Current applications and limitations of surgical treatments for movement disorders
Open accessAbstract
Functional neurosurgery for the treatment of both psychiatric and neurological disorders has been performed regularly since the 1940s. However, misuse in the early days and the appearance of effective medical treatments, such as levodopa and neuroleptic drugs, greatly reduced surgical approaches over several decades. The development of a comprehensive model of basal ganglia pathophysiology in the 1990s facilitated the resurgence of functional neurosurgery, mainly for the treatment of levodopa‐related motor complications in Parkinson's disease. This led first to the re‐emergence of posteroventral pallidotomy and subsequently to deep brain stimulation. Thirty years on from this turning point, we find ourselves looking at a new scenario. Although deep brain stimulation is accepted worldwide and technical advances continue to improve this therapy, new questions and challenges such as long‐term benefits and optimal targeting have emerged. In addition, new nonincisional tools used to perform ablative treatments, such as high‐intensity focused ultrasound and gamma‐knife, are challenging classical reluctance to therapeutic lesioning, and it remains to be determined how these approaches will fit into the array of movement disorder treatments. This review discusses the current clinical state of the art of functional neurosurgery in the treatment of Parkinson's disease, tremor, and dystonia. © 2017 International Parkinson and Movement Disorder Society
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Surgery, deep brain stimulation, and focused ultrasound are effective second-line treatments for tremor.
“In summary, surgery, DBS, and focused ultrasound are effective second-line treatments (50–52).”
From A Review on Wearable Technologies for Tremor Suppression (2021) · cites this paper as [51]
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InfluentialSelf-citationLeksell's posteroventral pallidotomy in the treatment of Parkinson's disease.
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BackgroundSubthalamic nucleus deep brain stimulation: Summary and meta-analysis of outcomes
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InfluentialStimulation of the Subthalamic Nucleus Changes the Firing Pattern of Pallidal Neurons
Hashimoto, T., Elder, C. M., Okun, M., Patrick, S. K., & Vitek, J. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-05-01916.2003 · Cited by 925 · cited 1× · see citing works
“Thus, from Benabid s initial suggestion of a “jamming” effect,(21) it evolved to a dual mechanism of excitation of axons and inhibition of cell bodies and, more recently, to a switching of aberrant neuronal activity into a more physiological neuronal pattern.(22) Today, the technological progress in DBS is still rapid.”
BackgroundA pilot study of focused ultrasound thalamotomy for essential tremor.
Elias, W., Huss, D., Voss, T., Loomba, J., Khaled, M., Zadicario, E., Frysinger, R. C., Sperling, S., Wylie, S., Monteith, S., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1300962 · Cited by 833 · cited 3× · see citing works
“Recently there have been developments in the ablative treatment of movement disorders, involving newer techniques such as gamma-knife and highintensity focused ultrasound, which do not require open skull surgery and are, therefore, non-incisional and much less invasive.(83,152,153) When compared with ablative surgery,…”
BackgroundInfluentialOdekerken, V., van Laar, T., Staal, M., Mosch, A., Hoffmann, C., Nijssen, P., Beute, G., van Vugt, J. V., Lenders, M., Contarino, M., et al. (2013) · Lancet Neurology · doi:10.1016/s1474-4422(12)70264-8 · Cited by 775 · cited 10× · see citing works
“Improvement in the quality of life was also found for GPi-DBS.16,17 Off-drug motor UPDRS scores were reduced by 36% to 53% with STN-DBS (see Table 1).15,38-40 A statistically significant but clinically minor improvement in parkinsonism was also found in the on-stimulation/on-medication condition in 2 studies using pat…”
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“Although best medical treatment resulted in no change in PDQ-39 scores, STN-DBS patients experienced a significant improvement in the quality of life when compared with baseline.(15,38,40) It is worth noting that STN-DBS has recently been shown(41) to be more cost-effective than best medical treatment when performed o…”
BackgroundResultInfluentialSubthalamic nucleus or internal pallidal stimulation in young onset Parkinson's disease.
Krack, P., Pollak, P., Limousin, P., Hoffmann, D., Xie, J., Benazzouz, A., & Benabid, A. (1998) · Brain : a journal of neurology · doi:10.1093/brain/121.3.451 · Cited by 649 · cited 5× · see citing works
“A more limited number of early publications on GPiDBS in PD, which also provide evidence of positive outcomes, are available.(29,31,35,36) UPDRS III score improvements varied from 39% to 56%.”
BackgroundResultInfluentialSelf-citationMR-guided focused ultrasound thalamotomy for essential tremor: a proof-of-concept study
Lipsman, N., Schwartz, M. L., Huang, Y., Lee, L., Sankar, T., Chapman, M., Hynynen, K., & Lozano, A. M. (2013) · The Lancet Neurology · doi:10.1016/s1474-4422(13)70048-6 · Cited by 604 · cited 2× · see citing works
“Recently there have been developments in the ablative treatment of movement disorders, involving newer techniques such as gamma-knife and highintensity focused ultrasound, which do not require open skull surgery and are, therefore, non-incisional and much less invasive.(83,152,153) When compared with ablative surgery,…”
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“These were often an exacerbation of pre-existing cognitive deterioration or behavioral disorders.(131,132) Many neuropsychiatric side effects are difficult to evaluate.”
BackgroundMechanisms of deep brain stimulation
Herrington, T. M., Cheng, J. J., & Eskandar, E. N. (2016) · Journal of Neurophysiology · doi:10.1152/jn.00281.2015 · Cited by 551 · see citing works
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“…6 months 71 ND 41a ND 56 71 87.5 67.4 Thobois et al (2002)32 18 6 months 55 ND ND ND 65.5 ND Vesper et al (2002)33 38 12 months 48.5 35 72b ND 53 ND Anderson et al (2005)29 10 12 months 48 ND 62a ND 38 44 89 48 Kleiner-Fisman et al (2006)167 (meta-analysis) 921 14.8 months (mean) 52 ND 68.2 69.1…”
BackgroundInfluentialExenatide and the treatment of patients with Parkinson's disease
Aviles-Olmos, I., Dickson, J., Kefalopoulou, Z., Djamshidian, A., Ell, P., Soderlund, T., Whitton, P., Wyse, R., Isaacs, T., Lees, A., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci68295 · Cited by 529 · cited 1× · see citing works
“Indeed, long-term follow-up studies of DBS indicate that cognitive decline after surgery is part of the natural evolution of the disease rather than a side effect of stimulation.(46,53,55,130) The overall preference of the STN over the GPi resulted in a growing number of reports on STN-DBS–related cognitive and behavi…”
BackgroundThobois, S., Ardouin, C., Lhommée, E., Klinger, H., Lagrange, C., Xie, J., Fraix, V., Braga, M.-C. C., Hassani, R., Kistner, A., et al. (2010) · Brain · doi:10.1093/brain/awq032 · Cited by 519 · cited 1× · see citing works
“It has, for instance, been shown that postoperative apathy is related to the withdrawal of dopaminergic treatment and can be reversed with its reinstatement.(141,142) STN-DBS has been shown to improve nonmotor fluctuations, which can be the main disability in a subgroup of patients.”
BackgroundSelf-citationMulticentre European study of thalamic stimulation in parkinsonian and essential tremor
Limousin, P., Speelman, J., Gielen, F., & Janssens, M. (1999) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.66.3.289 · Cited by 506 · cited 3× · see citing works
“Finally, Vim-DBS has been shown to elicit improvements of around 90% in tremor scores in PD, achieving total tremor suppression in many cases.(8,61,62) Follow-ups lasting 3 to 7 years demonstrated that this benefit was sustained (class III studies, grade of recommendation C).”
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A multicentre study on suicide outcomes following subthalamic stimulation for Parkinson's disease.
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“Indeed, long-term follow-up studies of DBS indicate that cognitive decline after surgery is part of the natural evolution of the disease rather than a side effect of stimulation.(46,53,55,130) The overall preference of the STN over the GPi resulted in a growing number of reports on STN-DBS–related cognitive and behavi…”
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“began to rehabilitate Leksell s pallidotomy, targeting the postero-ventral part of the globus pallidus internus (GPi), which had been associated with the alleviation of akinesia and rigidity in parkinsonism before the advent of levodopa.(2) Their 1992 publication showing major alleviation not only of the parkinsonian…”
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Motor and cognitive outcome in patients with Parkinson's disease 8 years after subthalamic implants.
Fasano, A., Romito, L., Daniele, A., Piano, C., Zinno, M., Bentivoglio, A., & Albanese, A. (2010) · Brain : a journal of neurology · doi:10.1093/brain/awq221 · Cited by 428 · cited 1× · see citing works
“…ND 54.4 59 74 66 Romito et al (2009)52 20 5 years 54.2 ND 80b1e ND 61.9 41 95 56.2 Moro et al (2010)53 35 5-6 years 50.5 ND 67a ND 46 30.8 81.1 59.1 Fasano et al (2010)54 20 8 years 39 ND ND ND 60.3 26.4 73 49 Zibetti et al (2011)55 14 >9 years 42 64% 65b ND 39 41.6 71.4 43.3 76.5e Castrioto et al…”
InfluentialVidailhet, M., Vercueil, L., Houeto, J., Krystkowiak, P., Lagrange, C., Yelnik, J., Bardinet, É., Benabid, A., Navarro, S., Dormont, D., et al. (2007) · Lancet Neurology · doi:10.1016/s1474-4422(07)70035-2 · Cited by 428 · cited 2× · see citing works
“These findings were corroborated in the 3- and 5-year extensions of both trials.(111,112) Open-label studies with follow-ups of up to 10 years showed sustained benefits in motor features for generalized, segmental, and focal dystonia as well as improvements in disability and quality of life.”
BackgroundResultStimulation of the subthalamic nucleus in Parkinson's disease: a 5 year follow up
Schüpbach, M. W. M. (2005) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2005.063206 · Cited by 419 · see citing works
Ten-year outcome of subthalamic stimulation in Parkinson disease: a blinded evaluation.
Castrioto, A., Lozano, A., Poon, Y., Lang, A., Fallis, M., & Moro, E. (2011) · Archives of Neurology · doi:10.1001/archneurol.2011.182 · Cited by 411 · cited 1× · see citing works
“…30.8 81.1 59.1 Fasano et al (2010)54 20 8 years 39 ND ND ND 60.3 26.4 73 49 Zibetti et al (2011)55 14 >9 years 42 64% 65b ND 39 41.6 71.4 43.3 76.5e Castrioto et al (2011)56 18 10 years 22.8 47% 62.5b ND 36.3 8 77 41.4 85e Weaver et al (2012)42 70 3 years 30 ND 75b1e 8.5 35.6 19.5 75 39…”
InfluentialOkun, M., Gallo, B. V., Mandybur, G., Jagid, J., Foote, K., Revilla, F., Alterman, R., Jankovic, J., Simpson, R., Junn, F., et al. (2012) · Lancet Neurology · doi:10.1016/s1474-4422(11)70308-8 · Cited by 380 · cited 3× · see citing works
“…78 6 months 41 68 54a 25 49 ND Williams et al (2010)38 183 1 year 36 ND 50b 14 35 ND Follet et al (2010)16 147 2 years 25 42.4 65c 9 31.5 ND Okun et al (2012)39 101 3 months 39 ND 50d ND 37.5 ND Odekerken et al (2013)17 63 24 months 45 24 23c 20 44 ND Schuepbach et al (2013)40 124 24…”
BackgroundResultInfluentialLong-term evaluation of deep brain stimulation of the thalamus
Pahwa, R., Lyons, K. E., Wilkinson, S. B., Simpson, R. K., Ondo, W. G., Tarsy, D., Norregaard, T., Hubble, J. P., Smith, D. A., Hauser, R. A., et al. (2006) · Journal of Neurosurgery · doi:10.3171/jns.2006.104.4.506 · Cited by 377 · cited 3× · see citing works
“Pahwa et al (2006)67 9 unilateral 5 bilateral 5 years 82% improvement in contralateral tremor, improvement of 90%- 100% in bilaterally treated patients.”
BackgroundZesiewicz, T. A., Elble, R., Louis, E. D., Hauser, R. A., Sullivan, K. L., Dewey, R. B., Ondo, W. G., Gronseth, G. S., & Weiner, W. J. (2005) · Neurology · doi:10.1212/01.wnl.0000163769.28552.cd · Cited by 371 · cited 2× · see citing works
“Gamma-knife radiosurgery Zesiewicz et al (2005)84 (systematic review) 61 unilateral multiple 70% to 85% improvement in CRST. Lim et al (2010)139 11 unilateral 6 months No improvement in the motor part of FTM, significant reduction (13.7”
BackgroundInfluentialOpposite motor effects of pallidal stimulation in Parkinson's disease
Krack, P., Pollak, P., Limousin, P., Hoffmann, D., Benazzouz, A., Bas, J. L., Koudsie, A., & Benabid, A. (1998) · Annals of Neurology · doi:10.1002/ana.410430208 · Cited by 358 · cited 2× · see citing works
“…55.9 Foltynie et al (2011)34 79 12 months 52 ND 55b1e 18 ND ND Gpi-DBS studies Volkmann et al (1998)35 9 3 months 55.8 ND 84.6a ND 12 48 71.4 62.5 Krack et al (1998)31 5 6 months 39 ND 82a ND 1 29 30 60 51 Ghika et al (1998)36 6 24 months 50 75 29b1c ND 12 14.1 >90 32 Anderson et al (2005)29 10…”
InfluentialSelf-citationVolkmann, J., Wolters, A., Kupsch, A., Müller, J., Kühn, A., Schneider, G., Poewe, W., Hering, S., Eisner, W., Müller, J., et al. (2012) · Lancet Neurology · doi:10.1016/s1474-4422(12)70257-0 · Cited by 348 · cited 2× · see citing works
“Volkmann et al (2012)112 38 bilateral DBS for primary d. 5 years 57.8% reduction in the motor score of the BFMDRS and 47% in the disability score.”
BackgroundResultInfluentialBehavioural disorders, Parkinson's disease, and subthalamic stimulation
Brown, R. G. (2002) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.72.6.689 · Cited by 314 · cited 1×
“These were often an exacerbation of pre-existing cognitive deterioration or behavioral disorders.(131,132) Many neuropsychiatric side effects are difficult to evaluate.”
BackgroundKoller, W. C., Lyons, K., Wilkinson, S., Tröster, A., & Pahwa, R. (2001) · Movement Disorders · doi:10.1002/mds.1089 · Cited by 312 · see citing works
Vidailhet, M., Yelnik, J., Lagrange, C., Fraix, V., Grabli, D., Thobois, S., Burbaud, P., Welter, M., Xie-Brustolin, J., Braga, M., et al. (2009) · Lancet Neurology · doi:10.1016/s1474-4422(09)70151-6 · Cited by 311 · see citing works
Self-citationLong‐term efficacy of thalamic deep brain stimulation for tremor: Double‐blind assessments
Rehncrona, S., Johnels, B., Widner, H., Törnqvist, A., Hariz, M., & Sydow, O. (2003) · Movement Disorders · doi:10.1002/mds.10309 · Cited by 307 · cited 1× · see citing works
“Rehncrona et al (2003)64 12 unilateral 6-7 years 65% improvement of UPDRS III subitems for tremor in the hemi- body treated.”
BackgroundPallidal stimulation for Parkinson's disease
Bejjani, B., Damier, P., Arnulf, I., Bonnet, A., Vidailhet, M., Dormont, D., Pidoux, B., Cornu, P., Marsault, C., & Agid, Y. (1997) · Neurology · doi:10.1212/wnl.49.6.1564 · Cited by 298
Axial disability and deep brain stimulation in patients with Parkinson disease
Fasano, A., Aquino, C., Krauss, J., Honey, C., & Bloem, B. (2015) · Nature Reviews Neurology · doi:10.1038/nrneurol.2014.252 · Cited by 296 · see citing works
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Mood and behavioural effects of subthalamic stimulation in Parkinson's disease.
Castrioto, A., Lhommée, E., Moro, E., & Krack, P. (2014) · Lancet Neurology · doi:10.1016/s1474-4422(13)70294-1 · Cited by 288 · see citing works
Self-citationSubthalamotomy in parkinsonian monkeys. Behavioural and biochemical analysis.
Guridi, J., Herrero, M., Luquin, M., Guillén, J., Ruberg, M., Laguna, J., Vila, M., Javoy-Agid, F., Agid, Y., Hirsch, E., et al. (1996) · Brain : a journal of neurology · doi:10.1093/brain/119.5.1717 · Cited by 287 · see citing works
Self-citationHamani, C., Richter, E. O., Schwalb, J., & Lozano, A. (2005) · Neurosurgery · doi:10.1227/01.neu.0000159714.28232.c4 · Cited by 286 · cited 1× · see citing works
“There was a 9% incidence of hardware-related adverse events (infections, lead and pulse generator problems).(44) In a series of 1096 patients from the 6 largest available controlled studies on STN and GPi, fatal outcomes related to hemorrhage (0.”
BackgroundSubthalamic stimulation in Parkinson's disease: restoring the balance of motivated behaviours.
Lhommée, E., Klinger, H., Thobois, S., Schmitt, E., Ardouin, C., Bichon, A., Kistner, A., Fraix, V., Xie, J., Aya-Kombo, M., et al. (2012) · Brain : a journal of neurology · doi:10.1093/brain/aws078 · Cited by 283 · see citing works
Self-citationLong-term follow-up of unilateral pallidotomy in advanced Parkinson's disease.
Fine, J., Duff, J., Chen, R., Chir, B., Hutchison, W., Lozano, A., & Lang, A. (2000) · New England Journal of Medicine · doi:10.1056/nejm200006083422304 · Cited by 279 · see citing works
MRI-guided STN DBS in Parkinson's disease without microelectrode recording: efficacy and safety
Foltynie, T., Zrinzo, L., Martínez-Torres, I., Tripoliti, E., Petersen, E., Holl, E., Avilés-Olmos, I., Jahanshahi, M., Hariz, M., & Limousin, P. (2010) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2010.205542 · Cited by 278 · cited 1× · see citing works
“…et al (2005)29 10 12 months 48 ND 62a ND 38 44 89 48 Kleiner-Fisman et al (2006)167 (meta-analysis) 921 14.8 months (mean) 52 ND 68.2 69.1 34.5 55.9 Foltynie et al (2011)34 79 12 months 52 ND 55b1e 18 ND ND Gpi-DBS studies Volkmann et al (1998)35 9 3 months 55.8 ND 84.6a ND 12 48 71.4 62.5 Krack…”
InfluentialMulticentre European study of thalamic stimulation in essential tremor: a six year follow up
Sydow, O., Thobois, S., Alesch, F., & Speelman, J. (2003) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.74.10.1387 · Cited by 269 · see citing works
Mania following deep brain stimulation for Parkinson's disease.
Kulisevsky, J., Berthier, M., Gironell, A., Pascual-Sedano, B., Molet, J., & Parés, P. (2002) · Neurology · doi:10.1212/wnl.59.9.1421 · Cited by 267 · see citing works
Funkiewiez, A., Ardouin, C., Krack, P., Fraix, V., Blercom, N. V., Xie, J., Moro, E., Benabid, A., & Pollak, P. (2003) · Movement Disorders · doi:10.1002/mds.10441 · Cited by 266 · see citing works
Self-citationGhika, J., Villemure, J., Fankhauser, H., Favre, J., Assal, G., & Ghika-Schmid, F. (1998) · Journal of Neurosurgery · doi:10.3171/jns.1998.89.5.0713 · Cited by 265 · cited 2× · see citing works
“A more limited number of early publications on GPiDBS in PD, which also provide evidence of positive outcomes, are available.(29,31,35,36) UPDRS III score improvements varied from 39% to 56%.”
BackgroundInfluentialLong‐term results of bilateral pallidal stimulation in Parkinson's disease
Volkmann, J., Allert, N., Voges, J., Sturm, V., Schnitzler, A., & Freund, H. (2004) · Annals of Neurology · doi:10.1002/ana.20091 · Cited by 263 · cited 3×
“…18 45.1 16.5 73.9 45.2 12 8-11 years 26.5 ND 52.3b1e 1.5 48.6 23.2 77.2 50 Odekerken et al (2016)43 63 3 years 31.7 ND ND ND 51.7 ND GPi-DBS studies Volkmann et al (2004)58 11 5 years 27.9 83 70a ND 21 12 29 47.6 Rodriguez-Oroz et al (2005)48 20 3-4 years 39 45 72a ND Unchanged 29.5 85 38 Moro et…”
BackgroundInfluentialParkinsonian apathy responds to dopaminergic stimulation of D2/D3 receptors with piribedil.
Thobois, S., Lhommée, E., Klinger, H., Ardouin, C., Schmitt, E., Bichon, A., Kistner, A., Castrioto, A., Xie, J., Fraix, V., et al. (2013) · Brain : a journal of neurology · doi:10.1093/brain/awt067 · Cited by 258 · see citing works
Self-citationRandomized trial of pallidotomy versus medical therapy for Parkinson's disease
Vitek, J., Bakay, R., Freeman, A., Evatt, M., Green, J., McDonald, W., Haber, M., Barnhart, H., Wahlay, N., Triche, S. D., et al. (2003) · Annals of Neurology · doi:10.1002/ana.10517 · Cited by 257 · see citing works
Pathological gambling after bilateral subthalamic nucleus stimulation in Parkinson disease
Smeding, H., Goudriaan, A., Foncke, E., Schuurman, P., Speelman, J., & Schmand, B. (2006) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2006.102061 · Cited by 245 · see citing works
Bilateral high‐frequency stimulation of the internal globus pallidus in advanced Parkinson's disease
Volkmann, J., Sturm, V., Weiss, P. H., Kappler, J., Voges, J., Koulousakis, A., Lehrke, R., Hefter, H., & Freund, H.-J. (1998) · Annals of Neurology · doi:10.1002/ana.410440615 · Cited by 244 · cited 2× · see citing works
“A more limited number of early publications on GPiDBS in PD, which also provide evidence of positive outcomes, are available.(29,31,35,36) UPDRS III score improvements varied from 39% to 56%.”
BackgroundInfluentialSubthalamic nucleus deep brain stimulation in primary cervical dystonia
Ostrem, J., Racine, C., Glass, G. A., Grace, J., Volz, M., Heath, S., & Starr, P. (2011) · Neurology · doi:10.1212/wnl.0b013e31820f2e4f · Cited by 241 · cited 1× · see citing works
“STN-DBS studies Ostrem et al (2011)118 9 bilateral 12 months 62.9% reduction in TWSTRS scores for the assessment of cervical dystonia.”
BackgroundInfluentialFirst experience with MR-guided focused ultrasound in the treatment of Parkinson's disease
Magara, A. E., Bühler, R., Moser, D., Kowalski, M., Pourtehrani, P., & Jeanmonod, D. (2014) · Journal of Therapeutic Ultrasound · doi:10.1186/2050-5736-2-11 · Cited by 239 · see citing works
Hardware-Related Complications of Deep Brain Stimulation: A Review of the Published Literature
Hamani, C., & Lozano, A. (2006) · Stereotactic and Functional Neurosurgery · doi:10.1159/000096499 · Cited by 225 · see citing works
Bilateral subthalamotomy in Parkinson's disease: initial and long-term response.
Alvarez, L., Macias, R., López, G., Alvarez, E., Pavón, N., Rodríguez-Oroz, M., Juncos, J., Maragoto, C., Guridi, J., Litvan, I., et al. (2005) · Brain : a journal of neurology · doi:10.1093/brain/awh397 · Cited by 221 · cited 3× · see citing works
“Such risks may be minimized by staged rather than simultaneous lesioning.(89) Hemichorea and even hemiballism are often observed while inducing a STN lesion, but this typically disappears with short-term evolution.”
BackgroundSelf-citationDoes subthalamic nucleus stimulation induce apathy in Parkinson’s disease?
Drapier, D., Drapier, S., Sauleau, P., Haegelen, C., Raoul, S., Biseul, I., Péron, J., Lallement, F., Rivier, I., Reymann, J., et al. (2006) · Journal of Neurology · doi:10.1007/s00415-006-0177-0 · Cited by 220 · see citing works
Chang, W. S., Jung, H. H., Kweon, E. J., Zadicario, E., Rachmilevitch, I., & Chang, J. W. (2015) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp-2014-307642 · Cited by 219 · see citing works
Beyond nine years of continuous subthalamic nucleus deep brain stimulation in Parkinson's disease
Zibetti, M., Merola, A., Rizzi, L., Ricchi, V., Angrisano, S., Azzaro, C., Artusi, C., Arduino, N., Marchisio, A., Lanotte, M., et al. (2011) · Movement Disorders · doi:10.1002/mds.23903 · Cited by 212 · cited 2× · see citing works
“Indeed, long-term follow-up studies of DBS indicate that cognitive decline after surgery is part of the natural evolution of the disease rather than a side effect of stimulation.(46,53,55,130) The overall preference of the STN over the GPi resulted in a growing number of reports on STN-DBS–related cognitive and behavi…”
BackgroundInfluentialDeep brain stimulation in the posterior subthalamic area in the treatment of essential tremor
Blomstedt, P., Sandvik, U., & Tisch, S. (2010) · Movement Disorders · doi:10.1002/mds.22758 · Cited by 210 · cited 1× · see citing works
“Recent studies have suggested that this region might be a better surgical target than the thalamic Vim itself.(108,109) The rationale here, according with MRI DTI tractography, is to impact the cerebellothalamic tract, which is intimately involved in tremor pathogenesis and runs throughout the posterior subthalamic re…”
BackgroundLong-term follow-up of thalamic deep brain stimulation for essential and parkinsonian tremor
Kumar, R., Lozano, A. M., Sime, E., & Lang, A. E. (2003) · Neurology · doi:10.1212/01.wnl.0000096012.07360.1c · Cited by 210 · cited 1× · see citing works
“Kumar et al (2003)65 7 unilateral 5 years Contralateral arm tremor scores improved by 86%.”
BackgroundThalamic deep brain stimulation in the treatment of essential tremor: a long-term follow-up
Blomstedt, P., Hariz, G.-M., Hariz, M. I., & Koskinen, L.-O. D. (2007) · British Journal of Neurosurgery · doi:10.1080/02688690701552278 · Cited by 207 · see citing works
Long‐term follow‐up of thalamic stimulation versus thalamotomy for tremor suppression
Schuurman, P., Bosch, D. A., Merkus, M., & Speelman, J. (2008) · Movement Disorders · doi:10.1002/mds.22059 · Cited by 206 · cited 3× · see citing works
“Schuurman et al (2008)69 17 patients 5 years Total abolition of tremor in 70% of patients at 5 years.”
BackgroundTisch, S., Zrinzo, L., Limousin, P., Bhatia, K., Quinn, N., Ashkan, K., & Hariz, M. (2007) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2006.109694 · Cited by 203 · cited 1× · see citing works
“device malfunction or infection except for stimulationinduced dysarthria and the appearance of akinesia in some patients.(117) There is also some evidence of the efficacy of STN stimulation in the treatment of different types of dystonia(118,119); however, its possible therapeutic effect is still under debate.”
BackgroundBilateral subthalamic nucleus stimulation in advanced Parkinson’s disease: Five year follow-up
Gervais-Bernard, H., Xie-Brustolin, J., Mertens, P., Polo, G., Klinger, H., Adamec, D., Broussolle, E., & Thobois, S. (2009) · Journal of Neurology · doi:10.1007/s00415-009-0076-2 · Cited by 196 · cited 1× · see citing works
“…when compared with baseline, % UPDRS III (off medication) Off-time Dyskinesia (on med) QoL Decrease in LDEAkinesia Tremor Rigidity 22.2 67.3 44.8 Gervais-Bernard et al (2009)51 23 5 years 55 ND ND ND 54.4 59 74 66 Romito et al (2009)52 20 5 years 54.2 ND 80b1e ND 61.9 41 95 56.2 Moro et al…”
InfluentialLong-term results of thalamic deep brain stimulation for essential tremor: Clinical article
Zhang, K., Bhatia, S., Oh, M. Y., Cohen, D., Angle, C., & Whiting, D. (2010) · Journal of Neurosurgery · doi:10.3171/2009.10.jns09371 · Cited by 190 · see citing works
Unilateral subthalamotomy in the treatment of Parkinson's disease.
Patel, N., Heywood, P., O'Sullivan, K., Mccarter, R., Love, S., & Gill, S. (2003) · Brain : a journal of neurology · doi:10.1093/brain/awg111 · Cited by 189 · cited 1× · see citing works
“Nevertheless, subthalamotomy was performed in some open trials and was shown to induce marked improvement without necessarily causing severe dyskinesia.(88,89) Over the following years, lesion topography varied and could include the whole subthalamic area or be limited to the smallest possible area of the sensorimotor…”
BackgroundAvilés-Olmos, I., Kefalopoulou, Z., Tripoliti, E., Candelario, J., Akram, H., Martínez-Torres, I., Jahanshahi, M., Foltynie, T., Hariz, M., Zrinzo, L., et al. (2014) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2013-306907 · Cited by 186 · cited 1× · see citing works
“…76.5e Castrioto et al (2011)56 18 10 years 22.8 47% 62.5b ND 36.3 8 77 41.4 85e Weaver et al (2012)42 70 3 years 30 ND 75b1e 8.5 35.6 19.5 75 39 Aviles-Olmos et al (2014)57 42 5 years 33 ND 61.4b1e 18 45.1 16.5 73.9 45.2 12 8-11 years 26.5 ND 52.3b1e 1.5 48.6 23.2 77.2 50 Odekerken et al…”
InfluentialUnilateral pallidotomy in Parkinson's disease: a randomised, single-blind, multicentre trial.
de Bie, R. D., de Haan, R., Nijssen, P., Rutgers, A., Beute, G., Bosch, D., Haaxma, R., Schmand, B. A., Schuurman, P., Staal, M., et al. (1999) · The Lancet · doi:10.1016/s0140-6736(99)03556-4 · Cited by 181 · see citing works
The safety and efficacy of thalamic deep brain stimulation in essential tremor: 10 years and beyond
Baizabal-Carvallo, J. F., Kagnoff, M. N., Jimenez-Shahed, J., Fekete, R., & Jankovic, J. (2014) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp-2013-304943 · Cited by 181 · cited 1× · see citing works
“The rate of improvement when compared with baseline and Offstimulation state ranges from about a 40% reduction in tremor scores to complete tremor suppression, resulting in clinically significant improvements in disability and quality of life.(61,67,99-101,103) Bilateral procedures improve tremor to a similar extent o…”
BackgroundSubthalamic nucleus stimulation in Parkinson's disease
Thobois, S., Mertens, P., Guénot, M., Hermier, M., Mollion, H., Bouvard, M., Chazot, G., Broussolle, E., & Sindou, M. (2002) · Journal of Neurology · doi:10.1007/s004150200059 · Cited by 172 · cited 1× · see citing works
“…ND 50 55.8 67.6 80.4 Kumar et al (1998)30 7 6 months 65.2 65 85a ND 40 56.9 87.4 62.7 Krack et al (1998)31 8 6 months 71 ND 41a ND 56 71 87.5 67.4 Thobois et al (2002)32 18 6 months 55 ND ND ND 65.5 ND Vesper et al (2002)33 38 12 months 48.5 35 72b ND 53 ND Anderson et al (2005)29 10 12 months…”
InfluentialParkinson's Disease, the Subthalamic Nucleus, Inhibition, and Impulsivity
Jahanshahi, M., Obeso, I., Baunez, C., Alegre, M., & Krack, P. (2015) · Movement Disorders · doi:10.1002/mds.26049 · Cited by 168 · see citing works
Self-citationTimmermann, L., Jain, R., Chen, L., Maarouf, M., Barbe, M., Allert, N., Brücke, T., Kaiser, I., Beirer, S., Sejio, F., et al. (2015) · Lancet Neurology · doi:10.1016/s1474-4422(15)00087-3 · Cited by 167 · see citing works
Alvarez, L., Macías, R., Pavón, N., López, G., Rodríguez-Oroz, M., Rodriguez, R., Alvarez, M., Pedroso, I., Teijeiro, J., Fernández, R., et al. (2009) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2008.154948 · Cited by 160 · cited 2×
“This was severe enough in 8 of the total sample of 89 patients (9%) to require pallidotomy in a second operation.(95)”
BackgroundSelf-citationSamuel, M., Caputo, E., Brooks, D., Schrag, A., Scaravilli, T., Branston, N., Rothwell, J., Marsden, C., Thomas, D. G. T., Lees, A., et al. (1998) · Brain : a journal of neurology · doi:10.1093/brain/121.1.59 · Cited by 160
Long‐term follow‐up of DYT1 dystonia patients treated by deep brain stimulation: An open‐label study
Cif, L., Vasques, X., González, V., Ravel, P., Biolsi, B., Collod‐Béroud, G., Tuffery‐Giraud, S., Fertit, H. E., Claustres, M., & Coubes, P. A. (2010) · Movement Disorders · doi:10.1002/mds.22802 · Cited by 157 · cited 1× · see citing works
“Cif et al (2010)115 18 bilateral 8 double bilateral 10 years 59.5% improvement in the motor part of the BFMDRS, 50% improvement in disability at final follow-up.”
BackgroundInfluentialGuridi, J., & Obeso, J. (2001) · Brain : a journal of neurology · doi:10.1093/brain/124.1.5 · Cited by 155 · see citing works
Self-citationPepper, J., Zrinzo, L., Mirza, B., Foltynie, T., Limousin, P., & Hariz, M. (2012) · Stereotactic and Functional Neurosurgery · doi:10.1159/000343202 · Cited by 154 · see citing works
Multicentre European study of thalamic stimulation for parkinsonian tremor: a 6 year follow-up
Hariz, M., Krack, P., Alesch, F., Augustinsson, L., Bosch, A., Ekberg, R., Johansson, F., Johnels, B., Meyerson, B., N'guyen, J., et al. (2007) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2007.118653 · Cited by 154 · cited 1× · see citing works
“Hariz et al (2008)68 30 unilateral 8 bilateral 6.6 years At final follow-up there was a 93% improvement in tremor on the treated body side when compared with baseline, and 82% improvement for the on versus off DBS assessment.”
BackgroundInfluentialSelf-citationHamel, W., Herzog, J., Kopper, F., Pinsker, M., Weinert, D., Müller, D., Krack, P., Deuschl, G., & Mehdorn, H. (2007) · Acta Neurochirurgica · doi:10.1007/s00701-007-1230-1 · Cited by 151 · cited 1× · see citing works
“Recent studies have suggested that this region might be a better surgical target than the thalamic Vim itself.(108,109) The rationale here, according with MRI DTI tractography, is to impact the cerebellothalamic tract, which is intimately involved in tremor pathogenesis and runs throughout the posterior subthalamic re…”
BackgroundSelf-citationA prospective single-blind study of Gamma Knife thalamotomy for tremor
Witjas, T., Carron, R., Krack, P., Eusebio, A., Vaugoyeau, M., Hariz, M., Azulay, J., & Régis, J. (2015) · Neurology · doi:10.1212/wnl.0000000000002087 · Cited by 148 · cited 2× · see citing works
“Recently there have been developments in the ablative treatment of movement disorders, involving newer techniques such as gamma-knife and highintensity focused ultrasound, which do not require open skull surgery and are, therefore, non-incisional and much less invasive.(83,152,153) When compared with ablative surgery,…”
BackgroundMethodInfluentialSelf-citationSTN vs. GPi Deep Brain Stimulation: Translating the Rematch into Clinical Practice
Williams, N. R., Foote, K., & Okun, M. (2014) · Movement Disorders Clinical Practice · doi:10.1002/mdc3.12004 · Cited by 148 · cited 1× · see citing works
“The choice between GPi and STN-DBS in advanced PD is still a source of controversy.(121) The first comparison between STN and GPi-DBS was made in the early years of DBS in a small group of patients (STN 5 8; GPi 5 5).”
Gamma knife thalamotomy for Parkinson disease and essential tremor: a prospective multicenter study.
Ohye, C., Higuchi, Y., Shibazaki, T., Hashimoto, T., Koyama, T., Hirai, T., Matsuda, S., Serizawa, T., Hori, T., Hayashi, M., et al. (2012) · Neurosurgery · doi:10.1227/neu.0b013e3182350893 · Cited by 146 · cited 1× · see citing works
“Ohye et al (2012)81 13 unilateral 24 months 60% of patients scored 0 in UPDRS III tremor subscores.”
BackgroundDeep brain stimulation for dystonia: outcome at long-term follow-up
Loher, T., Capelle, H., Kaelin-Lang, A., Weber, S., Weigel, R., Burgunder, J., & Krauss, J. (2008) · Journal of Neurology · doi:10.1007/s00415-008-0798-6 · Cited by 145 · cited 1×
“Loher et al (2008)113 7 bilateral 1 unilateral 10 years 49% improvement in cervical dystonia at final follow-up, 70% and 82% for generalized dystonia patients.”
BackgroundUnilateral pallidotomy versus bilateral subthalamic nucleus stimulation in PD
Smeding, H., Esselink, R., Schmand, B., Koning-Haanstra, M., Nijhuis, I., Wijnalda, E. M., & Speelman, J. (2005) · Journal of Neurology · doi:10.1007/s00415-005-0628-z · Cited by 144 · see citing works
Levodopa response in long‐term bilateral subthalamic stimulation for Parkinson's disease
Piboolnurak, P., Lang, A. E., Lozano, A. M., Miyasaki, J., Saint-Cyr, J., Poon, Y., Hutchison, W., Dostrovsky, J., & Moro, E. (2007) · Movement Disorders · doi:10.1002/mds.21482 · Cited by 143 · cited 1× · see citing works
“…ND 63 49 75 70.9 58e Sch€upbach et al (2005)47 37 5 years 54 ND 79b1e ND 58 ND Rodriguez-Oroz et al (2005)48 49 3-4 years 50 56 45a ND 35 43 87 60 Piboolnurak et al (2007)49 33 5 years 35.1 ND 76.5b ND 39.8 25 68 55 94e Wider et al (2008)50 50 5 years 29.6 84 85b1e ND 57 (Continued) 38 Movement…”
InfluentialThalamic deep brain stimulation: comparison between unilateral and bilateral placement.
Ondo, W., Almaguer, M., Jankovic, J., & Simpson, R. (2001) · Archives of Neurology · doi:10.1001/archneur.58.2.218 · Cited by 142 · cited 2× · see citing works
“Finally, Vim-DBS has been shown to elicit improvements of around 90% in tremor scores in PD, achieving total tremor suppression in many cases.(8,61,62) Follow-ups lasting 3 to 7 years demonstrated that this benefit was sustained (class III studies, grade of recommendation C).”
BackgroundLong‐term outcomes of surgical therapies for Parkinson's disease
Rodríguez-Oroz, M., Moro, E., & Krack, P. (2012) · Movement Disorders · doi:10.1002/mds.25214 · Cited by 141 · cited 3× · see citing works
“levodopa-unresponsive or nonmotor manifestations associated with disease progression have given rise to a new PD phenotype for DBS-treated patients who suffer from the so-called “long STN-DBS syndrome,”(59) whereby classic motor problems are no longer the most important therapeutic challenge.(60) Thus, in the long ter…”
BackgroundSelf-citationWorsening essential tremor following deep brain stimulation: disease progression versus tolerance
Favilla, C. G., Ullman, D., Shukla, A. W., Foote, K. D., Jacobson, C. E., & Okun, M. S. (2012) · Brain · doi:10.1093/brain/aws026 · Cited by 138 · cited 1× · see citing works
“A recent series with less severe ET patients suggests that, the increase on tremor may likely be related to progression of the disease rather than to a loss of benefit from stimulation.(107)”
BackgroundWider, C., Pollo, C., Bloch, J., Burkhard, P., & Vingerhoets, F. (2008) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2007.06.012 · Cited by 134 · cited 1×
“…ND 58 ND Rodriguez-Oroz et al (2005)48 49 3-4 years 50 56 45a ND 35 43 87 60 Piboolnurak et al (2007)49 33 5 years 35.1 ND 76.5b ND 39.8 25 68 55 94e Wider et al (2008)50 50 5 years 29.6 84 85b1e ND 57 (Continued) 38 Movement Disorders, Vol. 32, No. 1, 2017 Complications of DBS are typically…”
InfluentialParkin, S., Gregory, R., Scott, R., Bain, P., Silburn, P., Hall, B., Boyle, R., Joint, C., & Aziz, T. (2002) · Movement Disorders · doi:10.1002/mds.10186 · Cited by 133 · see citing works
Short- and long-term outcome of chronic pallidal neurostimulation in monogenic isolated dystonia
Bruggemann, N., Kühn, A., Schneider, S., Kamm, C., Wolters, A., Krause, P., Moro, E., Steigerwald, F., Wittstock, M., Tronnier, V., et al. (2015) · Neurology · doi:10.1212/wnl.0000000000001312 · Cited by 128 · cited 1× · see citing works
“Br€uggemann et al (2015)116 55 bilateral DBS for primary d. 22-92 months Improvement of 42% in the BFMDRS motor score for DYT6 patients, 44% for Dyt1, and 61% for non-DYT patients.”
BackgroundGamma Knife thalamotomy for tremor in the magnetic resonance imaging era.
Kooshkabadi, A., Lunsford, L., Tonetti, D. A., Flickinger, J., & Kondziolka, D. (2013) · Journal of Neurosurgery · doi:10.3171/2013.1.jns121111 · Cited by 125 · cited 1× · see citing works
“KooshKAbAdi et al (2013) 48 unilateral 23 months 48% improvement in tremor as assessed by the FTM scale.”
MethodGallay, M., Moser, D., Rossi, F., Pourtehrani, P., Magara, A. E., Kowalski, M., Arnold, A., & Jeanmonod, D. (2016) · Journal of Therapeutic Ultrasound · doi:10.1186/s40349-016-0049-8 · Cited by 124 · cited 2× · see citing works
“The rationale here, according with MRI DTI tractography, is to impact the cerebellothalamic tract, which is intimately involved in tremor pathogenesis and runs throughout the posterior subthalamic region.(110)”
BackgroundGPi vs STN deep brain stimulation for Parkinson disease: Three-year follow-up
Sidiropoulos, C., LeWitt, P., Odekerken, V., Schuurman, P., & de Bie, R. D. (2016) · Neurology · doi:10.1212/wnl.0000000000003027 · Cited by 120 · cited 5×
“Such differences between studies regarding cognitive status persisted at 3 years follow-up, with the Veterans Affairs trial showing an increased risk of cognitive worsening after STN-DBS than following GPi-DBS and the Dutch study reporting no difference between targets.(42,43) S U R G I C A L T R E A T M E N T S F O R…”
ResultInfluentialSchjerling, L., Hjermind, L., Jespersen, B., Madsen, F., Brennum, J., Jensen, S., Løkkegaard, A., & Karlsborg, M. (2013) · Journal of Neurosurgery · doi:10.3171/2013.8.jns13844 · Cited by 118 · cited 1× · see citing works
“Gpi-DBS vs STN-DBS randomized crossover study Schjerling et al (2013)119 12 bilateral 6 months for target All DBS patients improved motor scores on the BFMDRS, but this change was significant only for STN-DBS patients.”
MethodMRI Guided Focused Ultrasound Thalamotomy for Moderate-to-Severe Tremor in Parkinson's Disease
Schlesinger, I., Eran, A., Sinai, A., Erikh, I., Nassar, M., Goldsher, D., & Zaaroor, M. (2015) · Parkinson's Disease · doi:10.1155/2015/219149 · Cited by 117 · see citing works
Subthalamic nucleus stimulation and compulsive use of dopaminergic medication in Parkinson's disease
Eusebio, A., Witjas, T., Cohen, J., Fluchère, F., Jouve, E., Régis, J., & Azulay, J. (2013) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2012-302387 · Cited by 117 · see citing works
Rothlind, J. C., York, M., Carlson, K., Luo, P., Marks, W., Weaver, F., Stern, M., Follett, K., & Reda, D. (2014) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2014-308119 · Cited by 110 · cited 1× · see citing works
“They advised further caution in interpreting these small target differences given the absence of statistical correction for multiple comparisons.(129) In another randomized, controlled, multicenter study(17) comparing STN to GPi-DBS, no difference was found between GPi and STN 1 year after surgery in a composite score…”
MethodWhat happened to posteroventral pallidotomy for Parkinson’s disease and dystonia?
Gross, R. (2008) · Neurotherapeutics · doi:10.1016/j.nurt.2008.02.001 · Cited by 109 · see citing works
Simultaneous bilateral pallidoansotomy for idiopathic dystonia musculorum deformans.
Iacono, R., Kuniyoshi, S., Lonser, R., Maeda, G., Inae, A. M., & Ashwal, S. (1996) · Pediatric Neurology · doi:10.1016/0887-8994(96)00003-3 · Cited by 109
Gamma knife thalamotomy for disabling tremor: a blinded evaluation.
Lim, S.-Y., Hodaie, M., Fallis, M., Poon, Y., Mazzella, F., & Moro, E. (2010) · Archives of Neurology · doi:10.1001/archneurol.2010.69 · Cited by 107 · cited 1× · see citing works
“Gamma-knife radiosurgery Zesiewicz et al (2005)84 (systematic review) 61 unilateral multiple 70% to 85% improvement in CRST. Lim et al (2010)139 11 unilateral 6 months No improvement in the motor part of FTM, significant reduction (13.7”
BackgroundInfluentialClinical outcome of deep brain stimulation for Parkinson's disease.
Deuschl, G., Paschen, S., & Witt, K. (2013) · Handbook of Clinical Neurology · doi:10.1016/b978-0-444-53497-2.00010-3 · Cited by 105 · cited 1× · see citing works
“4%).(45) The results of the long-term follow-up series with 4to 10-year follow-up for STN-DBS(46-57) and 3- to 6year follow-up for pallidal stimulation(48,53,58) are detailed in Table 1 and show the sustained benefits of DBS on parkinsonism and dyskinesia in both targets despite progression of the disease.”
BackgroundFunkiewiez, A., Ardouin, C., Cools, R., Krack, P., Fraix, V., Batir, A., Chabardès, S., Benabid, A., Robbins, T., & Pollak, P. (2006) · Movement Disorders · doi:10.1002/mds.21029 · Cited by 103 · see citing works
Self-citationResurgence of functional neurosurgery for Parkinson's disease: A historical perspective
Speelman, J., & Bosch, D. (1998) · Movement Disorders · doi:10.1002/mds.870130336 · Cited by 101 · cited 1×
“The brain target for ablative surgery in PD gradually moved from the pallidum to the thalamus because of the more reliable effect of the latter on tremor.(1) Following the introduction of levodopa, very few centers worldwide continued to perform thalamotomies for tremor.”
BackgroundShih, L. C., LaFaver, K., Lim, C., Papavassiliou, E., & Tarsy, D. (2013) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2013.03.006 · Cited by 100 · see citing works
Lyons, K., Koller, W., Wilkinson, S., & Pahwa, R. (2001) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.71.5.682 · Cited by 99 · cited 1× · see citing works
“Vim-DBS long-term follow-up studies ( 3 years) Lyons et al (2001)63 12 unilateral 3-4 years 87.5% improvement in tremor subitems in the hemibody treated.”
BackgroundInfluentialFailure of long-term pallidal stimulation corrected by subthalamic stimulation in PD
Houeto, J., Bejjani, P., Damier, P., Staedler, C., Bonnet, A., Pidoux, B., Dormont, D., Cornu, P., & Agid, Y. (2000) · Neurology · doi:10.1212/wnl.55.5.728 · Cited by 99 · cited 1×
“replacement of GPi-DBS by STN-DBS in 2 patients in whom GPi stimulation failed to give long-term relief.(126) The D€ usseldorf-Cologne group also reported the loss of an excellent initial effect on akinesia in 4 of 11 patients while the benefit on dyskinesia remained stable.”
BackgroundDeep brain stimulation for Huntington's disease: long-term results of a prospective open-label study
González, V., Cif, L., Biolsi, B., Ptacek, S. G., Seychelles, A., Sanrey, E., Descours, I., Coubes, C., de Moura, A. M. R., Corlobé, A., et al. (2014) · Journal of neurosurgery · doi:10.3171/2014.2.jns131722 · Cited by 97 · see citing works
Vesper, J., Klostermann, F., Stockhammer, F., Funk, T., & Brock, M. (2002) · Surgical Neurology · doi:10.1016/s0090-3019(02)00691-2 · Cited by 94 · cited 2× · see citing works
“Off-time during the day was reduced by 35% to 65%.(30,33) Such a substantial degree of motor improvement allowed levodopa equivalent daily doses to be decreased by 65%, resulting in marked reductions in levodopa-induced dyskinesia.”
BackgroundInfluentialHariz, G., Lindberg, M., & Bergenheim, A. (2002) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.72.1.47 · Cited by 92 · see citing works
Romito, L., Contarino, M., Vanacore, N., Bentivoglio, A., Scerrati, M., & Albanese, A. (2009) · Movement Disorders · doi:10.1002/mds.22390 · Cited by 91 · cited 1× · see citing works
“…med) QoL Decrease in LDEAkinesia Tremor Rigidity 22.2 67.3 44.8 Gervais-Bernard et al (2009)51 23 5 years 55 ND ND ND 54.4 59 74 66 Romito et al (2009)52 20 5 years 54.2 ND 80b1e ND 61.9 41 95 56.2 Moro et al (2010)53 35 5-6 years 50.5 ND 67a ND 46 30.8 81.1 59.1 Fasano et al…”
InfluentialAmami, P., Dekker, I., Piacentini, S., Ferré, F., Romito, L., Franzini, A., Foncke, E., & Albanese, A. (2014) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2013-307214 · Cited by 88 · cited 6×
“Levodopa daily equivalents continued to be lower than baseline in patients with STN-DBS.”
ResultInfluentialGamma knife radiosurgery in movement disorders: Indications and limitations
Higuchi, Y., Matsuda, S., & Serizawa, T. (2017) · Movement Disorders · doi:10.1002/mds.26625 · Cited by 82 · see citing works
Hariz, M., & Bergenheim, A. T. (2001) · Journal of Neurosurgery · doi:10.3171/jns.2001.94.4.0552 · Cited by 76
Treatment of advanced Parkinson's disease by subthalamotomy: One‐year results
Su, P., Tseng, H.-M., Liu, H.-M., Yen, R., & Liou, H. (2003) · Movement Disorders · doi:10.1002/mds.10393 · Cited by 75 · see citing works
Subthalamic stimulation may inhibit the beneficial effects of levodopa on akinesia and gait
Fleury, V., Pollak, P., Gere, J., Tommasi, G., Romito, L., Combescure, C., Bardinet, É., Chabardès, S., Momjian, S., Krainik, A., et al. (2016) · Movement Disorders · doi:10.1002/mds.26545 · Cited by 73 · cited 1×
“Recently, the same effect was reported with the stimulation of pallidothalamic fibers in close vicinity to the STN using suboptimally placed electrodes.(125) The Paris group reported the successful TABLE 4.”
BackgroundSelf-citationMehrkens, J., Bötzel, K., Steude, U., Zeitler, K., Schnitzler, A., Sturm, V., & Voges, J. (2008) · Stereotactic and Functional Neurosurgery · doi:10.1159/000177623 · Cited by 73 · cited 1× · see citing works
“Mehrkens et al (2009)114 ND 3-7 years 39.4% improvement in the motor BFMDRS for generalized dystonia and 59.8% reduction in Tsui scale score for focal/segmental dystonia.”
BackgroundInfluentialUncoupling of dopaminergic and subthalamic stimulation: Life‐threatening DBS withdrawal syndrome
Reuter, S., Deuschl, G., Falk, D., Mehdorn, M., & Witt, K. (2015) · Movement Disorders · doi:10.1002/mds.26324 · Cited by 69 · see citing works
Merello, M., Tenca, E., Lloret, S. P., Martín, M. E., Bruno, V., Cavanagh, S., Antico, J., Cerquetti, D., & Leiguarda, R. (2008) · British Journal of Neurosurgery · doi:10.1080/02688690801971667 · Cited by 64 · cited 7× · see citing works
“The overall outcome has been positive in the case of akinesia, rigidity, tremor, and L-dopa-induced dyskinesia, with reductions in dopaminergic treatment to the same extent as in studies using STN-DBS.(94,97) The antiparkinsonian benefit has been seen to persist for up to 36 months.”
BackgroundResultInfluentialStereotactic neurosurgery for tremor
Speelman, J., Schuurman, R., de Bie, R. D., Esselink, R., & Bosch, D. (2002) · Movement Disorders · doi:10.1002/mds.10147 · Cited by 57 · cited 2× · see citing works
“Unilateral pallidotomy is safe and well tolerated,(4) whereas bilateral lesions are associated with a risk of severe adverse effects, such as corticobulbar syndrome with dysarthria and dysphagia.(60,76) There is TABLE 2.”
BackgroundInhibition of levodopa effects by internal pallidal stimulation
Krack, P., Pollak, P., Limousin, P., Hoffmann, D., Benazzouz, A., & Benabid, A. (1998) · Movement Disorders · doi:10.1002/mds.870130407 · Cited by 52 · cited 2×
“…55.9 Foltynie et al (2011)34 79 12 months 52 ND 55b1e 18 ND ND Gpi-DBS studies Volkmann et al (1998)35 9 3 months 55.8 ND 84.6a ND 12 48 71.4 62.5 Krack et al (1998)31 5 6 months 39 ND 82a ND 1 29 30 60 51 Ghika et al (1998)36 6 24 months 50 75 29b1c ND 12 14.1 >90 32 Anderson et al (2005)29 10…”
InfluentialSelf-citationTherapeutic stimulation versus ablation.
Hariz, M., & Hariz, G. (2013) · Handbook of Clinical Neurology · doi:10.1016/b978-0-444-53497-2.00006-1 · Cited by 51 · cited 3× · see citing works
“Their 1992 publication showing major alleviation not only of the parkinsonian triad but also of L-dopa-induced dyskinesia heralded a new surge in functional neurosurgery for movement disorders.(3,4) This coincided with the development of a new pathophysiological model of the basal ganglia, providing a scientific ratio…”
BackgroundServello, D., Zekaj, E., Saleh, C., Lange, N., & Porta, M. (2016) · Neurosurgery · doi:10.1227/neu.0000000000001004 · Cited by 50
Cost‐effectiveness of neurostimulation in Parkinson's disease with early motor complications
Dams, J., Balzer-Geldsetzer, M., Siebert, U., Deuschl, G., Schuepbach, W. M. M., Krack, P., Timmermann, L., Schnitzler, A., Reese, J., Dodel, R., et al. (2016) · Movement Disorders · doi:10.1002/mds.26740 · Cited by 49 · see citing works
Self-citationFraix, V., Pollak, P., Moro, E., Chabardès, S., Xie, J., Ardouin, C., & Benabid, A. (2005) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2003.022707 · Cited by 48 · see citing works
Lesioning the Subthalamic Nucleus in the Treatment of Parkinson’s Disease
Parkin, S., Nandi, D., Giladi, N., Joint, C., Gregory, R., Bain, P. G., Scott, R., & Aziz, T. (2002) · Stereotactic and Functional Neurosurgery · doi:10.1159/000064599 · Cited by 44
Long-term outcome of deep brain stimulation in generalised dystonia: a series of 60 cases
Fitzgerald, J., Rosendal, F., de Pennington, N., Joint, C., Forrow, B., Fletcher, C., Green, A., & Aziz, T. (2014) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2013-306833 · Cited by 43 · cited 1×
“FitzGerald et al (2014)169 60 bilateral DBS for primary and secondary d. 5 years 43% reduction in the motor BFMDRS for primary dystonia and 27% for secondary dystonia.”
BackgroundMalignant deep brain stimulation‐withdrawal syndrome in a patient with Parkinson's disease
Neuneier, J., Barbe, M., Dohmen, C., Maarouf, M., Wirths, J., Fink, G., & Timmermann, L. (2013) · Movement Disorders · doi:10.1002/mds.25494 · Cited by 43
Postoperative management of deep brain stimulation in Parkinson's disease.
Castrioto, A., Volkmann, J., & Krack, P. (2013) · Handbook of Clinical Neurology · doi:10.1016/b978-0-444-53497-2.00011-5 · Cited by 43 · see citing works
Self-citationPsychostimulant effect of levodopa: reversing sensitisation is possible
Castrioto, A., Kistner, A., Klinger, H., Lhommée, E., Schmitt, E., Fraix, V., Chabardès, S., Mertens, P., Quesada, J., Broussolle, E., et al. (2012) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2012-302444 · Cited by 42 · cited 1× · see citing works
“As the disease progresses, DBS can be adapted over the years to accompany the very progressive desensitization that develops after drug withdrawal.(146) Successful ablative surgery does, however, have several advantages.”
BackgroundSelf-citationPostoperative management of Vim DBS for tremor
Dowsey-Limousin, P. (2002) · Movement Disorders · doi:10.1002/mds.10165 · Cited by 39 · cited 1× · see citing works
“The decay of benefit, which occurs in some patients with thalamic stimulation,(104) has led to a recommendation of switching off Vim-DBS during sleep to prevent a potential effect of tolerance in the long term.(105,106) This phenomenon was observed and reported right from the early days of Vim-DBS and the recommendati…”
BackgroundBilateral subthalamotomy for advanced Parkinson disease.
Tseng, H.-M., Su, P., Liu, H.-M., Liou, H., & Yen, R. (2007) · Surgical Neurology · doi:10.1016/j.surneu.2007.05.058 · Cited by 34 · see citing works
Progression of Parkinson’s Disease following Thalamic Deep Brain Stimulation for Tremor
Tarsy, D., Scollins, L., Corapi, K. M., O’Herron, S., Apetauerova, D., & Norregaard, T. (2006) · Stereotactic and Functional Neurosurgery · doi:10.1159/000091953 · Cited by 34 · cited 1×
“Tarsy et al (2005)66 5 unilateral 4 bilateral 5.5 years Significant improvement (>90”
BackgroundInfluentialMerello, M., Nouzeilles, M., Cammarota, Á., Betti, O., & Leiguarda, R. (1999) · Neurosurgery · doi:10.1097/00006123-199903000-00011 · Cited by 34 · see citing works
Five-year follow-up of unilateral posteroventral pallidotomy in Parkinson's disease.
Strutt, A., Lai, E., Jankovic, J., Atassi, F., Soety, E., Levin, H., Grossman, R., & York, M. (2009) · Surgical Neurology · doi:10.1016/j.surneu.2008.03.039 · Cited by 32
Subthalamotomy in the treatment of Parkinson's disease: clinical aspects and mechanisms of action.
Jourdain, V., Schechtmann, G., & Paolo, T. D. (2014) · Journal of Neurosurgery · doi:10.3171/2013.10.jns13332 · Cited by 31 · cited 6× · see citing works
“The overall outcome has been positive in the case of akinesia, rigidity, tremor, and L-dopa-induced dyskinesia, with reductions in dopaminergic treatment to the same extent as in studies using STN-DBS.(94,97) The antiparkinsonian benefit has been seen to persist for up to 36 months.”
ResultInfluentialÇoban, A., Hanağası, H., Karamürsel, S., & Barlas, O. (2009) · British Journal of Neurosurgery · doi:10.1080/02688690802507775 · Cited by 27
Long-term results of ventrolateral thalamotomy for patients with Parkinson's disease.
Moriyama, E., Beck, H., & Miyamoto, T. (1999) · Neurologia medico-chirurgica · doi:10.2176/nmc.39.350 · Cited by 24
Parkinson disease: Deep brain stimulation in Parkinson disease—what went wrong?
Krack, P., & Hariz, M. (2010) · Nature Reviews Neurology · doi:10.1038/nrneurol.2010.141 · Cited by 22 · cited 1× · see citing works
“A caveat in generalizing these findings was expressed based on suboptimal outcomes of bilateral DBS in both targets, which were not better than those of unilateral pallidotomy.(128) The authors have developed their analysis of neuropsychological outcomes of DBS more recently and have confirmed slightly greater reducti…”
Self-citationUnilateral subthalamic nucleus lesioning: a safe and effective treatment for Parkinson's disease.
Vilela, O., & da Silva, D. D. (2002) · Arquivos de Neuro-Psiquiatria · doi:10.1590/s0004-282x2002000600010 · Cited by 19 · see citing works
Lamberti, V. M. J., Pereira, B., Lhommée, E., Bichon, A., Schmitt, E., Pelissier, P., Kistner, A., Fraix, V., Castrioto, A., Esselink, R., et al. (2016) · Journal of Parkinson's Disease · doi:10.3233/jpd-150698 · Cited by 18 · cited 6× · see citing works
“Levodopa daily equivalents continued to be lower than baseline in patients with STN-DBS.”
BackgroundInfluentialSelf-citationDeep brain stimulation for treatment of dystonia secondary to stroke or trauma
Slow, E., Hamani, C., Lozano, A., Poon, Y., & Moro, E. (2014) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2014-308943 · Cited by 15
Eight-years failure of subthalamic stimulation rescued by globus pallidus implant.
Minafra, B., Fasano, A., Pozzi, N., Zangaglia, R., Servello, D., & Pacchetti, C. (2014) · Brain Stimulation · doi:10.1016/j.brs.2013.12.011 · Cited by 15 · cited 1×
“Although, in some cases it is GPi-DBS which has been successfully added to STN-DBS as a result of long-term failure.(127) Based on these first experiences in small patient series in pioneering groups, the STN rapidly became the favorite target for PD in a large majority of centers worldwide.”
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Obeso, J. A., Stamelou, M., Goetz, C. G., Poewe, W., Lang, A. E., Weintraub, D., Burn, D., Halliday, G. M., Bezard, E., Przedborski, S., et al. (2017) · Movement Disorders · doi:10.1002/mds.27115 · Cited by 859 · see citing works
“ICD behaviors typically resolve after discontinuing DA treatment; however, some patients develop a DA withdrawal syndrome.(61) The relationship between DBS and ICDs is complex, with both improvement and worsening reported post-DBS surgery.”
Self-citationEight-hours adaptive deep brain stimulation in patients with Parkinson disease
Arlotti, M., Marceglia, S., Foffani, G., Volkmann, J., Lozano, A., Moro, E., Cogiamanian, F., Prenassi, M., Bocci, T., Cortese, F., et al. (2018) · Neurology · doi:10.1212/wnl.0000000000005121 · Cited by 228 · see citing works
18F-FDG PET in Parkinsonism: Differential Diagnosis and Evaluation of Cognitive Impairment
Meyer, P. T., Frings, L., Rücker, G., & Hellwig, S. (2017) · Journal of Nuclear Medicine · doi:10.2967/jnumed.116.186403 · Cited by 251 · see citing works
“For the management of advanced PD (when intractable levodopa-induced motor complications develop) invasive techniques, including deep-brain stimulation, stereotactic neurosurgery or other ablative treatments, and subcutaneous apomorphine therapy or intraduodenal levodopa infusion, are available (22,23).”
BackgroundProbabilistic sweet spots predict motor outcome for deep brain stimulation in Parkinson disease
Dembek, T., Roediger, J., Horn, A., Reker, P., Oehrn, C., Dafsari, H., Li, N.-F., Kühn, A., Fink, G., Visser-Vandewalle, V., et al. (2019) · Annals of Neurology · doi:10.1002/ana.25567 · Cited by 199 · see citing works
“shown to improve motor function and reduce motor fluctuations as well as medication intake.(1) However, the opti-”
BackgroundDeep Brain Stimulation in Movement Disorders: From Experimental Surgery to Evidence‐Based Therapy
Krack, P., Volkmann, J., Tinkhauser, G., & Deuschl, G. (2019) · Movement Disorders · doi:10.1002/mds.27860 · Cited by 186 · see citing works
Self-citationMedical and surgical management of advanced Parkinson's disease
Antonini, A., Moro, E., Godeiro, C., & Reichmann, H. (2018) · Movement Disorders · doi:10.1002/mds.27340 · Cited by 168 · see citing works
“Lesion surgeries have also been performed, such as thalamotomy, pallidotomy, subthalamotomy, and gammaknife thalamotomy, but their indication in the present time is much more limited because of the risks associated with a surgical lesion, particularly with bilateral procedures.(62,63) Other surgical techniques, such a…”
BackgroundCost‐effectiveness of focused ultrasound, radiosurgery, and DBS for essential tremor
Ravikumar, V. K., Parker, J., Hornbeck, T. S., Santini, V., Pauly, K., Wintermark, M., Ghanouni, P., Stein, S., & Halpern, C. H. (2017) · Movement Disorders · doi:10.1002/mds.26997 · Cited by 103 · see citing works
“Our analysis did not incorporate radiofrequency (RF) thalamotomy for a number of reasons, even though it continues to be used in many experienced centers with efficacy.(54) DBS quickly overcame RF thalamotomy broadly given its reversibility and titratability, with RF reserved for severe unilateral tremor and patients…”
BackgroundJung, N., Park, C., Kim, M., Lee, P., Sohn, Y., & Chang, J. W. (2019) · Journal of Neurosurgery · doi:10.3171/2018.2.jns172514 · Cited by 93 · see citing works
“15,20 Despite these successful outcomes, DBS has limitations, including complications related to device implantation or electrical stimulation and relatively higher maintenance costs.”
Focused Ultrasound for Essential Tremor: Review of the Evidence and Discussion of Current Hurdles
Rohani, M., & Fasano, A. (2017) · Tremor and Other Hyperkinetic Movements · doi:10.7916/d8z89jn1 · Cited by 90 · see citing works
“Stereotactic brain lesioning has been used for decades and it is a well-established effective treatment for medically refractory patients with ET and certain patients with PD (asymmetric tremor-dominant or dyskinetic patients).(31) The scientific community shifted attention from lesioning to DBS when the latter became…”
BackgroundMethodInfluentialThe role of high‐intensity focused ultrasound as a symptomatic treatment for Parkinson's disease
Moosa, S., Martínez-Fernández, R., Elias, W., del Álamo, M., Eisenberg, H., & Fishman, P. S. (2019) · Movement Disorders · doi:10.1002/mds.27779 · Cited by 84 · see citing works
“Beneficial effects of GPi DBS that are similar to that of pallidotomy are well documented using this strategy to ameliorate motor features of PD.(25,65-67) DBS is, however, still an open surgical procedure and shares with radiofrequency pallidotomy the risk of intracranial bleeding and infection.”
BackgroundResultInfluentialDeep brain stimulation: potential for neuroprotection
McKinnon, C., Gros, P., Lee, D. J., Hamani, C., Lozano, A. M., Kalia, L. V., & Kalia, S. K. (2018) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.682 · Cited by 96 · see citing works
“Most longitudinal cohort studies have reported stabilization or a trend towards improvement in off-medication/off-stimulation motor scores compared with preoperative baseline.(28) Despite evidence of slowed progression of motor deficits, a recent (18)F-fluorodopa positron emission tomography (PET) study reported conti…”
BackgroundResultMR-guided focused ultrasound pallidotomy for Parkinson's disease: safety and feasibility.
Eisenberg, H., Krishna, V., Elias, W., Cosgrove, G. R., Gandhi, D., Aldrich, C., & Fishman, P. S. (2020) · Journal of Neurosurgery · doi:10.3171/2020.6.jns192773 · Cited by 75
Surgical Treatment of Parkinson’s Disease: Devices and Lesion Approaches
Sharma, V. D., Patel, M., & Miocinovic, S. (2020) · Neurotherapeutics · doi:10.1007/s13311-020-00939-x · Cited by 72 · see citing works
“ly cheaper and reduces postoperative care and hardwarerelated complications [114]; however, LS is not reversible and postprocedure optimization is not possible without revision surgery.”
BackgroundGenetics of Parkinson’s disease and related disorders
Zhang, P.-L., Chen, Y., Zhang, C.-H., Wang, Y., & Fernández-Fúnez, P. (2017) · Journal of Medical Genetics · doi:10.1136/jmedgenet-2017-105047 · Cited by 88 · see citing works
Modifying the progression of Alzheimer's and Parkinson's disease with deep brain stimulation.
Jakobs, M., Lee, D. J., & Lozano, A. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.107860 · Cited by 68 · see citing works
Pallidal deep brain stimulation for dystonia: a long term study
Meoni, S., Fraix, V., Castrioto, A., Benabid, A., Seigneuret, É., Vercueil, L., Pollak, P., Krack, P., Chevrier, E., Chabardès, S., et al. (2017) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2016-315504 · Cited by 66 · see citing works
Self-citationA Review on Wearable Technologies for Tremor Suppression
Lora-Millan, J. S., Delgado-Oleas, G., Benito-León, J., & Rocon, E. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.700600 · Cited by 62 · see citing works
Safinamide: a new hope for Parkinson's disease?
Teixeira, F., Gago, M., Marques, P., Moreira, P., Magalhães, R., Sousa, N., & Salgado, A. (2018) · Drug Discovery Today · doi:10.1016/j.drudis.2018.01.033 · Cited by 55
Medical and Surgical Treatments for Dystonia
Jinnah, H. (2020) · Neurologic clinics · doi:10.1016/j.ncl.2020.01.003 · Cited by 49 · see citing works
Pineda-Pardo, J., Urso, D., Martínez-Fernández, R., Rodríguez-Rojas, R., del Álamo, M., Vernetti, P. M., Máñez-Miró, J., Hernández-Fernández, F., de Luis-Pastor, E., Vela-Desojo, L., et al. (2019) · Neurosurgery · doi:10.1093/neuros/nyz395 · Cited by 49 · see citing works
Self-citationTreatment of essential tremor: current status
Sharma, S., & Pandey, S. (2019) · Postgraduate Medical Journal · doi:10.1136/postgradmedj-2019-136647 · Cited by 54 · see citing works
Martínez-Fernández, R., Natera-Villalba, E., Miró, J. M. M., Rodríguez-Rojas, R., Álamo, M. M. D., Pineda-Pardo, J., Ammann, C., Obeso, I., Mata-Marín, D., Hernández-Fernández, F., et al. (2023) · Neurology · doi:10.1212/wnl.0000000000206771 · Cited by 43
Self-citationMarsili, L., Bologna, M., Miyasaki, J., & Colosimo, C. (2020) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2020.10.042 · Cited by 41
Pineda‐Pardo, J. A., Martínez‐Fernández, R., Rodríguez‐Rojas, R., Del‐Alamo, M., Hernández, F., Foffani, G., Dileone, M., Máñez-Miró, J. U., de Luis-Pastor, E., Vela, L., et al. (2019) · Human Brain Mapping · doi:10.1002/hbm.24569 · Cited by 42 · see citing works
“Ablation of the VIM is well known to provide benefit in cases of tremor (Krack et al., 2017; Speelman, Schuurman, de Bie, Esselink, & Bosch, 2002), which is believed to be mediated by impact on the dentato-rubro-thalamic tract (DRTT) (Klein et al.”
BackgroundSelf-citationCurrent treatment of behavioral and cognitive symptoms of Parkinson's disease
Rektorová, I. (2019) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2019.02.042 · Cited by 36 · see citing works
“While PD patients with major cognitive impairment are not good candidates for STN DBS surgery [169,170], advanced PD patients with cognitive decline may still be indicated for continuous infusion therapies with levodopa or apomorphine [171,172].”
BackgroundSubthalamotomy for Parkinson’s disease: clinical outcome and topography of lesions
Rodríguez-Rojas, R., Carballo-Barreda, M., Alvarez, L., Guridi, J., Pavón, N., García-Maeso, I., Macias, R., Rodríguez-Oroz, M., & Obeso, J. (2017) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2017-316241 · Cited by 38
Self-citationFocused ultrasound in Parkinson's disease: A twofold path toward disease modification
Foffani, G., Trigo-Damas, I., Pineda-Pardo, J., Blesa, J., Rodríguez-Rojas, R., Martínez-Fernández, R., & Obeso, J. (2019) · Movement Disorders · doi:10.1002/mds.27805 · Cited by 36 · see citing works
Self-citationAdaptive Deep Brain Stimulation (aDBS) for Tourette Syndrome
Marceglia, S., Rosa, M., Servello, D., Porta, M., Barbieri, S., Moro, E., & Priori, A. (2017) · Brain Science · doi:10.3390/brainsci8010004 · Cited by 36
“While the optimal target has already been determined in other pathologies, such as dystonia, essential tremor, and Parkinson’s disease [3], several different targets have been reported for TS [2,4].”
BackgroundThe Dystonia Coalition: A Multicenter Network for Clinical and Translational Studies
Kilic-Berkmen, G., Wright, L. J., Perlmutter, J., Comella, C., Hallett, M., Teller, J., Richardson, S. P., Peterson, D. A., Cruchaga, C., Lungu, C., et al. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.660909 · Cited by 34 · see citing works
“, age, duration, and combination with other problems) (17, 18, 26, 27).”
BackgroundHolland, M. T., Trapp, N. T., McCormick, L. M., Jareczek, F. J., Zanaty, M., Close, L. N., Beeghly, J. H. L., & Greenlee, J. D. W. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00055 · Cited by 38 · see citing works
“These observations, combined with the knowledge of the clinical benefits from lesioning procedures in treating medicallyrefractory OCD, led to the development of DBS for OCD (28).”
BackgroundNon-invasive electrical stimulation of peripheral nerves for the management of tremor
Valdunciel, A. P., Rajagopal, A., Pons, J. L., & Delp, S. L. (2022) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2022.120195 · Cited by 34 · see citing works
“2 can cause irreversible neurological damage, and as a result have low patient acceptance [17].”
BackgroundRodríguez-Rojas, R., Pineda-Pardo, J., Martínez-Fernández, R., Kogan, R. V., Sanchez-Catasus, C. A., del Álamo, M., Hernández, F., Garcia-Cañamaque, L., Leenders, K., & Obeso, J. (2019) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-019-04497-z · Cited by 32
Self-citationImproved accuracy using a modified registration method of ROSA in deep brain stimulation surgery.
Xu, F., Jin, H.-L., Yang, X., Sun, X., Wang, Y., Xu, M.-T., & Tao, Y.-Q. (2018) · Neurosurgical Focus · doi:10.3171/2018.4.focus1815 · Cited by 32
Deep Brain Stimulation in Psychiatry
Bilge, M. T., Gosai, A. K., & Widge, A. S. (2018) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2018.04.003 · Cited by 35 · see citing works
Seventy years of pallidotomy for movement disorders
Cif, L., & Hariz, M. (2017) · Movement Disorders · doi:10.1002/mds.27054 · Cited by 31 · see citing works
Essential Tremor – Deep Brain Stimulation vs. Focused Ultrasound
Borges, Y. F. F., Cheyuo, C., Lozano, A., & Fasano, A. (2023) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2023.2221789 · Cited by 31 · see citing works
“As expected, the number of tracks is clearly associated with a higher risk of bleeding [20,36,112,114].”
BackgroundBretsztajn, L., & Gedroyc, W. (2018) · British Journal of Radiology · doi:10.1259/bjr.20170481 · Cited by 31 · see citing works
The use of nonhuman primate models to understand processes in Parkinson’s disease
Blesa, J., Trigo‐Damas, I., del Rey, N. L., & Obeso, J. A. (2017) · Journal of Neural Transmission · doi:10.1007/s00702-017-1715-x · Cited by 33 · see citing works
“Several clinical trials have been registered to test the use of ultrasound to ablate thalamic nuclei to treat essential tre- mor and to ablate the GP to treat dyskinesia (Guridi et al. 2016; Krack et al. 2017).”
BackgroundInfluentialSelf-citationNew neurosurgical approaches for tremor and Parkinson's disease
Fasano, A., Lozano, A., & Cubo, E. (2017) · Current Opinion in Neurology · doi:10.1097/wco.0000000000000465 · Cited by 30 · see citing works
An update on advanced therapies for Parkinson's disease: From gene therapy to neuromodulation
Serva, S. N., Bernstein, J. E., Thompson, J. A., Kern, D. S., & Ojemann, S. (2022) · Frontiers in Surgery · doi:10.3389/fsurg.2022.863921 · Cited by 29 · see citing works
“Lesioning procedures are relatively cheaper and reduce postoperative care and hardware-related complications compared to DBS (71).”
BackgroundPostoperative rehabilitation after deep brain stimulation surgery for movement disorders.
Allert, N., Cheeran, B., Deuschl, G., Barbe, M., Csoti, I., Ebke, M., Glaser, M., Kang, J.-S., Kelm, S., Krack, P., et al. (2018) · Clinical Neurophysiology · doi:10.1016/j.clinph.2017.12.035 · Cited by 28 · see citing works
Self-citationMR-guided focused ultrasound in movement disorders and beyond: Lessons learned and new frontiers.
Natera-Villalba, E., Ruiz-Yanzi, M.-A., Gasca-Salas, C., Matarazzo, M., & Martínez-Fernández, R. (2024) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2024.106040 · Cited by 27 · see citing works
Identification and measurement of dystonia in cerebral palsy
Supiot, F. (2017) · Developmental Medicine & Child Neurology · doi:10.1111/dmcn.13543 · Cited by 25
“The effects of functional stereotactic neurosurgery of various targets in the central nervous system are now well established, especially the globus pallidus internum, although these are less consistent and dramatic in secondary dystonia, such as occurs in CP.(3) Intrathecal baclofen administration results in reductio…”
BackgroundPlocksties, F. V., Kober, M., Niemann, C., Heller, J., Fauser, M., Nüssel, M., Uster, F., Franz, D., Zwar, M., Lüttig, A., et al. (2021) · Journal of Neural Engineering · doi:10.1088/1741-2552/ac23e1 · Cited by 24 · see citing works
Zhang, C.-C., Wang, L.-B., Hu, W., Wang, T., Zhao, Y.-J., Pan, Y.-X., Almeida, L., Ramirez-Zamora, A., Sun, B.-M., & Li, D.-Y. (2020) · Neurosurgery · doi:10.1093/neuros/nyaa201 · Cited by 24
A novel device for continuous monitoring of tremor and other motor symptoms
Battista, L., & Romaniello, A. (2018) · Neurological Sciences · doi:10.1007/s10072-018-3414-2 · Cited by 22 · see citing works
Neuroprotective Surgical Strategies in Parkinson’s Disease: Role of Preclinical Data
Torres-Martinez, N., Molet, J., Moro, C., Mitrofanis, J., & Benabid, A. L. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18102190 · Cited by 19 · see citing works
“DBS STN is the standard alternative to motor fluctuation in advance Parkinson disease [129] and also recommended in some centers as an early intervention on Parkinson disease, not because of neuroprotective effect, but because its effects in the overall quality of life and avoidance of complications [130].”
BackgroundMarceglia, S., Conti, C., Svanidze, O., Foffani, G., Lozano, A., Moro, E., Volkmann, J., Arlotti, M., Rossi, L., & Priori, A. (2022) · BMJ Open · doi:10.1136/bmjopen-2021-049955 · Cited by 20 · see citing works
Waters, S., Sonesson, C., Svensson, P., Tedroff, J., Carta, M., Ljung, E., Gunnergren, J., Edling, M., Svanberg, B., Fagerberg, A., et al. (2020) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.119.264226 · Cited by 20 · see citing works
“Surgical procedures, including deep brain stimulation, are used in some cases to alleviate dyskinesias and improve overall motor function in PD (Krack et al., 2017).”
BackgroundAdvances in DBS Technology and Novel Applications: Focus on Movement Disorders
Potel, S., Marceglia, S., Meoni, S., Kalia, S., Cury, R., & Moro, E. (2022) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-022-01221-7 · Cited by 19 · see citing works
Update on current and emerging therapies for dystonia.
Lizárraga, K., Al-Shorafat, D. M., & Fox, S. (2019) · Neurodegenerative Disease Management · doi:10.2217/nmt-2018-0047 · Cited by 19 · see citing works
Novel Electrode Designs for Neurostimulation in Regenerative Medicine: Activation of Stem Cells
Iwasa, S. N., Shi, H., Hong, S., Chen, T., Marquez-Chin, M., Iorio-Morin, C., Kalia, S., Popovic, M., Naguib, H. E., & Morshead, C. (2020) · Bioelectricity · doi:10.1089/bioe.2020.0034 · Cited by 18 · see citing works
“108 113 Another example is Alzheimer’s disease where DBS of the fornix leads to a reduction in the rate of hippocampal atrophy.”
BackgroundNagrale, S. S., Yousefi, A., Netoff, T. I., & Widge, A. S. (2023) · Journal of Neural Engineering · doi:10.1088/1741-2552/acd0d5 · Cited by 18 · see citing works
Natural products: An emerging tool in parkinson’s disease therapeutics
Desai, S., Doke, R., Pansare, P. A., Sainani, S., & Bhalchim, V. (2019) · IP Indian Journal of Neurosciences · doi:10.18231/j.ijn.2019.014 · Cited by 15 · see citing works
Prenassi, M., Borellini, L., Bocci, T., Scola, E., Barbieri, S., Priori, A., Ferrucci, R., Cogiamanian, F., Locatelli, M., Rampini, P., et al. (2022) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2022.950434 · Cited by 14 · see citing works
“DBS provides electrical neuromodulation to the target area that depends on the treated pathology (Krack et al., 2017).”
BackgroundRodríguez-Rojas, R., Máñez-Miró, J., Pineda-Pardo, J., del Álamo, M., Martínez-Fernández, R., & Obeso, J. (2024) · Science Advances · doi:10.1126/sciadv.adr9891 · Cited by 13 · see citing works
“…pathway fits with previous experience in PD whereby the response to medication (i.e., levodopa and dopaminergic drugs) is more evident against bradykinesia and rigidity than tremor, but the opposite has generally been the case in response to functional neurosurgery (ablation and DBS) ( 19 ).”
Self-citationPresent and future of subthalamotomy in the management of Parkinson´s disease: a systematic review
Máñez-Miró, J., Rodríguez-Rojas, R., del Álamo, M., Martínez-Fernández, R., & Obeso, J. (2021) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2021.1911649 · Cited by 13 · see citing works
Self-citationKnudsen, K., Krack, P., Tonder, L., Houeto, J., Rau, J., Schade-Brittinger, C., Hartmann, A., Hälbig, T., Paschen, S., Barbe, M., et al. (2019) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2019.05.023 · Cited by 12 · see citing works
Self-citationMartínez-Fernández, R., Matarazzo, M., Máñez-Miró, J., & Obeso, J. (2021) · Movement Disorders Clinical Practice · doi:10.1002/mdc3.13223 · Cited by 11 · see citing works
Self-citationMagnetic resonance–guided stereotactic laser pallidotomy for dystonia
Gross, R., & Stern, M. A. (2018) · Movement Disorders · doi:10.1002/mds.27400 · Cited by 11
“Moreover, we are reminded that, regardless of technique, bilateral simultaneous pallidotomy should be a procedure of last resort.(7)”
MethodA Scientometric Analysis of the 100 Most Cited Articles on Pallidotomy
Agrawal, M., Garg, K., Samala, R., Rajan, R., & Singh, M. (2021) · Stereotactic and Functional Neurosurgery · doi:10.1159/000516237 · Cited by 10 · see citing works
Deep brain stimulation and other surgical modalities for the management of essential tremor
Wang, K., Ren, Q.-W., Chiu, S. Y., Patel, B., Meng, F.-G., Hu, W., & Shukla, A. (2020) · Expert Review of Medical Devices · doi:10.1080/17434440.2020.1806709 · Cited by 10 · see citing works
Fernández-García, C., Alonso-Frech, F., Monje, M., & Matías-Guiu, J. (2020) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2020.1677465 · Cited by 10 · see citing works
“[81], they analyzed several studies of STN and”
BackgroundBocci, T., Ferrara, R., Albizzati, T., Averna, A., Guidetti, M., Marceglia, S., & Priori, A. (2024) · Brain Communications · doi:10.1093/braincomms/fcae201 · Cited by 9 · see citing works
“25,26 In addition, aDBS triggered by power beta oscillations does not significantly reduce either speech or axial disturbances over time.”
BackgroundPrenassi, M., Arlotti, M., Borellini, L., Bocci, T., Cogiamanian, F., Locatelli, M., Rampini, P., Barbieri, S., Priori, A., & Marceglia, S. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.643841 · Cited by 9
Is there a role for MR‐guided focused ultrasound in Parkinson's disease?
Meng, Y., Voisin, M. R., Suppiah, S., Kalia, S. K., Kalia, L. V., Hamani, C., & Lipsman, N. (2018) · Movement Disorders · doi:10.1002/mds.27308 · Cited by 10 · see citing works
“DBS is often favored over ablative procedures for treating movement disorders because of its reversibility and the ability to treat bilaterally.(17) The development of MRgFUS ablation has now introduced an alternative ablative strategy, which mitigates the risks of open neurosurgery, potentially reducing infection and…”
BackgroundPeng, S., Mao, M., & He, Q. (2025) · Angewandte Chemie · doi:10.1002/anie.202519696 · Cited by 8 · see citing works
Electrophysiological insights into deep brain stimulation of the network disorder dystonia
Franz, D., Richter, A., & Köhling, R. (2023) · Pflügers Archiv: European Journal of Physiology · doi:10.1007/s00424-023-02845-5 · Cited by 8 · see citing works
“Despite an increase in clinical trial datasets, it remains hard to predict the outcome of DBS for individual patients [121], which also depends on careful patient selection [22, 60].”
BackgroundA deeply superficial brain stimulation
Bouthour, W., Krack, P., & Lüscher, C. (2017) · Movement Disorders · doi:10.1002/mds.27111 · Cited by 8
Self-citationDoke, R. R., Pansare, P. A., Sainani, S., Bhalchim, V., Rode, K., & Desai, S. (2021) · Journal of scientific research · doi:10.37398/jsr.2021.650119 · Cited by 8 · see citing works
“neuroprotective potential in contradiction of different neurodegenerative pathways tangled in PD and to encourage the expansion of upcoming novel treatment stratagems based on natural sources(Fox et al., 2018; Krack et al., 2017) II.”
BackgroundGuidetti, M., Marceglia, S. R. F., Bocci, T., Duncan, R. P., Fasano, A. A., Foote, K. D., Hamani, C., Krauss, J. K., Kühn, A. A., Lena, F., et al. (2025) · Journal of NeuroEngineering and Rehabilitation · doi:10.1186/s12984-025-01616-w · Cited by 11 · see citing works
“Although a number of clinical studies suggests long-term improvement in symptoms such as tremor, rigidity, and akinesia [1], the effect of stimulation on motor axial (e.g., postural instability, trunk posture alterations) and gait impairments (e.g., freezing of gait–FOG) is still unclear [3, 4].”
Zhong, C., Guo, N., Hu, C., Ni, R.-J., Zhang, X., Meng, Z.-Y., Liu, T., Ding, S.-Q., Ding, W., Zhao, Y.-W., et al. (2024) · Trials · doi:10.1186/s13063-024-08092-y · Cited by 7 · see citing works
“However, DBS has some drawbacks with invasiveness, including stimulation tolerance, infection, hemorrhage, and other risks as therapy with implanted devices [9].”
BackgroundBéreau, M., Kibleur, A., Bouthour, W., Chaoui, E. T., Maling, N., Nguyen, T. K. K., Momjian, S., Gomez, M. I. V., Zacharia, A., Bally, J. F., et al. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.00532 · Cited by 7
“Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a well-established treatment for advanced Parkinson’s disease (PD) (1).”
BackgroundSelf-citationRecent advances in understanding and managing dystonia
Tisch, S. (2018) · F1000Research · doi:10.12688/f1000research.13823.1 · Cited by 7 · see citing works
David, R., Scala, M., & Ellenbogen, J. R. (2023) · Journal of Neurosurgery: Pediatrics · doi:10.3171/2023.10.peds23275 · Cited by 6 · see citing works
Igarashi, A., Tanaka, M., Abe, K., Richard, L., Peirce, V., & Yamada, K. (2019) · PLoS ONE · doi:10.1371/journal.pone.0219929 · Cited by 6 · see citing works
Radiofrequency Ablation: How to Ensure Worldwide Availability of Surgery for Parkinson's Disease
Merello, M., & Hariz, M. (2023) · Movement Disorders Clinical Practice · doi:10.1002/mdc3.13945 · Cited by 5
Deep Brain Stimulation for Parkinson's Disease‐the Developing World's Perspective
Patel, K., Puthanveedu, D. K., Vijayaraghavan, A., Kesavapisharady, K., Sarma, G., Sarma, S., & Krishnan, S. (2023) · Movement Disorders Clinical Practice · doi:10.1002/mdc3.13901 · Cited by 5
“1,2 DBS may also have a favorable impact on survival.”
BackgroundCase-Study on Visible Light Communication for Implant Monitoring
Koschay, M., Richter, H., Statz, M., Kober, M., Puschmann, J., Plocksties, F., Storch, A., Kühn, V., & Timmermann, D. (2022) · Biomedical Circuits and Systems Conference · doi:10.1109/biocas54905.2022.9948625 · Cited by 5
Krauss, J., & Fernandes, F. W. (2021) · Movement Disorders Clinical Practice · doi:10.1002/mdc3.13370 · Cited by 5 · see citing works
Jain, K., Ramesh, R., Krishnan, S., Kesavapisharady, K., Divya, K., Sarma, S., & Kishore, A. (2021) · Acta Neurologica Belgica · doi:10.1007/s13760-021-01778-z · Cited by 5 · see citing works
“The efficacy of DBS to control motor symptoms and improve functioning and quality of life has been demonstrated by several randomized controlled studies and systematic, protocol-based long-term follow-up studies [2, 4].”
BackgroundPros and Cons of Ablation for Functional Neurosurgery in the Neurostimulation Age.
Hariz, M. (2023) · Neurosurgery clinics of North America · doi:10.1016/j.nec.2022.11.006 · Cited by 4
Geoffrey, T., Ali, T. A., Arvind, S., Ute, P., & HuLiang, L. (2019) · Journal of clinical neuroscience · doi:10.1016/j.jocn.2019.02.009 · Cited by 4
Surgical Treatment of Levodopa-induced Dyskinesia in Parkinson's Disease
Krishnan, S., & Pisharady, K. K. (2017) · Annals of Indian Academy of Neurology · doi:10.4103/aian.aian_244_17 · Cited by 3
“Pallidotomy is considered to have effects very similar to unilateral GPi DBS with regard to improvement of LID and motor signs.[22] Pallidotomy and STN DBS provide similar degree of control of LID; however, STN DBS improves”
BackgroundResultInfluentialHariz, M., & Obeso, J. (2017) · Movement Disorders · doi:10.1002/mds.26911 · Cited by 3
“Parkinson, their best judgment and tools to individualize decisions at every level.(16) More recently, the possibility of achieving a marked improvement in tremor and other movement disorders by less-invasive procedures, such as gamma knife and HIFU, are gaining momentum.”
BackgroundSelf-citationFive‐Year Follow‐Up of Unilateral Focused Ultrasound Subthalamotomy for Parkinson's Disease
Natera-Villalba, E., Martínez-Fernández, R., Jiménez-Castellanos, T., Rodríguez-Rojas, R., del Álamo, M., Pineda-Pardo, J., Gasca-Salas, C., Matarazzo, M., Alonso-Frech, F., & Obeso, J. (2026) · Movement Disorders · doi:10.1002/mds.70307 · Cited by 2
“14,15 ,16-19 The long-term ef fi cacy of STN-DBS has been demonstrated in numerous reports.”
Self-citationKrystkowiak, P., & Aubignat, M. (2019) · Pratique Neurologique - FMC · doi:10.1016/j.praneu.2019.01.009 · Cited by 2 · see citing works
Diagnosis in the age of massive computing power
Day, S., & Reynolds, R. J. (2017) · Developmental Medicine & Child Neurology · doi:10.1111/dmcn.13593 · Cited by 2
Stereotactic ablative surgery does not just mean “adding another lesion”
Hariz, M. (2017) · Movement Disorders · doi:10.1002/mds.27064 · Cited by 2
“As discussed more extensively in our article, we excluded drugs without a recognized dopamine action because the role of these drugs in causing parkinsonism remains uncertain; however, we agree that additional drugs can potentially cause parkinsonism.(1) The observation that the proportion of DIP among patients with p…”
BackgroundApplications of the stem cell secretome in regenerative medicine
Mendes-Pinheiro, B., Marote, A., Marques, C. R., Teixeira, F. G., Ribeiro, J. C., & Salgado, A. J. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819713-4.00005-0 · Cited by 3 · see citing works
Ali, H., Guidetti, M., Caffi, L., Arlotti, M., Rossi, L., Palmisano, C., Priori, A., Brun, F., Isaias, I., & Marceglia, S. (2026) · Frontiers in Bioinformatics · doi:10.3389/fbinf.2026.1820165 · Cited by 1
“Traditional continuous DBS (cDBS) applies constant stimulation throughout the day, regardless of the patient’s clinical state and is often associated to side effects such as speech, gait, or sleep impairments (Perlmutter and Mink, 2006; Meidahl et al., 2017; Krack et al., 2017).”
Utilizing secretomes as a novel molecular-based therapy for Parkinson's disease: A scoping review
Hutabarat, E. A. J., Suroto, S., Soetrisno, S., Mirawati, D., Pamungkasari, E., & Wasita, B. (2025) · Journal of Applied Pharmaceutical Sciences · doi:10.7324/japs.2025.219807 · Cited by 1
“Deep brain stimulation is an option for individuals with motor complications or levodopa-related fluctuations, where electrodes are implanted in the brain to modulate activity and control symptoms while reducing medication side effects [6–9].”
An Unusual Case of Essential Tremor Deep Brain Stimulation: Where is the Lead?
Spears, C., Almeida, L., Okun, M., & Deeb, W. (2019) · Tremor and Other Hyperkinetic Movements · doi:10.7916/d8-xj6w-cm53 · Cited by 1 · see citing works
“These advances have collectively led to more precision in ablative ET procedures.15 Tractography, for example, allows the clinician to see the cerebellothalamic tract passing through the PSA, which could be useful for management and placement of DBS.16 One important note in this case was that one of the leads was subo…”
InfluentialCas 5. Addictions comportementales et apathie dans la maladie de Parkinson : d’un extrême à l’autre
Chiuvé, S. C., dos Santos, J. F. A., Burkhard, P., & Krack, P. (2018) · 13 cas cliniques en neuropsychologie des émotions · doi:10.3917/dunod.peron.2018.01.0113 · Cited by 1 · see citing works
Self-citationConnectomic DBS in Parkinson’s disease, essential tremor and dystonia
Ferreira, F., & Akram, H. (2022) · Connectomic Deep Brain Stimulation · doi:10.1016/b978-0-12-821861-7.00005-1 · Cited by 1 · see citing works
Surgical treatments for Parkinson’s disease
Tokarev, A. S., Rozhnova, E., Sinkin, M., Tomskiy, A., Rak, V., Stepanov, V. N., & Viktorova, O. (2021) · Russian neurological Journal · doi:10.30629/2658-7947-2021-26-4-4-14
Cruz, J. P. M., Cataniag, P., Ocampos, M., Mancol, J., Dimaano, D., Ong, J. N., Teleg, R., Oropilla, J. Q., Diesta, C., & Saranza, G. (2026) · Journal of neural transmission · doi:10.1007/s00702-026-03219-8
Albakry, A., & Elshabrawy, A. A. (2026) · The Egyptian Journal of Neurology Psychiatry and Neurosurgery · doi:10.1186/s41983-026-01195-0
“The outcome and benefits of stereotactic lesioning to deep brain nuclei have been discussed in detail by many authors and in many publications [4, 31–33].”
Paradigm Shift in Surgery for Movement Disorders; Again?
Hariz, M., & Blomstedt, P. (2026) · Movement Disorders · doi:10.1002/mds.70370
Pistoia, F., Sucapane, P., Asci, F., Saporito, G., Costantini, G., Cesarini, V., Saggio, G., Sacco, S., & Suppa, A. (2026) · Scientific Reports · doi:10.1038/s41598-026-45935-x
- Authors
- Krack, P., Martinez‐Fernandez, R., del Alamo, M., & Obeso, J. A.
- Affiliations
- University Hospital of Geneva (CH)
- CINAC‐Hospital Universitario HM Puerta del Sur CEU‐San Pablo University Madrid Spain
- Universidad San Pablo CEU (ES)
- Corresponding author
- Krack, Paul
- Venue
- Movement Disorders
- Publisher
- Wiley
- Published
- 2017-01
- Volume
- 32
- Issue
- 1
- Pages
- 36-52
- ISSN
- 0885-3185 (ISSN-L)
- 1531-8257
- OpenAlex
- W2582022757
- Cited by
- 122
- References
- 169
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 6 · 2023: 12 · 2022: 7 · 2021: 14 · 2020: 14 · 2019: 19 · 2018: 16 · 2017: 21
- FWCI
- 2.55
- Type
- journal article
- Language
- en
- Open access
- Locations
- Movement Disorders (publishedVersion)
- PubMed (publishedVersion)
- Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
- Topics
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Neurological and metabolic disorders
- Keywords
- functional neurosurgery, Parkinson's disease, deep brain stimulation, posteroventral pallidotomy, levodopa-induced motor complications, tremor, dystonia, high-intensity focused ultrasound, gamma knife radiosurgery, lesioning, surgical targeting, long-term outcomes
- MeSH terms
- Humans, Movement Disorders, Radiosurgery, Neurosurgical Procedures, Deep Brain Stimulation, High-Intensity Focused Ultrasound Ablation
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