The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Role of FGFs/FGFRs in skeletal development and bone regeneration
Abstract
Fibroblast growth factor (FGF)/FGF (FGFR) signaling is an important pathway involved in skeletal development. Missense mutations in FGFs and FGFRs were found clinically to cause multiple congenital skeleton diseases including chondrodysplasia, craniosynostosis, syndromes with dysregulated phosphate metabolism. FGFs/FGFRs also have crucial roles in bone fracture repair and bone regeneration. Understanding the molecular mechanisms for the role of FGFs/FGFRs in the regulation of skeletal development, genetic skeletal diseases, and fracture healing will ultimately lead to better treatment of skeleton diseases caused by mutations of FGFs/FGFRs and fracture. This review summarizes the major findings on the role of FGF signaling in skeletal development, genetic skeletal diseases and bone healing, and discusses issues that remain to be resolved in applying FGF signaling‐related measures to promote bone healing. This review has also provided a perspective view on future work for exploring the roles and action mechanisms of FGF signaling in skeletal development, genetic skeletal diseases, and fracture healing. J. Cell. Physiol. 227: 3731–3743, 2012. © 2012 Wiley Periodicals, Inc.
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Feng, J. Q., Ward, L. M., Liu, S., Lu, Y., Xie, Y., Yuan, B., Yu, X., Rauch, F., Davis, S. I., Zhang, S., et al. (2006) · Nature Genetics · doi:10.1038/ng1905 · Cited by 1,199 · cited 3×
“…et al., 2001), autosomal dominant hypophosphatemic rickets (ADHR) (Consortium, 2000), autosomal recessive hypophosphatemic rickets/osteomalacia (ARHR) (Feng et al., 2006), and X-linked hypophosphatemic rickets (XLH) (Jonsson et al., 2003; Fukumoto and Yamashita, 2007; Yoshiko et al., 2007).”
BackgroundSelf-citationGenetic Control of Bone Formation
Karsenty, G., Kronenberg, H. M., & Settembre, C. (2009) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.042308.113308 · Cited by 667
Disruption of the fibroblast growth factor-2 gene results in decreased bone mass and bone formation
Montero, A., Okada, Y., Tomita, M., Ito, M., Tsurukami, H., Nakamura, T., Doetschman, T., Coffin, J. D., & Hurley, M. M. (2000) · Journal of Clinical Investigation · doi:10.1172/jci8641 · Cited by 483 · cited 1×
“…of FGFs/FGFRs in skeletal development and human skeletal diseases has been carried out by using mouse models with genetically modified FGFs/FGFRs.FGF2 deficient mice have no gross abnormalities in developing skeleton, however, they show osteopenia phenotypes in adult stage (Montero et al., 2000).”
BackgroundIdentification of Sef, a novel modulator of FGF signalling
Tsang, M., Friesel, R., Kudoh, T., & Dawid, I. B. (2002) · Nature Cell Biology · doi:10.1038/ncb749 · Cited by 304
Cited by
The Fibroblast Growth Factor signaling pathway
Ornitz, D. M., & Itoh, N. (2015) · WIREs Developmental Biology · doi:10.1002/wdev.176 · Cited by 2,050
FGF/FGFR signaling in health and disease
Xie, Y., Su, N., Yang, J., Tan, Q., Huang, S., Jin, M., Ni, Z., Zhang, B., Zhang, D., Luo, F., et al. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00222-7 · Cited by 904
Self-citationThe roles of signaling pathways in bone repair and regeneration
Majidinia, M., Sadeghpour, A., & Yousefi, B. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.26042 · Cited by 513
Blood vessel formation and function in bone
Sivaraj, K. K., & Adams, R. H. (2016) · Development · doi:10.1242/dev.136861 · Cited by 441
Lu, P., Blesch, A., & Tuszynski, M. H. (2004) · Journal of Neuroscience Research · doi:10.1002/jnr.20148 · Cited by 435
Metadata
- Authors
- Du, X., Xie, Y., Xian, C. J., & Chen, L.
- Venue
- Journal of Cellular Physiology
- Publisher
- Wiley
- Published
- 2012-08-23
- Volume
- 227
- Issue
- 12
- Pages
- 3731-3743
- ISSN
- 0021-9541 (ISSN-L)
- 1097-4652
- OpenAlex
- W2089071506
- Cited by
- 185
- References
- 4
- FWCI
- 4.30
- Type
- journal article
- Language
- en
- Open access
- closed
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- Du, X., Xie, Y., Xian, C. J., & Chen, L. (2012). Role of FGFs/FGFRs in skeletal development and bone regeneration. Journal of Cellular Physiology. https://doi.org/10.1002/jcp.24083
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
