Design, Degradation Mechanism and Long‐Term Cytotoxicity of Poly(l‐lactide) and Poly(Lactide‐co‐ϵ‐Caprolactone) Terpolymer Film and Air‐Spun Nanofiber Scaffold
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Degradable nanofiber scaffold is known to provide a suitable, versatile and temporary structure for tissue regeneration. However, synthetic nanofiber scaffold must be properly designed to display appropriate tissue response during the degradation process. In this context, this publication focuses on the design of a finely‐tuned poly(lactide‐co‐ϵ‐caprolactone) terpolymer (PLCL) that may be appropriate for vascular biomaterials applications and its comparison with well‐known semi‐crystalline poly(l‐lactide) (PLLA). The degradation mechanism of polymer film and nanofiber scaffold and endothelial cells behavior cultured with degradation products is elucidated. The results highlights benefits of using PLCL terpolymer as vascular biomaterial compared to PLLA.
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In drug delivery systems or skin wound repair materials, a faster degradation rate is often required, and a higher L-lactide ratio can be used to synthesize low molecular weight PLCL.
“For example, in the design of drug delivery systems or skin wound repair materials, a faster degradation rate is often required, and a higher L-lactide ratio can be used to synthesize low molecular weight PLCL [43].”
From Application of PLCL as a biodegradable polymer in biomedical engineering (2026) · cites this paper as [43]
The Abstract (page unavailable) says PLCL degradation rates can be adjusted through monomer ratio and polymer molecular weight, and the Discussion (page unavailable) describes tuning degradation through synthesis conditions. Our copy does not say that a higher L-lactide ratio is used to synthesize low-molecular-weight PLCL, or that faster degradation is required for skin wound repair or drug delivery materials. (LLM, conf=0.84)
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- Authors
- Sabbatier, G., Larrañaga, A., Guay‐Bégin, A., Fernandez, J., Diéval, F., Durand, B., Sarasua, J., & Laroche, G.
- Affiliations
- Université de Haute-Alsace (FR)
- University of the Basque Country (ES)
- Centre hospitalier universitaire de Québec (CA)
- Department of Mining‐Metallurgy Engineering and Materials Science, School of Engineering University of the Basque Country (UPV/EHU) Alameda de Urquijo s/n 48013 Bilbao Spain
- Corresponding author
- Laroche, Gaétan
- Venue
- Macromolecular Bioscience
- Publisher
- Wiley
- Published
- 2015-06-08
- Volume
- 15
- Issue
- 10
- Pages
- 1392-1410
- ISSN
- 1616-5187 (ISSN-L)
- 1616-5195
- OpenAlex
- W2164655618
- Cited by
- 32
- References
- 64
- Citations by year
- 2026: 1 · 2025: 5 · 2023: 3 · 2022: 3 · 2021: 4 · 2020: 1 · 2019: 1 · 2018: 2 · 2017: 8 · 2016: 3 · 2015: 1
- FWCI
- 1.69
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- Locations
- Macromolecular Bioscience (publishedVersion)
- PubMed (publishedVersion)
- Communities in ADDI (University of the Basque Country) (submittedVersion, other-oa)
- HAL (submittedVersion)
- Corpus Université Laval (Université Laval) (submittedVersion)
- Hispana (submittedVersion, other-oa)
- Funders
- National Science and Engineering Research Council (NSERC) of Canada
- Centre Québécois sur les Matériaux Fonctionnels (CQMF)
- Topics
- Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
- Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
- Physical Sciences › Materials Science › Biomaterials › Silk-based biomaterials and applications
- Keywords
- poly(L-lactic acid), nanofibrous scaffolds, polymer films, degradation mechanism, endothelial cells, tissue regeneration, biodegradable polymers, degradation products
- MeSH terms
- Calorimetry, Differential Scanning, Cell Adhesion, Chromatography, Gel, Humans, Hydrogen-Ion Concentration, Molecular Weight, Polyesters, Saphenous Vein, Time Factors, Cell Death, Endothelial Cells, Cell Proliferation, Tissue Scaffolds, Nanofibers
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