The DOI matches its Crossref record; 225 of the 225 references it cites were found in a registry or an index.
The roles of signaling pathways in bone repair and regeneration
Abstract
Regenerative medicine has sparked interest in potential strategies for bone repair. Bone defects are widespread and could be caused by trauma, congenital malformations, infections, and surgery. Although bone has a large self‐healing capacity, some defects or fractures are too big to regenerate. To regenerate bone structures which can be used for treatment of patients, bone growth must be induced by a number of bioactive implantable materials, cell types and intracellular, and extracellular molecular signaling pathways. Since mesenchymal stem cells (MSCs) and their differentiation during remodeling processes have important roles in bone regeneration, it is believed that understanding molecular signaling pathways involved is crucial to the development of bone implants, bone substitute materials, and cell‐based scaffolds for bone regeneration. In this review, we briefly introduce concepts in fracture repair and regeneration following bone injuries, and then discuss the current clinical methods in bone regeneration. In the next section, we review the involvement of the various key signaling pathways in bone regeneration.
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Current Status of the Diagnosis and Management of Osteoporosis
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Zhai, M., Zhu, Y., Yang, M., & Mao, C. (2020) · Advanced Science · doi:10.1002/advs.202001334 · Cited by 277
Vlashi, R., Zhang, X., Wu, M., & Chen, G. (2023) · Genes & Diseases · doi:10.1016/j.gendis.2022.07.011 · Cited by 165
Molecular mechanisms in liver repair and regeneration: from physiology to therapeutics
Ma, X., Huang, T., Chen, X., Li, Q., Liao, M., Fu, L., Huang, J., Yuan, K., Wang, Z., & Zeng, Y. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-02104-8 · Cited by 133
The Role of Low-Level Laser Therapy in Bone Healing: Systematic Review
Berni, M., Brancato, A. M., Torriani, C., Bina, V., Annunziata, S., Cornella, E., Trucchi, M., Jannelli, E., Mosconi, M., Gastaldi, G., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24087094 · Cited by 106
Metadata
- Authors
- Majidinia, M., Sadeghpour, A., & Yousefi, B.
- Venue
- Journal of Cellular Physiology
- Publisher
- Wiley
- Published
- 2017-08-03
- Volume
- 233
- Issue
- 4
- Pages
- 2937-2948
- ISSN
- 0021-9541 (ISSN-L)
- 1097-4652
- OpenAlex
- W2623277425
- Cited by
- 513
- References
- 225
- FWCI
- 13.39
- Type
- journal article
- Language
- en
- Open access
- closed
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- Majidinia, M., Sadeghpour, A., & Yousefi, B. (2018). The roles of signaling pathways in bone repair and regeneration. Journal of Cellular Physiology. https://doi.org/10.1002/jcp.26042
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
