/nature03988 · Cited by 1,251 · see citing works

Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice

Seale, P., Conroe, H. M., Estall, J. L., Kajimura, S., Frontini, A., Ishibashi, J., Cohen, P., Cinti, S., & Spiegelman, B. M. (2010) · Journal of Clinical Investigation · doi:10.1172/jci44271 · Cited by 1,241 · see citing works

The Organization, Promoter Analysis, and Expression of the Human PPARγ Gene

Lluis Fajas, A., Auboeuf, D., Raspé, E., Schoonjans, K., Lefebvre, A., Saladin, R., Najib, J., Laville, M., Fruchart, J., Deeb, S. S., et al. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.30.18779 · Cited by 1,188 · see citing works

Transcriptional Control of Brown Fat Determination by PRDM16

Seale, P., Kajimura, S., Yang, W., Chin, S., Rohas, L. M., Uldry, M., Tavernier, G., Langin, D., & Spiegelman, B. M. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.06.001 · Cited by 1,174 · see citing works

Establishment and characterization of a cloned line of C3H mouse embryo cells sensitive to postconfluence inhibition of division.

Reznikoff, C. A., Brankow, D. W., & Heidelberger, C. (1973) · PubMed · Cited by 1,125 · see citing works

Positional cloning of the mouse obese gene and its human homologue

Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1995) · Nature · doi:10.1038/374479a0 · Cited by 1,125 · see citing works

An established pre-adipose cell line and its differentiation in culture

Green, H., & Meuth, M. (1974) · Cell · doi:10.1016/0092-8674(74)90116-0 · Cited by 1,108 · see citing works

Interleukin-6 (IL-6) Induces Insulin Resistance in 3T3-L1 Adipocytes and Is, Like IL-8 and Tumor Necrosis Factor-α, Overexpressed in Human Fat Cells from Insulin-resistant Subjects

Rotter, V., Nagaev, I., & Smith, U. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301977200 · Cited by 1,062 · see citing works

Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis

Nguyen, K. D., Qiu, Y., Cui, X., Goh, Y. P. S., Mwangi, J., David, T., Mukundan, L., Brombacher, F., Locksley, R. M., & Chawla, A. (2011) · Nature · doi:10.1038/nature10653 · Cited by 1,038 · see citing works

ADD1/SREBP1 promotes adipocyte differentiation and gene expression linked to fatty acid metabolism.Preprint

Kim, J. B., & Spiegelman, B. M. (1996) · Genes & Development · doi:10.1101/gad.10.9.1096 · Cited by 1,026 · see citing works

Adiponectin Stimulates Production of Nitric Oxide in Vascular Endothelial Cells

Chen, H., Montagnani, M., Funahashi, T., Shimomura, I., & Quon, M. J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m307878200 · Cited by 993 · see citing works

Adipose-specific peroxisome proliferator-activated receptor γ knockout causes insulin resistance in fat and liver but not in muscle

He, W., Barak, Y., Hevener, A. L., Olson, P., Liao, D., Le, J., Nelson, M. C., Ong, E. S., Olefsky, J. M., & Evans, R. M. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2536828100 · Cited by 978 · see citing works

Scissors-Grip Model for DNA Recognition by a Family of Leucine Zipper Proteins

Vinson, C., Sigler, P. B., & McKnight, S. L. (1989) · Science · doi:10.1126/science.2683088 · Cited by 973 · see citing works

SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene

Yokoyama, C., Wang, X., Briggs, M. R., Admon, A., Wu, J., Hua, X., Goldstein, J. L., & Brown, M. S. (1993) · Cell · doi:10.1016/s0092-8674(05)80095-9 · Cited by 968 · see citing works

Cascade regulation of terminal adipocyte differentiation by three members of the C/EBP family of leucine zipper proteins.Preprint

Yeh, W., Cao, Z. D., Classon, M., & McKnight, S. L. (1995) · Genes & Development · doi:10.1101/gad.9.2.168 · Cited by 926 · see citing works

Resistin is expressed in human macrophages and directly regulated by PPARγ activators

Patel, L., Buckels, A. C., Kinghorn, I. J., Murdock, P. R., Holbrook, J. D., Plumpton, C., Macphee, C. H., & Smith, S. A. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)02841-3 · Cited by 920 · see citing works

Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARγ by Cdk5

Choi, J. H., Banks, A. S., Estall, J. L., Kajimura, S., Boström, P., Laznik, D., Ruas, J. L., Chalmers, M. J., Kamenecka, T. M., Blüher, M., et al. (2010) · Nature · doi:10.1038/nature09291 · Cited by 886 · see citing works

Adiponectin Stimulates AMP-Activated Protein Kinase in the Hypothalamus and Increases Food Intake

Kubota, N., Yano, W., Kubota, T., Yamauchi, T., Itoh, S., Kumagai, H., Kozono, H., Takamoto, I., Okamoto, S., Shiuchi, T., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.06.003 · Cited by 844 · see citing works

Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells.

Shimano, H., Horton, J. D., Shimomura, I., Hammer, R. E., Brown, M. S., & Goldstein, J. L. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119248 · Cited by 842 · see citing works

Spontaneous heritable changes leading to increased adipose conversion in 3T3 cells

Green, H., & Kehinde, O. (1976) · Cell · doi:10.1016/0092-8674(76)90260-9 · Cited by 833 · see citing works

Adipose Tissue Selective Insulin Receptor Knockout Protects against Obesity and Obesity-Related Glucose Intolerance

Blüher, M., Michael, M. D., Peroni, O. D., Ueki, K., Carter, N., Kahn, B. B., & Kahn, C. R. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00199-5 · Cited by 806 · see citing works

Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy

Shimomura, I., Hammer, R. E., Richardson, J. A., Ikemoto, S., Bashmakov, Y., Goldstein, J. L., & Brown, M. S. (1998) · Genes & Development · doi:10.1101/gad.12.20.3182 · Cited by 790 · see citing works

βAR Signaling Required for Diet-Induced Thermogenesis and Obesity Resistance

Bachman, E. S., Dhillon, H., Zhang, C.-Y., Cinti, S., Bianco, A. C., Kobilka, B. K., & Lowell, B. B. (2002) · Science · doi:10.1126/science.1073160 · Cited by 782 · see citing works

Life without white fat: a transgenic mousePreprint

Moitra, J., Mason, M. M., Olive, M., Krylov, D. Y., Gavrilova, O., Marcus‐Samuels, B., Feigenbaum, L., Lee, E., Aoyama, T., Eckhaus, M., et al. (1998) · Genes & Development · doi:10.1101/gad.12.20.3168 · Cited by 776 · see citing works

Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells.

Shimomura, I., Shimano, H., Horton, J. D., Goldstein, J. L., & Brown, M. S. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119247 · Cited by 760 · see citing works

The emergence of cold-induced brown adipocytes in mouse white fat depots is determined predominantly by white to brown adipocyte transdifferentiation

Barbatelli, G., Murano, I., Madsen, L., Hao, Q., Jimenez, M., Kristiansen, K., Giacobino, J., Matteis, R. D., & Cinti, S. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00600.2009 · Cited by 751 · see citing works

Resistin / Fizz3 Expression in Relation to Obesity and Peroxisome Proliferator–Activated Receptor-γ Action in Humans

Savage, D. B., Sewter, C. P., Klenk, E. S., Segal, D. G., Vidal‐Puig, A., Considine, R. V., & O’Rahilly, S. (2001) · Diabetes · doi:10.2337/diabetes.50.10.2199 · Cited by 748 · see citing works

Regulation of Wnt Signaling during Adipogenesis

Bennett, C. N., Ross, S. E., Longo, K. A., Bajnok, L., Hemati, N., Johnson, K. W., Harrison, S. D., & MacDougald, O. A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m204527200 · Cited by 743 · see citing works

Aromatase-deficient (ArKO) mice have a phenotype of increased adiposity

Jones, M. E. E., Thorburn, A. W., Britt, K. L., Hewitt, K. N., Wreford, N. G., Proietto, J., Oz, O. K., Leury, B. J., Robertson, K. M., Yao, S., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.23.12735 · Cited by 729 · see citing works

The presence of UCP1 demonstrates that metabolically active adipose tissue in the neck of adult humans truly represents brown adipose tissue

Zingaretti, M. C., Crosta, F., Vitali, A., Guerrieri, M., Frontini, A., Cannon, B., Nedergaard, J., & Cinti, S. (2009) · The FASEB Journal · doi:10.1096/fj.09-133546 · Cited by 725 · see citing works

Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2.

Horton, J. D., Shimomura, I., Brown, M. S., Hammer, R. E., Goldstein, J. L., & Shimano, H. (1998) · Journal of Clinical Investigation · doi:10.1172/jci2961 · Cited by 703 · see citing works

Regulation of activity of the transcription factor GATA-1 by acetylation

Boyes, J., Byfield, P., Nakatani, Y., & Ogryzko, V. (1998) · Nature · doi:10.1038/25166 · Cited by 694 · see citing works

Pref-1, a protein containing EGF-like repeats, inhibits adipocyte differentiation

Smas, C. M., & Sul, H. S. (1993) · Cell · doi:10.1016/0092-8674(93)90252-l · Cited by 677 · see citing works

Adiponectin-mediated modulation of hypertrophic signals in the heart

Shibata, R., Ouchi, N., Ito, M., Kihara, S., Shiojima, I., Pimentel, D. R., Kumada, M., Sato, K., Schiekofer, S., Ohashi, K., et al. (2004) · Nature Medicine · doi:10.1038/nm1137 · Cited by 671 · see citing works

Development of hormone receptors and hormonal responsiveness in vitro. Insulin receptors and insulin sensitivity in the preadipocyte and adipocyte forms of 3T3-L1 cells.

Rubin, C. S., Hirsch, A. H., Fung, C. K., & Rosen, O. M. (1978) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)34541-6 · Cited by 670 · see citing works

Occurrence of brown adipocytes in rat white adipose tissue: molecular and morphological characterization

Cousin, B., Cinti, S., Morroni, M., Raimbault, S., Ricquier, D., Pénicaud, L., & Casteilla, L. (1992) · Journal of Cell Science · doi:10.1242/jcs.103.4.931 · Cited by 665 · see citing works

FIZZ1, a novel cysteine‐rich secreted protein associated with pulmonary inflammation, defines a new gene family

Holcomb, I. N., Kabakoff, R. C., Chan, B., Baker, T. W., Gurney, A. L., Henzel, W. J., Nelson, C., Lowman, H. B., Wright, B. D., Skelton, N. J., et al. (2000) · The EMBO Journal · doi:10.1093/emboj/19.15.4046 · Cited by 658 · see citing works

Emergence of brown adipocytes in white fat in mice is under genetic control. Effects on body weight and adiposity.

Guerra, C., Koza, R. A., Yamashita, H., Walsh, K., & Kozak, L. P. (1998) · Journal of Clinical Investigation · doi:10.1172/jci3155 · Cited by 635 · see citing works

Induction of Peroxisome Proliferator-Activated Receptor γ during the Conversion of 3T3 Fibroblasts into Adipocytes Is Mediated by C/EBPβ, C/EBPδ, and Glucocorticoids

Wu, Z., Bucher, N. L. R., & Farmer, S. R. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.8.4128 · Cited by 605 · see citing works

ADD1: a Novel Helix-Loop-Helix Transcription Factor Associated with Adipocyte Determination and Differentiation

Tontonoz, P., Kim, J. B., Graves, R. A., & Spiegelman, B. M. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.8.4753-4759.1993 · Cited by 599 · see citing works

Glucocorticoids, metabolism and metabolic diseases

Vegiopoulos, A., & Herzig, S. (2007) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2007.05.015 · Cited by 535 · see citing works

Function of GATA Transcription Factors in Preadipocyte-Adipocyte Transition

Tong, Q., Dalgin, G., Xu, H., Ting, C.-N., Leiden, J. M., & Hotamışlıgil, G. S. (2000) · Science · doi:10.1126/science.290.5489.134 · Cited by 534 · see citing works

A dual effector theory of growth-hormone action

Green, H., Morikawa, M., & Mxon, T. (1985) · Differentiation · doi:10.1111/j.1432-0436.1985.tb00316.x · Cited by 521 · see citing works

A Macrophage Factor Inhibits Adipocyte Gene Expression: An in Vitro Model of Cachexia

Torti, F. M., Dieckmann, B. S., Beutler, B., Cerami, A., & RINGOLD, G. M. (1985) · Science · doi:10.1126/science.3839597 · Cited by 519 · see citing works

Insulin-like growth factor-I is an essential regulator of the differentiation of 3T3-L1 adipocytes.

Smith, P. J., Wise, L. S., Berkowitz, R., Wan, C. F., & Rubin, C. S. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)76555-7 · Cited by 511 · see citing works

Nucleoprotein complexes that regulate gene expression in adipocyte differentiation: direct participation of c-fos

Distel, R. J., Ro, J., Rosen, B. S., Groves, D. L., & Spiegelman, B. M. (1987) · Cell · doi:10.1016/0092-8674(87)90621-0 · Cited by 506 · see citing works

Only UCP1 can mediate adaptive nonshivering thermogenesis in the cold

Golozoubova, V., Hohtola, E., Matthias, A., Jacobsson, A., Cannon, B., & Nedergaard, J. (2001) · The FASEB Journal · doi:10.1096/fj.00-0536fje · Cited by 503 · see citing works

Failure of adipocyte differentiation causes type II diabetes mellitus?

Danforth, E. (2000) · Nature Genetics · doi:10.1038/79111 · Cited by 487 · see citing works

Differential activation of adipogenesis by multiple PPAR isoforms.Preprint

Brun, R. P., Tontonoz, P., FORMAN, B. M., Ellis, R., Chen, J., Evans, R. M., & Spiegelman, B. M. (1996) · Genes & Development · doi:10.1101/gad.10.8.974 · Cited by 474 · see citing works

Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex

Kajimura, S., Seale, P., Tomaru, T., Erdjument-Bromage, H., Cooper, M. P., Ruas, J. L., Chin, S., Tempst, P., Lazar, M. A., & Spiegelman, B. M. (2008) · Genes & Development · doi:10.1101/gad.1666108 · Cited by 468 · see citing works

Mice Lacking Paternally Expressed Pref-1/Dlk1 Display Growth Retardation and Accelerated Adiposity

Moon, Y. S., Smas, C. M., Lee, K., Villena, J. A., Kim, K., Yun, E. J., & Sul, H. S. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.15.5585-5592.2002 · Cited by 462 · see citing works

Krüppel-like transcription factor KLF5 is a key regulator of adipocyte differentiation

Oishi, Y., Manabe, I., Tobe, K., Tsushima, K., Shindo, T., Fujiu, K., Nishimura, G., Maemura, K., Yamauchi, T., Kubota, N., et al. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2004.11.005 · Cited by 461 · see citing works

The biology of the mammalian Krüppel-like family of transcription factors

Dang, D. T., Pevsner, J., & Yang, V. W. (2000) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(00)00059-5 · Cited by 458 · see citing works

Elevated levels of SREBP-2 and cholesterol synthesis in livers of mice homozygous for a targeted disruption of the SREBP-1 gene.

Shimano, H., Shimomura, I., Hammer, R. E., Herz, J., Goldstein, J. L., Brown, M. S., & Horton, J. D. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119746 · Cited by 447 · see citing works

Regulation of Peroxisome Proliferator-activated Receptor γ Activity by Mitogen-activated Protein Kinase

Camp, H. S., & Tafuri, S. R. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.16.10811 · Cited by 447 · see citing works

Fibronectin modulation of cell shape and lipogenic gene expression in 3t3-adipocytes

Spiegelman, B. M., & Ginty, C. A. (1983) · Cell · doi:10.1016/0092-8674(83)90098-3 · Cited by 446 · see citing works

GATA transcription factors: key regulators of hematopoiesis.

Weiss, M. J., & Orkin, S. H. (1995) · PubMed · Cited by 415 · see citing works

Commitment of C3H10T1/2 pluripotent stem cells to the adipocyte lineage

Tang, Q.-Q., Otto, T. C., & Lane, M. D. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403100101 · Cited by 415 · see citing works

A conserved family of nuclear proteins containing structural elements of the finger protein encoded by Krüppel, a Drosophila segmentation gene

Schuh, R., Aicher, W. K., Gaul, U., Côté, S., Preiss, A., Maier, D., Seifert, E., Nauber, U., Schröder, C., Kemler, R., et al. (1986) · Cell · doi:10.1016/0092-8674(86)90817-2 · Cited by 410 · see citing works

Improved insulin-sensitivity in mice heterozygous for PPAR-γ deficiency

Miles, P. D. G., Barak, Y., He, W., Evans, R. M., & Olefsky, J. M. (2000) · Journal of Clinical Investigation · doi:10.1172/jci8538 · Cited by 400 · see citing works

Expression and involvement of c-fos and c-jun protooncogenes in programmed cell death induced by growth factor deprivation in lymphoid cell lines.

Colotta, F., Polentarutti, N., Sironi, M., & Mantovani, A. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)36956-x · Cited by 396 · see citing works

Chronic interleukin-6 (IL-6) treatment increased IL-6 secretion and induced insulin resistance in adipocyte: prevention by rosiglitazone

Lagathu, C., Bastard, J.-P., Auclair, M., Maachi, M., Capeau, J., & Caron, M. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2003.10.013 · Cited by 385 · see citing works

Wnt10b Inhibits Development of White and Brown Adipose Tissues

Longo, K. A., Hahn, W. S., Kang, S., Gerin, I., Chiang, S.-H., Lucas, P. C., Opp, M. R., & MacDougald, O. A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402937200 · Cited by 372 · see citing works

Testosterone Inhibits Adipogenic Differentiation in 3T3-L1 Cells: Nuclear Translocation of Androgen Receptor Complex with β-Catenin and T-Cell Factor 4 May Bypass Canonical Wnt Signaling to Down-Regulate Adipogenic Transcription Factors

Singh, R., Artaza, J. N., Taylor, W. E., Braga, M., Yuan, X., Gonzalez-Cadavid, N. F., & Bhasin, S. (2006) · Endocrinology · doi:10.1210/en.2004-1649 · Cited by 369 · see citing works

Degradation of the Peroxisome Proliferator-activated Receptor γ Is Linked to Ligand-dependent Activation

Hauser, S., Adelmant, G., Sarraf, P., Wright, H. M., Mueller, E., & Spiegelman, B. M. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m001297200 · Cited by 367 · see citing works

PPARγ knockdown by engineered transcription factors: exogenous PPARγ2 but not PPARγ1 reactivates adipogenesisPreprint

Ren, D., Collingwood, T. N., Rebar, E. J., Wolffe, A. P., & Camp, H. S. (2002) · Genes & Development · doi:10.1101/gad.953802 · Cited by 362 · see citing works

Transcriptional Regulation of Adipogenesis by KLF4

Birsoy, K., Chen, Z., & Friedman, J. M. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.02.001 · Cited by 340 · see citing works

Role of Krüppel-like Factor 15 (KLF15) in Transcriptional Regulation of Adipogenesis

Mori, T., Sakaue, H., Iguchi, H., Gomi, H., Okada, Y., Takashima, Y., Nakamura, K., Nakamura, T., Yamauchi, T., Kubota, N., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m410515200 · Cited by 340 · see citing works

The occurrence of brown adipose tissue in outdoor workers

Huttunen, P., Hirvonen, J., & Kinnula, V. L. (1981) · European Journal of Applied Physiology · doi:10.1007/bf00422121 · Cited by 335 · see citing works

Organelle relationships in cultured 3T3-L1 preadipocytes.

Novikoff, A. B., Novikoff, P. M., Rosen, O. M., & Rubin, C. S. (1980) · The Journal of Cell Biology · doi:10.1083/jcb.87.1.180 · Cited by 331 · see citing works

Adipose tissue distribution and function.

Carmelli, D., McElroy, M. R., & Rosenman, R. H. (1991) · PubMed · Cited by 320 · see citing works

Resistin Gene Expression in Human Adipocytes Is Not Related to Insulin Resistance

Janke, J., Engeli, S., Gorzelniak, K., Luft, F. C., & Sharma, A. M. (2002) · Obesity Research · doi:10.1038/oby.2002.1 · Cited by 318 · see citing works

Peroxisome-proliferator-activated receptor γ suppresses Wnt/β-catenin signalling during adipogenesis

Moldes, M., Zuo, Y., Morrison, R. F., Silva, D., Park, B.-H., Liu, J., & Farmer, S. R. (2003) · Biochemical Journal · doi:10.1042/bj20030426 · Cited by 308 · see citing works

Similarity of mouse perivascular and brown adipose tissues and their resistance to diet-induced inflammation

Fitzgibbons, T. P., Kogan, S., Aouadi, M., Hendricks, G. M., Straubhaar, J., & Czech, M. (2011) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00376.2011 · Cited by 305 · see citing works

Structure of the human gene encoding sterol regulatory element binding protein-1 (SREBF1) and localization of SREBF1 and SREBF2 to chromosomes 17p11.2 and 22q13

Hua, X., Wu, J., Goldstein, J. L., Brown, M. S., & Hobbs, H. H. (1995) · Genomics · doi:10.1016/0888-7543(95)80009-b · Cited by 302 · see citing works

The Krüppel-like Factor KLF2 Inhibits Peroxisome Proliferator-activated Receptor-γ Expression and Adipogenesis

Banerjee, S. S., Feinberg, M. W., Watanabe, M., Gray, S., Haspel, R. L., Denkinger, D. J., Kawahara, R. S., Hauner, H., & Jain, M. K. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210859200 · Cited by 301 · see citing works

Increased Hepatic Cell Proliferation and Lung Abnormalities in Mice Deficient in CCAAT/Enhancer Binding Protein α

Flodby, P., Barlow, C., Kylefjord, H., Åhrlund-Richter, L., & Xanthopoulos, K. G. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.40.24753 · Cited by 293 · see citing works

Formation of normally differentiated subcutaneous fat pads by an established preadipose cell line

Green, H., & Kehinde, O. (1979) · Journal of Cellular Physiology · doi:10.1002/jcp.1041010119 · Cited by 286 · see citing works

Cellular Transformation and Malignancy Induced by ras Require c-jun

Johnson, R., Spiegelman, B., Hanahan, D., & Wisdom, R. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.8.4504 · Cited by 282 · see citing works

Functional relationship of thyroid hormone-induced lipogenesis, lipolysis, and thermogenesis in the rat.

Oppenheimer, J. H., Schwartz, H. L., Lane, J. T., & Thompson, M. P. (1991) · Journal of Clinical Investigation · doi:10.1172/jci114961 · Cited by 278 · see citing works

T‐Cell Recruitment and Th1 Polarization in Adipose Tissue During Diet‐Induced Obesity in C57BL/6 Mice

Strissel, K. J., DeFuria, J., Shaul, M. E., Bennett, G., Greenberg, A. S., & Obin, M. S. (2010) · Obesity · doi:10.1038/oby.2010.1 · Cited by 276 · see citing works

Fat Tissue: A Steroid Reservoir and Site of Steroid Metabolism

DESLYPERE, J. P., VERDONCK, L., & VERMEULEN, A. (1985) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-61-3-564 · Cited by 272 · see citing works

Interferon γ Attenuates Insulin Signaling, Lipid Storage, and Differentiation in Human Adipocytes via Activation of the JAK/STAT Pathway

McGillicuddy, F. C., Chiquoine, E. H., Hinkle, C. C., Kim, R. J., Shah, R. D., Roche, H. M., Smyth, E. M., & Reilly, M. P. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.061655 · Cited by 255 · see citing works

Microarray Analyses during Adipogenesis: Understanding the Effects of Wnt Signaling on Adipogenesis and the Roles of Liver X Receptor α in Adipocyte Metabolism

Ross, S. E., Erickson, R. L., Gerin, I., DeRose, P. M., Bajnok, L., Longo, K. A., Misek, D. E., Kuick, R. D., Hanash, S., Atkins, K. B., et al. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.16.5989-5999.2002 · Cited by 255 · see citing works

Appearance of brown adipocytes in white adipose tissue during CL 316,243-induced reversal of obesity and diabetes in Zucker fa/fa rats

Ghorbani, M., & Himms‐Hagen, J. (1997) · International Journal of Obesity · doi:10.1038/sj.ijo.0800432 · Cited by 250 · see citing works

Interaction between GATA and the C/EBP Family of Transcription Factors Is Critical in GATA-Mediated Suppression of Adipocyte Differentiation

Tong, Q., Tsai, J., Tan, G., Dalgin, G., & Hotamışlıgil, G. S. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.2.706-715.2005 · Cited by 248 · see citing works

High Local Concentrations and Effects on Differentiation Implicate Interleukin‐6 as a Paracrine Regulator

Sopasakis, V. R., Sandqvist, M., Gustafson, B., Hammarstedt, A., Schmelz, M., Yang, X., Jansson, P., & Smith, U. (2004) · Obesity Research · doi:10.1038/oby.2004.51 · Cited by 243 · see citing works

The Kru¨ppel-like Factor KLF15 Regulates the Insulin-sensitive Glucose Transporter GLUT4

Gray, S., Feinberg, M. W., Hull, S., Kuo, C. T., Watanabe, M., Banerjee, S. S., DePina, A., Haspel, R. L., & Jain, M. K. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m201304200 · Cited by 243 · see citing works

Macrophage-derived human resistin exacerbates adipose tissue inflammation and insulin resistance in mice

Qatanani, M., Szwergold, N. R., Greaves, D. R., Ahima, R. S., & Lazar, M. A. (2009) · Journal of Clinical Investigation · doi:10.1172/jci37273 · Cited by 229 · see citing works

Opposite Effects of Androgens and Estrogens on Adipogenesis in Rat Preadipocytes: Evidence for Sex and Site-Related Specificities and Possible Involvement of Insulin-Like Growth Factor 1 Receptor and Peroxisome Proliferator-Activated Receptor 2

Dieudonné, M., Pecquery, R., Leneveu, M.-C., & Giudicelli, Y. (2000) · Endocrinology · doi:10.1210/endo.141.2.7293 · Cited by 219 · see citing works

Minireview: Pref-1: Role in Adipogenesis and Mesenchymal Cell Fate

Sul, H. S. (2009) · Molecular Endocrinology · doi:10.1210/me.2009-0160 · Cited by 218 · see citing works

Cleavage of Membrane-Associated pref-1 Generates a Soluble Inhibitor of Adipocyte Differentiation

Smas, C. M., Chen, L., & Sul, H. S. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.2.977 · Cited by 206 · see citing works

Genetic Modulation of PPARγ Phosphorylation Regulates Insulin Sensitivity

Rangwala, S. M., Rhoades, B., Shapiro, J. S., Rich, A. S., Kim, J. K., Shulman, G. I., Kaestner, K. H., & Lazar, M. A. (2003) · Developmental Cell · doi:10.1016/s1534-5807(03)00274-0 · Cited by 204 · see citing works

Androgen receptors in human preadipocytes and adipocytes: regional specificities and regulation by sex steroids

Dieudonné, M., Pecquery, R., Boumédiène, A., Leneveu, M.-C., & Giudicelli, Y. (1998) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1998.274.6.c1645 · Cited by 197 · see citing works

Depot-specific differences in inflammatory mediators and a role for NK cells and IFN-γ in inflammation in human adipose tissue

O’Rourke, R. W., Metcalf, M. D., White, A. E., Madala, A., Winters, B. R., Maizlin, I. I., Jobe, B. A., Roberts, C. T., Slifka, M. K., & Marks, D. L. (2009) · International Journal of Obesity · doi:10.1038/ijo.2009.133 · Cited by 196 · see citing works

Interferon-γ-mediated Activation and Ubiquitin-Proteasome-dependent Degradation of PPARγ in Adipocytes

Floyd, Z. E., & Stephens, J. M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m108473200 · Cited by 187 · see citing works

Transcriptional Activity of Peroxisome Proliferator-activated Receptor γ Is Modulated by SUMO-1 Modification

Ohshima, T., Koga, H., & Shimotohno, K. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m403866200 · Cited by 185 · see citing works

The Origins of Brown Adipose Tissue

Enerbäck, S. (2009) · New England Journal of Medicine · doi:10.1056/nejmcibr0809610 · Cited by 185 · see citing works

Evidence for functional estrogen receptors α and β in human adipose cells: regional specificities and regulation by estrogens

Dieudonné, M., Leneveu, M.-C., Giudicelli, Y., & Pecquery, R. (2004) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00321.2003 · Cited by 182 · see citing works

Gonadal influences on adiposity.

Wade, G. N., Gray, J., & Tj, B. (1985) · PubMed · Cited by 181 · see citing works

Krüppel-like Factor-6 Promotes Preadipocyte Differentiation through Histone Deacetylase 3-dependent Repression of DLK1

Li, D., Yea, S., Li, S., Zhu, C. X., Narla, G., Banck, M. S., Laborda, J., Tan, S., Friedman, J. M., Friedman, S. L., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m500463200 · Cited by 177 · see citing works

The Effects of Androgens and Estrogens on Preadipocyte Proliferation in Human Adipose Tissue: Influence of Gender and Site

Anderson, L. A., McTernan, P. G., Barnett, A. H., & Kumar, S. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.10.7955 · Cited by 175 · see citing works

Tumor necrosis factor alpha and interleukin 11 secreted by malignant breast epithelial cells inhibit adipocyte differentiation by selectively down-regulating CCAAT/enhancer binding protein alpha and peroxisome proliferator-activated receptor gamma: mechanism of desmoplastic reaction.

Li, M., Zhou, J., Sasano, H., Suzuki, T., Zeitoun, K. M., & Bulun, S. E. (2001) · PubMed · Cited by 169 · see citing works

Exclusive occurrence of thermogenin antigen in brown adipose tissue

Cannon, B., Hedin, A., & Nedergaard, J. (1982) · FEBS Letters · doi:10.1016/0014-5793(82)81319-7 · Cited by 164 · see citing works

The Expression and Regulation of STATs during 3T3-L1 Adipocyte Differentiation

Stephens, J. M., Morrison, R. F., & Pilch, P. F. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.18.10441 · Cited by 157 · see citing works

Molecular cloning of cDNA encoding adipogenesis inhibitory factor and identity with interleukin‐11

Kawashima, I., Ohsumi, J., Mita-Honjo, K., Shimoda-Takano, K., Ishikawa, H., Sakakibara, S., Miyadai, K., & Takiguchi, Y. (1991) · FEBS Letters · doi:10.1016/0014-5793(91)80587-s · Cited by 155 · see citing works

Suppression of PPAR-γ attenuates insulin-stimulated glucose uptake by affecting both GLUT1 and GLUT4 in 3T3-L1 adipocytes

Liao, W., Nguyen, M. T., Yoshizaki, T., Favelyukis, S., Patsouris, D., Imamura, T., Verma, I. M., & Olefsky, J. M. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00695.2006 · Cited by 142 · see citing works

Glucocorticoid regulation of adipocyte differentiation: hormonal triggering of the developmental program and induction of a differentiation-dependent gene.

Chapman, A. B., Knight, D. M., & RINGOLD, G. M. (1985) · The Journal of Cell Biology · doi:10.1083/jcb.101.4.1227 · Cited by 141 · see citing works

De novo generation of white adipocytes from the myeloid lineage via mesenchymal intermediates is age, adipose depot, and gender specific

Majka, S. M., Fox, K. E., Psilas, J. C., Helm, K. M., Childs, C. R., Acosta, A. S., Janssen, R. C., Friedman, J. E., Woessner, B. T., Shade, T. R., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1003512107 · Cited by 140 · see citing works

STAT5A Promotes Adipogenesis in Nonprecursor Cells and Associates With the Glucocorticoid Receptor During Adipocyte Differentiation

Floyd, Z. E., & Stephens, J. M. (2003) · Diabetes · doi:10.2337/diabetes.52.2.308 · Cited by 140 · see citing works

The transactivating function of peroxisome proliferator‐activated receptor γ is negatively regulated by SUMO conjugation in the amino‐terminal domain

Yamashita, D., Yamaguchi, T., Shimizu, M., Nakata, N., Hirose, F., & Osumi, T. (2004) · Genes to Cells · doi:10.1111/j.1365-2443.2004.00786.x · Cited by 139 · see citing works

Effects of Wnt Signaling on Brown Adipocyte Differentiation and Metabolism Mediated by PGC-1α

Kang, S., Bajnok, L., Longo, K. A., Petersen, R. K., Hansen, J. B., Kristiansen, K., & MacDougald, O. A. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.4.1272-1282.2005 · Cited by 135 · see citing works

Overexpression of Kruppel-Like Factor 7 Regulates Adipocytokine Gene Expressions in Human Adipocytes and Inhibits Glucose-Induced Insulin Secretion in Pancreatic β-Cell Line

Kawamura, Y., Tanaka, Y., Kawamori, R., & Maeda, S. (2005) · Molecular Endocrinology · doi:10.1210/me.2005-0138 · Cited by 131 · see citing works

Transcriptional Responses to Polypeptide Ligands: The JAK-STAT Pathway

Stevens, R. C. (1995) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.64.1.621 · Cited by 130 · see citing works

gp130 receptor ligands as potential therapeutic targets for obesity

Febbraio, M. A. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30453 · Cited by 124 · see citing works

Leukemia Inhibitory Factor and Its Receptor Promote Adipocyte Differentiation via the Mitogen-activated Protein Kinase Cascade

Aubert, J., Dessolin, S., Belmonte, N., Li, M., McKenzie, F. R., Staccini-Lavenant, L., Villageois, P., Barhanin, B., Vernallis, A. B., Smith, A. G., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.35.24965 · Cited by 119 · see citing works

The KLF2 Transcription Factor Does Not Affect the Formation of Preadipocytes but Inhibits Their Differentiation into Adipocytes

Wu, J., Srinivasan, S. V., Neumann, J. C., & Lingrel, J. B. (2005) · Biochemistry · doi:10.1021/bi050166i · Cited by 117 · see citing works

Identification of Estrogen Receptor β RNA in Human Breast and Abdominal Subcutaneous Adipose Tissue

Crandall, D. L., Busler, D. E., Novak, T. J., Weber, R. V., & Kral, J. G. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.8997 · Cited by 113 · see citing works

Oncostatin M promotes osteogenesis and suppresses adipogenic differentiation of human adipose tissue‐derived mesenchymal stem cells

Song, H. Y., Jeon, E. S., Kim, J.-I., et al. (2007) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21245 · Cited by 107 · see citing works

Regulation of bone marrow stromal cell differentiation by cytokines whose receptors share the gp130 Protein

Gimble, J. M., Wanker, F., Wang, C., et al. (1994) · Journal of Cellular Biochemistry · doi:10.1002/jcb.240540113 · Cited by 104 · see citing works

Signal transducer and activator of transcription 3 (STAT3) regulates adipocyte differentiation via peroxisome‐proliferator‐activated receptor γ (PPARγ)

Wang, D., Zhou, Y., Lei, W., Zhang, K., Shi, J., Hu, Y., Shu, G., & Song, J. (2010) · Biology of the Cell · doi:10.1042/bc20090070 · Cited by 100 · see citing works

Transcriptional Regulation of Gene Expression During Adipocyte Differentiation

MacDougald, O. A. (1995) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.64.1.345 · Cited by 97 · see citing works

Stimulation of 3T3-L1 Adipogenesis by Signal Transducer and Activator of Transcription 5

Nanbu-Wakao, R., Morikawa, Y., Matsumura, I., Masuho, Y., Muramatsu, M., Senba, E., & Wakao, H. (2002) · Molecular Endocrinology · doi:10.1210/mend.16.7.0862 · Cited by 96 · see citing works

Growth hormone stimulates adipogenesis of 3T3-L1 cells through activation of the Stat5A/5B-PPARγ pathway

Kawai, M., Namba, N., Mushiake, S., Etani, Y., Nishimura, R., Makishima, M., & Ozono, K. (2007) · Journal of Molecular Endocrinology · doi:10.1677/jme.1.02154 · Cited by 96 · see citing works

Oncostatin M Inhibits Adipogenesis through the RAS/ERK and STAT5 Signaling Pathways

Miyaoka, Y., Tanaka, M., Naiki, T., & Miyajima, A. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m606089200 · Cited by 89 · see citing works

Up-regulation of androgen receptor binding in male rat fat pad adipose precursor cells exposed to testosterone: Study in a whole cell assay system

Pergola, G. D., Xu, X., Yang, S., GIORGINO, R., & Björntorp, P. A. (1990) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(90)90400-f · Cited by 88 · see citing works

Adipose-specific disruption of signal transducer and activator of transcription 3 increases body weight and adiposity

Cernkovich, E. R., Deng, J., Bond, M. C., Combs, T. P., & Harp, J. B. (2008) · Endocrinology · doi:10.1210/en.2007-1148 · Cited by 87 · see citing works

Activation of Signal Transducers and Activators of Transcription 1 and 3 by Leukemia Inhibitory Factor, Oncostatin-M, and Interferon-γ in Adipocytes

Stephens, J. M., Lumpkin, S. J., & Fishman, J. B. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.47.31408 · Cited by 87 · see citing works

Regulation of transcription factor mRNA accumulation during 3T3-L1 preadipocyte differentiation by tumour necrosis factor-α

Stephens, J. M., Butts, M., & Pekala, P. H. (1992) · Journal of Molecular Endocrinology · doi:10.1677/jme.0.0090061 · Cited by 86 · see citing works

Control of terminal differentiation of adipose precursor cells by glucocorticoids

Gaillard, D., Wabitsch, M., Pipy, B., & Négrel, R. (1991) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)42044-9 · Cited by 83 · see citing works

Peroxisome proliferator-activated receptor γ ligands attenuate immunological symptoms of experimental allergic asthma

Mueller, C., Weaver, V. C., Heuvel, J. P. V., August, A., & Cantorna, M. T. (2003) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2003.08.006 · Cited by 81 · see citing works

Regression of white adipose tissue in diabetic rats

Géloën, A., Roy, P. E., & Bukowiecki, L. J. (1989) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1989.257.4.e547 · Cited by 78 · see citing works

Wnt signaling: An embarrassment of receptors

Bejsovec, A. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00852-6 · Cited by 77 · see citing works

The Regulation and Activation of Ciliary Neurotrophic Factor Signaling Proteins in Adipocytes

Zvonic, S., Cornelius, P. K., Stewart, W. C., Mynatt, R. L., & Stephens, J. M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m205871200 · Cited by 76 · see citing works

Modification of GATA-2 Transcriptional Activity in Endothelial Cells by the SUMO E3 Ligase PIASy

Chun, T., Itoh, H., Subramanian, L., Iñiguez-Lluhı́, J. A., & Nakao, K. (2003) · Circulation Research · doi:10.1161/01.res.0000076893.70898.36 · Cited by 76 · see citing works

Characterization of the novel brown adipocyte cell line hib 1b adrenergic pathways involved in regulation of uncoupling protein gene expression

Klaus, S., Choy, L., Champigny, O., Cassard, A., Ross, S. R., Spiegelman, B. M., & Ricquier, D. (1994) · Journal of Cell Science · doi:10.1242/jcs.107.1.313 · Cited by 75 · see citing works

PPARγ Ligand-Dependent Induction of STAT1, STAT5A, and STAT5B during Adipogenesis

Stephens, J. M., Morrison, R. F., Wu, Z., et al. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.0889 · Cited by 75 · see citing works

Control of Peroxisome Proliferator‐Activated Receptor γ2 Stability and Activity by SUMOylation

Floyd, Z. E., & Stephens, J. M. (2004) · Obesity Research · doi:10.1038/oby.2004.112 · Cited by 71 · see citing works

Activation of Signal Transducer and Activator of Transcription-3 during Proliferative Phases of 3T3-L1 Adipogenesis

Deng, J., Hua, K., Lesser, S. S., & Harp, J. B. (2000) · Endocrinology · doi:10.1210/en.141.7.2370 · Cited by 70 · see citing works

Differential Expression of Signal Transducers and Activators of Transcription during Human Adipogenesis

Harp, J. B., Franklin, D. M., Vanderpuije, A. A., & Gimble, J. M. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.4460 · Cited by 69 · see citing works

Growth Hormone-dependent Differentiation of 3T3-F442A Preadipocytes Requires Janus Kinase/Signal Transducer and Activator of Transcription but Not Mitogen-activated Protein Kinase or p70 S6 Kinase Signaling

Yarwood, S. J., Sale, E. M., Sale, G. J., Houslay, M. D., Kilgour, E., & Anderson, N. G. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.13.8662 · Cited by 66 · see citing works

Constitutively Active Signal Transducer and Activator of Transcription 5 Can Replace the Requirement for Growth Hormone in Adipogenesis of 3T3-F442A Preadipocytes

Shang, C. A., & Waters, M. J. (2003) · Molecular Endocrinology · doi:10.1210/me.2003-0139 · Cited by 65 · see citing works

Mitogenic and Antiadipogenic Properties of Human Growth Hormone in Differentiating Human Adipocyte Precursor Cells in Primary Culture1

Wabitsch, M., Braun, S., Hauner, H., et al. (1996) · Pediatric Research · doi:10.1203/00006450-199609000-00014 · Cited by 65 · see citing works

Effects of Cardiotrophin on Adipocytes

Zvonic, S., Hogan, J. C., Arbour-Reily, P., Mynatt, R. L., & Stephens, J. M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m403998200 · Cited by 63 · see citing works

Familial Partial Lipodystrophy Phenotype Resulting from a Single-Base Mutation in Deoxyribonucleic Acid-Binding Domain of Peroxisome Proliferator-Activated Receptor-γ

Monajemi, H., Zhang, L., Li, G., et al. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-1807 · Cited by 63 · see citing works

Biological effects of human growth hormone in rat adipocyte precursor cells and newly differentiated adipocytes in primary culture

Wabitsch, M., Heinze, E., Hauner, H., et al. (1996) · Metabolism · doi:10.1016/s0026-0495(96)90197-3 · Cited by 61 · see citing works

Transcriptional targets in adipocyte biology

Rosen, E. D., Eguchi, J., & Xu, Z. (2009) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728220903039706 · Cited by 61 · see citing works

Importance of the regulation of nuclear receptor degradation

Andrew, P. (2001) · Frontiers in bioscience · doi:10.2741/dennis · Cited by 61 · see citing works

Conditional gp130 deficient mouse mutants

Fasnacht, N., & Müller, W. (2008) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2008.07.001 · Cited by 60 · see citing works

Inhibition of the conversion of 3T3 fibroblast clones to adipocytes by dehydroepiandrosterone and related anticarcinogenic steroids.

Gordon, G., Newitt, J. A., Shantz, L. M., Weng, D. E., & Talalay, P. (1986) · PubMed · Cited by 57 · see citing works

Highly Specific and Quantitative Activation of STATs in 3T3-L1 Adipocytes

Balhoff, J. P., & Stephens, J. M. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.8890 · Cited by 56 · see citing works

Regulation of signal transducers and activators of transcription (STATs) by effectors of adipogenesis: coordinate regulation of STATs 1, 5A, and 5B with peroxisome proliferator-activated receptor-γ and C/AAAT enhancer binding protein-α

Stewart, W. C., Morrison, R. F., Young, S. L., & Stephens, J. M. (1999) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/s0167-4889(99)00129-9 · Cited by 55 · see citing works

Noradrenaline increases glucose transport into brown adipocytes in culture by a mechanism different from that of insulin

Shimizu, Y., Kielar, D., Minokoshi, Y., & Shimazu, T. (1996) · Biochemical Journal · doi:10.1042/bj3140485 · Cited by 53 · see citing works

Estrogen Deficiency, Obesity, and Skeletal Abnormalities in Follicle-Stimulating Hormone Receptor Knockout (FORKO) Female Mice

Danilovich, N. (2000) · Endocrinology · doi:10.1210/en.141.11.4295 · Cited by 52 · see citing works

PPAR‐γ AF‐2 Domain Functions as a Component of a Ubiquitin‐dependent Degradation Signal

Kilroy, G. E., Zhang, X., & Floyd, Z. E. (2009) · Obesity · doi:10.1038/oby.2008.616 · Cited by 50 · see citing works

Interleukin 11 signaling in 3T3‐L1 adipocytes

Tenney, R., Stansfield, K. A., & Pekala, P. H. (2004) · Journal of Cellular Physiology · doi:10.1002/jcp.20100 · Cited by 43 · see citing works

Effects of leukemia inhibitory factor on 3T3-L1 adipocytes

Hogan, J. C., & Stephens, J. M. (2005) · Journal of Endocrinology · doi:10.1677/joe.1.05980 · Cited by 43 · see citing works

Body composition changes and inhibition of fat development in vivo implicates androgen in regulation of stem cell lineage allocation

Semirale, A. A., Zhang, X., & Wiren, K. M. (2011) · Journal of Cellular Biochemistry · doi:10.1002/jcb.23098 · Cited by 42 · see citing works

Differential Effects of Adiposity on Peroxisomal Proliferator-Activated Receptor γ1 and γ2 Messenger Ribonucleic Acid Expression in Human Adipocytes

Sewter, C. P., Blows, F. M., Considine, R. V., Vidal‐Puig, A., & O’Rahilly, S. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-011511 · Cited by 41 · see citing works

Analysis of gene expression during adipogenesis in 3T3‐F442A preadipocytes: Insulin and dexamethasone control

Moustaïd, N., Lasnier, F., Hainque, B., Quignard‐Boulangé, A., & Pairault, J. (1990) · Journal of Cellular Biochemistry · doi:10.1002/jcb.240420407 · Cited by 39 · see citing works

GATA Proteins Work Together with Friend of GATA (FOG) and C-terminal Binding Protein (CTBP) Co-regulators to Control Adipogenesis

Jack, B. H. A., & Crossley, M. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.141317 · Cited by 38 · see citing works

Protein inhibitor of activated STAT3 inhibits adipogenic gene expression

Deng, J., Hua, K., Caveney, E. J., Takahashi, N., & Harp, J. B. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.10.217 · Cited by 35 · see citing works

Dehydroepiandrosterone and related steroids alter 3T3-L1 preadipocyte proliferation and differentiation

Lea-Currie, Y. R., Monroe, D., & McIntosh, M. K. (1999) · Comparative Biochemistry and Physiology Part C Pharmacology Toxicology and Endocrinology · doi:10.1016/s0742-8413(99)00003-1 · Cited by 33 · see citing works

Neuropoietin Attenuates Adipogenesis and Induces Insulin Resistance in Adipocytes

White, U. A., Stewart, W. C., Mynatt, R. L., & Stephens, J. M. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m710462200 · Cited by 32 · see citing works

Determination of estrogen receptor messenger ribonucleic acid (mRNA) and cytochrome P450 aromatase mRNA levels in adipocytes and adipose stromal cells by competitive polymerase chain reaction amplification

Price, T. M. (1993) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.77.4.1041 · Cited by 31 · see citing works

Effects of thyroid hormones on adipose tissue development in Sherman and Zucker rats

Levacher, C., Sztalryd, C., Kinebanyan, M. F., et al. (1984) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1984.246.1.c50 · Cited by 29 · see citing works

Dehydroepiandrosterone attenuates preadipocyte growth in primary cultures of stromal-vascular cells

McIntosh, M., Hausman, D. B., Martin, R. J., & Hausman, G. (1998) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1998.275.2.e285 · Cited by 26 · see citing works

Inhibition of adipogenesis and development of glucose intolerance by soluble preadipocyte factor–1 (Pref-1)

Lee, K., Villena, J. A., Moon, Y. S., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200315924 · Cited by 26 · see citing works

cDNA cloning and expression analysis of mouse zf9, a Krüppel-like transcription factor gene that is induced by adipogenic hormonal stimulation in 3T3-L1 cells

Inuzuka, H., Wakao, H., Masuho, Y., Muramatsu, M.-A., Tojo, H., & Nanbu-Wakao, R. (1999) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/s0167-4781(99)00161-x · Cited by 24 · see citing works

Androgen receptors in cultured rat adipose precursor cells during proliferation and differentiation: regional specificities and regulation by testosterone

Dieudonné, M., Pecquery, R., Leneveu, M.-C., Jaubert, A., & Giudicelli, Y. (1995) · Endocrine · doi:10.1007/bf02738830 · Cited by 23 · see citing works

Effects of sex steroid hormones on differentiation of adipose precursor cells in primary culture

Xu, X., & Björntorp, P. A. (1987) · Experimental Cell Research · doi:10.1016/0014-4827(87)90273-4 · Cited by 23 · see citing works

Obesity increases the production of pro-inflammatory mediators from adipose tissue T cells and compromises TCR repertoire diversity: Implications for systemic inflammation and insulin-resistance (87.32)

Youm, Y., Yang, H., Badanmagsar, B., et al. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.184.supp.87.32 · Cited by 20 · see citing works

Thyroid Hormone and the Adipocyte

Mariash, C. N. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031800 · Cited by 17 · see citing works

Interleukin-11 inhibits adipogenesis and stimulates myelopoiesis in human long-term marrow cultures

Keller, D. C., Du, X., Srour, E., et al. (1993) · Blood · doi:10.1182/blood.v82.5.1428.bloodjournal8251428 · Cited by 13 · see citing works

Adipose tissue hyperplasia and hypertrophy in common and syndromic obesity-the case of BBS obesity

Horwitz, A., & Birk, R. (2023) · Nutrients · doi:10.3390/nu15153445 · Cited by 143 · see citing works

Exerkines and Sarcopenia: Unveiling the Mechanism Behind Exercise-Induced Mitochondrial Homeostasis

Wang, J., Jia, D., Zhang, Z., & Wang, D. (2025) · Metabolites · doi:10.3390/metabo15010059 · Cited by 23 · see citing works

MiR-15a/b promote adipogenesis in porcine pre-adipocyte via repressing FoxO1

Peiyue, Dong, Yin, Y., et al. (2014) · 生物化学与生物物理学报：英文版

MiR-15a/b promote adipogenesis in porcine pre-adipocyte via repressing FoxO1

Dong, P., Mai, Y., Zhang, Z., Mi, L., Wu, G., Chu, G., Yang, G., & Sun, S. (2014) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmu043 · Cited by 45 · see citing works

microRNAs regulate adipocyte differentiation

Chen, L., Song, J., Cui, J., Hou, J., Zheng, X., Li, C., & Liu, L. (2013) · Cell Biology International · doi:10.1002/cbin.10063 · Cited by 69 · see citing works

CBMG, a novel derivative of mansonone G suppresses adipocyte differentiation via suppression of PPARγ activity

Kim, H. K., Hairani, R., Jeong, H., Jeong, M. G., Chavasiri, W., & Hwang, E. S. (2017) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2017.06.017 · Cited by 5 · see citing works

Harnessing adipogenesis to prevent obesity

Haider, N., & Larose, L. (2019) · Adipocyte · doi:10.1080/21623945.2019.1583037 · Cited by 71 · see citing works