Reduced striatal tyrosine hydroxylase in incidental Lewy body disease
Open accessAbstract
Incidental Lewy body disease (ILBD) is the term used when Lewy bodies are found in the nervous system of subjects without clinically documented parkinsonism or dementia. The prevalence of ILBD in the elderly population has been estimated at between 3.8 and 30%, depending on subject age and anatomical site of sampling. It has been speculated that ILBD represents the preclinical stage of Parkinson's disease (PD) and/or dementia with Lewy bodies (DLB). Studies of ILBD could potentially identify early diagnostic signs of these disorders. At present, however, it is impossible to know whether ILBD is a precursor to PD or DLB or is just a benign finding of normal aging. We hypothesized that, if ILBD represents an early stage of PD or DLB, it should be associated with depletion of striatal dopaminergic markers. Eleven subjects with ILBD and 27 control subjects were studied. The ILBD subjects ranged in age from 74 to 96 years (mean 86.5) while the control subjects' age ranged from 75 to 102 years (mean 86.7). Controls and subjects did not differ in terms of age, postmortem interval, gender distribution, medical history conditions, brain weight, neuritic plaque density or Braak neurofibrillary stage. Quantitative ELISA measurement of striatal tyrosine hydroxylase (TH), the principal enzyme for dopamine synthesis, showed a 49.8% (P = 0.01) reduction in ILBD cases, as compared with control cases. The finding suggests that ILBD is not a benign condition but is likely a precursor to PD and/or DLB.
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LBD observed in individuals without apparent cognitive or motor deficit may represent pre-clinical LBD.
“this may represent pre-clinical LBD [12,22,31].”
From National Institute on Aging–Alzheimer’s Association guidelines for the neuropathologic assessment of Alzheimer’s disease: a practical approach (2012) · cites this paper as [12]
Neocortical LBD is correlated with greater likelihood of cognitive impairment.
“For cases with incomplete clinical history, we note that “Neocortical LBD” is correlated with greater likelihood of cognitive impairment [1,11-13,22,31-33,38,46,49,52].”
From National Institute on Aging–Alzheimer’s Association guidelines for the neuropathologic assessment of Alzheimer’s disease: a practical approach (2012) · cites this paper as [12]
The Results and discussion (page unavailable) report that the studied cases were brainstem-predominant or limbic, with no neocortical cases. They also report no significant MMSE difference between the assessed incidental Lewy body disease cases and controls. The paper therefore does not address whether neocortical Lewy body disease is associated with a greater likelihood of cognitive impairment. (LLM, conf=0.76)
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Cites
Neuropathological stageing of Alzheimer-related changes.
Braak, H., & Braak, E. (1991) · Acta Neuropathologica · doi:10.1007/bf00308809 · Cited by 16,123 · see citing works
Staging of brain pathology related to sporadic Parkinson’s disease
Braak, H., Tredici, K. D., Rüb, U., de Vos, R. A. I., Jansen Steur, E. N. H., & Braak, E. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00065-9 · Cited by 10,777 · see citing works
Diagnosis and management of dementia with Lewy bodies: Third report of the DLB consortium
McKeith, I. G., Dickson, D. W., Lowe, J., Emre, M., O'Brien, J. T., Feldman, H., Cummings, J., Duda, J. E., Lippa, C., Perry, E. K., et al. (2005) · Neurology · doi:10.1212/01.wnl.0000187889.17253.b1 · Cited by 5,069 · see citing works
Mirra, S. S., Heyman, A., McKeel, D., Sumi, S. M., Crain, B. J., Brownlee, L. M., Vogel, F. S., Hughes, J. P., Belle, G. V., Berg, L., et al. (1991) · Neurology · doi:10.1212/wnl.41.4.479 · Cited by 4,961 · see citing works
AGEING AND PARKINSON'S DISEASE: SUBSTANTIA NIGRA REGIONAL SELECTIVITY
FEARNLEY, J. M., & LEES, A. J. (1991) · Brain · doi:10.1093/brain/114.5.2283 · Cited by 3,529 · see citing works
The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease.
Gibb, W. R., & Lees, A. J. (1988) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.51.6.745 · Cited by 3,481 · see citing works
Consortium to Establish a Registry for Alzheimer's Disease (CERAD)
Fillenbaum, G., & Heyman, A. (2002) · doi:10.1002/0470846410.ch42(iii · Cited by 2,859 · see citing works
Stages in the development of Parkinson’s disease-related pathology
Braak, H., Ghebremedhin, E., Rüb, U., Bratzke, H., & Del Tredici, K. (2004) · Cell and Tissue Research · doi:10.1007/s00441-004-0956-9 · Cited by 2,689 · see citing works
Bernheimer, H., Birkmayer, W., Hornykiewicz, O., Jellinger, K. A., & SEITELBERGER, F. (1973) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(73)90175-5 · Cited by 2,650 · see citing works
α-Synuclein is phosphorylated in synucleinopathy lesions
Fujiwara, H., Hasegawa, M., Dohmae, N., Kawashima, A., Masliah, E., Goldberg, M., Shen, J., Takio, K., & Iwatsubo, T. (2002) · Nature Cell Biology · doi:10.1038/ncb748 · Cited by 1,906 · see citing works
HYMAN, B. T., & TROJANOWSKI, J. Q. (1997) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/00005072-199710000-00002 · Cited by 1,542 · see citing works
Consensus Recommendations for the Postmortem Diagnosis of Alzheimer’s Disease
(1997) · Neurobiology of Aging · doi:10.1016/s0197-4580(97)00057-2 · Cited by 981 · see citing works
Frequency of Bowel Movements and the Future Risk of Parkinson’s Disease
Abbott, R. D., Petrovitch, H., White, L. R., Masaki, K. H., Tanner, C. M., Curb, J. D., Grandinetti, A., Blanchette, P. L., Popper, J. S., & Ross, G. W. (2001) · Neurology · doi:10.1212/wnl.57.3.456 · Cited by 839 · see citing works
Braak, H., Tredici, K. D., Bratzke, H., Hamm-Clement, J., Sandmann-Keil, D., & Rüb, U. (2002) · Journal of Neurology · doi:10.1007/s00415-002-1301-4 · Cited by 710 · see citing works
Incidence and prediction of falls in Parkinson's disease: a prospective multidisciplinary study
Wood, B. (2002) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.72.6.721 · Cited by 695 · see citing works
Parkinson's disease: the presence of Lewy bodies in Auerbach's and Meissner's plexuses
Wakabayashi, K., Takahashi, H., Takeda, S., Ohama, E., & Ikuta, F. (1988) · Acta Neuropathologica · doi:10.1007/bf00687767 · Cited by 528 · see citing works
Bézard, E., Doveró, S., Prunier, C., Ravenscroft, P., Chalon, S., Guilloteau, D., Crossman, A. R., Bioulac, B. H., Brotchie, J. M., & Gross, C. E. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-17-06853.2001 · Cited by 484 · see citing works
Microscopic analysis of polymerization dynamics with individual actin filaments
Fujiwara, I., Takahashi, S., Tadakuma, H., Funatsu, T., & Ishiwata, S. (2002) · Nature Cell Biology · doi:10.1038/ncb841 · Cited by 420 · see citing works
Cardiac Sympathetic Denervation in Parkinson Disease
Goldstein, D. S., Holmes, C., Li, S.-T., Bruce, S., Metman, L. V., & Cannon, R. O. (2000) · Annals of Internal Medicine · doi:10.7326/0003-4819-133-5-200009050-00009 · Cited by 372 · see citing works
Carlsson, A., & Winblad, B. G. (1976) · Journal of Neural Transmission · doi:10.1007/bf01249444 · Cited by 330 · see citing works
Bloch, A., Probst, A., Bissig, H., Adams, H., & Tolnay, M. (2006) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2006.00727.x · Cited by 330 · see citing works
Dexter, D. T., Sian, J., Rose, S., Hindmarsh, J. G., Mann, V. M., Cooper, J. A. D., Wells, F. R., Daniel, S. E., Lees, A. J., Schapira, A. H. V., et al. (1994) · Annals of Neurology · doi:10.1002/ana.410350107 · Cited by 317 · see citing works
A systematic review of depression and mental illness preceding Parkinson's disease
Ishihara, L., & Brayne, C. (2006) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.2006.00579.x · Cited by 312 · see citing works
Jager, W. A. D. H., & Bethlem, J. (1960) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.23.4.283 · Cited by 292 · see citing works
The anterior olfactory nucleus in Parkinson's disease
Pearce, R. K. B., Hawkes, C. H., & Daniel, S. E. (1995) · Movement Disorders · doi:10.1002/mds.870100309 · Cited by 289 · see citing works
Lewy body–type degeneration in cardiac plexus in Parkinson’s and incidental Lewy body diseases
Iwanaga, K., Wakabayashi, K., Yoshimoto, M., Tomita, I., Satoh, H., Takashima, H., Satoh, A., Seto, M., Tsujihata, M., & Takahashi, H. (1999) · Neurology · doi:10.1212/wnl.52.6.1269 · Cited by 274 · see citing works
Lewy body-related ?-synucleinopathy in the aged human brain
Jellinger, K. A. (2004) · Journal of Neural Transmission · doi:10.1007/s00702-004-0138-7 · Cited by 253 · see citing works
Swallowing disorders in Parkinson's disease
Potulska‐Chromik, A., Friedman, A., Królicki, L., & Spychała, A. (2003) · Parkinsonism & Related Disorders · doi:10.1016/s1353-8020(03)00045-2 · Cited by 236 · see citing works
Depression and Parkinson?s disease
Lemke, M. R., Fuchs, G., Gemende, I., Herting, B., Oehlwein, C., Reichmann, H., Rieke, J., & Volkmann, J. (2004) · Journal of Neurology · doi:10.1007/s00415-004-1606-6 · Cited by 204 · see citing works
Lewy Body-Related α-Synucleinopathy in Aging
Saito, Y., Ruberu, N. N., Sawabe, M., Arai, T., Kazama, H., Hosoi, T., Yamanouchi, H., & Murayama, S. (2004) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/63.7.742 · Cited by 200 · see citing works
Association of olfactory dysfunction with incidental Lewy bodies
Ross, G. W., Abbott, R. D., Petrovitch, H., Tanner, C. M., Davis, D. G., Nelson, J. R., Markesbery, W. R., Hardman, J. M., Masaki, K., Launer, L. J., et al. (2006) · Movement Disorders · doi:10.1002/mds.21076 · Cited by 194 · see citing works
Do α-synuclein aggregates in autonomic plexuses predate Lewy body disorders?
Mínguez‐Castellanos, A., Chamorro, C. E., Sevilla, F. E., Ortega-Moreno, A., Rebollo, A. C., Gómez-Río, M., Concha, A., & Muñoz, D. G. (2007) · Neurology · doi:10.1212/01.wnl.0000264429.59379.d9 · Cited by 183 · see citing works
Reduced Risk Factors for Vascular Disorders in Parkinson Disease Patients
Scigliano, G., Musicco, M., Soliveri, P., Piccolo, I., Ronchetti, G., & Girotti, F. (2006) · Stroke · doi:10.1161/01.str.0000217384.03237.9c · Cited by 182 · see citing works
Profound Cardiac Sympathetic Denervation Occurs in Parkinson Disease
Amino, T., Orimo, S., Itoh, Y., Takahashi, A., Uchihara, T., & Mizusawa, H. (2006) · Brain Pathology · doi:10.1111/j.1750-3639.2005.tb00097.x · Cited by 178 · see citing works
Nonmotor complications in Parkinson's disease
Adler, C. H. (2005) · Movement Disorders · doi:10.1002/mds.20460 · Cited by 165 · see citing works
Self-citationUltrastructure of Lewy bodies in the stellate ganglion
Forno, L. S., & Norville, R. L. (1976) · Acta Neuropathologica · doi:10.1007/bf00688674 · Cited by 162 · see citing works
Risk factors for parkinson’s disease: The leisure world cohort study
Paganini-Hill, A. (2001) · Neuroepidemiology · doi:10.1159/000054770 · Cited by 159 · see citing works
Olfaction and Parkinson's syndromes: its role in differential diagnosis
Katzenschlager, R., & Lees, A. J. (2004) · Current Opinion in Neurology · doi:10.1097/01.wco.0000137531.76491.c2 · Cited by 157 · see citing works
Does striatal pathology distinguish Parkinson disease with dementia and dementia with Lewy bodies?
Jellinger, K. A., & Attems, J. (2006) · Acta Neuropathologica · doi:10.1007/s00401-006-0088-2 · Cited by 152 · see citing works
Satoh, A., Serita, T., Seto, M., Tomita, I., Satoh, H., Iwanaga, K., Takashima, H., & Tsujihata, M. (1999) · PubMed · Cited by 139 · see citing works
Olfaction in Neurodegenerative Disorder
Hawkes, C. H. (2006) · KARGER eBooks · doi:10.1159/000093759 · Cited by 136 · see citing works
Tsuboi, Y., Wszołek, Z. K., Graff‐Radford, N. R., Cookson, N., & Dickson, D. W. (2003) · Neuropathology and Applied Neurobiology · doi:10.1046/j.1365-2990.2003.00453.x · Cited by 132 · see citing works
Hornykiewicz, O. (1993) · PubMed · Cited by 132 · see citing works
Swallowing and esophageal function in Parkinson's disease.
Johnston, B. T., Li, Q., Castell, J. A., & Do, C. (1995) · PubMed · Cited by 130 · see citing works
Taki, J., Yoshita, M., Yamada, M., & Tonami, N. (2004) · Annals of Nuclear Medicine · doi:10.1007/bf02984560 · Cited by 130 · see citing works
Preliminary diagnosis of Parkinson's disease by olfactory bulb pathology
Daniel, S. E., & Hawkes, C. (1992) · The Lancet · doi:10.1016/0140-6736(92)93275-r · Cited by 125 · see citing works
Progressive loss of cardiac sympathetic innervation in Parkinson's disease
Li, S., Dendi, R., Holmes, C. S., & Goldstein, D. S. (2002) · Annals of Neurology · doi:10.1002/ana.10236 · Cited by 96 · see citing works
Perfusion-fixation of the human brain for immunohistochemistry: comparison with immersion-fixation
Beach, T. G., Tago, H., Nagai, T., Kimurâ, H., McGeer, P. L., & McGeer, E. G. (1987) · Journal of Neuroscience Methods · doi:10.1016/s0165-0270(87)80001-8 · Cited by 87 · see citing works
Self-citationLewy bodies in the lower sacral parasympathetic neurons of a patient with Parkinson's disease
Oyanagi, K., Wakabayashi, K., Ohama, E., Takeda, S., Horikawa, Y., Morita, T., & Ikuta, F. (1990) · Acta Neuropathologica · doi:10.1007/bf00294619 · Cited by 68 · see citing works
Nabilone increases choreatic movements in Huntington's disease
Müller‐Vahl, K., Schneider, U., & Emrich, H. M. (1999) · Movement Disorders · doi:10.1002/1531-8257(199911)14:6 · Cited by 65 · see citing works
Parkinson's disease with involvement of the parasympathetic ganglia
Takeda, S., Yamazaki, K., Miyakawa, T., & Arai, H. (1993) · Acta Neuropathologica · doi:10.1007/bf00369454 · Cited by 63 · see citing works
Neurotransmitter specificity of sympathetic denervation in Parkinson’s disease
Sharabi, Y., Li, S.-T., Dendi, R., Holmes, C. S., & Goldstein, D. S. (2003) · Neurology · doi:10.1212/01.wnl.0000052690.91036.ff · Cited by 39 · see citing works
Kövari, E., Burkhardt, K., Lobrinus, J. A., & Bouras, C. (2007) · Acta Neuropathologica · doi:10.1007/s00401-007-0233-6 · Cited by 13 · see citing works
Nakajima, R., Takahashi, K., Nakamura, H., Otomo, E., & Kameyama, M. (1981) · PubMed · Cited by 9 · see citing works
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Hyman, B. T., Phelps, C. H., Beach, T. G., Bigio, E. H., Cairns, N. J., Carrillo, M. C., Dickson, D. W., Duyckaerts, C., Frosch, M. P., Masliah, E., et al. (2012) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2011.10.007 · Cited by 3,092 · see citing works
Self-citationMontine, T. J., Phelps, C. H., Beach, T. G., Bigio, E. H., Cairns, N. J., Dickson, D. W., Duyckaerts, C., Frosch, M. P., Masliah, E., Mirra, S. S., et al. (2012) · Acta Neuropathologica · doi:10.1007/s00401-011-0910-3 · Cited by 2,992 · see citing works
“Clinico-pathologic correlation for individuals without cognitive impairment should indicate that, although much less common than AD neuropathologic change, LBD has been observed in individuals without apparent cognitive or motor deficit [1, 49]; this may represent pre-clinical LBD [12, 22, 31].”
Self-citationDisease duration and the integrity of the nigrostriatal system in Parkinson’s disease
Kordower, J. H., Olanow, C. W., Dodiya, H. B., Chu, Y., Beach, T. G., Adler, C. H., Halliday, G. M., & Bartus, R. T. (2013) · Brain · doi:10.1093/brain/awt192 · Cited by 1,294 · see citing works
Self-citationGoedert, M., Spillantini, M. G., Del Tredici, K., & Braak, H. (2013) · Nature Reviews Neurology · doi:10.1038/nrneurol.2012.242 · Cited by 1,190 · see citing works
Clinical progression in Parkinson disease and the neurobiology of axons
Cheng, H., Ulane, C. M., & Burke, R. E. (2010) · Annals of Neurology · doi:10.1002/ana.21995 · Cited by 1,012 · see citing works
“In an assessment of ILB brains, Beach and colleagues determined that the putamen had a 50% reduction in tyrosine hydroxylase (TH) protein.(30) Although counts of remaining neurons in the SN are not likely to be altered by factors affecting the quality of postmortem tissue preservation, biochemical assess-”
BackgroundResultInfluentialNeuropathological assessment of Parkinson’s disease: refining the diagnostic criteria
Dickson, D. W., Braak, H., Duda, J. E., Duyckaerts, C., Gasser, T., Halliday, G. M., Hardy, J., Leverenz, J. B., Del Tredici, K., Wszolek, Z. K., et al. (2009) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70238-8 · Cited by 972 · see citing works
PGC-1 α, A Potential Therapeutic Target for Early Intervention in Parkinson’s Disease
Zheng, B., Liao, Z., Locascio, J. J., Lesniak, K. A., Roderick, S. S., Watt, M. L., Eklund, A. C., Zhang‐James, Y., Kim, P. D., Hauser, M. A., et al. (2010) · Science Translational Medicine · doi:10.1126/scitranslmed.3001059 · Cited by 854 · see citing works
Self-citationthe Arizona Parkinson’s Disease Consortium, Beach, T. G., Adler, C. H., Lue, L., Sue, L. I., Bachalakuri, J., Henry-Watson, J., Sasse, J., Boyer, S., Shirohi, S., et al. (2009) · Acta Neuropathologica · doi:10.1007/s00401-009-0538-8 · Cited by 698 · see citing works
Self-citationThe Synucleinopathies: Twenty Years On
Goedert, M., Jakes, R., & Spillantini, M. G. (2017) · Journal of Parkinson s Disease · doi:10.3233/jpd-179005 · Cited by 566 · see citing works
Invited Article: Nervous system pathology in sporadic Parkinson disease
Braak, H., & Tredici, K. D. (2008) · Neurology · doi:10.1212/01.wnl.0000312279.49272.9f · Cited by 536 · see citing works
The Lewy Body in Parkinson’s Disease and Related Neurodegenerative Disorders
Wakabayashi, K., Tanji, K., Odagiri, S., Miki, Y., Mori, F., & Takahashi, H. (2012) · Molecular Neurobiology · doi:10.1007/s12035-012-8280-y · Cited by 478 · see citing works
Beach, T. G., Adler, C. H., Sue, L. I., Serrano, G., Shill, H. A., Walker, D. G., Lue, L., Roher, A. E., Dugger, B. N., Maarouf, C., et al. (2015) · Neuropathology · doi:10.1111/neup.12189 · Cited by 460 · see citing works
Self-citationNeuropathology of sporadic Parkinson's disease: Evaluation and changes of concepts
Jellinger, K. A. (2011) · Movement Disorders · doi:10.1002/mds.23795 · Cited by 448 · see citing works
Glia: Initiators and progressors of pathology in Parkinson's disease
Halliday, G. M., & Stevens, C. H. (2011) · Movement Disorders · doi:10.1002/mds.23455 · Cited by 423 · see citing works
Braak, H., & Del Tredici, K. (2017) · Journal of Parkinson’s Disease · doi:10.3233/jpd-179001 · Cited by 372 · see citing works
Evidence that incidental Lewy body disease is pre-symptomatic Parkinson’s disease
Dickson, D. W., Fujishiro, H., DelleDonne, A., Menke, J., Ahmed, Z., Klos, K. J., Josephs, K. A., Frigerio, R., Burnett, M., Parisi, J. E., et al. (2008) · Acta Neuropathologica · doi:10.1007/s00401-008-0345-7 · Cited by 364 · see citing works
Retrograde Axonal Degeneration in Parkinson Disease
Tagliaferro, P., & Burke, R. E. (2016) · Journal of Parkinson’s Disease · doi:10.3233/jpd-150769 · Cited by 272 · see citing works
Olfactory bulb α-synucleinopathy has high specificity and sensitivity for Lewy body disorders
Beach, T. G., White, C. L., Hladik, C. L., Sabbagh, M. N., Connor, D. J., Shill, H. A., Sue, L. I., Sasse, J., Bachalakuri, J., Henry-Watson, J., et al. (2008) · Acta Neuropathologica · doi:10.1007/s00401-008-0450-7 · Cited by 237 · see citing works
Self-citationMotor and non-motor circuit disturbances in early Parkinson disease: which happens first?
Blesa, J., Foffani, G., Dehay, B., Bezard, E., & Obeso, J. A. (2022) · Nature Reviews Neuroscience · doi:10.1038/s41583-021-00542-9 · Cited by 232 · see citing works
A critical evaluation of current staging of α-synuclein pathology in Lewy body disorders
Jellinger, K. A. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2008.07.006 · Cited by 229 · see citing works
A critical reappraisal of current staging of Lewy-related pathology in human brain
Jellinger, K. A. (2008) · Acta Neuropathologica · doi:10.1007/s00401-008-0406-y · Cited by 229 · see citing works
Neuropathological basis of nonmotor manifestations of Parkinson's disease
Adler, C. H., & Beach, T. G. (2016) · Movement Disorders · doi:10.1002/mds.26605 · Cited by 230 · see citing works
Self-citationIncidental Lewy Body Disease and Preclinical Parkinson Disease
DelleDonne, A., Klos, K. J., Fujishiro, H., Ahmed, Z., Parisi, J. E., Josephs, K. A., Frigerio, R., Burnett, M. S., Wszołek, Z. K., Uitti, R. J., et al. (2008) · Archives of Neurology · doi:10.1001/archneur.65.8.1074 · Cited by 197 · see citing works
Milestones in Parkinson's disease—Clinical and pathologic features
Halliday, G. M., Lees, A. J., & Stern, M. (2011) · Movement Disorders · doi:10.1002/mds.23669 · Cited by 197 · see citing works
Lewy pathology and neurodegeneration in premotor Parkinson's disease
Tredici, K. D., & Braak, H. (2012) · Movement Disorders · doi:10.1002/mds.24921 · Cited by 184 · see citing works
Essential tremor: evolving clinicopathological concepts in an era of intensive post-mortem enquiry
Louis, E. D. (2010) · The Lancet Neurology · doi:10.1016/s1474-4422(10)70090-9 · Cited by 185 · see citing works
Evaluation of α-synuclein immunohistochemical methods used by invited experts
Beach, T. G., White, C. L., Hamilton, R. L., Duda, J. E., Iwatsubo, T., Dickson, D. W., Leverenz, J. B., Roncaroli, F., Buttini, M., Hladik, C. L., et al. (2008) · Acta Neuropathologica · doi:10.1007/s00401-008-0409-8 · Cited by 182 · see citing works
Self-citationFrigerio, R., Fujishiro, H., Ahn, T. B., Josephs, K. A., Maraganore, D. M., DelleDonne, A., Parisi, J. E., Klos, K. J., Boeve, B. F., Dickson, D. W., et al. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.05.019 · Cited by 172 · see citing works
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Milber, J. M., Noorigian, J. V., Morley, J. F., Petrovitch, H., White, L., Ross, G. W., & Duda, J. E. (2012) · Neurology · doi:10.1212/wnl.0b013e318278fe32 · Cited by 163 · see citing works
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Gaig, C., & TOLOSA, E. S. (2009) · Movement Disorders · doi:10.1002/mds.22672 · Cited by 162 · see citing works
Wakabayashi, K., Mori, F., Tanji, K., Orimo, S., & Takahashi, H. (2010) · Acta Neuropathologica · doi:10.1007/s00401-010-0706-x · Cited by 156 · see citing works
Incidental Lewy body disease: Clinical comparison to a control cohort
Adler, C. H., Connor, D. J., Hentz, J. G., Sabbagh, M. N., Caviness, J. N., Shill, H. A., Noble, B., & Beach, T. G. (2010) · Movement Disorders · doi:10.1002/mds.22971 · Cited by 143 · see citing works
Self-citationParkinson's disease: convergence on synaptic homeostasis
Soukup, S., Vanhauwaert, R., & Verstreken, P. (2018) · The EMBO Journal · doi:10.15252/embj.201898960 · Cited by 129 · see citing works
Neuropathology of incidental Lewy body & prodromal Parkinson’s disease
Koeglsperger, T., Rumpf, S.-L., Schließer, P., Struebing, F. L., Brendel, M., Levin, J., Trenkwalder, C., Höglinger, G. U., & Herms, J. W. (2023) · Molecular Neurodegeneration · doi:10.1186/s13024-023-00622-7 · Cited by 133 · see citing works
Is Braak staging valid for all types of Parkinson’s disease?
Jellinger, K. A. (2018) · Journal of Neural Transmission · doi:10.1007/s00702-018-1898-9 · Cited by 125 · see citing works
Neurodegeneration and the ordered assembly of α-synuclein
Spillantini, M. G., & Goedert, M. (2017) · Cell and Tissue Research · doi:10.1007/s00441-017-2706-9 · Cited by 123 · see citing works
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Iacono, D., Geraci-Erck, M., Rabin, M., Adler, C. H., Serrano, G. E., Beach, T. G., & Kurlan, R. (2015) · Neurology · doi:10.1212/wnl.0000000000002102 · Cited by 116 · see citing works
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Self-citationOld and new challenges in Parkinson's disease therapeutics
Pires, A. O., Teixeira, F. G., Mendes-Pinheiro, B., Serra, S. C., Sousa, N., & Salgado, A. J. (2017) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2017.04.006 · Cited by 94 · see citing works
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Toulorge, D., Schapira, A. H. V., & Hajj, R. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13696 · Cited by 92 · see citing works
Evaluation of the Braak hypothesis: how far can it explain the pathogenesis of Parkinson's disease?
Halliday, G. M., McCann, H., & Shepherd, C. E. (2012) · Expert Review of Neurotherapeutics · doi:10.1586/ern.12.47 · Cited by 74 · see citing works
Kon, T., Tomiyama, M., & Wakabayashi, K. (2019) · Neuropathology · doi:10.1111/neup.12597 · Cited by 74 · see citing works
Where and how alpha‐synuclein pathology spreads in Parkinson’s disease:
Wakabayashi, K. (2020) · Neuropathology · doi:10.1111/neup.12691 · Cited by 74 · see citing works
Beach, T. G., Adler, C. H., Sue, L. I., Shill, H. A., Driver‐Dunckley, E. D., Mehta, S. H., Intorcia, A. J., Glass, M. J., Walker, J. E., Arce, R. A., et al. (2021) · Journal of Parkinson s Disease · doi:10.3233/jpd-212733 · Cited by 72 · see citing works
Self-citationBeach, T. G., Adler, C. H., Serrano, G. E., Sue, L. I., Walker, D. G., Dugger, B. N., Shill, H. A., Driver‐Dunckley, E. D., Caviness, J. N., Intorcia, A. J., et al. (2016) · Journal of Parkinson s Disease · doi:10.3233/jpd-150680 · Cited by 70 · see citing works
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Tredici, K. D., & Braak, H. (2008) · Acta Neuropathologica · doi:10.1007/s00401-008-0355-5 · Cited by 67 · see citing works
Mazzetti, S., Basellini, M. J., Ferri, V., Cassani, E., Cereda, E., Paolini, M., Calogero, A. M., Bolliri, C., Leonardis, M. D., Sacilotto, G., et al. (2020) · Brain · doi:10.1093/brain/awaa008 · Cited by 66 · see citing works
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Eisen, A. (2009) · Muscle & Nerve · doi:10.1002/mus.21404 · Cited by 63 · see citing works
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Slow, E., & Lang, A. E. (2019) · DeckerMed Transitional Year Weekly Curriculum™ · doi:10.2310/tywc.1178 · Cited by 62 · see citing works
Prasad, K., Beach, T. G., Hedreen, J. C., & Richfield, E. K. (2012) · Brain Pathology · doi:10.1111/j.1750-3639.2012.00597.x · Cited by 61 · see citing works
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Self-citationJellinger, K. A. (2019) · Journal of Neural Transmission · doi:10.1007/s00702-019-02028-6 · Cited by 55 · see citing works
Essential Tremor is Not a Neurodegenerative Disease
Rajput, A. H., Adler, C. H., Shill, H. A., & Rajput, A. H. (2012) · Neurodegenerative Disease Management · doi:10.2217/nmt.12.23 · Cited by 53 · see citing works
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Mao, P. (2012) · Journal of Neurodegenerative Diseases · doi:10.1155/2013/319898 · Cited by 55 · see citing works
Alpha-synuclein aggregates in epicardial fat tissue in living subjects without parkinsonism
Navarro‐Otano, J., Gelpí, E., Mestres, C. A., Quintana, E., Rauek, S. G., Ribalta, T., Santiago, V., & TOLOSA, E. S. (2012) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2012.07.005 · Cited by 48 · see citing works
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Jellinger, K. A. (2017) · International review of neurobiology · doi:10.1016/bs.irn.2017.05.005 · Cited by 47 · see citing works
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Olfactory loss and nigrostriatal dopaminergic denervation in the elderly
Wong, K. K., Müller, M. L. T. M., Kuwabara, H., Studenski, S. A., & Bohnen, N. I. (2010) · Neuroscience Letters · doi:10.1016/j.neulet.2010.08.037 · Cited by 45 · see citing works
Walker, D. G., Lue, L., Serrano, G. E., Adler, C. H., Caviness, J. N., Sue, L. I., & Beach, T. G. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00507 · Cited by 44 · see citing works
Self-citationBeach, T. G., Adler, C. H., Zhang, N., Serrano, G. E., Sue, L. I., Driver‐Dunckley, E. D., Mehta, S. H., Zamrini, E., Sabbagh, M. N., Shill, H. A., et al. (2020) · PLoS ONE · doi:10.1371/journal.pone.0231720 · Cited by 43 · see citing works
Self-citationVernon, A. C., Ballard, C. G., & Modo, M. (2010) · Brain Research Reviews · doi:10.1016/j.brainresrev.2010.05.006 · Cited by 43 · see citing works
Low nigrostriatal reserve for motor parkinsonism in nonhuman primates
Tabbal, S. D., Tian, L., Karimi, M., Brown, C., Loftin, S. K., & Perlmutter, J. S. (2012) · Experimental Neurology · doi:10.1016/j.expneurol.2012.07.008 · Cited by 42 · see citing works
Dugger, B. N., Serrano, G. E., Sue, L. I., Walker, D. G., Adler, C. H., Shill, H. A., Sabbagh, M. N., Caviness, J. N., Hidalgo, J., Saxon‐LaBelle, M., et al. (2012) · Journal of Parkinson s Disease · doi:10.3233/jpd-2012-11073 · Cited by 41 · see citing works
Self-citationLewy body‐related α‐synucleinopathy in the spinal cord of cases with incidental Lewy body disease
Tamura, T., Yoshida, M., Hashizume, Y., & Sobue, G. (2011) · Neuropathology · doi:10.1111/j.1440-1789.2011.01211.x · Cited by 36 · see citing works
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Jellinger, K. A. (2009) · Annals of Neurology · doi:10.1002/ana.21638 · Cited by 36 · see citing works
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Frigerio, R., Fujishiro, H., Maraganore, D. M., Klos, K. J., DelleDonne, A., Heckman, M. G., Crook, J. E., Josephs, K. A., Parisi, J. E., Boeve, B. F., et al. (2009) · Archives of Neurology · doi:10.1001/archneurol.2009.170 · Cited by 35 · see citing works
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Moráles, I., Sánchez, A., Rodriguez‐Sabate, C., & Rodrı́guez, M. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.04.019 · Cited by 34 · see citing works
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Adler, C. H. (2011) · International Journal of Neuroscience · doi:10.3109/00207454.2011.620192 · Cited by 34 · see citing works
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Geibl, F. F., Henrich, M. T., & Oertel, W. H. (2019) · Journal of Neural Transmission · doi:10.1007/s00702-019-01970-9 · Cited by 34 · see citing works
Mazzocchi, M., Goulding, S. R., Wyatt, S. L., Collins, L., Sullivan, A. M., & O’Keeffe, G. W. (2021) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2021.103642 · Cited by 33 · see citing works
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Ross, G. W., Abbott, R. D., Petrovitch, H., Duda, J. E., Tanner, C. M., Zarow, C., Uyehara‐Lock, J. H., Masaki, K., Launer, L. J., Studabaker, W. B., et al. (2018) · Movement Disorders · doi:10.1002/mds.27594 · Cited by 32 · see citing works
Nie, T., He, Z., Zhu, J., Chen, K., Howard, G. P., Pacheco‐Torres, J., Minn, I., Zhao, P., Bhujwalla, Z. M., Mao, H., et al. (2021) · Nano Research · doi:10.1007/s12274-020-3280-0 · Cited by 32 · see citing works
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Iarkov, A., Mendoza, C., & Echeverrı́a, V. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.665820 · Cited by 34 · see citing works
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Tiklová, K., Gillberg, L., Volakakis, N., Lundén-Miguel, H., Dahl, L., Serrano, G. E., Adler, C. H., Beach, T. G., & Perlmann, T. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.763777 · Cited by 26 · see citing works
Self-citationZhao, H., Xie, J., Wu, S., Zhao, X., Sánchez, O. F., Min, S.-H., Rochet, J., Freeman, J. L., & Yuan, C. (2023) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2023.168307 · Cited by 22 · see citing works
Regional analysis and genetic association of nigrostriatal degeneration in Lewy body disease
Kasanuki, K., Heckman, M. G., Diehl, N. N., Murray, M. E., Koga, S., Soto, A. I., Ross, O. A., & Dickson, D. W. (2017) · Movement Disorders · doi:10.1002/mds.27184 · Cited by 22 · see citing works
Mason, D. M., Wang, Y., Bhatia, T. N., Miner, K. M., Trbojevic, S., Stolz, J. F., Luk, K. C., & Leak, R. K. (2019) · Brain Pathology · doi:10.1111/bpa.12718 · Cited by 22 · see citing works
Lage, L., Rodriguez-Perez, A. I., Villar‐Cheda, B., Labandeira-García, J. L., & Dominguez‐Meijide, A. (2024) · npj Parkinson s Disease · doi:10.1038/s41531-024-00650-0 · Cited by 21 · see citing works
Miner, K. M., Jamenis, A. S., Bhatia, T. N., Clark, R. N., Rajasundaram, D., Sauvaigo, S., Mason, D. M., Posimo, J. M., Abraham, N., DeMarco, B. A., et al. (2022) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2022.102307 · Cited by 15 · see citing works
Walter, U. (2009) · Expert Review of Neurotherapeutics · doi:10.1586/ern.09.41 · Cited by 15 · see citing works
Eagle, A. L., Olumolade, O., & Otani, H. (2014) · Neuroscience Research · doi:10.1016/j.neures.2014.11.002 · Cited by 14 · see citing works
Jellinger, K. A. (2011) · doi:10.1002/9781444341256.ch21 · Cited by 14 · see citing works
de Fàbregues, O., Sellés, M. C., Ramos-Vicente, D., Roch, G., Vila, M., & Bové, J. (2023) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106308 · Cited by 13 · see citing works
Caviness, J. N., Adler, C. H., Hentz, J. G., Shill, H. A., Evidente, V. G. H., Driver‐Dunckley, E. D., Sabbagh, M. N., Sue, L. I., & Beach, T. G. (2011) · Clinical Neurophysiology · doi:10.1016/j.clinph.2011.03.033 · Cited by 13 · see citing works
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Karabayir, İ., Butler, L., Goldman, S. M., Kamaleswaran, R., Güntürkün, F., Davis, R. L., Ross, G. W., Petrovitch, H., Masaki, K., Tanner, C. M., et al. (2021) · Journal of Parkinson s Disease · doi:10.3233/jpd-212876 · Cited by 11 · see citing works
Fernández‐Espejo, E., & Bis‐Humbert, C. (2018) · NeuroToxicology · doi:10.1016/j.neuro.2018.06.002 · Cited by 11 · see citing works
Mao, P. (2012) · Advances in Biological Chemistry · doi:10.4236/abc.2012.22022 · Cited by 10 · see citing works
Olfactory Dysfunction in Incidental Lewy Body Disease and Parkinson's Disease: An Update.
Hasan, S., Adler, C. H., Zhang, N., Serrano, G. E., Sue, L. I., Shill, H. A., Mehta, S. H., Beach, T. G., & Driver‐Dunckley, E. D. (2022) · PubMed Central · Cited by 9 · see citing works
Self-citationIncreased Free Water in the Putamen in Idiopathic REM Sleep Behavior Disorder
Zhang, D., Zhou, L., Yao, J., Shi, Y., He, H., Wei, H., Tong, Q., Liu, J., & Wu, T. (2023) · Movement Disorders · doi:10.1002/mds.29499 · Cited by 9 · see citing works
Sekiyama, K., Takamatsu, Y., Koike, W., Waragai, M., Takenouchi, T., Sugama, S., & Hashimoto, M. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-151015 · Cited by 9 · see citing works
Presymptomatic Parkinson's disease: The Arizona experience
Caviness, J. N. (2011) · Parkinsonism & Related Disorders · doi:10.1016/s1353-8020(11)70063-3 · Cited by 9 · see citing works
Self-citationAlpha-synuclein pathology enhances peripheral and CNS immune responses to bacterial endotoxins
Hartke, A.-S., Schreiber, C. S., Lau, K., Wiesweg, I., Waltl, I., Kalinke, U., Richter, F., & Käufer, C. (2024) · Neurobiology of Disease · doi:10.1016/j.nbd.2024.106773 · Cited by 7 · see citing works
Microorganisms associated with increased risk of Parkinson’s disease
Fernández‐Espejo, E. (2022) · Neurología (English Edition) · doi:10.1016/j.nrleng.2020.08.023 · Cited by 7 · see citing works
Lewy bodies in essential tremor are no different than in controls
Shill, H. A., Adler, C. H., & Beach, T. G. (2015) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2015.11.025 · Cited by 7 · see citing works
Self-citationAlpha-Synuclein in Neurodegeneration: From Shared Biology to Disease-Specific Phenotypes
Su, F., Kim, W. S., Halliday, G. M., & Fu, Y. (2026) · Cells · doi:10.3390/cells15050451 · Cited by 6 · see citing works
- Authors
- Beach, T. G., Adler, C. H., Sue, L. I., Peirce, J. B., Bachalakuri, J., Dalsing-Hernandez, J. E., Lue, L. F., Caviness, J. N., Connor, D. J., Sabbagh, M. N., & Walker, D. G.
- Affiliations
- Banner Sun Health Research Institute (US)
- Mayo Clinic (US)
- Corresponding author
- Beach, Thomas Gerald
- Venue
- Acta Neuropathologica
- Published
- 2007-11-06
- Volume
- 115
- Issue
- 4
- Pages
- 445-451
- ISSN
- 0001-6322 (ISSN-L)
- 1432-0533
- PMC
- PMC2724592
- OpenAlex
- W2087361379
- Cited by
- 128
- References
- 55
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 7 · 2023: 5 · 2022: 6 · 2021: 7 · 2020: 6 · 2019: 5 · 2018: 4 · 2017: 7 · 2016: 7 · 2015: 5 · 2014: 4 · 2013: 3 · 2012: 15
- FWCI
- 5.79
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Acta Neuropathologica (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (P30-AG-19610, P30AG019610)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nuclear Receptors and Signaling
- Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
- Keywords
- incidental Lewy body disease, tyrosine hydroxylase, striatum, dopamine depletion, Parkinson's disease, dementia with Lewy bodies, preclinical Parkinson's disease, Lewy bodies, dopamine synthesis, postmortem brain
- MeSH terms
- Aged, Aged, 80 and over, Cell Count, Corpus Striatum, Female, Humans, Male, Neurons, Tyrosine 3-Monooxygenase, Incidence, Statistics, Nonparametric, Lewy Body Disease
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