The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Nrf2–ARE signaling in cellular protection: Mechanism of action and the regulatory mechanisms
Open accessAbstract
Oxidative stress is the increase in cellular oxidant concentration in comparison to antioxidant titer. Toxic insults and many other diseased conditions are mediated through the formation of such condition. Once the redox equilibrium is disrupted, the cellular antioxidant system functions to bring back the cell to redox homeostasis state. The field players of the cytoprotective machinery are the xenobiotic‐metabolizing enzymes that are transcriptionally controlled by upstream regulatory pathways like the Nrf2–ARE pathway and AhR–XRE pathway. The importance of Nrf2 lies in the fact that it is activated by a variety of compounds and has a wide range of inducers including metals, organic toxicants and so forth. The present review article aims to discuss the role of Nrf2 in cellular protection and also intends to illuminate the regulatory mechanisms that control Nrf2 itself. This can add to our knowledge of how the cell reacts and survives against such stressed conditions.
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Cites
Role of nrf2 in oxidative stress and toxicity
Ma, Q. (2013) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-011112-140320 · Cited by 4,903
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“…β transducin repeat containing E3 ubiquitin‐protein ligase (βTrCP) and subsequently tagged by Cul3/Rbx1 (Cuadrado, 2015, Mathur, Pandey, & Kakkar, 2018; Vomund et al., 2017) or Cul1 E3 ligase complex (Rada et al., 2011; Yamamoto, Kensler, & Motohashi, 2018) for proteasomal degradation (Figure 2).”
BackgroundNrf2, the Master Regulator of Anti-Oxidative Responses
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Molecular Basis of Electrophilic and Oxidative Defense: Promises and Perils of Nrf2
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Identification of aldo-keto reductases as NRF2-target marker genes in human cells
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Cited by
Dietary phytochemicals targeting Nrf2 for chemoprevention in breast cancer
Wang, P., Long, F., Lin, H., & Wang, T. (2022) · Food & Function · doi:10.1039/d2fo00186a · Cited by 28
Delgado-Wicke, P., Rodríguez-Luna, A., Ikeyama, Y., Honma, Y., Kume, T., Gutierrez, M., Lorrio, S., Juarranz, Á., & González, S. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/2908108 · Cited by 20
Metadata
- Authors
- Shaw, P., & Chattopadhyay, A.
- Venue
- Journal of Cellular Physiology
- Publisher
- Wiley
- Published
- 2019-09-23
- Volume
- 235
- Issue
- 4
- Pages
- 3119-3130
- ISSN
- 0021-9541 (ISSN-L)
- 1097-4652
- OpenAlex
- W2975823818
- Cited by
- 431
- References
- 11
- FWCI
- 10.89
- Type
- journal article
- Language
- en
- Open access
- green
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