The DOI matches its Crossref record; 149 of the 149 references it cites were found in a registry or an index.
Gene Therapies for Cancer: Strategies, Challenges and Successes
Open accessAbstract
Gene therapy, which involves replacement of a defective gene with a functional, healthy copy of that gene, is a potentially beneficial cancer treatment approach particularly over chemotherapy, which often lacks selectivity and can cause non‐specific toxicity. Despite significant progress pre‐clinically with respect to both enhanced targeting and expression in a tumor‐selective manner several hurdles still prevent success in the clinic, including non‐specific expression, low‐efficiency delivery and biosafety. Various innovative genetic approaches are under development to reconstruct vectors/transgenes to make them safer and more effective. Utilizing cutting‐edge delivery technologies, gene expression can now be targeted in a tissue‐ and organ‐specific manner. With these advances, gene therapy is poised to become amenable for routine cancer therapy with potential to elevate this methodology as a first line therapy for neoplastic diseases. This review discusses recent advances in gene therapy and their impact on a pre‐clinical and clinical level. J. Cell. Physiol. 230: 259–271, 2015. © 2014 Wiley Periodicals, Inc.
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Metadata
- Authors
- Das, S. K., Menezes, M. E., Bhatia, S., Wang, X., Emdad, L., Sarkar, D., & Fisher, P. B.
- Venue
- Journal of Cellular Physiology
- Publisher
- Wiley
- Published
- 2014-10-28
- Volume
- 230
- Issue
- 2
- Pages
- 259-271
- ISSN
- 0021-9541 (ISSN-L)
- 1097-4652
- OpenAlex
- W1591560031
- Cited by
- 284
- References
- 149
- FWCI
- 4.56
- Type
- journal article
- Language
- en
- Open access
- green
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