The DOI matches its Crossref record; 141 of the 141 references it cites were found in a registry or an index.
Tendon and Ligament Healing and Current Approaches to Tendon and Ligament Regeneration
Open accessAbstract
Ligament and tendon injuries are common problems in orthopedics. There is a need for treatments that can expedite nonoperative healing or improve the efficacy of surgical repair or reconstruction of ligaments and tendons. Successful biologically‐based attempts at repair and reconstruction would require a thorough understanding of normal tendon and ligament healing. The inflammatory, proliferative, and remodeling phases, and the cells involved in tendon and ligament healing will be reviewed. Then, current research efforts focusing on biologically‐based treatments of ligament and tendon injuries will be summarized, with a focus on stem cells endogenous to tendons and ligaments. Statement of clinical significance: This paper details mechanisms of ligament and tendon healing, as well as attempts to apply stem cells to ligament and tendon healing. Understanding of these topics could lead to more efficacious therapies to treat ligament and tendon injuries. © 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 38:7–12, 2020
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Citations
Cites
Insulin-Like Growth Factors and Their Binding Proteins: Biological Actions*
JONES, J. I., & CLEMMONS, D. R. (1995) · Endocrine Reviews · doi:10.1210/edrv-16-1-3 · Cited by 4,710
A perivascular origin for mesenchymal stem cells in multiple human organs
Crisan, M., Yap, S., Casteilla, L., Chen, C.-W., Corselli, M., Park, T. S., Andriolo, G., Sun, B., Zheng, B., Zhang, L., et al. (2008) · Cell Stem Cell · doi:10.1016/j.stem.2008.07.003 · Cited by 3,991 · cited 1×
“PSCs have demonstrated the ability to self‐renew and differentiate into various mesenchymal lineages in vitro.(60) We are currently using a murine genetic lineage tracing method to identify the contribution of PSCs in tendon healing.”
MethodBi, Y., Ehirchiou, D., Kilts, T. M., Inkson, C. A., Embree, M. C., Sonoyama, W., Li, L., Leet, A. I., Seo, B.-M., Zhang, L., et al. (2007) · Nature Medicine · doi:10.1038/nm1630 · Cited by 1,486
The Roles of Growth Factors in Tendon and Ligament Healing
Molloy, T., Wang, Y., & Murrell, G. A. C. (2003) · Sports Medicine · doi:10.2165/00007256-200333050-00004 · Cited by 948
Analysis of the tendon cell fate using Scleraxis, a specific marker for tendons and ligaments
Schweitzer, R., Chyung, J. H., Murtaugh, L. C., Brent, A. E., Rosen, V., Olson, E. N., Lassar, A., & Tabin, C. J. (2001) · Development · doi:10.1242/dev.128.19.3855 · Cited by 859
Biology of tendon injury: healing, modeling and remodeling.
Sharma, P., & Maffulli, N. (2006) · PubMed · Cited by 837
Use of mesenchymal stem cells in a collagen matrix for achilles tendon repair
Young, R. G., Butler, D. L., Weber, W., Caplan, A. I., Gordon, S. L., & Fink, D. J. (1998) · Journal of Orthopaedic Research · doi:10.1002/jor.1100160403 · Cited by 791
Mechanisms of tendon injury and repair
Thomopoulos, S., Parks, W. C., Rifkin, D. B., & Derwin, K. A. (2015) · Journal of Orthopaedic Research · doi:10.1002/jor.22806 · Cited by 564
Autologous Mesenchymal Stem Cell-Mediated Repair of Tendon
Awad, H. A., Butler, D. L., Boivin, G. P., Smith, F. N. L., Malaviya, P., Huibregtse, B., & Caplan, A. I. (1999) · Tissue Engineering · doi:10.1089/ten.1999.5.267 · Cited by 543
Tendon and ligament regeneration and repair: Clinical relevance and developmental paradigm
Yang, G., Rothrauff, B. B., & Tuan, R. S. (2013) · Birth Defects Research Part C: Embryo Today: Reviews · doi:10.1002/bdrc.21041 · Cited by 469
Research works printed but not linked: 15
- 10.2106/00004623-199309000-00009 · doi:10.2106/00004623-199309000-00009
- Langan P, 1987, Rupture of the patellar tendon after use of its central third, Orthop Rev, 16, 317
- Larson RV, 1996, Anterior cruciate ligament: injuries and treatment, Instr Course Lect, 45, 235
- 10.1210/er.16.1.3 · DOI
- 10.1002/jor.1100150215 · doi:10.1002/jor.1100150215
- 10.1016/j.jhsa.2004.12.006 · doi:10.1016/j.jhsa.2004.12.006
- 10.1097/00000658-197406000-00012 · doi:10.1097/00000658-197406000-00012
- 10.1007/BF00387577 · doi:10.1007/bf00387577
- 10.1053/jhsu.2003.50044 · doi:10.1053/jhsu.2003.50044
- 10.1126/sciadv.1600874 · DOI
- 10.1155/2018/7172034 · doi:10.1155/2018/7172034
- 10.1055/s-0038-1675170 · doi:10.1055/s-0038-1675170
- 10.1016/j.jse.2017.02.014 · doi:10.1016/j.jse.2017.02.014
- 10.1016/j.arthro.2013.01.019 · doi:10.1016/j.arthro.2013.01.019
- 10.1172/JCI81589 · doi:10.1172/jci81589
Cited by
Platelet-Rich Plasma: Review of Current Literature on its Use for Tendon and Ligament Pathology
Kia, C., Baldino, J., Bell, R., Ramji, A., Uyeki, C., & Mazzocca, A. (2018) · Current Reviews in Musculoskeletal Medicine · doi:10.1007/s12178-018-9515-y · Cited by 94
Mesenchymal Stem Cells for Enhanced Healing of the Medial Collateral Ligament of the Knee Joint
Lee, C.-S., Jeon, O.-H., Han, S.-B., & Jang, K.-M. (2023) · Medicina · doi:10.3390/medicina59040725 · Cited by 7
Metadata
- Authors
- Leong, N. L., Kator, J. L., Clemens, T. L., James, A., Enamoto‐Iwamoto, M., & Jiang, J.
- Venue
- Journal of Orthopaedic Research
- Publisher
- Wiley
- Published
- 2019-09-30
- Volume
- 38
- Issue
- 1
- Pages
- 7-12
- ISSN
- 0736-0266 (ISSN-L)
- 1554-527X
- OpenAlex
- W2973744859
- Cited by
- 286
- References
- 141
- FWCI
- 18.01
- Type
- journal article
- Language
- en
- Open access
- bronze
- Funders
- U.S. Department of Veterans Affairs (IK2 BX004879)
- Arthroscopy Association of North America
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR070099)
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- Leong, N. L., Kator, J. L., Clemens, T. L., James, A., Enamoto‐Iwamoto, M., & Jiang, J. (2020). Tendon and Ligament Healing and Current Approaches to Tendon and Ligament Regeneration. Journal of Orthopaedic Research. https://doi.org/10.1002/jor.24475
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.