Recreational physical activity and risk of Parkinson's disease
Open accessAbstract
The purpose of this study was to investigate associations between recreational physical activity and Parkinson's disease (PD) risk. We prospectively followed 143,325 participants in the Cancer Prevention Study II Nutrition Cohort from 1992 to 2001 (mean age at baseline = 63). Recreational physical activity was estimated at baseline from the reported number of hours per week on average spent performing light intensity activities (walking, dancing) and moderate to vigorous intensity activities (jogging/running, lap swimming, tennis/racquetball, bicycling/stationary bike, aerobics/calisthenics). Incident cases of PD (n = 413) were confirmed by treating physicians and medical record review. Relative risks (RR) were estimated using proportional hazards models, adjusting for age, gender, smoking, and other risk factors. Risk of PD declined in the highest categories of baseline recreational activity. The RR comparing the highest category of total recreational activity (men ≥ 23 metabolic equivalent task‐hours/week [MET‐h/wk], women ≥ 18.5 MET‐h/wk) to no activity was 0.8 (95% CI: 0.6, 1.2; P trend = 0.07). When light activity and moderate to vigorous activity were examined separately, only the latter was found to be associated with PD risk. The RR comparing the highest category of moderate to vigorous activity (men ≥ 16 MET‐h/wk, women ≥ 11.5 MET‐h/wk) to the lowest (0 MET‐h/wk) was 0.6 (95% CI: 0.4, 1.0; P trend = 0.02). These results did not differ significantly by gender. The results were similar when we excluded cases with symptom onset in the first 4 years of follow‐up. Our results may be explained either by a reduction in PD risk through moderate to vigorous activity, or by decreased baseline recreational activity due to preclinical PD. © 2007 Movement Disorder Society
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Parkinson disease risk in humans is significantly reduced by midlife exercise, documented in large prospective studies.
“PD risk in humans is significantly reduced by midlife exercise, documented in large prospective studies.”
From Does vigorous exercise have a neuroprotective effect in Parkinson disease? (2011) · cites this paper as [4]
Moderate to vigorous exercise habits in midlife significantly reduced the risk of later-developing Parkinson disease in three large cohorts, although this was confined to men in one study.
“Moderate to vigorous exercise habits in midlife significantly reduced the risk of later-developing PD in 3 large cohorts, [3][4][5] although confined to men in one study.3”
From Does vigorous exercise have a neuroprotective effect in Parkinson disease? (2011) · cites this paper as [4]
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- Authors
- Thacker, E. L., Chen, H., Patel, A. V., McCullough, M. L., Calle, E. E., Thun, M. J., Schwarzschild, M. A., & Ascherio, A.
- Affiliations
- Harvard University (US)
- National Institutes of Health (US)
- American Cancer Society (US)
- Massachusetts General Hospital (US)
- Brigham and Women's Hospital (US)
- Corresponding author
- Thacker, Evan L.
- ORCID
- Venue
- Movement Disorders
- Publisher
- Wiley
- Published
- 2008-01
- Volume
- 23
- Issue
- 1
- Pages
- 69-74
- ISSN
- 0885-3185 (ISSN-L)
- 1531-8257
- PMC
- PMC2387117
- OpenAlex
- W2076762973
- Cited by
- 185
- References
- 21
- Citations by year
- 2026: 2 · 2025: 8 · 2024: 12 · 2023: 11 · 2022: 4 · 2021: 7 · 2020: 11 · 2019: 15 · 2018: 17 · 2017: 9 · 2016: 9 · 2015: 10 · 2014: 7 · 2013: 12 · 2012: 16
- FWCI
- 5.76
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Movement Disorders (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (1z01es101986-03, Z01-ES101986)
- National Institute of Neurological Disorders and Stroke (NS048517, R01NS048517)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Parkinson's disease, leisure-time physical activity, moderate-to-vigorous physical activity, light physical activity, disease risk, preclinical Parkinson's disease, Cancer Prevention Study II Nutrition Cohort
- MeSH terms
- Adult, Beverages, Energy Intake, Coffee, Female, Follow-Up Studies, Humans, Male, Motor Activity, Parkinson Disease, Prospective Studies, Surveys and Questionnaires, Recreation, Risk Factors, Smoking, Cohort Studies, Body Mass Index
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