The DOI matches its Crossref record; 110 of the 110 references it cites were found in a registry or an index.
STAT3: A critical transcription activator in angiogenesis
Abstract
Angiogenesis, the formation of new blood vessels from the pre‐existing vasculature, is a complex multistage process regulated by a number of signal transduction pathways. Accumulating evidence suggests that signal transducer and activator of transcription (STATs), mainly STAT3, play an important role in angiogenesis under both physiological and pathological conditions in addition to cell survival, proliferation, differentiation, and oncogenesis. STAT3, as a critical multifunctional mediator, regulates many aspects of angiogenesis at the transcriptional level. This review will highlight the pivotal role of STAT3 in well‐studied tumorous angiogenesis and cardiac angiogenesis, and summarize various potential mechanisms utilized by STAT3 to regulate the transcriptional activation of VEGF. © 2007 Wiley Periodicals, Inc. Med Res Rev, 28, No. 2, 185–200, 2008
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Cites
Targeting HIF-1 for cancer therapy
Semenza, G. L. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1187 · Cited by 6,717
Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele
Carmeliet, P., Ferreira, V., Breier, G., Pollefeyt, S., Kieckens, L., Gertsenstein, M., Fahrig, M., Vandenhoeck, A., Harpal, K., Eberhardt, C., et al. (1996) · Nature · doi:10.1038/380435a0 · Cited by 4,117
Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1
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Principles of interleukin (IL)-6-type cytokine signalling and its regulation
HEINRICH, P. C., BEHRMANN, I., HAAN, S., HERMANNS, H. M., MÜLLER-NEWEN, G., & SCHAPER, F. (2003) · Biochemical Journal · doi:10.1042/bj20030407 · Cited by 3,272 · cited 2×
“In fact, binding of IL-6 to its receptor triggers signaling cascades through Jak/STAT, Ras/MAPK, and PI3-K/Akt pathways.(44) Both PI3-K/ Akt and Ras/MAPK signaling pathways have been found to be involved in the regulation of VEGF gene under certain circumstances.”
STATs: transcriptional control and biological impact
Levy, D. E., & Darnell, J. E. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm909 · Cited by 3,201
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The STATs of cancer — new molecular targets come of age
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Vascular Endothelial Growth Factor and Angiogenesis
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Cited by
Role of STAT3 in Cancer Metastasis and Translational Advances
Kamran, M. Z., Patil, P., & Gude, R. P. (2013) · BioMed Research International · doi:10.1155/2013/421821 · Cited by 393
Paracrine Mechanisms of Mesenchymal Stromal Cells in Angiogenesis
Maacha, S., Sidahmed, H., Jacob, S., Gentilcore, G., Calzone, R., Grivel, J.-C., & Cugno, C. (2020) · Stem Cells International · doi:10.1155/2020/4356359 · Cited by 259
Zhao, M., Gao, F.-H., Wang, J.-Y., Liu, F., Yuan, H.-H., Zhang, W.-Y., & Jiang, B. (2011) · Lung Cancer · doi:10.1016/j.lungcan.2011.01.002 · Cited by 161
Mu, X., Zhao, T., Xu, C., Shi, W., Geng, B., Shen, J., Zhang, C., Pan, J., Yang, J., Hu, S., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.14485 · Cited by 124
STAT3-YAP/TAZ signaling in endothelial cells promotes tumor angiogenesis
Shen, Y., Wang, X., Liu, Y., Singhal, M., Gürkaşlar, C., Valls, A. F., Lei, Y., Hu, W., Schermann, G., Adler, H., et al. (2021) · Science Signaling · doi:10.1126/scisignal.abj8393 · Cited by 121
Metadata
- Authors
- Chen, Z., & Han, Z. C.
- Venue
- Medicinal Research Reviews
- Publisher
- Wiley
- Published
- 2007-04-24
- Volume
- 28
- Issue
- 2
- Pages
- 185-200
- ISSN
- 0198-6325 (ISSN-L)
- 1098-1128
- OpenAlex
- W2100382285
- Cited by
- 305
- References
- 110
- FWCI
- 3.71
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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