The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
M2b macrophage polarization and its roles in diseases
Open accessAbstract
Macrophages play an important role in a wide variety of physiologic and pathologic processes. Plasticity and functional polarization are hallmarks of macrophages. Macrophages commonly exist in two distinct subsets: classically activated macrophages (M1) and alternatively activated macrophages (M2). M2b, a subtype of M2 macrophages, has attracted increasing attention over the past decade due to its strong immune-regulated and anti-inflammatory effects. A wide variety of stimuli and multiple factors modulate M2b macrophage polarization in vitro and in vivo. M2b macrophages possess both protective and pathogenic roles in various diseases. Understanding the mechanisms of M2b macrophage activation and the modulation of their polarization might provide a great perspective for the design of novel therapeutic strategies. The purpose of this review is to discuss current knowledge of M2b macrophage polarization, the roles of M2b macrophages in a variety of diseases and the stimuli to modulate M2b macrophage polarization.
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Cites
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Macrophage Polarization in Physiological and Pathological Pregnancy
Yao, Y., Xu, X.-H., & Jin, L. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00792 · Cited by 825
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Tumor-associated macrophages: an effective player of the tumor microenvironment
Basak, U., Sarkar, T., Mukherjee, S., Chakraborty, S., Dutta, A., Dutta, S., Nayak, D., Kaushik, S., Das, T., & Sa, G. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1295257 · Cited by 333
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Metadata
- Authors
- Wang, L.-X., Zhang, S.-X., Wu, H.-J., Rong, X.-L., & Guo, J.
- Venue
- Journal of Leukocyte Biology
- Publisher
- Oxford University Press (OUP)
- Published
- 2018-12-21
- Volume
- 106
- Issue
- 2
- Pages
- 345-358
- ISSN
- 0741-5400 (ISSN-L)
- 1938-3673
- OpenAlex
- W2905827542
- Cited by
- 884
- References
- 24
- FWCI
- 16.40
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Wang, L.-X., Zhang, S.-X., Wu, H.-J., Rong, X.-L., & Guo, J. (2019). M2b macrophage polarization and its roles in diseases. Journal of Leukocyte Biology. https://doi.org/10.1002/jlb.3ru1018-378rr
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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