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Cited by 192

The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.

Salivary Exosomes: Emerging Roles in Systemic Disease

Open access
Han, Yineng, Jia, Lingfei, Zheng, Yunfei, Li, Weiran·2018·International Journal of Biological Sciences
DOI 10.7150/ijbs.25018
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Abstract

Saliva, which contains biological information, is considered a valuable diagnostic tool for local and systemic diseases and conditions because, similar to blood, it contains important molecules like DNA, RNA, and proteins. Exosomes are cell-derived vesicles 30-100 nm in diameter with substantial biological functions, including intracellular communication and signalling. These vesicles, which are present in bodily fluids, including saliva, are released upon fusion of multivesicular bodies (MVBs) with the cellular plasma membrane. Salivary diagnosis has notable advantages, which include noninvasiveness, ease of collection, absence of coagulation, and a similar content as plasma, as well as increased patient compliance compared to other diagnostic approaches. However, investigation of the roles of salivary exosomes is still in its early years. In this review, we first describe the characteristics of endocytosis and secretion of salivary exosomes, as well as database and bioinformatics analysis of exosomes. Then, we describe strategies for the isolation of exosomes from human saliva and the emerging role of salivary exosomes as potential biomarkers of oral and other systemic diseases. Given the ever-growing role of salivary exosomes, defining their functions and understanding their specific mechanisms will provide novel insights into possible applications of salivary exosomes in the diagnosis and treatment of systemic diseases.

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Metadata

Authors
Han, Y., Jia, L., Zheng, Y., & Li, W.
Venue
International Journal of Biological Sciences
Publisher
Ivyspring International Publisher
Published
2018
Volume
14
Issue
6
Pages
633-643
ISSN
1449-2288 (ISSN-L)
DOI
10.7150/ijbs.25018
OpenAlex
W2804826922
Cited by
192
References
8
FWCI
6.36
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: Salivary Exosomes: Emerging Roles in Systemic Disease. https://app.cochat.ai/papers/10.7150/ijbs.25018
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Han, Y., Jia, L., Zheng, Y., & Li, W. (2018). Salivary Exosomes: Emerging Roles in Systemic Disease. International Journal of Biological Sciences. https://doi.org/10.7150/ijbs.25018

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.