CoChat
Sign Up
Cited by 300Tendon Structure and TreatmentPeriodontal Regeneration and TreatmentsKnee injuries and reconstruction techniques

The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.

Enhanced histologic repair in a central wound in the anterior cruciate ligament with a collagen–platelet‐rich plasma scaffold

Open access
Murray, Martha M., Spindler, Kurt P., Ballard, Percy, Welch, Tyler P., Zurakowski, David, Nanney, Lillian B.·2007·Journal of Orthopaedic Research
DOI 10.1002/jor.20367
Open this paper in CoChat — free accountOpen PDF

Abstract

The anterior cruciate ligament (ACL) of the knee is an intra‐articular ligament that fails to heal after primary repair. The medial collateral ligament (MCL) of the knee is an extra‐articular ligament that heals uneventfully in the majority of cases. Why these two ligaments have such different responses to injury remains unclear. In this article, we address two hypotheses: first, that the histologic response to injury is different in intra‐articular and extra‐articular ligaments, and second, that the response of the intra‐articular ligaments can be altered by placing a collagen–platelet‐rich plasma (collagen‐PRP) hydrogel in the wound site. Wounds were created in extra‐articular ligaments (MCL and/or patellar ligament) and an intra‐articular ligament (ACL) in canine knees, and the histologic response to injury evaluated at 3 days (n = 3), 7 days (n = 4), 3 weeks (n = 5), and 6 weeks (n = 5). In the 3‐week (n = 5) and 6‐week (n = 5) animals, bilateral central wounds were made in the ACLs and the wounds in one knee of each animal treated with a collagen‐PRP hydrogel while the contralateral side was untreated. Extra‐articular ligament wounds had greater filling of the wound site and increased presence in the wound site of fibrinogen, fibronectin, PDGF‐A, TGF‐β1, FGF‐2, and von Willebrand's factor when compared to intra‐articular ligament wounds. Treatment of the intra‐articular wound with a collagen‐PRP hydrogel resulted in increased filling of the wound site with repair tissue that had similar profiles of growth factor and protein expression to the extra‐articular ligament wounds. The use of a collagen‐PRP scaffold can ameliorate histologic differences noted between healing extra‐articular ligamentous wounds and nonhealing intra‐articular ligamentous wounds. This study supports the hypothesis that premature scaffold failure may play a key role in the normally expected failure of the ACL to heal after injury. Published by Wiley Periodicals, Inc. J Orthop Res 25:1007–1017, 2007

Overview

Integrity signals

Registry

Crossref · 10.1002/jor.20367

Cites

28 of 28 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 28 references

Cited by

Sorted by citations

Related

See all

Metadata

Authors
Murray, M. M., Spindler, K. P., Ballard, P., Welch, T. P., Zurakowski, D., & Nanney, L. B.
Affiliations
  • Boston Children's Hospital (US)
  • Vanderbilt University (US)
Corresponding author
Murray, Martha M.
ORCID
Venue
Journal of Orthopaedic Research
Publisher
Wiley
Published
2007-04-05
Volume
25
Issue
8
Pages
1007-1017
ISSN
  • 0736-0266 (ISSN-L)
  • 1554-527X
DOI
10.1002/jor.20367
OpenAlex
W2051763141
Cited by
300
References
28
Citations by year
2026: 4 · 2025: 6 · 2024: 9 · 2023: 10 · 2022: 13 · 2021: 20 · 2020: 10 · 2019: 9 · 2018: 10 · 2017: 23 · 2016: 17 · 2015: 25 · 2014: 18 · 2013: 35 · 2012: 17
FWCI
18.37
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Journal of Orthopaedic Research® (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Vanderbilt University
  • Vanderbilt University Medical Center
  • National Institute of Arthritis and Musculoskeletal and Skin Diseases (K02AR049346)
Topics
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Tendon Structure and Treatment
  • Health Sciences › Dentistry › Periodontics › Periodontal Regeneration and Treatments
  • Health Sciences › Medicine › Surgery › Knee injuries and reconstruction techniques
Keywords
anterior cruciate ligament, ligament healing, scaffolds, medial collateral ligament, patellar tendon, wound healing, growth factors, fibrinogen, fibronectin, PDGF-A, TGF-β1, FGF2, von Willebrand factor, canine model
MeSH terms
Anterior Cruciate Ligament Injuries, Animals, Collagen, Dogs, Knee Injuries, Wound Healing, Anterior Cruciate Ligament, Medial Collateral Ligament, Knee, Hydrogels, Platelet-Rich Plasma

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review