Chronic morphine induces premature mitosis of proliferating cells in the adult mouse subgranular zone

Mandyam, Chitra D.; Norris, Rebekah D.; Eisch, Amelia J.

doi:10.1002/jnr.20090

Cited by 116Neurogenesis and neuroplasticity mechanismsNeuropeptides and Animal PhysiologyPharmacological Receptor Mechanisms and Effects

Chronic morphine induces premature mitosis of proliferating cells in the adult mouse subgranular zone

Mandyam, Chitra D., Norris, Rebekah D., Eisch, Amelia J.·2004·Journal of Neuroscience Research

DOI 10.1002/jnr.20090

Open this paper in CoChat — free account

Abstract

The birth of cells with neurogenic potential in the adult brain is assessed commonly by detection of exogenous S phase markers, such as bromodeoxyuridine (BrdU). Analysis of other phases of the cell cycle, however, can provide insight into how external factors, such as opiates, influence the cycling of newly born cells. To this end, we examined the expression of two endogenous cell cycle markers in relation to BrdU: proliferating cell nuclear antigen (PCNA) and phosphorylated histone H3 (pHisH3). Two hours after one intraperitoneal BrdU injection, BrdU‐, PCNA‐, and pHisH3‐immunoreactive (IR) cells exhibited similar distribution in the adult mouse subgranular zone (SGZ). Quantitative analysis within the SGZ revealed a relative abundance of cells labeled for PCNA > BrdU >> pHisH3. Similar to our reports in rat SGZ, chronic morphine treatment decreased BrdU‐ and PCNA‐IR cells in mouse SGZ by 28 and 38%, respectively. We also show that pHisH3‐IR cells are influenced by chronic morphine to a greater extent (58% decrease) than are BrdU‐ or PCNA‐IR cells. Cell cycle phase analysis of SGZ BrdU‐IR cells using triple labeling for BrdU, PCNA, and pHisH3 revealed premature mitosis in chronic morphine‐treated mice. These results suggest that morphine‐treated mice have a shorter Gap2/mitosis (G 2/M) phase when compared to sham‐treated mice. These findings demonstrate the power of using a combination of exogenous and endogenous cell cycle markers and nuclear morphology to track proliferating cells through different phases of the cell cycle and to reveal the regulation of cell cycle phase by chronic morphine. © 2004 Wiley‐Liss, Inc.

Integrity signals

Registry

Crossref · 10.1002/jnr.20090

Cites

67 of 67 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Chronic administration of morphine leads to reduced hippocampal neurogenesis and cell proliferation.
“Critically, not only do opioids interfere with memory acquisition and retrieval, but they also interfere with hippocampal neurogenesis, where chronic administration of morphine leads to reduced hippocampal neurogenesis and cell proliferation (Eisch et al., 2000;Kahn et al., 2005;Mandyam et al., 2004).”
From A review of the relation between dissociation, memory, executive functioning and social cognition in military members and civilians with neuropsychiatric conditions (2016) · cites this paper as Mandyam et al., 2004
Opioids interfere with memory acquisition and retrieval.
“Critically, not only do opioids interfere with memory acquisition and retrieval, but they also interfere with hippocampal neurogenesis, where chronic administration of morphine leads to reduced hippocampal neurogenesis and cell proliferation (Eisch et al., 2000;Kahn et al., 2005;Mandyam et al., 2004).”
From A review of the relation between dissociation, memory, executive functioning and social cognition in military members and civilians with neuropsychiatric conditions (2016) · cites this paper as Mandyam et al., 2004

Functional neurogenesis in the adult hippocampus
van Praag, H., Schinder, A. F., Christie, B. R., Toni, N., Palmer, T. D., & Gage, F. H. (2002) · Nature · doi:10.1038/4151030a · Cited by 2,853 · see citing works
Neurogenesis in the adult is involved in the formation of trace memories
Shors, T. J., Miesegaes, G. R., Beylin, A. V., Zhao, M., Rydel, T. A., & Gould, E. (2001) · Nature · doi:10.1038/35066584 · Cited by 2,014 · see citing works
Mitosis-specific phosphorylation of histone H3 initiates primarily within pericentromeric heterochromatin during G2 and spreads in an ordered fashion coincident with mitotic chromosome condensation
Hendzel, M. J., Wei, Y., Mancini, M. A., Hooser, A. A. V., Ranalli, T. A., Brinkley, B. R., Bazett‐Jones, D. P., & Allis, C. D. (1997) · Chromosoma · doi:10.1007/s004120050256 · Cited by 1,860 · see citing works
Adult neurogenesis produces a large pool of new granule cells in the dentate gyrus
Cameron, H. A., & Mckay, R. D. G. (2001) · Journal of Comparative Neurology · doi:10.1002/cne.1040 · Cited by 1,585 · see citing works
Neurogenesis in the Dentate Gyrus of the Adult Tree Shrew Is Regulated by Psychosocial Stress and NMDA Receptor Activation
Gould, E., McEwen, B. S., Tanapat, P., Galea, L. A. M., & Fuchs, E. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-07-02492.1997 · Cited by 1,496 · see citing works
Astrocytes give rise to new neurons in the adult mammalian hippocampus
Seri, B., Garcı́a-Verdugo, J. M., McEwen, B. S., & Alvarez-Buylla, A. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-18-07153.2001 · Cited by 1,495 · see citing works
Neurogenesis in the Adult Rat: Electron Microscopic Analysis of Light Radioautographs
Kaplan, M., & Hinds, J. W. (1977) · Science · doi:10.1126/science.887941 · Cited by 1,478 · see citing works
Is a p53-Regulated Inhibitor of G2/M Progression
Hermeking, H., Lengauer, C., Polyak, K., He, T.-C., Zhang, L., Thiagalingam, S., Kinzler, K. W., & Vogelstein, B. (1997) · Molecular Cell · doi:10.1016/s1097-2765(00)80002-7 · Cited by 1,251 · see citing works
Differentiation of newly born neurons and glia in the dentate gyrus of the adult rat
Cameron, H. A., Woolley, C. S., McEwen, B. S., & Gould, E. (1993) · Neuroscience · doi:10.1016/0306-4522(93)90335-d · Cited by 1,215 · see citing works
Neurogenesis in dentate subgranular zone and rostral subventricular zone after focal cerebral ischemia in the rat
Jin, K., Minami, M., Lan, J., Mao, X., Batteur, S., Simon, R., & Greenberg, D. A. (2001) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.081011098 · Cited by 1,117 · see citing works
Autoradiographic and histological studies of postnatal neurogenesis. I. A longitudinal investigation of the kinetics, migration and transformation of cells incoorporating tritiated thymidine in neonate rats, with special reference to postnatal neurogenesis in some brain regions
Altman, J., & Das, G. D. (1966) · The Journal of Comparative Neurology · doi:10.1002/cne.901260302 · Cited by 921 · see citing works
Autoantibody to a nuclear antigen in proliferating cells
Miyachi, K., Fritzler, M. J., & Tan, E. M. (1978) · The Journal of Immunology · doi:10.4049/jimmunol.121.6.2228 · Cited by 874 · see citing works
Regional expression of a gene encoding a neuron-specific Na+-dependent inorganic phosphate cotransporter (DNPI) in the rat forebrain
Hisano, S., Hoshi, K., Ikeda, Y., Maruyama, D., Kanemoto, M., Ichijo, H., Kojima, I., Takeda, J., & Nogami, H. (2000) · Molecular Brain Research · doi:10.1016/s0169-328x(00)00194-7 · Cited by 806 · see citing works
The utility of Ki-67 and BrdU as proliferative markers of adult neurogenesis
Kee, N., Sivalingam, S., Boonstra, R., & Wojtowicz, J. M. (2002) · Journal of Neuroscience Methods · doi:10.1016/s0165-0270(02)00007-9 · Cited by 775 · see citing works
Dual regulation of adenylate cyclase accounts for narcotic dependence and tolerance.
Sharma, S. K., Klee, W. A., & Nirenberg, M. W. (1975) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.72.8.3092 · Cited by 671 · see citing works
Mitotic Phosphorylation of Histone H3: Spatio-Temporal Regulation by Mammalian Aurora Kinases
Crosio, C., Fimia, G. M., Loury, R., Kimura, M., Okano, Y., Zhou, H., Sen, S., Allis, C. D., & Sassone‐Corsi, P. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.3.874-885.2002 · Cited by 668 · see citing works
S-phase checkpoint proteins Tof1 and Mrc1 form a stable replication-pausing complex
Katou, Y., Kanoh, Y., Bando, M., Noguchi, H., Tanaka, H., Ashikari, T., Sugimoto, K., & Shirahige, K. (2003) · Nature · doi:10.1038/nature01900 · Cited by 649 · see citing works
Subpopulations of proliferating cells of the adult hippocampus respond differently to physiologic neurogenic stimuli
Kronenberg, G., Reuter, K., Steiner, B., Brandt, M. D., Jessberger, S., Yamaguchi, M., & Kempermann, G. (2003) · Journal of Comparative Neurology · doi:10.1002/cne.10945 · Cited by 640 · see citing works
Cell cycle-dependent variations in the distribution of the nuclear protein cyclin proliferating cell nuclear antigen in cultured cells: subdivision of S phase.
Celis, J. E., & Celis, A. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.10.3262 · Cited by 636 · see citing works
Short‐term and long‐term survival of new neurons in the rat dentate gyrus
Dayer, A. G., Ford, A. A., Cleaver, K. M., Yassaee, M., & Cameron, H. A. (2003) · Journal of Comparative Neurology · doi:10.1002/cne.10675 · Cited by 628 · see citing works
Use of bromodeoxyuridine-immunohistochemistry to examine the proliferation, migration and time of origin of cells in the central nervous system
Miller, M. W., & Nowakowski, R. S. (1988) · Brain Research · doi:10.1016/0006-8993(88)90055-8 · Cited by 610 · see citing works
Opiates inhibit neurogenesis in the adult rat hippocampus
Eisch, A. J., Barrot, M., Schad, C. A., Self, D. W., & Nestler, E. J. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.120552597 · Cited by 599 · see citing works
Self-citation
Increased cell proliferation and neurogenesis in the adult human Huntington's disease brain
Curtis, M., Penney, E., Pearson, A. G., van Roon-Mom, W. V., Butterworth, N., Dragunow, M., Connor, B., & Faull, R. (2003) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.1532244100 · Cited by 559 · see citing works
Mitotic neuroblasts in the 9-day-old and 11-month-old rodent hippocampus
Kaplan, M., & Bell, D. (1984) · Journal of Neuroscience · doi:10.1523/jneurosci.04-06-01429.1984 · Cited by 455 · see citing works
The subependymal layer of the mouse brain and its cell production as shown by radioautography after thymidine‐H3 injection
Smart, I. H. M. (1961) · The Journal of Comparative Neurology · doi:10.1002/cne.901160306 · Cited by 449 · see citing works
Evidence that granule cells generated in the dentate gyrus of adult rats extend axonal projections
Stanfield, B. B., & Trice, J. (1988) · Experimental Brain Research · doi:10.1007/bf00250261 · Cited by 431 · see citing works
Localization of orphanin FQ (nociceptin) peptide and messenger RNA in the central nervous system of the rat
Neal, C. R., Mansour, A., Reinscheid, R. K., Nothacker, H., Civelli, O., & Watson, S. J. (1999) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19990419)406:4 · Cited by 399 · see citing works
Hippocampal development in the rat: Cytogenesis and morphogenesis examined with autoradiography and low‐level X‐irradiation
Bayer, S. A., & Altman, J. (1974) · Journal of Comparative Neurology · doi:10.1002/cne.901580105 · Cited by 344 · see citing works
The assessment of cellular proliferation by immunohistochemistry: A review of currently available methods and their applications
Yu, C. C. W., Woods, A. L., & Levison, D. A. (1992) · The Histochemical Journal · doi:10.1007/bf01047461 · Cited by 306 · see citing works
The time of origin of neurons in the hippocampal region of the rhesus monkey
RAKIC, P. T., & Nowakowski, R. S. (1981) · The Journal of Comparative Neurology · doi:10.1002/cne.901960109 · Cited by 305 · see citing works
Mechanism by which caffeine potentiates lethality of nitrogen mustard.
Lau, C. C., & Pardee, A. B. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.9.2942 · Cited by 290 · see citing works
Changes in cell-cycle kinetics during the development and evolution of primate neocortex
Kornack, D. R., & RAKIC, P. T. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.3.1242 · Cited by 288 · see citing works
Sex and seasonal changes in the rate of cell proliferation in the dentate gyrus of adult wild meadow voles
Galea, L. A. M., & McEwen, B. S. (1999) · Neuroscience · doi:10.1016/s0306-4522(98)00345-5 · Cited by 276 · see citing works
Endogenous opioid systems regulate cell proliferation in the developing rat brain
Zagon, I. S., & MacLaughlin, P. J. (1987) · Brain Research · doi:10.1016/0006-8993(87)91440-5 · Cited by 228 · see citing works
Regional and Cellular Mapping of cAMP Response Element-Mediated Transcription during Naltrexone-Precipitated Morphine Withdrawal
Shaw-Lutchman, T. Z., Barrot, M., Wallace, T. L., Gilden, L., Zachariou, V., Impey, S., Duman, R. S., Storm, D. R., & Nestler, E. J. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-09-03663.2002 · Cited by 205 · see citing works
Dynamics of cell proliferation in the adult dentate gyrus of two inbred strains of mice
Hayes, N. L., & Nowakowski, R. S. (2002) · Developmental Brain Research · doi:10.1016/s0165-3806(01)00324-8 · Cited by 201 · see citing works
Spatial and temporal expression of short, long/medium, or both opsins in human fetal cones
Xiao, M., & Hendrickson, A. E. (2000) · The Journal of Comparative Neurology · doi:10.1002/1096-9861(20001002)425:4 · Cited by 165 · see citing works
RB and Cdc2 expression in brain: correlations with 3H-thymidine incorporation and neurogenesis
Okano, H. J., Pfaff, D. W., & Gibbs, R. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-07-02930.1993 · Cited by 140 · see citing works
Opiates, opioids and addiction.
Kreek, M. J. (1996) · PubMed · Cited by 128 · see citing works
Cell cycle and cell fate in the nervous system
Ohnuma, S., Philpott, A., & Harris, W. A. (2001) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00175-6 · Cited by 127 · see citing works
μ-Opioid receptor-induced Ca2+ mobilization and astroglial development: morphine inhibits DNA synthesis and stimulates cellular hypertrophy through a Ca2+-dependent mechanism
Hauser, K. F., Stiene‐Martin, A., Mattson, M. P., Elde, R. P., Ryan, S., & Godleske, C. C. (1996) · Brain Research · doi:10.1016/0006-8993(96)00103-5 · Cited by 126 · see citing works
Expression Patterns of Retinoblastoma Protein in Parkinson Disease
Jordan-Sciutto, K. L., Dorsey, R., Chalovich, E. M., Hammond, R. R., & Achim, C. L. (2003) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/62.1.68 · Cited by 121 · see citing works
Meiotic events at the centromeric heterochromatin: histone H3 phosphorylation, topoisomerase IIα localization and chromosome condensation
Cobb, J. A., Miyaike, M., Kikuchi, A., & Handel, M. A. (1999) · Chromosoma · doi:10.1007/s004120050393 · Cited by 121 · see citing works
Chemically induced premature mitosis: differential response in rodent and human cells and the relationship to cyclin B synthesis and p34cdc2/cyclin B complex formation.
Steinmann, K. E., Belinsky, G. S., Lee, D. H.-Y., & Schlegel, R. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.15.6843 · Cited by 102 · see citing works
Adult neurogenesis: implications for psychiatry
Eisch, A. J. (2002) · Progress in brain research · doi:10.1016/s0079-6123(02)38085-3 · Cited by 97 · see citing works
Self-citation
Neuropsychological performance in opiate addicts after rapid detoxification
Guerra, D. (1987) · Drug and Alcohol Dependence · doi:10.1016/0376-8716(87)90036-6 · Cited by 97 · see citing works
Altered Distribution of Cell Cycle Transcriptional Regulators during Alzheimer Disease
Jordan‐Sciutto, K. L., Malaiyandi, L. M., & Bowser, R. P. (2002) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/61.4.358 · Cited by 95 · see citing works
Effects of morphine on DNA synthesis in neonatal rat brain
Kornblum, H. I., Loughlin, S. E., & Leslie, F. M. (1987) · Developmental Brain Research · doi:10.1016/0165-3806(87)90081-2 · Cited by 94 · see citing works
Impulse control differences between abstinent heroin users and matched controls
Lee, T. M. C., & Pau, C. W. H. (2002) · Brain Injury · doi:10.1080/02699050210128915 · Cited by 86 · see citing works
Neural stem cells: From fly to vertebrates
Doe, C. Q., Fuerstenberg, S., & Peng, C. (1998) · Journal of Neurobiology · doi:10.1002/(sici)1097-4695(199808)36:2 · Cited by 85 · see citing works
Cell proliferation and differentiation during fracture healing are influenced by locally applied IGF‐I and TGF‐β1: Comparison of two proliferation markers, PCNA and BrdU
Wildemann, B., Schmidmaier, G., Ordel, S., Stange, R., Haas, N. P., & Raschke, M. (2003) · Journal of Biomedical Materials Research Part B Applied Biomaterials · doi:10.1002/jbm.b.10512 · Cited by 79 · see citing works
The G2 DNA Damage Checkpoint Delays Expression of Genes Encoding Mitotic Regulators
Crawford, D. F., & Piwnica-Worms, H. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m103414200 · Cited by 79 · see citing works
PCNA-binding to DNA at the G1/S transition in proliferating cells of the developing cerebral wall
Takahashi, T., & Caviness, V. S. (1993) · Journal of Neurocytology · doi:10.1007/bf01235751 · Cited by 76 · see citing works
Chondroitin sulfate proteoglycan expression pattern in hippocampal development: Potential regulation of axon tract formation
Wilson, M. T., & Snow, D. M. (2000) · The Journal of Comparative Neurology · doi:10.1002/1096-9861(20000828)424:3 · Cited by 72 · see citing works
Cdc25C interacts with PCNA at G2/M transition
Kawabe, T., Suganuma, M., Ando, T., Kimura, M., Hori, H., & Okamoto, T. (2002) · Oncogene · doi:10.1038/sj.onc.1205229 · Cited by 65 · see citing works
Hippocampal Formation in the Mouse and Rat — Structural Organization and Development: A Review
Reznikov, K. Y. (1991) · Advances in anatomy, embryology and cell biology · doi:10.1007/978-3-642-76447-9_1 · Cited by 62 · see citing works
Morphological analysis of active microglia--rod and ramified microglia in human brains affected by some neurological diseases (SSPE, Alzheimer's disease and Wilson's disease).
Wierzba‐Bobrowicz, T., Gwiazda, E., Kosno-Kruszewska, E., Lewandowska, E., Lechowicz, W., Bertrand, E., Szpak, G. M., & Schmidt-Sidor, B. (2002) · PubMed · Cited by 53 · see citing works
Opioids modulate cell division in the germinal zone of the late embryonic neocortex
Reznikov, K. Y., Hauser, K. F., Nazarevskaja, G., Trunova, Y. A., Derjabin, V., & Bakalkin, G. Y. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00680.x · Cited by 45 · see citing works
Making scents of olfactory neurogenesis
Carleton, A., Rochefort, C., Morante, J., Desmaisons, D., Vincent, J., Gheusi, G., & Lledo, P. (2002) · Journal of Physiology-Paris · doi:10.1016/s0928-4257(01)00087-0 · Cited by 44 · see citing works
Adult neurogenesis in natural populations
Boonstra, R., Galea, L. A. M., Matthews, S., & Wojtowicz, J. M. (2001) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y00-135 · Cited by 43 · see citing works
Exposure to caffeine and suppression of DNA replication combine to stabilize the proteins and RNA required for premature mitotic events
Schlegel, R., Croy, R. G., & Pardee, A. B. (1987) · Journal of Cellular Physiology · doi:10.1002/jcp.1041310113 · Cited by 39 · see citing works
The effects of morphine on cell proliferation
Glasel, J. A. (2000) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-8385-6_2 · Cited by 26 · see citing works
Effect of morphine on 3H‐Thymidine incorporation in the subependyma of the rat: An autoradiographic study
Miller, C. R. D., O’Steen, W. K., & Deadwyler, S. A. (1982) · The Journal of Comparative Neurology · doi:10.1002/cne.902080209 · Cited by 20 · see citing works
Morphine induced increases in the incorporation of 3H-thymidine into brain striatal DNA
Messing, R. B., Miller, C. R. D., Waymire, J. C., LYNCH, G. S., & Deadwyler, S. A. (1979) · Brain Research Bulletin · doi:10.1016/0361-9230(79)90102-3 · Cited by 18 · see citing works
Premature expression of cyclin B sensitizes human HT1080 cells to caffeine‐induced premature mitosis
Tam, S. W., Belinsky, G. S., & Schlegel, R. (1995) · Journal of Cellular Biochemistry · doi:10.1002/jcb.240590306 · Cited by 14 · see citing works
Linkages of nuclear architecture to biological and pathological control of gene expression
Stein, G. S., van Wijnen, A. J., Stein, J. L., Lian, J. B., Pockwinse, S. M., & McNeil, S. M. (1998) · Journal of Cellular Biochemistry · doi:10.1002/(sici)1097-4644(1998)72:30/31+ · Cited by 6 · see citing works
Distinct neurochemical populations in the rat central nucleus of the amygdala and bed nucleus of the stria terminalis: Evidence for their selective activation by interleukin-1?
Day, H. E. W., Curran, E. J., Watson, S. J., & Akil, H. (1999) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19991011)413:1

Flagged first, then by citations

Sorted by citations

Dynamic Contribution of Nestin-Expressing Stem Cells to Adult Neurogenesis
Lagace, D. C., Whitman, M. C., Noonan, M. A., Ables, J. L., DeCarolis, N. A., Arguello, A. A., Donovan, M. H., Fischer, S. J., Farnbauch, L. A., Beech, R. D., et al. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.3812-07.2007 · Cited by 502 · see citing works
Self-citation
Decreased adult hippocampal neurogenesis in the PDAPP mouse model of Alzheimer's disease
Donovan, M. H., Yazdani, U., Norris, R. D., Games, D., German, D. C., & Eisch, A. J. (2006) · The Journal of Comparative Neurology · doi:10.1002/cne.20840 · Cited by 350 · see citing works
Self-citation
Notch1 is required for maintenance of the reservoir of adult hippocampal stem cells
Ables, J. L., DeCarolis, N. A., Johnson, M. A., Rivera, P. D., Gao, Z., Cooper, D. C., Radtke, F., Hsieh, J., & Eisch, A. J. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.4721-09.2010 · Cited by 292 · see citing works
Self-citation
Neurogenesis in the adult hippocampus
Christie, B. R., & Cameron, H. A. (2006) · Hippocampus · doi:10.1002/hipo.20151 · Cited by 224 · see citing works
Determination of key aspects of precursor cell proliferation, cell cycle length and kinetics in the adult mouse subgranular zone
Mandyam, C. D., Harburg, G. C., & Eisch, A. J. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2006.12.064 · Cited by 206 · see citing works
Self-citation
Prolactin-Induced Mitogenesis in the Subventricular Zone of the Maternal Brain during Early Pregnancy Is Essential for Normal Postpartum Behavioral Responses in the Mother
Larsen, C. M., & Grattan, D. R. (2010) · Endocrinology · doi:10.1210/en.2009-1385 · Cited by 201 · see citing works
The effects of exercise and stress on the survival and maturation of adult‐generated granule cells
Snyder, J. S., Glover, L. R., Sanzone, K. M., Kamhi, J. F., & Cameron, H. A. (2009) · Hippocampus · doi:10.1002/hipo.20552 · Cited by 181 · see citing works
Traumatic Brain Injury-Induced Hippocampal Neurogenesis Requires Activation of Early Nestin-Expressing Progenitors
Yu, T., Zhang, G., Liebl, D. J., & Kernie, S. G. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.4629-08.2008 · Cited by 180 · see citing works
Opiates, psychostimulants, and adult hippocampal neurogenesis: Insights for addiction and stem cell biology
Eisch, A. J., & Harburg, G. C. (2006) · Hippocampus · doi:10.1002/hipo.20161 · Cited by 172 · see citing works
Self-citation
Extended Access to Cocaine Self-Administration Produces Long-Lasting Prefrontal Cortex-Dependent Working Memory Impairments
George, O., Mandyam, C. D., Wee, S., & Koob, G. F. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301626 · Cited by 160 · see citing works
Self-citation
Exposure to RepetitiveVersusVaried Stress during Prenatal Development Generates Two Distinct Anxiogenic and Neuroendocrine Profiles in Adulthood
Richardson, H. N., Zorrilla, E. P., Mandyam, C. D., & RIVIER, C. L. (2006) · Endocrinology · doi:10.1210/en.2005-1054 · Cited by 161 · see citing works
Self-citation
Progranulin expression in the developing and adult murine brain
Petkau, T. L., Neal, S. J., Orban, P. C., MacDonald, J. L., Hill, A. M., Lu, G., Feldman, H. H., Mackenzie, I. R. A., & Leavitt, B. R. (2010) · Journal of Comparative Neurology · doi:10.1002/cne.22430 · Cited by 152 · see citing works
Gender and endogenous levels of estradiol do not influence adult hippocampal neurogenesis in mice
Lagace, D. C., Fischer, S. J., & Eisch, A. J. (2007) · Hippocampus · doi:10.1002/hipo.20265 · Cited by 139 · see citing works
Self-citation
α1-Noradrenergic system role in increased motivation for cocaine intake in rats with prolonged access
Wee, S., Mandyam, C. D., Lekić, D., & Koob, G. F. (2007) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2007.08.003 · Cited by 138 · see citing works
Self-citation
Methamphetamine Self-Administration and Voluntary Exercise Have Opposing Effects on Medial Prefrontal Cortex Gliogenesis
Mandyam, C. D., Wee, S., Eisch, A. J., Richardson, H. N., & Koob, G. F. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.2505-07.2007 · Cited by 136 · see citing works
Self-citation
Decreased neurogenesis in aged rats results from loss of granule cell precursors without lengthening of the cell cycle
Olariu, A., Cleaver, K. M., & Cameron, H. A. (2007) · The Journal of Comparative Neurology · doi:10.1002/cne.21268 · Cited by 135 · see citing works
Deletion or activation of the aryl hydrocarbon receptor alters adult hippocampal neurogenesis and contextual fear memory
Latchney, S. E., Hein, A. M., O’Banion, M. K., DiCicco-Bloom, E. M., & Opanashuk, L. A. (2012) · Journal of Neurochemistry · doi:10.1111/jnc.12130 · Cited by 132 · see citing works
Varied Access to Intravenous Methamphetamine Self-Administration Differentially Alters Adult Hippocampal Neurogenesis
Mandyam, C. D., Wee, S., Crawford, E. F., Eisch, A. J., Richardson, H. N., & Koob, G. F. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.04.010 · Cited by 120 · see citing works
Self-citation
Levels of Neural Progenitors in the Hippocampus Predict Memory Impairment and Relapse to Drug Seeking as a Function of Excessive Methamphetamine Self-Administration
Recinto, P., Samant, A. R. H., Chávez, G., Kim, A., Yuan, C. J., Soleiman, M. T., Grant, Y., Edwards, S., Wee, S., Koob, G. F., et al. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.315 · Cited by 112 · see citing works
Self-citation
Withdrawal from Cocaine Self-Administration Normalizes Deficits in Proliferation and Enhances Maturity of Adult-Generated Hippocampal Neurons
Noonan, M. A., Choi, K. H., Self, D. W., & Eisch, A. J. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.4661-07.2008 · Cited by 107 · see citing works
Self-citation
c-Myb Is Required for Neural Progenitor Cell Proliferation and Maintenance of the Neural Stem Cell Niche in Adult Brain
Malaterre, J., Mantamadiotis, T., Dworkin, S., Lightowler, S., Yang, Q., Ransome, M. I., Turnley, A. M., Nichols, N. R., Emambokus, N. R., Frampton, J., et al. (2007) · Stem Cells · doi:10.1634/stemcells.2007-0293 · Cited by 97 · see citing works
A review of the relation between dissociation, memory, executive functioning and social cognition in military members and civilians with neuropsychiatric conditions
McKinnon, M. C., Boyd, J. E., Frewen, P. A., Lanius, U. F., Jetly, R., Richardson, J. D., & Lanius, R. A. (2016) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2016.07.017 · Cited by 94 · see citing works
“…not only do opioids interfere with memory acquisition and retrieval, but they also interfere with hippocampal neurogenesis, where chronic administration of morphine leads to reduced hippocampal neurogenesis and cell proliferation (Eisch et al., 2000; Kahn et al., 2005; Mandyam et al., 2004).”
Dynamic expression of TrkB receptor protein on proliferating and maturing cells in the adult mouse dentate gyrus
Donovan, M. H., Yamaguchi, M., & Eisch, A. J. (2008) · Hippocampus · doi:10.1002/hipo.20410 · Cited by 95 · see citing works
Self-citation
Neurogenic Actions of Atypical Antipsychotic Drugs and Therapeutic Implications
Newton, S. S., & Duman, R. S. (2007) · CNS Drugs · doi:10.2165/00023210-200721090-00002 · Cited by 94 · see citing works
Stress experienced in utero reduces sexual dichotomies in neurogenesis, microenvironment, and cell death in the adult rat hippocampus
Mandyam, C. D., Crawford, E. F., Eisch, A. J., RIVIER, C. L., & Richardson, H. N. (2008) · Developmental Neurobiology · doi:10.1002/dneu.20600 · Cited by 89 · see citing works
Self-citation
Knockout of the mu opioid receptor enhances the survival of adult-generated hippocampal granule cell neurons
Harburg, G. C., Hall, F. S., Harrist, A. V., Sora, I., Uhl, G. R., & Eisch, A. J. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2006.09.018 · Cited by 87 · see citing works
Self-citation
Endogenous opiates and behavior: 2004
Bodnar, R. J., & Klein, G. E. (2005) · Peptides · doi:10.1016/j.peptides.2005.06.010 · Cited by 86 · see citing works
Permanent impairment of birth and survival of cortical and hippocampal proliferating cells following excessive drinking during alcohol dependence
Richardson, H. N., Chan, S. H., Crawford, E. F., Lee, Y. K., Funk, C. K., Koob, G. F., & Mandyam, C. D. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.05.021 · Cited by 84 · see citing works
Self-citation
Non-nociceptive roles of opioids in the CNS: opioids’ effects on neurogenesis, learning, memory and affect
Kibaly, C., Xu, C., Cahill, C. M., Evans, C. J., & Law, P. (2018) · Nature reviews. Neuroscience · doi:10.1038/s41583-018-0092-2 · Cited by 79 · see citing works
Time course of morphine's effects on adult hippocampal subgranular zone reveals preferential inhibition of cells in S phase of the cell cycle and a subpopulation of immature neurons
Arguello, A. A., Harburg, G. C., Schonborn, J. R., Mandyam, C. D., Yamaguchi, M., & Eisch, A. J. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.08.064 · Cited by 80 · see citing works
Self-citation
Juvenile Administration of Methylphenidate Attenuates Adult Hippocampal Neurogenesis
Lagace, D. C., Yee, J. K., Bolaños, C. A., & Eisch, A. J. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.04.009 · Cited by 79 · see citing works
Self-citation
Adolescent binge alcohol exposure alters hippocampal progenitor cell proliferation in rats: Effects on cell cycle kinetics
McClain, J. A., Hayes, D. M., Morris, S. A. V., & Nixon, K. (2011) · The Journal of Comparative Neurology · doi:10.1002/cne.22647 · Cited by 75 · see citing works
G-Protein-Coupled Receptors in Adult Neurogenesis
Doze, V. A., & Perez, D. M. (2012) · Pharmacological Reviews · doi:10.1124/pr.111.004762 · Cited by 73 · see citing works
Opioidergic regulation of astroglial/neuronal proliferation: where are we now?
Sargeant, T. J., Miller, J. H., & Day, D. J. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05671.x · Cited by 69 · see citing works
The Interesting Interplay Between Interneurons and Adult Hippocampal Neurogenesis
Masiulis, I., Yun, S., & Eisch, A. J. (2011) · Molecular Neurobiology · doi:10.1007/s12035-011-8207-z · Cited by 70 · see citing works
Self-citation
Functional and mechanistic exploration of an adult neurogenesis‐promoting small molecule
Petřík, D., Jiang, Y., Birnbaum, S. G., Powell, C. M., Kim, M., Hsieh, J., & Eisch, A. J. (2012) · The FASEB Journal · doi:10.1096/fj.11-201426 · Cited by 68 · see citing works
Self-citation
Structural reorganization of pyramidal neurons in the medial prefrontal cortex of alcohol dependent rats is associated with altered glial plasticity
Kim, A., Zamora-Martinez, E. R., Edwards, S., & Mandyam, C. D. (2014) · Brain Structure and Function · doi:10.1007/s00429-014-0755-3 · Cited by 64 · see citing works
Self-citation
Chronic pain and adult hippocampal neurogenesis: translational implications from preclinical studies
Grilli, M. (2017) · Journal of Pain Research · doi:10.2147/jpr.s146399 · Cited by 60 · see citing works
Electroconvulsive Seizures Stimulate Glial Proliferation and Reduce Expression of Sprouty2 within the Prefrontal Cortex of Rats
Öngür, D., Pohlman, J., Dow, A. L., Eisch, A. J., Edwin, F., Heckers, S., Cohen, B. M., Patel, T. B., & Carlezon, W. A. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.11.014 · Cited by 56 · see citing works
Self-citation
Effect of Opioid on Adult Hippocampal Neurogenesis
Zhang, Y., Loh, H. H., & Law, P. (2016) · The Scientific World JOURNAL · doi:10.1155/2016/2601264 · Cited by 56 · see citing works
Interactions of HIV and Drugs of Abuse
Hauser, K. F., & Knapp, P. E. (2014) · International review of neurobiology · doi:10.1016/b978-0-12-801284-0.00009-9 · Cited by 55 · see citing works
Chronic wheel running reduces maladaptive patterns of methamphetamine intake: regulation by attenuation of methamphetamine-induced neuronal nitric oxide synthase
Engelmann, A. J., Aparicio, M. B., Kim, A., Sobieraj, J. C., Yuan, C. J., Grant, Y., & Mandyam, C. D. (2013) · Brain Structure and Function · doi:10.1007/s00429-013-0525-7 · Cited by 54 · see citing works
Self-citation
Effect of chronic morphine on the dentate gyrus neurogenic microenvironment
Arguello, A. A., Fischer, S. J., Schonborn, J. R., Markus, R., Brekken, R. A., & Eisch, A. J. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.01.020 · Cited by 53 · see citing works
Self-citation
Opiate Drugs with Abuse Liability Hijack the Endogenous Opioid System to Disrupt Neuronal and Glial Maturation in the Central Nervous System
Hauser, K. F., & Knapp, P. E. (2018) · Frontiers in Pediatrics · doi:10.3389/fped.2017.00294 · Cited by 55 · see citing works
Chronic methadone treatment and repeated withdrawal impair cognition and increase the expression of apoptosis-related proteins in mouse brain
Tramullas, M., Martínez‐Cué, C., & Hurlé, M. A. (2007) · Psychopharmacology · doi:10.1007/s00213-007-0751-x · Cited by 51 · see citing works
Adult hippocampal neurogenesis: regulation by HIV and drugs of abuse
Venkatesan, A., Nath, A., Ming, G., & Song, H. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-7063-5 · Cited by 50 · see citing works
Chronic wheel running-induced reduction of extinction and reinstatement of methamphetamine seeking in methamphetamine dependent rats is associated with reduced number of periaqueductal gray dopamine neurons
Sobieraj, J. C., Kim, A., Fannon, M. J., & Mandyam, C. D. (2014) · Brain Structure and Function · doi:10.1007/s00429-014-0905-7 · Cited by 50 · see citing works
Self-citation
p-MAPK1/3 and DUSP6 Regulate Epididymal Cell Proliferation and Survival in a Region-Specific Manner in Mice1
Xu, B., Yang, L., Lye, R. J., & Hinton, B. T. (2010) · Biology of Reproduction · doi:10.1095/biolreprod.110.085613 · Cited by 47 · see citing works
Recent advances in nucleotide analogue-based techniques for tracking dividing stem cells: An overview
Solius, G. M., Maltsev, D. I., Belousov, V. V., & Podgorny, O. V. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.101345 · Cited by 46 · see citing works
Extended access methamphetamine decreases immature neurons in the hippocampus which results from loss and altered development of neural progenitors without altered dynamics of the S-phase of the cell cycle
Yuan, C. J., Quiocho, J., Kim, A., Wee, S., & Mandyam, C. D. (2011) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2011.08.004 · Cited by 45 · see citing works
Self-citation
Short-term sleep deprivation may alter the dynamics of hippocampal cell proliferation in adult rats
Junek, A., Rusak, B., & Semba, K. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.08.018 · Cited by 42 · see citing works
Neurogenesis during Abstinence Is Necessary for Context-Driven Methamphetamine-Related Memory
Galinato, M. H., Takashima, Y., Fannon, M. J., Quach, L. W., Silva, R. J. M., Mysore, K. K., Terranova, M. J., Dutta, R. R., Ostrom, R. W., Somkuwar, S. S., et al. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.2011-17.2018 · Cited by 42 · see citing works
Self-citation
Effects of voluntary and treadmill exercise on spontaneous withdrawal signs, cognitive deficits and alterations in apoptosis-associated proteins in morphine-dependent rats
Mokhtari‐Zaer, A., Ghodrati-Jaldbakhan, S., Vafaei, A. A., Miladi‐Gorji, H., Akhavan, M. M., Bandegi, A. R., & Rashidy‐Pour, A. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.05.061 · Cited by 41 · see citing works
Effects of addictive drugs on adult neural stem/progenitor cells
Xu, C., Loh, H. H., & Law, P. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-2067-z · Cited by 40 · see citing works
Cocaine Alters Proliferation, Migration, and Differentiation of Human Fetal Brain-Derived Neural Precursor Cells
Hu, S., Cheeran, M. C. ‐., Sheng, W. S., Ni, H. T., Lokensgard, J. R., & Peterson, P. K. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.106.103853 · Cited by 39 · see citing works
Morphine blood levels, dependence, and regulation of hippocampal subgranular zone proliferation rely on administration paradigm
Fischer, S. J., Arguello, A. A., Charlton, J. L., Fuller, D. C., Zachariou, V., & Eisch, A. J. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.11.035 · Cited by 37 · see citing works
Self-citation
The Noradrenergic Component in Tapentadol Action Counteracts μ-Opioid Receptor–Mediated Adverse Effects on Adult Neurogenesis
Meneghini, V., Cuccurazzu, B., Bortolotto, V., Ramazzotti, V., Ubezio, F., Tzschentke, T., Canonico, P. L., & Grilli, M. (2014) · Molecular Pharmacology · doi:10.1124/mol.113.091520 · Cited by 37 · see citing works
Extended access nicotine self-administration with periodic deprivation increases immature neurons in the hippocampus
Cohen, A., Soleiman, M. T., Talia, R., Koob, G. F., George, O., & Mandyam, C. D. (2014) · Psychopharmacology · doi:10.1007/s00213-014-3685-0 · Cited by 34 · see citing works
Self-citation
Regional, cellular, and subcellular localization of RGS10 in rodent brain
Waugh, J. L., Lou, A. C., Eisch, A. J., Monteggia, L. M., Muly, E. C., & Gold, S. J. (2004) · The Journal of Comparative Neurology · doi:10.1002/cne.20372 · Cited by 33 · see citing works
Self-citation
56Fe Particle Exposure Results in a Long-Lasting Increase in a Cellular Index of Genomic Instability and Transiently Suppresses Adult Hippocampal Neurogenesis in Vivo
DeCarolis, N. A., Rivera, P. D., Ahn, F., Amaral, W. Z., Leblanc, J. A., Malhotra, S., Shih, H.-Y., Petrik, D., Melvin, N., Chen, B. P. C., et al. (2014) · Life sciences and space research · doi:10.1016/j.lssr.2014.06.004 · Cited by 36 · see citing works
Self-citation
Hippocampal Neurogenesis and Cortical Cellular Plasticity in Wahlberg’s Epauletted Fruit Bat: A Qualitative and Quantitative Study
Gatome, C. W., Mwangi, D. K., Lipp, H., & Amrein, I. (2010) · Brain Behavior and Evolution · doi:10.1159/000320210 · Cited by 33 · see citing works
Mu opioid receptors are expressed on radial glia but not migrating neuroblasts in the late embryonic mouse brain
Sargeant, T. J., Day, D. J., Mrkusich, E. M., Foo, D. F., & Miller, J. H. (2007) · Brain Research · doi:10.1016/j.brainres.2007.07.091 · Cited by 29 · see citing works
Opiate Analgesics as Negative Modulators of Adult Hippocampal Neurogenesis: Potential Implications in Clinical Practice
Bortolotto, V., & Grilli, M. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00254 · Cited by 28 · see citing works
Acute in utero morphine exposure slows G2 / M phase transition in radial glial and basal progenitor cells in the dorsal telencephalon of the E15.5 embryonic mouse
Sargeant, T. J., Day, D. J., Miller, J. H., & Steel, R. W. J. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06412.x · Cited by 28 · see citing works
Neuron‐specific caveolin‐1 overexpression improves motor function and preserves memory in mice subjected to brain trauma
Egawa, J., Schilling, J. M., Cui, W., Posadas, E., Sawada, A., Alas, B. F., Zemljic‐Harpf, A. E., Fannon, M. J., Mandyam, C. D., Roth, D. M., et al. (2017) · The FASEB Journal · doi:10.1096/fj.201601288rrr · Cited by 28 · see citing works
Self-citation
Inducible knockout of Mef2a, ‐c, and ‐d from nestin‐expressing stem/progenitor cells and their progeny unexpectedly uncouples neurogenesis and dendritogenesis in vivo
Latchney, S. E., Jiang, Y., Petřík, D., Eisch, A. J., & Hsieh, J. (2015) · The FASEB Journal · doi:10.1096/fj.15-275651 · Cited by 27 · see citing works
Self-citation
Effects of ADAM10 deletion on Notch-1 signaling pathway and neuronal maintenance in adult mouse brain
Zhuang, J., Wei, Q., Lin, Z., & Zhou, C. (2014) · Gene · doi:10.1016/j.gene.2014.10.056 · Cited by 27 · see citing works
GPCRs in Stem Cell Function
Doze, V., & Perez, D. (2013) · Progress in Molecular Biology and Translational Science · doi:10.1016/b978-0-12-394587-7.00005-1 · Cited by 24 · see citing works
Increased cell proliferation and granule cell number in the dentate gyrus of protein repair‐deficient mice
Farrar, C. E., Huang, C., Clarke, S. G., & Houser, C. R. (2005) · The Journal of Comparative Neurology · doi:10.1002/cne.20780 · Cited by 26 · see citing works
Wheel running reduces ethanol seeking by increasing neuronal activation and reducing oligodendroglial/neuroinflammatory factors in the medial prefrontal cortex
Somkuwar, S. S., Fannon, M. J., Ghofranian, A., Quigley, J. A., Dutta, R. R., Galinato, M. H., & Mandyam, C. D. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.08.006 · Cited by 26 · see citing works
Self-citation
Signaling mechanisms of μ-opioid receptor (MOR) in the hippocampus: disinhibition versus astrocytic glutamate regulation
Nam, M., Won, W., Han, K., & Lee, C. J. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03595-8 · Cited by 26 · see citing works
μ‐Opioid receptors mediate the effects of chronic ethanol binge drinking on the hippocampal neurogenic niche
Contet, C., Kim, A., Le, D., Iyengar, S. K., Kotzebue, R. W., Yuan, C. J., Kieffer, B. L., & Mandyam, C. D. (2013) · Addiction Biology · doi:10.1111/adb.12040 · Cited by 24 · see citing works
Self-citation
Developmental and Adult GAP-43 Deficiency in Mice Dynamically Alters Hippocampal Neurogenesis and Mossy Fiber Volume
Latchney, S. E., Masiulis, I., Zaccaria, K., Lagace, D., Powell, C., McCasland, J., & Eisch, A. (2014) · Developmental Neuroscience · doi:10.1159/000357840 · Cited by 29 · see citing works
Self-citation
Mapping of endogenous morphine‐like compounds in the adult mouse brain: Evidence of their localization in astrocytes and GABAergic cells
Laux‐Biehlmann, A., Muller, A. H., Miehe, M., Dirrig‐Grosch, S., Deloulme, J., Delalande, F., Stuber, D., Ciocca, D., DORSSELAER, A. V., Poisbeau, P., et al. (2011) · The Journal of Comparative Neurology · doi:10.1002/cne.22633 · Cited by 23 · see citing works
Chronic morphine administration induces over-expression of aldolase C with reduction of CREB phosphorylation in the mouse hippocampus
Yang, H., & Pu, X. (2009) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2009.03.028 · Cited by 21 · see citing works
Methadone does not alter key parameters of adult hippocampal neurogenesis in the heroin-naïve rat
Sankararaman, A., Masiulis, I., Richardson, D. R., Andersen, J. M., Mørland, J. G., & Eisch, A. J. (2012) · Neuroscience Letters · doi:10.1016/j.neulet.2012.03.066 · Cited by 21 · see citing works
Self-citation
Glucocorticoid Homeostasis in the Dentate Gyrus Is Essential for Opiate Withdrawal-Associated Memories
García‐Pérez, D., Ferenczi, S., Kovács, K., Laorden, M. L., Milanés, M. V., & Núñez, C. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0186-7 · Cited by 21 · see citing works
The effect of spaceflight on mouse olfactory bulb volume, neurogenesis, and cell death indicates the protective effect of novel environment
Latchney, S. E., Rivera, P. D., Mao, X. W., Ferguson, V. L., Bateman, T. A., Stodieck, L., Nelson, G. A., & Eisch, A. J. (2014) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01174.2013 · Cited by 19 · see citing works
Self-citation
Neuroadaptations in the dentate gyrus following contextual cued reinstatement of methamphetamine seeking
Takashima, Y., Fannon, M. J., Galinato, M. H., Steiner, N. L., An, M., Zemljic‐Harpf, A. E., Somkuwar, S. S., Head, B. P., & Mandyam, C. D. (2018) · Brain Structure and Function · doi:10.1007/s00429-018-1615-3 · Cited by 19 · see citing works
Self-citation
Stress-induced Decrease of Granule Cell Proliferation in Adult Rat Hippocampus: Assessment of Granule Cell Proliferation Using High Doses of Bromodeoxyuridine Before and After Restraint Stress
Kim, S.-J., Lee, K. J., Shin, Y.-C., Choi, S.-H., Do, E., Kim, S., Chun, B., Lee, M.-S., & Shin, K.-H. (2005) · Molecules and Cells · doi:10.1016/s1016-8478(23)13139-6 · Cited by 19 · see citing works
Regulation of Adult Neurogenesis by Non-coding RNAs: Implications for Substance Use Disorders
Oliver, R. J., & Mandyam, C. D. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00849 · Cited by 18 · see citing works
Self-citation
Dentate gyrus μ-opioid receptor-mediated neurogenic processes are associated with alterations in morphine self-administration
Zhang, H., Jia, M., Wang, X., Ye, C., Li, Y., Wang, N., Elefant, F., Ma, H., & Cui, C. (2019) · Scientific Reports · doi:10.1038/s41598-018-37083-8 · Cited by 18 · see citing works
Early Postnatal In Vivo Gliogenesis From Nestin-Lineage Progenitors Requires Cdk5
Petřík, D., Yun, S., Latchney, S. E., Kamrudin, S., LeBlanc, J. A., Bibb, J. A., & Eisch, A. J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0072819 · Cited by 18 · see citing works
Self-citation
Methamphetamine affects cell proliferation in the medial prefrontal cortex: A new niche for toxicity
Kim, A., & Mandyam, C. D. (2014) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2014.09.012 · Cited by 17 · see citing works
Self-citation
Steroid hormones and hippocampal neurogenesis in the adult mammalian brain
Hodges, T. E., Puri, T. A., Blankers, S. A., Qiu, W., & Galea, L. A. M. (2022) · Vitamins and hormones · doi:10.1016/bs.vh.2021.11.003 · Cited by 16 · see citing works
Opioid modulation of cell proliferation in the ventricular zone of adult zebra finches (Taenopygia guttata)
Khurshid, N., Hameed, L. S., Mohanasundaram, S., & Iyengar, S. (2010) · The FASEB Journal · doi:10.1096/fj.09-146746 · Cited by 16 · see citing works
Involvement of Extracellular Signal-Regulated Kinase (ERK1/2)-p53-p21 Axis in Mediating Neural Stem/Progenitor Cell Cycle Arrest in Co-Morbid HIV-Drug Abuse Exposure
Malik, S., Saha, R., & Seth, P. (2014) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-014-9523-7 · Cited by 16 · see citing works
Endogenous opioids inhibit ischemia‐induced generation of immature hippocampal neurons via the µ‐opioid receptor
Kolodziej, A., Stumm, R. K., Becker, A., & Höllt, V. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06111.x · Cited by 16 · see citing works
Regulation of Adult Neurogenesis
Cameron, H. A. (2007) · Wiley eBooks · doi:10.1002/9780470101001.hcn052 · Cited by 13 · see citing works
Methamphetamine reduces expression of caveolin-1 in the dorsal striatum: Implication for dysregulation of neuronal function
Somkuwar, S. S., Fannon, M. J., Head, B. P., & Mandyam, C. D. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.04.039 · Cited by 12 · see citing works
Self-citation
Could the endogenous opioid, morphine, prevent neural stem cell proliferation?
Shoae‐Hassani, A., Sharif, S., Mortazavi‐Tabatabaei, S. A., & Verdi, J. (2010) · Medical Hypotheses · doi:10.1016/j.mehy.2010.10.002 · Cited by 12 · see citing works
Effects of environmental enrichment on behavioral and spatial cognitive deficits in morphine-dependent and -withdrawn rats.
Abadi, A. H.-A., & Miladi-Gorji, H. (2017) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2016-0168 · Cited by 14 · see citing works
Transient Chemogenetic Inhibition of D1-MSNs in the Dorsal Striatum Enhances Methamphetamine Self-Administration
Oliver, R. J., Purohit, D. C., Kharidia, K. M., & Mandyam, C. D. (2019) · Brain Sciences · doi:10.3390/brainsci9110330 · Cited by 11 · see citing works
Self-citation
Central and peripheral endogenous morphine
Goumon, Y., Laux‐Biehlmann, A., Muller, A., & Aunis, D. (2009) · Hispana · Cited by 11 · see citing works
Loss of the mu opioid receptor on different genetic backgrounds leads to increased bromodeoxyuridine labeling in the dentate gyrus only after repeated injection
Cominski, T. P., Turchin, C. E., Hsu, M. S., Ansonoff, M. A., & Pintar, J. E. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2011.12.046 · Cited by 9 · see citing works
Impact of psychotropic drugs on adult hippocampal neurogenesis
Kubesova, A., Bubeníková‐Valešová, V., Mertlova, M., Páleníček, T., & Horáček, J. (2012) · Neuroscience Research · doi:10.1016/j.neures.2012.02.014 · Cited by 9 · see citing works
Chronic exposure to methadone impairs memory, induces microgliosis, astrogliosis and neuroinflammation in the hippocampus of adult male rats
Navaei, F., Fathabadi, F. F., Moghaddam, M. H., Fathi, M., Vakili, K. G., Abdollahifar, M., Boroujeni, M. E., Zamani, N., Zamani, N., Norouzian, M., et al. (2022) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2022.102139 · Cited by 7 · see citing works
Isoxazole‐9 reduces enhanced fear responses and retrieval in ethanol‐dependent male rats
Staples, M. C., Herman, M. A., Lockner, J. W., Avchalumov, Y., Kharidia, K. M., Janda, K. D., Roberto, M., & Mandyam, C. D. (2021) · Journal of Neuroscience Research · doi:10.1002/jnr.24932 · Cited by 6 · see citing works
Self-citation
Loss of the mu opioid receptor induces strain-specific alterations in hippocampal neurogenesis and spatial learning.
Cominski, T. P., Ansonoff, M., Turchin, C., & Pintar, J. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.07.039 · Cited by 6 · see citing works
Indices of dentate gyrus neurogenesis are unaffected immediately after or following withdrawal from morphine self-administration compared to saline self-administering control male rats
Bulin, S. E., Simmons, S. J., Richardson, D. R., Latchney, S. E., Deutsch, H. M., Yun, S., & Eisch, A. J. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.112448 · Cited by 6 · see citing works
Self-citation

Time course of morphine's effects on adult hippocampal subgranular zone reveals preferential inhibition of cells in S phase of the cell cycle and a subpopulation of immature neurons
Arguello, A. A., Harburg, G. C., Schonborn, J. R., Mandyam, C. D., Yamaguchi, M., & Eisch, A. J. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.08.064 · Cited by 80 · see citing works
Self-citation
Short Term Morphine Exposure In Vitro Alters Proliferation and Differentiation of Neural Progenitor Cells and Promotes Apoptosis via Mu Receptors
Willner, D., Cohen‐Yeshurun, A., Avidan, A., Ozersky, V., Shohami, E., & Leker, R. R. (2014) · PLoS ONE · doi:10.1371/journal.pone.0103043 · Cited by 67 · see citing works
Determination of key aspects of precursor cell proliferation, cell cycle length and kinetics in the adult mouse subgranular zone
Mandyam, C. D., Harburg, G. C., & Eisch, A. J. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2006.12.064 · Cited by 206 · see citing works
Self-citation
Effect of morphine on 3H‐Thymidine incorporation in the subependyma of the rat: An autoradiographic study
Miller, C. R. D., O’Steen, W. K., & Deadwyler, S. A. (1982) · The Journal of Comparative Neurology · doi:10.1002/cne.902080209 · Cited by 20 · see citing works
Short Term Morphine Exposure In Vitro Alters Proliferation and Differentiation of Neural Progenitor Cells and Promotes Apoptosis via
Receptors, M., Willner, D., Cohen‐Yeshurun, A., Avidan, E., Ozersky, V., Shohami, E., & Leker, R. R. (2016)

Authors: Mandyam, C. D., Norris, R. D., & Eisch, A. J.
Affiliations: The University of Texas Southwestern Medical Center (US)
Corresponding author: Eisch, Amelia J.
ORCID: Mandyam, Chitra D.
Eisch, Amelia J.
Venue: Journal of Neuroscience Research
Publisher: Wiley
Published: 2004-05-03
Volume: 76
Issue: 6
Pages: 783-794
ISSN: 0360-4012 (ISSN-L)
1097-4547
DOI: 10.1002/jnr.20090
OpenAlex: W2064038456
Cited by: 116
References: 67
Citations by year: 2026: 1 · 2023: 1 · 2022: 2 · 2021: 2 · 2020: 4 · 2019: 3 · 2018: 5 · 2017: 3 · 2016: 6 · 2015: 2 · 2014: 13 · 2013: 5 · 2012: 6
FWCI: 2.61
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Journal of Neuroscience Research (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Aging (P30AG012300, AG 12300)
National Institute on Drug Abuse (DA-07290)
Topics: Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pharmacological Receptor Mechanisms and Effects
Keywords: chronic morphine, subgranular zone, adult neurogenesis, premature mitosis, cell cycle phases, proliferating cell nuclear antigen, phosphorylated histone H3, bromodeoxyuridine, G2/M phase, opiates
MeSH terms: Animals, Bromodeoxyuridine, Cell Cycle, Cell Differentiation, Drug Administration Schedule, Hippocampus, Histones, Immunohistochemistry, Male, Mice, Inbred C57BL, Morphine, Neurons, Phosphorylation, Stem Cells, Biomarkers, Proliferating Cell Nuclear Antigen, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Chronic morphine induces premature mitosis of proliferating cells in the adult mouse subgranular zone

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks