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Role of LRP in TGFβ2‐mediated neuronal uptake of Aβ and effects on memory

Harris‐White, Marni E., Balverde, Zerlinde, Lim, Giselle P., Kim, Peter, Miller, Sheryl A., Hammer, Heidi, Galasko, Doug, Frautschy, Sally A.·2004·Journal of Neuroscience Research
DOI 10.1002/jnr.20149
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Abstract

There is increasing evidence that soluble amyloid‐β peptide (Aβ) uptake into neurons is an early event in the pathogenesis of Alzheimer's disease (AD). Identification of the early events leading to neuronal dysfunction is key to developing therapeutic strategies, but relative roles of receptors and factors modulating uptake are poorly understood. Studies have shown that transforming growth factor β (TGFβ), particularly TGFβ2, can influence the targeting of Aβ to cells in vitro. TGFβ2 can target Aβ to neurons in organotypic hippocampal slice cultures (OHSC). We examine a specific mechanism for TGFβ2‐mediated targeting of Aβ to neurons. The receptor‐associated protein (RAP), a low‐density lipoprotein receptor‐related protein (LRP) antagonist, can attenuate the cellular targeting of Aβ both in vitro and in vivo and prevent Aβ/TGFβ2‐induced memory retention deficits. Using both in vitro and in vivo methods, we identify LRP as playing a role in TGFβ2‐mediated Aβ uptake, neurodegeneration, and spatial memory impairment. © 2004 Wiley‐Liss, Inc.

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Metadata

Authors
Harris‐White, M. E., Balverde, Z., Lim, G. P., Kim, P., Miller, S. A., Hammer, H., Galasko, D., & Frautschy, S. A.
Venue
Journal of Neuroscience Research
Publisher
Wiley
Published
2004-05-20
Volume
77
Issue
2
Pages
217-228
ISSN
  • 0360-4012
  • 1097-4547
DOI
10.1002/jnr.20149
Cited by
20
References
4
Language
en
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)

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CoChat. (2026). Citation check: Role of LRP in TGFβ2‐mediated neuronal uptake of Aβ and effects on memory. https://app.cochat.ai/papers/10.1002/jnr.20149
The paper
Harris‐White, M. E., Balverde, Z., Lim, G. P., Kim, P., Miller, S. A., Hammer, H., Galasko, D., & Frautschy, S. A. (2004). Role of LRP in TGFβ2‐mediated neuronal uptake of Aβ and effects on memory. Journal of Neuroscience Research. https://doi.org/10.1002/jnr.20149