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The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.

Multiple, diverse senile plaque–associated proteins are ligands of an apolipoprotein e receptor, the α2‐macroglobulin receptor/low‐density‐lipoprotein receptor—related protein

Rebeck, G. William, Harr, Steven D., Hyman, Bradley T., Strickland, Dudley K.·1995·Annals of Neurology
DOI 10.1002/ana.410370212
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Abstract

Both apolipoprotein E and its receptor, the low‐density‐lipoprotein receptor‐related protein (LRP), are associated with senile plaques in Alzheimer's disease. We examined the relationship of other LRP‐related molecules to senile plaques. LRP is a multifunctional receptor that blinds and rapidly internalizes at least seven ligands: apolipoprotein E, activated α 2‐macroglobulin, tissue and urokinase‐type plasminogen activators, plasminogen activator inhibitor‐1, lipoprotein lipase, and lactoferrin. Using immunohistochemistry, we showed that all of these ligands, representing a diverse group of otherwise apparently unrelated proteins, accumulate on senile plaques. We also studied expression of the receptor‐associated protein, a physiological inhibitor of LRP, in the hippocampal formation from normal subjects and Alzheimer's disease patients. Receptor‐associated protein colocalizes with LRP on neuronal soma, but not on neuronal processes or reactive astrocytes. It is not present on senile plaques. These results suggest that senile plaque‐associated LRP can bind its ligands, but clearance of these compounds may be impaired in the vicinity of senile plaques.

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Crossref · 10.1002/ana.410370212

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8 of 8 references verified0 citation errors · 0 not checkable

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  • In senile plaques, LRP1 ligands co-deposit with Aβ, indicating a loss of LRP1 function in AD.

    “In senile plaques, LRP1 ligands, like apoE, urokinase-type plasminogen activator, tissue plasminogen activator, and lactoferrin, co-deposit with Aβ, all together indicating a loss of LRP1 function in AD (14).”

    From Endothelial LRP1 transports amyloid-β1–42 across the blood-brain barrier (2015) · cites this paper as [14]

  • Immunoreactivity for LRP and ligands including apoE and α2-macroglobulin is found associated with senile plaques.

    “Fourth, immunoreactivity for LRP and a number of its ligands including apoE and ␣ 2 -macroglobulin is found associated with senile plaques (30).”

    From Apolipoprotein E Receptors Mediate the Effects of β-Amyloid on Astrocyte Cultures (2000) · cites this paper as [30]

  • Activated astrocytes used in the experiments express both LDLR and LRP by immunostaining.

    “By immunostaining, these activated astrocytes express both the LDLR and LRP (data not shown), consistent with the previous observations summarized above that these are the two primary members of the LDLR family that are expressed by activated astrocytes (4 -7, 29 -31).”

    From Apolipoprotein E Receptors Mediate the Effects of β-Amyloid on Astrocyte Cultures (2000) · cites this paper as [30]

Citations

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Research works printed but not linked: 44

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Metadata

Authors
Rebeck, G. W., Harr, S. D., Hyman, B. T., & Strickland, D. K.
Venue
Annals of Neurology
Publisher
Wiley
Published
1995-02
Volume
37
Issue
2
Pages
211-217
ISSN
  • 0364-5134
  • 1531-8249
DOI
10.1002/ana.410370212
Cited by
232
References
8
Language
en
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 3537 d)

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