The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Adipose mesenchymal stem cell‐derived exosomes promote cell proliferation, migration, and inhibit cell apoptosis via Wnt/β‐catenin signaling in cutaneous wound healing
Abstract
Cutaneous wounds, a type of soft tissue injury, are difficult to heal in aging. Differentiation, migration, proliferation, and apoptosis of skin cells are identified as key factors during wound healing processes. Mesenchymal stem cells have been documented as possible candidates for wound healing treatment because their use could augment the regenerative capacity of many tissues. However, the effects of exosomes derived from adipose‐derived stem cell (ADSC‐exos) on cutaneous wound healing remain to be carefully elucidated. In this present study, HaCaT cells were exposed to hydrogen peroxide (H 2 O 2) for the establishment of the skin lesion model. Cell Counting Kit‐8 assay, migration assay, and flow cytometry assay were conducted to detect the biological function of ADSC‐exos in skin lesion model. Finally, the possible mechanism was further investigated using Western blot assay. The successful construction of the skin lesion model was confirmed by results of the enhanced cell apoptosis of HaCaT cells induced by H 2 O 2, the increased Bax expression and decreased Bcl‐2 expression. CD9 and CD63 expression evidenced the existence of ADSC‐exos. The results of functional experiments demonstrated that ADSC‐exos could prompt cell proliferation and migration of HaCaT cells, and repress cell apoptosis of HaCaT cells. In addition, the activation of Wnt/β‐catenin signaling was confirmed by the enhanced expression of β‐catenin at the protein level. Collectively, our findings suggest that ADSC‐exos play a positive role in cutaneous wound healing possibly via Wnt/β‐catenin signaling. Our study may provide new insights into the therapeutic target for cutaneous wound healing.
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Cites
HucMSC-Exosome Mediated-Wnt4 Signaling Is Required for Cutaneous Wound Healing
Zhang, B., Wang, M., Gong, A., Zhang, X., Wu, X., Zhu, Y., Shi, H., Wu, L., Zhu, W., Qian, H., et al. (2015) · Stem Cells · doi:10.1002/stem.1771 · Cited by 792
Transforming growth factor beta (TGF‐β) isoforms in wound healing and fibrosis
Lichtman, M. K., Otero‐Vinas, M., & Falanga, V. (2016) · Wound Repair and Regeneration · doi:10.1111/wrr.12398 · Cited by 626
Exosomes: New players in cell–cell communication
Bang, C., & Thum, T. (2012) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2012.08.007 · Cited by 505
Toh, W. S., Lai, R. C., Hui, J. H. P., & Lim, S. K. (2017) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2016.11.008 · Cited by 502
Zhang, W., Bai, X., Zhao, B., Li, Y., Zhang, Y., Li, Z., Wang, X., Luo, L., Han, F., Zhang, J., et al. (2018) · Experimental Cell Research · doi:10.1016/j.yexcr.2018.06.035 · Cited by 361
Age-Related Aspects of Cutaneous Wound Healing: A Mini-Review
Sgonc, R., & Gruber, J. (2013) · Gerontology · doi:10.1159/000342344 · Cited by 288
Beta‐catenin regulates wound size and mediates the effect of TGF‐beta in cutaneous healing
Cheon, S. S., Wei, Q., Gurung, A., Youn, A., Bright, T., Poon, R., Whetstone, H., Guha, A., & Alman, B. A. (2006) · The FASEB Journal · doi:10.1096/fj.05-4759com · Cited by 219
Zhao, P., Sui, B., Liu, N., Lv, Y., Zheng, C., Lu, Y., Huang, W., Zhou, C., Chen, J., Pang, D., et al. (2017) · Aging Cell · doi:10.1111/acel.12635 · Cited by 212
Salivary Exosomes: Emerging Roles in Systemic Disease
Han, Y., Jia, L., Zheng, Y., & Li, W. (2018) · International Journal of Biological Sciences · doi:10.7150/ijbs.25018 · Cited by 192
Bai, Y., Han, Y.-D., Yan, X.-L., Ren, J., Zeng, Q., Li, X.-D., Pei, X.-T., & Han, Y. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.04.065 · Cited by 168
Pu, C.-M., Liu, C.-W., Liang, C.-J., Yen, Y.-H., Chen, S.-H., Jiang-Shieh, Y.-F., Chien, C.-L., Chen, Y.-C., & Chen, Y.-L. (2017) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2016.12.030 · Cited by 160
Implications of mesenchymal stem cells in regenerative medicine
Kariminekoo, S., Movassaghpour, A. A., Rahimzadeh, A., Talebi, M., Shamsasenjan, K., & Akbarzadeh, A. (2016) · Artificial Cells Nanomedicine and Biotechnology · doi:10.3109/21691401.2015.1129620 · Cited by 128
An overview of the therapeutic potential of regenerative medicine in cutaneous wound healing
Pang, C., Ibrahim, A., Bulstrode, N., & Ferretti, P. (2017) · International Wound Journal · doi:10.1111/iwj.12735 · Cited by 126
Mesenchymal stem cells: The roles and functions in cutaneous wound healing and tumor growth
Motegi, S., & Ishikawa, O. (2016) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2016.11.005 · Cited by 124
Extracellular matrix dynamics during mesenchymal stem cells differentiation
Assis-Ribas, T., Forni, M. F., Winnischofer, S. M. B., Sogayar, M. C., & Trombetta-Lima, M. (2018) · Developmental Biology · doi:10.1016/j.ydbio.2018.03.002 · Cited by 123
Mesenchymal Stem Cells-Derived Exosomes for Wound Regeneration
Goodarzi, P., Larijani, B. A., Alavi-Moghadam, S., Tayanloo-Beik, A., Mohamadi-Jahani, F., Ranjbaran, N., Payab, M., Falahzadeh, K., Mousavi, M., & Arjmand, B. (2018) · Advances in experimental medicine and biology · doi:10.1007/5584_2018_251 · Cited by 105
Rodriguez-Menocal, L., Salgado, M., Ford, D., & Badiavas, E. V. (2012) · Stem Cells Translational Medicine · doi:10.5966/sctm.2011-0029 · Cited by 98
Yang, H., Tsai, Y.-C., Korivi, M., Chang, C., & Hseu, Y. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2016.10.021 · Cited by 93
Liu, X., Wang, S., Wu, S., Qian, H., Li, Y., Guo, Z., & Wang, W. (2018) · Stem Cell Research & Therapy · doi:10.1186/s13287-018-0899-9 · Cited by 73
Lewis, C. J., Mardaryev, A. N., Poterlowicz, K., Sharova, T. Y., Aziz, A., Sharpe, D. T., Botchkareva, N. V., & Sharov, A. A. (2013) · Journal of Investigative Dermatology · doi:10.1038/jid.2013.419 · Cited by 71
The role of exosomes on colorectal cancer: A review
Ruiz‐López, L., Blancas, I., Garrido, J. M., Mut‐Salud, N., Moya‐Jódar, M., Osuna, A., & Rodríguez‐Serrano, F. (2017) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.14049 · Cited by 65
miR-155 promotes cutaneous wound healing through enhanced keratinocytes migration by MMP-2
Yang, L., Zheng, Z., Zhou, Q., Bai, X., Fan, L., Chen, Y., Su, L., & Hu, D. (2017) · Journal of Molecular Histology · doi:10.1007/s10735-017-9713-8 · Cited by 59
Growth factor-functionalized silk membranes support wound healing in vitro
Bienert, M., Hoss, M., Bartneck, M., Weinandy, S., Böbel, M., Jockenhoevel, S., Knüchel, R., Pottbacker, K., Wöltje, M., Jahnen‐Dechent, W., et al. (2017) · Biomedical Materials · doi:10.1088/1748-605x/aa7695 · Cited by 47
Kindlin-1 contributes to EGF-induced re-epithelialization in skin wound healing
Shen, C., Sun, L., Zhu, N., & Qi, F. (2017) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2017.2911 · Cited by 44
Tao, J., Wang, H., Zhai, Y., Park, H., Wang, J., Ji, F., & Zhang, Z. (2016) · Experimental Cell Research · doi:10.1016/j.yexcr.2016.09.013 · Cited by 41
Pore‐forming toxin‐like protein complex expressed by frog promotes tissue repair
Gao, Z.-H., Deng, C., Xie, Y.-Y., Guo, X., Wang, Q., Liu, L., Lee, W., Li, S., & Zhang, Y. (2018) · The FASEB Journal · doi:10.1096/fj.201800087r · Cited by 25
PHD-2 Suppression in Mesenchymal Stromal Cells Enhances Wound Healing
Ko, S. H., Nauta, A., Morrison, S. D., Hu, M. S.-M., Zimmermann, A. S., Chung, M. T., Glotzbach, J. P., Wong, V., Walmsley, G. G., Lorenz, H. P., et al. (2017) · Plastic & Reconstructive Surgery · doi:10.1097/prs.0000000000003959 · Cited by 17
Cited by
Hong, P., Yang, H., Wu, Y., Li, K., & Tang, Z. (2019) · Stem Cell Research & Therapy · doi:10.1186/s13287-019-1358-y · Cited by 269
Wang, T., Jian, Z., Baskys, A., Yang, J., Li, J., Guo, H., Hei, Y., Xian, P., He, Z., Li, Z., et al. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.120264 · Cited by 266
Adipose-derived stem cells secretome and its potential application in “stem cell-free therapy”
Trzyna, A., & Banaś-Ząbczyk, A. (2021) · Biomolecules · doi:10.3390/biom11060878 · Cited by 201
Ma, Z.-J., Yang, J.-J., Lu, Y.-B., Liu, Z.-Y., & Wang, X.-X. (2020) · World Journal of Stem Cells · doi:10.4252/wjsc.v12.i8.814 · Cited by 155
Zhao, D., Yu, Z., Li, Y., Wang, Y., Li, Q., & Han, D. (2020) · Journal of Molecular Histology · doi:10.1007/s10735-020-09877-6 · Cited by 139
Metadata
- Authors
- Ma, T., Fu, B., Yang, X., Xiao, Y., & Pan, M.
- Venue
- Journal of Cellular Biochemistry
- Publisher
- Wiley
- Published
- 2019-01-25
- Volume
- 120
- Issue
- 6
- Pages
- 10847-10854
- ISSN
- 0730-2312 (ISSN-L)
- 1097-4644
- OpenAlex
- W2913512544
- Cited by
- 253
- References
- 27
- FWCI
- 18.05
- Type
- journal article
- Language
- en
- Open access
- closed
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