Incidental Lewy body disease: Clinical comparison to a control cohort
Open accessAbstract
Limited clinical information has been published on cases pathologically diagnosed with incidental Lewy body disease (ILBD). Standardized, longitudinal movement and cognitive data was collected on a cohort of subjects enrolled in the Sun Health Research Institute Brain and Body Donation Program. Of 277 autopsied subjects who had antemortem clinical evaluations within the previous 3 years, 76 did not have Parkinson's disease, a related disorder, or dementia of which 15 (20%) had ILBD. Minor extrapyramidal signs were common in subjects with and without ILBD. Cognitive testing revealed an abnormality in the ILBD group in the Trails B test only. ILBD cases had olfactory dysfunction; however, sample size was very small. This preliminary report revealed ILBD cases have movement and cognitive findings that for the most part were not out of proportion to similarly assessed and age‐similar cases without Lewy bodies. Larger sample size is needed to have the power to better assess group differences. © 2010 Movement Disorder Society
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LBD has been observed in individuals without apparent cognitive or motor deficit, though much less common than AD neuropathologic change.
“Clinico-pathologic correlation for individuals without cognitive impairment should indicate that, although much less common than AD neuropathologic change, LBD has been observed in individuals without apparent cognitive or motor deficit [1,49]; this may represent pre-clinical LBD [12,22,31].”
From National Institute on Aging–Alzheimer’s Association guidelines for the neuropathologic assessment of Alzheimer’s disease: a practical approach (2012) · cites this paper as [1]
The Abstract and Results describe autopsy-confirmed incidental Lewy body disease in people without diagnosed dementia or parkinsonism, with motor and cognitive findings largely comparable to controls. The paper does not establish that Lewy body disease is much less common than AD neuropathologic change; its AD count refers to excluded cases with an AD diagnosis, not the prevalence of neuropathologic change. (LLM, conf=0.85)
Experimental — accuracy not yet measuredNeocortical LBD is correlated with greater likelihood of cognitive impairment.
“For cases with incomplete clinical history, we note that “Neocortical LBD” is correlated with greater likelihood of cognitive impairment [1,11-13,22,31-33,38,46,49,52].”
From National Institute on Aging–Alzheimer’s Association guidelines for the neuropathologic assessment of Alzheimer’s disease: a practical approach (2012) · cites this paper as [1]
The Results report that none of the ILBD cases had neocortical Lewy body stage, so this cohort cannot establish whether neocortical LBD is associated with cognitive impairment. The Discussion says it is unclear whether cases at different stages would show different cognitive findings. I searched for a neocortical-stage comparison, but our copy does not report one. (LLM, conf=0.78)
Experimental — accuracy not yet measured
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Percentages, sums and reported differences re-computed from the paper’s own numbers.
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- Authors
- Adler, C. H., Connor, D. J., Hentz, J. G., Sabbagh, M. N., Caviness, J. N., Shill, H. A., Noble, B., & Beach, T. G.
- Affiliations
- Mayo Clinic in Arizona (US)
- Banner Sun Health Research Institute (US)
- Corresponding author
- Adler, Charles H.
- Venue
- Movement Disorders
- Publisher
- Wiley
- Published
- 2010-04-15
- Volume
- 25
- Issue
- 5
- Pages
- 642-646
- ISSN
- 0885-3185 (ISSN-L)
- 1531-8257
- PMC
- PMC2935627
- OpenAlex
- W2139388615
- Cited by
- 143
- References
- 4
- Citations by year
- 2026: 10 · 2025: 10 · 2024: 12 · 2023: 8 · 2022: 7 · 2021: 6 · 2020: 3 · 2019: 8 · 2018: 8 · 2017: 7 · 2016: 9 · 2015: 10 · 2014: 8 · 2013: 8 · 2012: 9
- FWCI
- 7.06
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Movement Disorders (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (P30AG019610)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
- Keywords
- incidental Lewy body disease, Lewy bodies, Parkinson's disease, dementia, extrapyramidal signs, cognitive impairment, Trail Making Test Part B, olfactory dysfunction, brain donation, autopsy
- MeSH terms
- Aged, Aged, 80 and over, Olfaction Disorders, Disability Evaluation, Female, Humans, Male, Neuropsychological Tests, Parkinson Disease, Retrospective Studies, Severity of Illness Index, Cohort Studies, Lewy Body Disease
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