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Alpha-Synuclein: Mechanisms of Release and Pathology Progression in Synucleinopathies

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α-Synuclein fibrils subvert lysosome structure and function for the propagation of protein misfolding between cells through tunneling nanotubes

Dilsizoglu Senol, A., Samarani, M., Syan, S., Guardia, C. M., Nonaka, T., Liv, N., Latour-Lambert, P., Hasegawa, M., Klumperman, J., Bonifacino, J. S., et al. (2021) · PLOS Biology · doi:10.1371/journal.pbio.3001287 · Cited by 134 · see citing works

The complex relationships between microglia, alpha-synuclein, and LRRK2 in Parkinson's disease

Schapansky, J., Nardozzi, J. D., & LaVoie, M. J. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2014.09.049 · Cited by 132 · see citing works

Enteric alpha‐synuclein expression is increased in <scp>P</scp>arkinson's disease but not <scp>A</scp>lzheimer's disease

Gold, A., Turkalp, Z. T., & Munoz, D. G. (2013) · Movement Disorders · doi:10.1002/mds.25298 · Cited by 132 · see citing works

Potential Pathways of Abnormal Tau and α-Synuclein Dissemination in Sporadic Alzheimer's and Parkinson's DiseasesPreprint

Braak, H., & Tredici, K. D. (2016) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a023630 · Cited by 129 · see citing works

Features of alpha-synuclein that could explain the progression and irreversibility of Parkinson's disease

Gallegos, S., Pacheco, C. R., Peters, C., Opazo, C., & Aguayo, L. G. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00059 · Cited by 128 · see citing works

Parkinson’s Disease–Associated LRRK2 Interferes with Astrocyte-Mediated Alpha-Synuclein Clearance

Streubel-Gallasch, L., Giusti, V., Sandre, M., Tessari, I., Plotegher, N., Giusto, E., Masato, A., Iovino, L., Battisti, I., Arrigoni, G., et al. (2021) · Molecular Neurobiology · doi:10.1007/s12035-021-02327-8 · Cited by 123 · see citing works

Alpha‐synuclein propagation: New insights from animal models

Dehay, B., Vila, M., Bézard, E., Brundin, P., & Kordower, J. H. (2015) · Movement Disorders · doi:10.1002/mds.26370 · Cited by 118 · see citing works

Principles of diffusion kurtosis imaging and its role in early diagnosis of neurodegenerative disorders

Arab, A., Wojna-Pelczar, A., Khairnar, A., Szabó, N., & Kučerová, J. (2018) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2018.01.015 · Cited by 116 · see citing works

Spreading of α-Synuclein and Tau: A Systematic Comparison of the Mechanisms Involved

Vasili, E., Dominguez‐Meijide, A., & Outeiro, T. F. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00107 · Cited by 117 · see citing works

The Interplay between Alpha-Synuclein Clearance and Spreading

da Fonseca, T. L., Villar‐Piqué, A., & Outeiro, T. F. (2015) · Biomolecules · doi:10.3390/biom5020435 · Cited by 110 · see citing works

α‐Synuclein: The Long Distance Runner

George, S., Rey, N. L., Reichenbach, N., Steiner, J. A., & Brundin, P. (2013) · Brain Pathology · doi:10.1111/bpa.12046 · Cited by 108 · see citing works

The prion-like spreading of α-synuclein: From in vitro to in vivo models of Parkinson’s disease

Vargas, J., Grudina, C., & Zurzolo, C. (2019) · Ageing Research Reviews · doi:10.1016/j.arr.2019.01.012 · Cited by 106 · see citing works

Temporal evolution of microglia and α-synuclein accumulation following foetal grafting in Parkinson’s disease

Olanow, C. W., Savolainen, M., Chu, Y., Halliday, G. M., & Kordower, J. H. (2019) · Brain · doi:10.1093/brain/awz104 · Cited by 112 · see citing works

Can Parkinson's disease pathology be propagated from one neuron to another?

Dunning, C. J. R., Reyes, J. F., Steiner, J. A., & Brundin, P. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.11.003 · Cited by 104 · see citing works

Alpha-Synuclein Targeting Therapeutics for Parkinson's Disease and Related Synucleinopathies

Menon, S. A., Armstrong, S. E. M., Hamzeh, A. M., Visanji, N. P., Sardi, S. P., & Tandon, A. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2022.852003 · Cited by 107 · see citing works

Cuminaldehyde as the Major Component of Cuminum cyminum , a Natural Aldehyde with Inhibitory Effect on Alpha‐Synuclein Fibrillation and Cytotoxicity

Morshedi, D., Aliakbari, F., Marvian, A. T., Fassihi, A., Pan-Montojo, F. J., & Pérez‐Sánchez, H. (2015) · Journal of Food Science · doi:10.1111/1750-3841.13016 · Cited by 103 · see citing works

Uptake and mitochondrial dysfunction of alpha-synuclein in human astrocytes, cortical neurons and fibroblasts

Braidy, N., Gai, W.-P., Xu, Y. H., Sachdev, P., Guillemin, G. J., Jiang, X.-M., Ballard, J. W. O., Horan, M. P., Fang, Z. M., Chong, B. H., et al. (2013) · Translational Neurodegeneration · doi:10.1186/2047-9158-2-20 · Cited by 91 · see citing works

LRRK2 and α-Synuclein: Distinct or Synergistic Players in Parkinson’s Disease?

O’Hara, D. M., Pawar, G. N., Kalia, S. K., & Kalia, L. V. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00577 · Cited by 84 · see citing works

Extracellular Vesicles for the Diagnosis and Treatment of Parkinson’s Disease

Upadhya, R., & Shetty, A. K. (2021) · Aging and Disease · doi:10.14336/ad.2021.0516 · Cited by 86 · see citing works

α-Synuclein-carrying extracellular vesicles in Parkinson’s disease: deadly transmitters

Chistiakov, D. A., & Chistiakov, A. A. (2016) · Acta Neurologica Belgica · doi:10.1007/s13760-016-0679-1 · Cited by 86 · see citing works

A cell culture model for monitoring α-synuclein cell-to-cell transfer

Reyes, J. F., Olsson, T. T., Lamberts, J. T., Devine, M. J., Kunath, T., & Brundin, P. (2014) · Neurobiology of Disease · doi:10.1016/j.nbd.2014.07.003 · Cited by 84 · see citing works

Rotenone induces regionally distinct α-synuclein protein aggregation and activation of glia prior to loss of dopaminergic neurons in C57Bl/6 mice

Rocha, S. M., Bantle, C. M., Aboellail, T., Chatterjee, D., Smeyne, R. J., & Tjalkens, R. B. (2022) · Neurobiology of Disease · doi:10.1016/j.nbd.2022.105685 · Cited by 83 · see citing works

Doxycycline Inhibits α-Synuclein-Associated Pathologies in Vitro and in Vivo

Dominguez-Meijide, A., Parrales, V., Vasili, E., González-Lizárraga, F., König, A., Lázaro, D. F., Lannuzel, A., Haik, S., Del Bel, E., Chehín, R., et al. (2021) · Neurobiology of Disease · doi:10.1016/j.nbd.2021.105256 · Cited by 81 · see citing works

Active immunization therapies for Parkinson's disease and multiple system atrophy

Schneeberger, A., Tierney, L., & Mandler, M. (2015) · Movement Disorders · doi:10.1002/mds.26377 · Cited by 81 · see citing works

The Contribution of α -Synuclein Spreading to Parkinson’s Disease Synaptopathy

Longhena, F., Faustini, G., Missale, C., Pizzi, M., Spano, P., & Bellucci, A. (2017) · Neural Plasticity · doi:10.1155/2017/5012129 · Cited by 81 · see citing works

Cellular mechanisms of protein aggregate propagation

Holmes, B. B., & Diamond, M. I. (2012) · Current Opinion in Neurology · doi:10.1097/wco.0b013e32835a3ee0 · Cited by 79 · see citing works

Dysbiosis of the gut microbiota and its effect on α-synuclein and prion protein misfolding: consequences for neurodegeneration

Mahbub, N. U., Islam, M. M., Hong, S., & Chung, H. (2024) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2024.1348279 · Cited by 88 · see citing works

Antidepressants reduce neuroinflammatory responses and astroglial alpha‐synuclein accumulation in a transgenic mouse model of multiple system atrophy

Valera, E., Ubhi, K. K., Mante, M., Rockenstein, E. M., & Masliah, E. (2013) · Glia · doi:10.1002/glia.22610 · Cited by 77 · see citing works

Αlpha-Synuclein as a Mediator in the Interplay between Aging and Parkinson’s Disease

Bobela, W., Aebischer, P., & Schneider, B. L. (2015) · Biomolecules · doi:10.3390/biom5042675 · Cited by 75 · see citing works

GABA transmission via ATP-dependent K + channels regulates α-synuclein secretion in mouse striatum

Emmanouilidou, E., Minakaki, G., Keramioti, M. V., Xylaki, M., Balafas, E., Chrysanthou‐Piterou, M., Kloukina, I., & Vekrellis, K. (2016) · Brain · doi:10.1093/brain/awv403 · Cited by 76 · see citing works

The pathology roadmap in Parkinson disease

Surmeier, D. J., & Sulzer, D. (2013) · Prion · doi:10.4161/pri.23582 · Cited by 74 · see citing works

Review: The future of cell therapies and brain repair: P arkinson's disease leads the way

Petit, G. H., Olsson, T. T., & Brundin, P. (2013) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12110 · Cited by 74 · see citing works

Spreading of α-synuclein in the face of axonal transport deficits in Parkinson's disease: A speculative synthesis

Lamberts, J. T., Hildebrandt, E. N., & Brundin, P. (2014) · Neurobiology of Disease · doi:10.1016/j.nbd.2014.07.002 · Cited by 74 · see citing works

How strong is the evidence that Parkinson's disease is a prion disorder?

Brundin, P., Ma, J., & Kordower, J. H. (2016) · Current Opinion in Neurology · doi:10.1097/wco.0000000000000349 · Cited by 72 · see citing works

The pathomechanisms underlying Parkinson's disease

Jellinger, K. A. (2014) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.2014.877842 · Cited by 69 · see citing works

Involvement of the immune system, endocytosis and EIF2 signaling in both genetically determined and sporadic forms of Parkinson's disease

Mutez, E., Nkiliza, A., Bélarbi, K., de Broucker, A., Vanbesien-Mailliot, C., Bleuse, S., Duflot, A., Comptdaer, T., Semaille, P., Blervaque, R., et al. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2013.11.007 · Cited by 69 · see citing works

Exocytosis and Spreading of Normal and Aberrant α‐Synuclein

Emmanouilidou, E., & Vekrellis, K. (2016) · Brain Pathology · doi:10.1111/bpa.12373 · Cited by 68 · see citing works

Presence of tau pathology within foetal neural allografts in patients with Huntington’s and Parkinson’s disease

Cisbani, G., Maxan, A., Kordower, J. H., Planel, E., Freeman, T. B., & Cicchetti, F. (2017) · Brain · doi:10.1093/brain/awx255 · Cited by 67 · see citing works

Trans-synaptic and retrograde axonal spread of Lewy pathology following pre-formed fibril injection in an in vivo A53T alpha-synuclein mouse model of synucleinopathy

Schaser, A. J., Stackhouse, T. L., Weston, L. J., Kerstein, P. C., Osterberg, V. R., López, C. S., Dickson, D. W., Luk, K. C., Meshul, C. K., Woltjer, R. L., et al. (2020) · Acta Neuropathologica Communications · doi:10.1186/s40478-020-01026-0 · Cited by 62 · see citing works

Deferiprone Rescues Behavioral Deficits Induced by Mild Iron Exposure in a Mouse Model of Alpha-Synuclein Aggregation

Carboni, E., Tatenhorst, L., Tönges, L., Barski, E., Dambeck, V., Bähr, M., & Lingor, P. (2017) · NeuroMolecular Medicine · doi:10.1007/s12017-017-8447-9 · Cited by 67 · see citing works

Review: Spreading the word: precise animal models and validated methods are vital when evaluating prion‐like behaviour of alpha‐synuclein

Rey, N. L., George, S., & Brundin, P. (2015) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12299 · Cited by 64 · see citing works

The Emerging Roles of Autophagy in Human Diseases

Lei, Y., & Klionsky, D. J. (2021) · Biomedicines · doi:10.3390/biomedicines9111651 · Cited by 66 · see citing works

Understanding the Role of Adenosine A2AR Heteroreceptor Complexes in Neurodegeneration and Neuroinflammation

Borroto‐Escuela, D. O., Hinz, S., Navarro, G., Franco, R., Müller, C. E., & Fuxé, K. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00043 · Cited by 66 · see citing works

The Hidden Cell-to-Cell Trail of α-Synuclein Aggregates

Neupane, S., Cecco, E. D., & Aguzzi, A. (2022) · Journal of Molecular Biology · doi:10.1016/j.jmb.2022.167930 · Cited by 66 · see citing works

Alpha-synuclein at the intracellular and the extracellular side: functional and dysfunctional implications

Ottolini, D., Calí, T., Szabó, I., & Brini, M. (2016) · Biological Chemistry · doi:10.1515/hsz-2016-0201 · Cited by 63 · see citing works

Found in Translation: The Utility of C. elegans Alpha-Synuclein Models of Parkinson’s Disease

Gaeta, A. L., Caldwell, K. A., & Caldwell, G. A. (2019) · Brain Sciences · doi:10.3390/brainsci9040073 · Cited by 65 · see citing works

Endogenous oligodendroglial alpha-synuclein and TPPP/p25α orchestrate alpha-synuclein pathology in experimental multiple system atrophy models

Mavroeidi, P., Arvanitaki, F., Karakitsou, A.-K., Vetsi, M., Kloukina, I., Zweckstetter, M., Giller, K., Becker, S., Sorrentino, Z. A., Giasson, B. I., et al. (2019) · Acta Neuropathologica · doi:10.1007/s00401-019-02014-y · Cited by 64 · see citing works

Autophagy in neuroinflammatory diseases

Muller, S., Brun, S., René, F., Seze, J. D., Loeffler, J., & Jeltsch‐David, H. (2017) · Autoimmunity Reviews · doi:10.1016/j.autrev.2017.05.015 · Cited by 63 · see citing works

What’s to like about the prion-like hypothesis for the spreading of aggregated α-synuclein in Parkinson disease?

Dunning, C. J. R., George, S., & Brundin, P. (2013) · Prion · doi:10.4161/pri.23806 · Cited by 63 · see citing works

Coordination and redox properties of copper interaction with α-synuclein

Valensin, D., Dell’Acqua, S., Kozłowski, H., & Casella, L. (2016) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2016.04.012 · Cited by 61 · see citing works

Impact of α-synuclein pathology on transplanted hESC-derived dopaminergic neurons in a humanized α-synuclein rat model of PD

Hoban, D. B., Shrigley, S., Mattsson, B., Breger, L. S., Jarl, U., Cardoso, T., Wahlestedt, J. N., Luk, K. C., Björklund, A., & Parmar, M. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2001305117 · Cited by 60 · see citing works

Current Limitations in the Treatment of Parkinson’s and Alzheimer’s Diseases: State-of-the-Art and Future Perspective of Polymeric Carriers

Tonda‐Turo, C., Origlia, N., Mattu, C., Accorroni, A., & Chiono, V. (2018) · Current Medicinal Chemistry · doi:10.2174/0929867325666180221125759 · Cited by 61 · see citing works

Specific Pesticide-Dependent Increases in α-Synuclein Levels in Human Neuroblastoma (SH-SY5Y) and Melanoma (SK-MEL-2) Cell Lines

Chorfa, A., Bétemps, D., Morignat, E., Lazizzera, C., Hogeveen, K. N., Andrieu, T., & Baron, T. (2013) · Toxicological Sciences · doi:10.1093/toxsci/kft076 · Cited by 57 · see citing works

Pathogenic Mutations Differentially Regulate Cell-to-Cell Transmission of α-Synuclein

Guan, Y., Zhao, X., Liu, F., Yan, S., Wang, Y., Du, C., Cui, X., Li, R., & Zhang, C. X. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00159 · Cited by 54 · see citing works

The role of glial autophagy in Alzheimer’s disease

Litwiniuk, A., Juszczak, G. R., Stankiewicz, A. M., & Urbańska, K. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02242-5 · Cited by 54 · see citing works

The Gut and Nonmotor Symptoms in Parkinson's Disease

Klingelhoefer, L., & Reichmann, H. (2017) · International review of neurobiology · doi:10.1016/bs.irn.2017.05.027 · Cited by 53 · see citing works

Neuropathology and pathogenesis of extrapyramidal movement disorders: a critical update—I. Hypokinetic-rigid movement disorders

Jellinger, K. A. (2019) · Journal of Neural Transmission · doi:10.1007/s00702-019-02028-6 · Cited by 55 · see citing works

Activated microglia facilitate the transmission of α-synuclein in Parkinson's disease

Zheng, T., & Zhang, Z. (2021) · Neurochemistry International · doi:10.1016/j.neuint.2021.105094 · Cited by 53 · see citing works

RT-QuIC and Related Assays for Detecting and Quantifying Prion-like Pathological Seeds of α-Synuclein

Srivastava, A., Alam, P., & Caughey, B. W. (2022) · Biomolecules · doi:10.3390/biom12040576 · Cited by 52 · see citing works

α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells

Hansen, C., Angot, E., Bergström, A.-L., Steiner, J. A., Pieri, L., Paul, G., Outeiro, T. F., Melki, R., Kallunki, P., Fog, K., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci43366 · Cited by 842 · see citing works

Transfer of host-derived alpha synuclein to grafted dopaminergic neurons in rat

Kordower, J. H., Dodiya, H. B., Kordower, A. M., Terpstra, B. T., Paumier, K. L., Madhavan, L., Sortwell, C. E., Steece‐Collier, K., & Collier, T. J. (2011) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.05.001 · Cited by 170 · see citing works

A cell culture model for monitoring α-synuclein cell-to-cell transfer

Reyes, J. F., Olsson, T. T., Lamberts, J. T., Devine, M. J., Kunath, T., & Brundin, P. (2014) · Neurobiology of Disease · doi:10.1016/j.nbd.2014.07.003 · Cited by 84 · see citing works

α-Synuclein Seeding in Dopaminergic Neurons Transplanted into the Putamen of Parkinson’s Disease PatientsPreprint

Duvernay, J. B., Killinger, B. A., Choi, S. G., Tittle, T., Bahrami, A., Tharp, M. E., Mercado, G., Chu, Y., Brundin, P., & Kordower, J. H. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.09.22.751740

Host-to-graft propagation of inoculated α-synuclein into transplanted human induced pluripotent stem cell-derived midbrain dopaminergic neurons

Gima, S., Oe, K., Nishimura, K., Ohgita, T., Ito, H., Kimura, H., Saito, H., & Takata, K. (2024) · Regenerative Therapy · doi:10.1016/j.reth.2023.12.019 · Cited by 9 · see citing works