Metabolic substrates other than glucose support axon function in central white matter
Abstract
We tested the hypothesis that non-glucose energy sources can support axon function in the rat optic nerve. Axon function was assessed by monitoring the stimulus-evoked compound action potential (CAP). CAP was maintained at full amplitude for 2 hr in 10 mM glucose. 20 mM lactate, 20 mM pyruvate, 10 mM fructose, or 10 mM mannose supported axon function as effectively as did glucose, and 10 mM glutamine provided partial support, but beta-hydroxybutyrate, octanoate, sorbitol, alanine, aspartate, and glutamate failed to support axon function. Our results indicated that a variety of compounds can sustain function in CNS myelinated axons. Axons probably use lactate, pyruvate, and glutamine directly as energy substrates, whereas mannose and fructose could be shuttled through astrocytes to lactate, which is then exported to axons.
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Either glucose or lactate can be used as an energy source for white matter.
“Either glucose or lactate can be used as an energy source for white matter (Brown et al., 2001; Saab et al., 2016),”
From Fueling thought: Management of glycolysis and oxidative phosphorylation in neuronal metabolism (2018) · cites this paper as Brown et al., 2001
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“Either glucose or lactate can be used as an energy source for white matter (Brown et al., 2001; Saab et al., 2016), and glial glycogen can supply energy to axons during aglycemia (Brown et al.”
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- Authors
- Brown, A. M., Wender, R., & Ransom, B. R.
- Affiliations
- University of Washington (US)
- Corresponding author
- Brown, Angus M.
- Venue
- Journal of Neuroscience Research
- Publisher
- Wiley
- Published
- 2001-11-30
- Volume
- 66
- Issue
- 5
- Pages
- 839-843
- ISSN
- 0360-4012 (ISSN-L)
- 1097-4547
- OpenAlex
- W2032542252
- Cited by
- 85
- References
- 25
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 4 · 2023: 3 · 2021: 2 · 2020: 7 · 2019: 3 · 2018: 11 · 2017: 3 · 2016: 4 · 2015: 2 · 2014: 5 · 2013: 5 · 2012: 3
- FWCI
- 0.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neuroscience Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (T32NS007144, R01NS015589, NS15589, T32NS07144)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Keywords
- optic nerve, lactate, pyruvate, fructose, mannose, glutamine, compound action potential, myelinated axons, axonal function
- MeSH terms
- Action Potentials, Amino Acids, Animals, Axons, Carboxylic Acids, Cell Survival, Central Nervous System, Energy Metabolism, Glucose, Monosaccharides, Nerve Fibers, Myelinated, Optic Nerve, Rats, Long-Evans, Rats
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