The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
The glutamate‐glutamine cycle is not stoichiometric: Fates of glutamate in brain
Open accessAbstract
Although glutamate is usually thought of as the major excitatory neurotransmitter in brain, it is important to note that glutamate has many other fates in brain, including oxidation for energy, incorporation into proteins, and formation of glutamine, γ‐aminobutyric acid (GABA), and glutathione. The compartmentation of glutamate in brain cells is complex and modulated by the presence and concentration of glutamate per se as well as by other metabolites. Both astrocytes and neurons distinguish between exogenous glutamate and glutamate formed endogenously from glutamine via glutaminase. There is evidence of multiple subcellular compartments of glutamate within both neurons and astrocytes, and the carbon skeleton of glutamate can be derived from other amino acids and many energy substrates including glucose, lactate, and 3‐hydroxybutyrate. Both astrocytes and neurons utilize glutamate, albeit for cell‐specific metabolic fates. Glutamate is readily formed in neurons from glutamine synthesized in astrocytes, released into the extracellular space, and taken up by neurons. However, the glutamate‐glutamine cycle is not a stoichiometric cycle but rather an open pathway that interfaces with many other metabolic pathways to varying extents depending on cellular requirements and priorities. © 2007 Wiley‐Liss, Inc.
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Cites
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Metabolism and functions of glutathione in brain
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Role of Branched‐Chain Aminotransferase Isoenzymes and Gabapentin in Neurotransmitter Metabolism
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“McKenna and coworkers reported (McKenna et al., 1993, 1996a) that the use of glutamine for energy by astrocytes proceeds primarily via AAT, or to some extent via BCAT (Hutson et al., 1998) in astrocytes, since it could be inhibited by 70% by the transaminase inhibitor aminooxyacetic acid (AOAA).”
BackgroundGlutamine in the central nervous system: function and dysfunction
Albrecht, J. (2007) · Frontiers in Bioscience · doi:10.2741/2067 · Cited by 168
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A Cellular Perspective on Brain Energy Metabolism and Functional Imaging
Magistretti, P. J., & Allaman, I. (2015) · Neuron · doi:10.1016/j.neuron.2015.03.035 · Cited by 1,285
Glutamate as a neurotransmitter in the healthy brain
Zhou, Y., & Danbolt, N. C. (2014) · Journal of Neural Transmission · doi:10.1007/s00702-014-1180-8 · Cited by 979
Dopamine and glutamate in schizophrenia: biology, symptoms and treatment
McCutcheon, R. A., Krystal, J. H., & Howes, O. D. (2020) · World Psychiatry · doi:10.1002/wps.20693 · Cited by 612
Pyruvate carboxylase is required for glutamine-independent growth of tumor cells
Cheng, T., Sudderth, J., Yang, C., Mullen, A. R., Jin, E. S., Matés, J. M., & DeBerardinis, R. J. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1016627108 · Cited by 475
Metadata
- Authors
- McKenna, M. C.
- Venue
- Journal of Neuroscience Research
- Publisher
- Wiley
- Published
- 2007-09-10
- Volume
- 85
- Issue
- 15
- Pages
- 3347-3358
- ISSN
- 0360-4012 (ISSN-L)
- 1097-4547
- OpenAlex
- W2025478209
- Cited by
- 382
- References
- 9
- FWCI
- 5.57
- Type
- journal article
- Language
- en
- Open access
- bronze
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