Cited by 85Neuroscience and Neuropharmacology ResearchAdvanced Neuroimaging Techniques and ApplicationsNerve injury and regeneration

Metabolic substrates other than glucose support axon function in central white matter

Brown, Angus M., Wender, Regina, Ransom, Bruce R.·2001·Journal of Neuroscience Research

Abstract

We tested the hypothesis that non-glucose energy sources can support axon function in the rat optic nerve. Axon function was assessed by monitoring the stimulus-evoked compound action potential (CAP). CAP was maintained at full amplitude for 2 hr in 10 mM glucose. 20 mM lactate, 20 mM pyruvate, 10 mM fructose, or 10 mM mannose supported axon function as effectively as did glucose, and 10 mM glutamine provided partial support, but beta-hydroxybutyrate, octanoate, sorbitol, alanine, aspartate, and glutamate failed to support axon function. Our results indicated that a variety of compounds can sustain function in CNS myelinated axons. Axons probably use lactate, pyruvate, and glutamine directly as energy substrates, whereas mannose and fructose could be shuttled through astrocytes to lactate, which is then exported to axons.

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Crossref · 10.1002/jnr.10081

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Authors
Brown, A. M., Wender, R., & Ransom, B. R.
Affiliations
University of Washington (US)
Corresponding author
Brown, Angus M.
Venue
Journal of Neuroscience Research
Publisher
Wiley
Published
2001-11-30
Volume
66
Issue
5
Pages
839-843
ISSN
  • 0360-4012 (ISSN-L)
  • 1097-4547
OpenAlex
W2032542252
Cited by
85
References
25
Citations by year
2026: 1 · 2025: 5 · 2024: 4 · 2023: 3 · 2021: 2 · 2020: 7 · 2019: 3 · 2018: 11 · 2017: 3 · 2016: 4 · 2015: 2 · 2014: 5 · 2013: 5 · 2012: 3
FWCI
0.86
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Neuroscience Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Neurological Disorders and Stroke (T32NS007144, R01NS015589, NS15589, T32NS07144)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Keywords
optic nerve, lactate, pyruvate, fructose, mannose, glutamine, compound action potential, myelinated axons, axonal function
MeSH terms
Action Potentials, Amino Acids, Animals, Axons, Carboxylic Acids, Cell Survival, Central Nervous System, Energy Metabolism, Glucose, Monosaccharides, Nerve Fibers, Myelinated, Optic Nerve, Rats, Long-Evans, Rats

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