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STAT3: A critical transcription activator in angiogenesis
Abstract
Angiogenesis, the formation of new blood vessels from the pre‐existing vasculature, is a complex multistage process regulated by a number of signal transduction pathways. Accumulating evidence suggests that signal transducer and activator of transcription (STATs), mainly STAT3, play an important role in angiogenesis under both physiological and pathological conditions in addition to cell survival, proliferation, differentiation, and oncogenesis. STAT3, as a critical multifunctional mediator, regulates many aspects of angiogenesis at the transcriptional level. This review will highlight the pivotal role of STAT3 in well‐studied tumorous angiogenesis and cardiac angiogenesis, and summarize various potential mechanisms utilized by STAT3 to regulate the transcriptional activation of VEGF. © 2007 Wiley Periodicals, Inc. Med Res Rev, 28, No. 2, 185–200, 2008
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Peroxynitrite increases VEGF expression in vascular endothelial cells via STAT3
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Expression and activation of STAT proteins during mouse retina development
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Leukemia Inhibitory Factor Induces Endothelial Differentiation in Cardiac Stem Cells
Mohri, T., Fujio, Y., Maeda, M., Ito, T., Iwakura, T., Oshima, Y., Uozumi, Y., Segawa, M., Yamamoto, H., Kishimoto, T., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m508969200 · Cited by 45
Expression and Activation of STAT3 in Ischemia-Induced Retinopathy
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Atiprimod is an inhibitor of cancer cell proliferation and angiogenesis.
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Cited by
Role of STAT3 in Cancer Metastasis and Translational Advances
Kamran, M. Z., Patil, P., & Gude, R. P. (2013) · BioMed Research International · doi:10.1155/2013/421821 · Cited by 393
Paracrine Mechanisms of Mesenchymal Stromal Cells in Angiogenesis
Maacha, S., Sidahmed, H., Jacob, S., Gentilcore, G., Calzone, R., Grivel, J.-C., & Cugno, C. (2020) · Stem Cells International · doi:10.1155/2020/4356359 · Cited by 259
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Mu, X., Zhao, T., Xu, C., Shi, W., Geng, B., Shen, J., Zhang, C., Pan, J., Yang, J., Hu, S., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.14485 · Cited by 124
STAT3-YAP/TAZ signaling in endothelial cells promotes tumor angiogenesis
Shen, Y., Wang, X., Liu, Y., Singhal, M., Gürkaşlar, C., Valls, A. F., Lei, Y., Hu, W., Schermann, G., Adler, H., et al. (2021) · Science Signaling · doi:10.1126/scisignal.abj8393 · Cited by 121
Metadata
- Authors
- Chen, Z., & Han, Z. C.
- Venue
- Medicinal Research Reviews
- Publisher
- Wiley
- Published
- 2007-04-24
- Volume
- 28
- Issue
- 2
- Pages
- 185-200
- ISSN
- 0198-6325 (ISSN-L)
- 1098-1128
- OpenAlex
- W2100382285
- Cited by
- 305
- References
- 110
- FWCI
- 3.71
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
