Combined identification of lncRNA NONHSAG004550 and NONHSAT125420 as a potential diagnostic biomarker of perinatal depression
Open accessAbstract
BACKGROUND: Perinatal depression (PD) is one of the most common complications of pregnancy, and timely diagnosis and treatment are still challenging in China due to the scarcity of psychiatrists. This study aimed to investigate whether long noncoding RNAs (lncRNAs) are potential diagnostic biomarkers of PD. METHODS: Using RT-PCR, six downregulated major depressive disorder (MDD)-associated lncRNAs (NONSUSG010267, NONHSAT140386, NONHSAG004550, NONHSAT125420, NONHSAG013606, and NONMMUG014361) were assessed in 39 pregnant women with PD (PD group), 20 PD patients undergoing mindfulness-integrated cognitive behavior therapy (MiCBT) (treatment group (TG)), and 51 normal pregnant women (normal control (NC) group) to identify significantly differentially expressed lncRNAs during the second trimester and at 42 days postpartum. RESULTS: Compared with the NC group, the six lncRNAs were significantly downregulated in the PD group during the second trimester and at 42 days postpartum (p<0.01~0.001). Expression of NONHSAG004550 and NONHSAT125420 was significantly upregulated after MiCBT therapy in TG (p<0.01~0.001), and no significant differences were observed between TG and the NC group at 42 days postpartum (p>0.05). NONHSAG004550 and NONHSAT125420 were significantly differentially expressed in the PD group, and this expression was altered according to the amelioration of depressive symptoms. Receiver operating characteristic (ROC) curve analysis revealed that the two lncRNAs combined had a good value in predicting PD, with an area under the curve (AUC) of 0.764 (95% confidence interval (CI): 0.639-0.888). CONCLUSION: The combination of lncRNAs NONHSAG004550 and NONHSAT125420 is a novel potential diagnostic biomarker of PD.
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In a very recent study, post-partum depression was demonstrated to be ameliorated in a group who received MiCBT and changes were detected at a chromosomal level.
“In a very recent study, post-partum depression was demonstrated to be ameliorated in a group who received MiCBT and changes were detected at a chromosomal level (35).”
From Group Mindfulness-Integrated Cognitive Behavior Therapy (MiCBT) Reduces Depression and Anxiety and Improves Flourishing in a Transdiagnostic Primary Care Sample Compared to Treatment-as-Usual: A Randomized Controlled Trial (2022) · cites this paper as [35]
The Discussion (page not provided) reports that MiCBT was given during the second trimester and that, at 42 days postpartum, the treatment group’s depression scores did not differ significantly from normal controls. It also reports changes in the expression of two lncRNAs after MiCBT. Those are molecular expression changes, not demonstrated changes to chromosomes; the participants were treated for depression during pregnancy rather than first receiving treatment for postpartum depression. (LLM, conf=0.86)
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- Authors
- Wang, L., Zhang, M., Zhu, H., Sun, L., Yu, B., & Cui, X.
- Affiliations
- Nanjing Medical University (CN)
- Corresponding author
- Yu, Bin
- Cui, Xuelian
- Venue
- Journal of Clinical Laboratory Analysis
- Publisher
- Wiley
- Published
- 2021-07-15
- Volume
- 35
- Issue
- 8
- Pages
- e23890-e23890
- ISSN
- 0887-8013 (ISSN-L)
- 1098-2825
- PMC
- PMC8373316
- OpenAlex
- W3178357074
- Cited by
- 21
- References
- 33
- Citations by year
- 2025: 6 · 2024: 5 · 2023: 5 · 2022: 4 · 2021: 1
- FWCI
- 3.25
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Journal of Clinical Laboratory Analysis (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Natural Science Foundation of Jiangsu Province (BK20190163)
- China Postdoctoral Science Foundation (2020KYZZ4070)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- perinatal depression, long non-coding RNA, diagnostic biomarkers, major depressive disorder, antenatal depression, postpartum depression, second trimester, lncRNA expression profiling
- MeSH terms
- Adult, Depression, Female, Humans, Maternal Age, Pregnancy, Pregnancy Complications, Pregnancy Trimester, Second, ROC Curve, Biomarkers, Gene Expression, Cognitive Behavioral Therapy, Case-Control Studies, Depression, Postpartum, RNA, Long Noncoding
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