Showing your ID: intrinsic disorder as an ID for recognition, regulation and cell signaling

Uversky, Vladimir N., Oldfield, Christopher J., Dunker, A. Keith·2005·Journal of Molecular Recognition

Cited by (847)

Items 101–200 of 847

  1. General Purpose Water Model Can Improve Atomistic Simulations of Intrinsically Disordered Proteins
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  2. Structural Investigation of Disordered Stress Proteins. Comparison of Full-Length Dehydrins with Isolated Peptides of Their Conserved Segments
    Jean‐Marie Mouillon, Petter Gustafsson, Pia Harryson · 2006 · PLANT PHYSIOLOGY
  3. The alphabet of intrinsic disorder
    Vladimir Nikolaevich Uversky · 2013 · Intrinsically Disordered Proteins
  4. The multifaceted roles of intrinsic disorder in protein complexes
    Vladimir Nikolaevich Uversky · 2015 · FEBS Letters
  5. Disordered Proteinaceous Machines
    Mónika Fuxreiter, Ágnes Tóth-Petróczy, Daniel Adam Kraut, Andreas T. Matouschek, Roderick Y. H. Lim, Bin Xue, Lukasz Kurgan, Vladimir Nikolaevich Uversky · 2014 · Chemical Reviews
  6. Disordered nucleiome: Abundance of intrinsic disorder in the DNA‐ and RNA‐binding proteins in 1121 species from Eukaryota, Bacteria and Archaea
    Chen Wang, Vladimir Nikolaevich Uversky, Lukasz Kurgan · 2016 · PROTEOMICS
  7. Can molecular dynamics simulations provide high‐resolution refinement of protein structure?
    Jianhan Chen, Charles L. Brooks · 2007 · Proteins Structure Function and Bioinformatics
  8. Abundance of intrinsically unstructured proteins in P. falciparum and other apicomplexan parasite proteomes
    Zhiping Feng, Xiuzhen Zhang, Pengfei Han, Neeraj Arora, Robin F. Anders, Raymond S. Norton · 2006 · Molecular and Biochemical Parasitology
  9. Liquid–liquid phase separation as an organizing principle of intracellular space: overview of the evolution of the cell compartmentalization concept
    Iuliia A. Antifeeva, Alexander V. Fonin, Anna S. Fefilova, Olesya V. Stepanenko, Olga I. Povarova, Sergey A. Silonov, Irina М. Kuznetsova, Vladimir Nikolaevich Uversky, Туроверов Константин Константинович · 2022 · Cellular and Molecular Life Sciences
  10. Conservation of Intrinsic Disorder in Protein Domains and Families: I. A Database of Conserved Predicted Disordered Regions
    Jessica Walton Chen, Pedro R Romero, Vladimir Nikolaevich Uversky, A. Keith Dunker · 2006 · Journal of Proteome Research
  11. Finding Our Way in the Dark Proteome
    Bhowmick, Asmit, Brookes, David H., Yost, Shane R., Dyson, H. Jane, Forman-Kay, Julie D., Gunter, Daniel, Head-Gordon, Martin, Hura, Gregory L., Pande, Vijay S., Wemmer, David E. et al. · 2016 · Journal of the American Chemical Society
  12. Crystal structures of fibronectin-binding sites from Staphylococcus aureus FnBPA in complex with fibronectin domains
    Richard J. Bingham, Enrique Rudiño-Piñera, Nicola A. G. Meenan, Ulrich Schwarz‐Linek, J.P. Turkenburg, Magnus Höök, Elspeth F. Garman, Jennifer R. Potts · 2008 · Proceedings of the National Academy of Sciences
  13. Recent advances in MeCP2 structure and functionThis paper is one of a selection of papers published in this Special Issue, entitled 29th Annual International Asilomar Chromatin and Chromosomes Conference, and has undergone the Journal’s usual peer review process.
    Kristopher C. Hite, Valerie H. Adams, Jeffrey C. Hansen · 2009 · Biochemistry and Cell Biology
  14. Role of metal ions in aggregation of intrinsically disordered proteins in neurodegenerative diseases
    Leonid Breydo, Vladimir Nikolaevich Uversky · 2011 · Metallomics
  15. Short Linear Motifs recognized by SH2, SH3 and Ser/Thr Kinase domains are conserved in disordered protein regions
    Siyuan Ren, Vladimir Nikolaevich Uversky, Zhengjun Chen, A. Keith Dunker, Zoran Obradovic A · 2008 · BMC Genomics
  16. More than just tails: intrinsic disorder in histone proteins
    Zhenling Peng, Marcin J. Mizianty, Bin Xue, Lukasz Kurgan, Vladimir Nikolaevich Uversky · 2012 · Molecular BioSystems
  17. Understanding COVID-19 via comparative analysis of dark proteomes of SARS-CoV-2, human SARS and bat SARS-like coronaviruses
    Rajanish Giri, Taniya Bhardwaj, Meenakshi Shegane, Bhuvaneshwari R. Gehi, Prateek Kumar, Kundlik Gadhave, Christopher J. Oldfield, Vladimir Nikolaevich Uversky · 2020 · Cellular and Molecular Life Sciences
  18. Bioinformatical approaches to characterize intrinsically disordered/unstructured proteins
    Zsuzsanna Dosztányi, Bálint Mészáros, István Simon · 2009 · Briefings in Bioinformatics
  19. Natively unstructured regions in proteins identified from contact predictions
    Avner Schlessinger, Marco Punta, Burkhard Rost · 2007 · Bioinformatics
  20. Potential lactoferrin activity against pathogenic viruses
    Elrashdy M Moustafa Mohamed Redwan, Vladimir Nikolaevich Uversky, Esmail M. El‐Fakharany, Hussein A. Almehdar · 2014 · Comptes Rendus Biologies
  21. MeDor: a metaserver for predicting protein disorder
    Philippe Lieutaud, Bruno Canard, Sonia Longhi · 2008 · BMC Genomics
  22. A Propensity Scale for Type II Polyproline Helices (PPII): Aromatic Amino Acids in Proline-Rich Sequences Strongly Disfavor PPII Due to Proline–Aromatic Interactions
    Alaina M. Brown, Neal Joseph Zondlo · 2012 · Biochemistry
  23. Intrinsic Disorder, Protein–Protein Interactions, and Disease
    Vladimir Nikolaevich Uversky · 2017 · Advances in protein chemistry and structural biology
  24. The RNA degradosome: life in the fast lane of adaptive molecular evolution
    María J. Marcaida, Mark A. DePristo, Vidya Chandran, Agamemnon J. Carpousis, Ben F. Luisi · 2006 · Trends in Biochemical Sciences
  25. Compartmentalization and Functionality of Nuclear Disorder: Intrinsic Disorder and Protein-Protein Interactions in Intra-Nuclear Compartments
    Fanchi Meng, Insung Na, Lukasz Kurgan, Vladimir Nikolaevich Uversky · 2015 · International Journal of Molecular Sciences
  26. The Importance of Being Flexible: The Case of Basic Region Leucine Zipper Transcriptional Regulators
    Maria Miller · 2009 · Current Protein and Peptide Science
  27. Intrinsically disordered proteins and novel strategies for drug discovery
    Vladimir Nikolaevich Uversky · 2012 · Expert Opinion on Drug Discovery
  28. Mapping α‐helical induced folding within the intrinsically disordered C‐terminal domain of the measles virus nucleoprotein by site‐directed spin‐labeling EPR spectroscopy
    Valérie Belle, Sabrina Rouger, Stéphanie Costanzo, Elodie Liquière, Janez Štrancar, Bruno Guigliarelli, André Fournel, Sonia Longhi · 2008 · Proteins Structure Function and Bioinformatics
  29. Intrinsically Disordered Energy Landscapes
    Yassmine Chebaro, Andrew J. Ballard, Debayan Chakraborty, David J. Wales · 2015 · Scientific Reports
  30. The Protein Folding Problem: The Role of Theory
    Roy Nassar, Gregory L. Dignon, Rostam M. Razban, Ken A. Dill · 2021 · Journal of Molecular Biology
  31. Structural disorder serves as a weak signal for intracellular protein degradation
    Péter Tompa, Jaime Prilusky, Israel Silman, Joel L. Sussman · 2007 · Proteins Structure Function and Bioinformatics
  32. Intrinsically disordered proteins in crowded milieu: when chaos prevails within the cellular gumbo
    Alexander V. Fonin, April L. Darling, Irina М. Kuznetsova, Туроверов Константин Константинович, Vladimir Nikolaevich Uversky · 2018 · Cellular and Molecular Life Sciences
  33. HMGA molecular network: From transcriptional regulation to chromatin remodeling
    Riccardo Sgarra, Salvina Zammitti, Alessandra Lo Sardo, Elisa Maurizio, Laura Arnoldo, Silvia Pegoraro, Vincenzo Giancotti, Guidalberto Manfioletti · 2009 · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
  34. Protein intrinsic disorder as a flexible armor and a weapon of HIV-1
    Bin Xue, Marcin J. Mizianty, Lukasz Kurgan, Vladimir Nikolaevich Uversky · 2011 · Cellular and Molecular Life Sciences
  35. Mimicking the Plant Cell Interior under Water Stress by Macromolecular Crowding: Disordered Dehydrin Proteins Are Highly Resistant to Structural Collapse
    Jean‐Marie Mouillon, Sylvia K. Eriksson, Pia Harryson · 2008 · PLANT PHYSIOLOGY
  36. Modularity of intrinsic disorder in the human proteome
    Melissa M. Pentony, David T. Jones · 2009 · Proteins Structure Function and Bioinformatics
  37. Wrecked regulation of intrinsically disordered proteins in diseases: pathogenicity of deregulated regulators
    Vladimir Nikolaevich Uversky · 2014 · Frontiers in Molecular Biosciences
  38. Functional Analysis of Human Hub Proteins and Their Interactors Involved in the Intrinsic Disorder-Enriched Interactions
    Gang Hu, Zhonghua Wu, Vladimir Nikolaevich Uversky, Lukasz Kurgan · 2017 · International Journal of Molecular Sciences
  39. Genome-wide identification, expression analysis and functional study of the GRAS gene family in Tartary buckwheat (Fagopyrum tataricum)
    Moyang Liu, Li Feng Huang, Zhaotang Ma, Wenjun Sun, Qi Wu, Zizhong Tang, Tongliang Bu, Chenglei Li, Hui Chen · 2019 · BMC Plant Biology
  40. Assessing Induced Folding of an Intrinsically Disordered Protein by Site-Directed Spin-Labeling Electron Paramagnetic Resonance Spectroscopy
    Benjamin M. Morin, Jean‐Marie Bourhis, Valérie Belle, Mireille Woudstra, Frédéric Carrière, Bruno Guigliarelli, André Fournel, Sonia Longhi · 2006 · The Journal of Physical Chemistry B
  41. Structural disorder promotes assembly of protein complexes
    Hédi Hegyi, Éva Schád, Péter Tompa · 2007 · BMC Structural Biology
  42. Multiple aromatic side chains within a disordered structure are critical for transcription and transforming activity of EWS family oncoproteins
    King Pan Ng, Gary Potikyan, Rupert O.V. Savene, Christopher T. Denny, Vladimir Nikolaevich Uversky, Kevin A. W. Lee · 2007 · Proceedings of the National Academy of Sciences
  43. Immunoinformatics may lead to a reappraisal of the nature of B cell epitopes and of the feasibility of synthetic peptide vaccines
    Marc H.V. Van Regenmortel · 2006 · Journal of Molecular Recognition
  44. The CP12 protein family: a thioredoxin-mediated metabolic switch?
    Patricia E. López‐Calcagno, Thomas P. Howard, Christine A. Raines · 2014 · Frontiers in Plant Science
  45. Calmodulin signaling: Analysis and prediction of a disorder‐dependent molecular recognition
    Predrag Radivojac A, Slobodan Vučetić, Timothy R. O'Connor, Vladimir Nikolaevich Uversky, Zoran Obradovic A, A. Keith Dunker · 2006 · Proteins Structure Function and Bioinformatics
  46. Agonism/antagonism switching in allosteric ensembles
    Hesam N. Motlagh, Vincent J. Hilser · 2012 · Proceedings of the National Academy of Sciences
  47. Multisteric Regulation by Structural Disorder in Modular Signaling Proteins: An Extension of the Concept of Allostery
    Péter Tompa · 2013 · Chemical Reviews
  48. MeCP2: structure and functionThis paper is one of a selection of papers published in a Special Issue entitled 31st Annual International Asilomar Chromatin and Chromosomes Conference, and has undergone the Journal’s usual peer review process.
    Nicholas L. Adkins, Philippe T. Georgel · 2011 · Biochemistry and Cell Biology
  49. Multiple Intrinsically Disordered Sequences Alter DNA Binding by the Homeodomain of the Drosophila Hox Protein Ultrabithorax
    Ying Liu, Kathleen Shive Matthews, Sarah E. Bondos · 2008 · Journal of Biological Chemistry
  50. Different Forms of DMP1 Play Distinct Roles in Mineralization
    Arne Gericke, Chunlin Qin, Yao Sun, Roberta E. Redfern, Duane A. Redfern, Yukiji Karen Fujimoto, Hayat Taleb, William T. Butler, Adele L. Boskey · 2010 · Journal of Dental Research
  51. Natively Unstructured Loops Differ from Other Loops
    Avner Schlessinger, Jinfeng Liu, Burkhard Rost · 2005 · PLoS Computational Biology
  52. Casein and casein micelle structures, functions and diversity in 20 species.
    Holt, Carl · 2016 · International Dairy Journal
  53. Multiparametric Analysis of Intrinsically Disordered Proteins: Looking at Intrinsic Disorder through Compound Eyes
    Vladimir Nikolaevich Uversky, A. Keith Dunker · 2011 · Analytical Chemistry
  54. Atomistic Details of the Disordered States of KID and pKID. Implications in Coupled Binding and Folding
    Debabani Ganguly, Jianhan Chen · 2009 · Journal of the American Chemical Society
  55. Biological importance of arginine: A comprehensive review of the roles in structure, disorder, and functionality of peptides and proteins
    Munishwar Nath Gupta, Vladimir Nikolaevich Uversky · 2023 · International Journal of Biological Macromolecules
  56. Reconciling binding mechanisms of intrinsically disordered proteins
    Michel Espinoza-Fonseca · 2009 · Biochemical and Biophysical Research Communications
  57. Structural Disorder within Henipavirus Nucleoprotein and Phosphoprotein: From Predictions to Experimental Assessment
    Johnny Habchi, Laurent Mamelli, Hervé Darbon, Sonia Longhi · 2010 · PLoS ONE
  58. Intrinsically disordered proteins of viruses: Involvement in the mechanism of cell regulation and pathogenesis
    Pushpendra Mani Mishra, Navneet Chandra Verma, Chethana Rao, Vladimir Nikolaevich Uversky, Chayan Kanti Nandi · 2020 · Progress in molecular biology and translational science
  59. The triple power of D³: Protein intrinsic disorder in degenerative diseases
    Vladimir Nikolaevich Uversky · 2014 · Frontiers in bioscience
  60. Pup, a prokaryotic ubiquitin-like protein, is an intrinsically disordered protein
    Shanhui Liao, Qiang Shang, Xuecheng Zhang, Jiahai Zhang, Chao Xu, Xiaoming Tu · 2009 · Biochemical Journal
  61. A hybrid machine learning-based method for classifying the Cushing's Syndrome with comorbid adrenocortical lesions
    Jack Y. Yang, Mary Qu Yang, Zuojie Luo, Yan Ma, Jianling Li, Youping Deng, Xudong Huang · 2008 · BMC Genomics
  62. Intrinsic Structural Disorder Confers Cellular Viability on Oncogenic Fusion Proteins
    Hédi Hegyi, László Buday, Péter Tompa · 2009 · PLoS Computational Biology
  63. Pathway of binding of the intrinsically disordered mitochondrial inhibitor protein to F 1 -ATPase
    John V. Bason, M.G. Montgomery, Andrew G. W. Leslie, John E. Walker · 2014 · Proceedings of the National Academy of Sciences
  64. The Nucleosome Remodeling Factor
    Suehyb G. Alkhatib, Joseph W. Landry · 2011 · FEBS Letters
  65. N-terminal Domains of DELLA Proteins Are Intrinsically Unstructured in the Absence of Interaction with GID1/Gibberellic Acid Receptors
    Xiaolin Sun, William T. Jones, Dawn Harvey, Patrick J. B. Edwards, Steven M. Pascal, Christopher A. Kirk, Thérèse Considine, David J. Sheerin, Jasna Rakonjac, Christopher J. Oldfield et al. · 2010 · Journal of Biological Chemistry
  66. Alternative O-GlcNAcylation/O-Phosphorylation of Ser16 Induce Different Conformational Disturbances to the N Terminus of Murine Estrogen Receptor β
    Yong‐Xiang Chen, Jintang Du, Lian‐Xiu Zhou, Xiao-Hong Liu, Yufen Zhao, Hiroshi Nakanishi, Yanmei Li · 2006 · Chemistry & Biology
  67. Intrinsically disordered regions of p53 family are highly diversified in evolution
    Bin Xue, Celeste J. Brown, A. Keith Dunker, Vladimir Nikolaevich Uversky · 2013 · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
  68. Emerging Roles of the Nucleolus in Regulating the DNA Damage Response: The Noncanonical DNA Repair Enzyme APE1/Ref-1 as a Paradigmatical Example
    Giulia Antoniali, Lisa Lirussi, Mattia Poletto, Gianluca Tell · 2013 · Antioxidants and Redox Signaling
  69. Refinement of α-Synuclein Ensembles Against SAXS Data: Comparison of Force Fields and Methods
    Mustapha Carab Ahmed, Line K. Skaanning, Alexander Jussupow, Estella A. Newcombe, Birthe Brandt Kragelund, Carlo Camilloni, Annette E. Langkilde, Kresten Lindorff‐Larsen · 2021 · Frontiers in Molecular Biosciences
  70. DNA induces folding in α-synuclein: Understanding the mechanism using chaperone property of osmolytes
    Muralidhar L. Hegde, K. S. Jagannatha Rao · 2007 · Archives of Biochemistry and Biophysics
  71. Residual Structures, Conformational Fluctuations, and Electrostatic Interactions in the Synergistic Folding of Two Intrinsically Disordered Proteins
    Weihong Zhang, Debabani Ganguly, Jianhan Chen · 2012 · PLoS Computational Biology
  72. Disordered plant LEA proteins as molecular chaperones
    Dénes Kovács, Bianka Ágoston, Péter Tompa · 2008 · Plant Signaling & Behavior
  73. Intrinsically Disordered Proteins: The Dark Horse of the Dark Proteome
    Prakash Kulkarni, V. Uversky · 2018 · Proteomics
  74. Mass spectrometry methods for intrinsically disordered proteins
    Rebecca Beveridge, Quentin Stern, Cait E. MacPhee, Perdita E. Barran · 2012 · The Analyst
  75. AlphaFold illuminates half of the dark human proteins
    Binder, Jessica L., Berendzen, Joel, Stevens, Amy O., He, Yi, Wang, Jian, Dokholyan, Nikolay V., Oprea, Tudor I. · 2022 · Current Opinion in Structural Biology
  76. Structural disorder within paramyxovirus nucleoproteins and phosphoproteins
    Johnny Habchi, Sonia Longhi · 2011 · Molecular BioSystems
  77. Reduction in Structural Disorder and Functional Complexity in the Thermal Adaptation of Prokaryotes
    Prasad V.L.S. Burra, Lajos Kalmár, Péter Tompa · 2010 · PLoS ONE
  78. Structure, stability and specificity of the binding of ssDNA and ssRNA with proteins
    Arumay Pal, Yaakov Levy · 2019 · PLoS Computational Biology
  79. Role of intrinsically disordered protein regions/domains in transcriptional regulation
    Anna S. Garza, Nihal Ahmad, Raj Kumar · 2008 · Life Sciences
  80. Therapeutic Implication of SOCS1 Modulation in the Treatment of Autoimmunity and Cancer
    Jatin Sharma, Joseph Larkin · 2019 · Frontiers in Pharmacology
  81. Ferroptosis – An iron- and disorder-dependent programmed cell death
    Mak B. Djulbegovic, Vladimir Nikolaevich Uversky · 2019 · International Journal of Biological Macromolecules
  82. Protein flexibility, not disorder, is intrinsic to molecular recognition
    Joël Janin, Michael J.E. Sternberg · 2013 · F1000 Biology Reports
  83. The Role of Intrinsically Disordered Regions in the Structure and Functioning of Small Heat Shock Proteins
    Maria V. Sudnitsyna, Evgeny V. Mymrikov, Alim S. Seit‐Nebi, Nikolai B. Gusev · 2012 · Current Protein and Peptide Science
  84. A careful disorderliness in the proteome: Sites for interaction and targets for future therapies
    Robert B. Russell, Toby J. Gibson · 2008 · FEBS Letters
  85. Towards the physical basis of how intrinsic disorder mediates protein function
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  86. Intrinsic disorder in Viral Proteins Genome-Linked: experimental and predictive analyses
    Eugénie Hébrard, Yannick Bessin, Thierry Michon, Sonia Longhi, Vladimir Nikolaevich Uversky, François Delalande, Alain VAN DORSSELAER, Pedro R Romero, Jocelyne J. Walter, Nathalie Declerk et al. · 2009 · Virology Journal
  87. Regulation of Escherichia coli SOS mutagenesis by dimeric intrinsically disordered umuD gene products
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  88. The roles of intrinsic disorder-based liquid-liquid phase transitions in the “Dr. Jekyll–Mr. Hyde” behavior of proteins involved in amyotrophic lateral sclerosis and frontotemporal lobar degeneration
    Vladimir Nikolaevich Uversky · 2017 · Autophagy
  89. Electrostatically Accelerated Encounter and Folding for Facile Recognition of Intrinsically Disordered Proteins
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  90. Flexible Nets of Malleable Guardians: Intrinsically Disordered Chaperones in Neurodegenerative Diseases
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  91. Computational approaches to investigating allostery
    Ora Schueler‐Furman, Shoshana J. Wodak · 2016 · Current Opinion in Structural Biology
  92. Protein intrinsic disorder and influenza virulence: the 1918 H1N1 and H5N1 viruses
    Gerard Kian‐Meng Goh, A. Keith Dunker, Vladimir Nikolaevich Uversky · 2009 · Virology Journal
  93. Insights into the regulation of intrinsically disordered proteins in the human proteome by analyzing sequence and gene expression data
    Yvonne J. K. Edwards, Anna Lobley, Melissa M. Pentony, David T. Jones · 2009 · Genome biology
  94. Binding of the Proline-Rich Segment of Myelin Basic Protein to SH3 Domains: Spectroscopic, Microarray, and Modeling Studies of Ligand Conformation and Effects of Posttranslational Modifications
    Eugenia Polverini, Godha Rangaraj, David S. Libich, Joan M. Boggs, George Harauz · 2007 · Biochemistry
  95. Prediction of Intrinsic Disorder in MERS-CoV/HCoV-EMC Supports a High Oral-Fecal Transmission
    Gerard Kian‐Meng Goh, A. Keith Dunker, Vladimir Nikolaevich Uversky · 2013 · PLoS Currents
  96. Unstructural biology of the dengue virus proteins
    Fanchi Meng, Raied Badierah, Hussein A. Almehdar, Elrashdy M Moustafa Mohamed Redwan, Lukasz Kurgan, Vladimir Nikolaevich Uversky · 2015 · FEBS Journal
  97. Role of lysine versus arginine in enzyme cold‐adaptation: Modifying lysine to homo‐arginine stabilizes the cold‐adapted α‐amylase from Pseudoalteramonas haloplanktis
    Khawar Sohail Siddiqui, Anne Poljak, Michael Guilhaus, Davide De Francisci, Paul M. G. Curmi, Georges Feller, Salvino D’Amico, Charles Gerday, Vladimir Nikolaevich Uversky, Ricardo Cavicchioli · 2006 · Proteins Structure Function and Bioinformatics
  98. Characterization of the Interactions between the Nucleoprotein and the Phosphoprotein of Henipavirus
    Johnny Habchi, Stéphanie Blangy, Laurent Mamelli, Malene Ringkjøbing Jensen, Martin J Blackledge, Hervé Darbon, Michael Oglesbee, Yaoling Shu, Sonia Longhi · 2011 · Journal of Biological Chemistry
  99. Intrinsic Disorder in Proteins with Pathogenic Repeat Expansions
    April L. Darling, Vladimir Nikolaevich Uversky · 2017 · Molecules
  100. Intrinsically Disordered Proteins in the Neurodegenerative Processes: Formation of Tau Protein Paired Helical Filaments and Their Analysis
    Rostislav Škrabana, Jozef Ševčı́k, Michal Novák · 2006 · Cellular and Molecular Neurobiology