Specificity of latent TGF-β binding protein (LTBP) incorporation into matrix: role of fibrillins and fibronectin
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Fibrillin microfibrils are extracellular matrix structures with essential functions in the development and the organization of tissues including blood vessels, bone, limbs and the eye. Fibrillin‐1 and fibrillin‐2 form the core of fibrillin microfibrils, to which multiple proteins associate to form a highly organized structure. Defining the components of this structure and their interactions is crucial to understand the pathobiology of microfibrillopathies associated with mutations in fibrillins and in microfibril‐associated molecules. In this study, we have analyzed both in vitro and in vivo the role of fibrillin microfibrils in the matrix deposition of latent TGF‐β binding protein 1 (LTBP‐1), ‐3 and ‐4; the three LTBPs that form a complex with TGF‐β. In Fbn1−/− ascending aortas and lungs, LTBP‐3 and LTBP‐4 are not incorporated into a matrix lacking fibrillin‐1 microfibrils, whereas LTBP‐1 is still deposited. In addition, in cultures of Fbn1−/− smooth muscle cells or lung fibroblasts, LTBP‐3 and LTBP‐4 are not incorporated into a matrix lacking fibrillin‐1 microfibrils, whereas LTBP‐1 is still deposited. Fibrillin‐2 is not involved in the deposition of LTBP‐1 in Fbn1−/− extracellular matrix as cells deficient for both fibrillin‐1 and fibrillin‐2 still incorporate LTBP‐1 in their matrix. However, blocking the formation of the fibronectin network in Fbn1−/− cells abrogates the deposition of LTBP‐1. Together, these data indicate that LTBP‐3 and LTBP‐4 association with the matrix depends on fibrillin‐1 microfibrils, whereas LTBP‐1 association depends on a fibronectin network. J. Cell. Physiol. 227: 3828–3836, 2012. © 2012 Wiley Periodicals, Inc.
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Fibrillin microfibrils are ECM structures with essential functions in the development and organization of several tissues including blood vessels, and they can bind a number of other extracellular proteins, including latent TGFβ binding proteins, fibulins, and laminins.
“Fibrillin microfibrils are ECM structures with essential functions in the development and the organization of several tissues including blood vessels, and they can bind a number of other extracellular proteins, including latent TGFβ binding proteins (LTBPs), fibulins, and laminins [28].”
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- Authors
- Zilberberg, L., Todorovic, V., Dabovic, B., Horiguchi, M., Couroussé, T., Sakai, L. Y., & Rifkin, D. B.
- Affiliations
- NYU Langone Health (US)
- Oregon Health & Science University (US)
- Corresponding author
- Rifkin, Daniel B.
- Venue
- Journal of Cellular Physiology
- Publisher
- Wiley
- Published
- 2012-08-23
- Volume
- 227
- Issue
- 12
- Pages
- 3828-3836
- ISSN
- 0021-9541 (ISSN-L)
- 1097-4652
- PMC
- PMC3404192
- OpenAlex
- W1982265133
- Cited by
- 181
- References
- 42
- Citations by year
- 2025: 11 · 2024: 8 · 2023: 10 · 2022: 16 · 2021: 16 · 2020: 17 · 2019: 12 · 2018: 14 · 2017: 17 · 2016: 16 · 2015: 22 · 2014: 6 · 2013: 9 · 2012: 7
- FWCI
- 8.48
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Cellular Physiology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Marfan Foundation
- NYU Langone Medical Center
- University of Wisconsin-Madison
- Marfan Foundation
- National Institutes of Health
- National Cancer Institute (R01CA034282, R01CA078422, CA034282)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (P01AR049698, AR-49698)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Connective tissue disorders research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Keywords
- latent TGF-beta binding protein, LTBP1, fibrillin-1, fibrillin-2, extracellular matrix deposition, smooth muscle cells, lung fibroblasts, aorta
- MeSH terms
- Fibrillins, Fibrillin-1, Fibrillin-2, Animals, Fibroblasts, Fibronectins, Gene Expression Regulation, Lung, Microfilament Proteins, Muscle, Smooth, Vascular, RNA, DNA, Complementary, Mice, Knockout, Myocytes, Smooth Muscle, Mice, Latent TGF-beta Binding Proteins, Adipokines, Real-Time Polymerase Chain Reaction
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