JNK signaling in cancer cell survival

Patterns of somatic mutation in human cancer genomes

Greenman, C. D., Stephens, P., Smith, R., Dalgliesh, G. L., Hunter, C., Bignell, G. R., Davies, H. R., Teague, J. W., Butler, A. P., Stevens, C., et al. (2007) · Nature · doi:10.1038/nature05610 · Cited by 3,143

Signal integration by JNK and p38 MAPK pathways in cancer development

Wagner, E. F., & Nebreda, Á. R. (2009) · Nature reviews. Cancer · doi:10.1038/nrc2694 · Cited by 2,635

The STATs of cancer — new molecular targets come of age

Yu, H., & Jove, R. (2004) · Nature Reviews Cancer · doi:10.1038/nrc1275 · Cited by 2,278

Autophagy Is Activated for Cell Survival after Endoplasmic ReticulumStress

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Requirement of JNK for Stress- Induced Activation of the Cytochrome c-Mediated Death Pathway

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TGF-β directly targets cytotoxic T cell functions during tumor evasion of immune surveillance

Thomas, D. A., & Massagué, J. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.10.012 · Cited by 1,355

JNK1-Mediated Phosphorylation of Bcl-2 Regulates Starvation-Induced Autophagy

Wei, Y., Pattingre, S., Sinha, S., Bassik, M., & Levine, B. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.06.001 · Cited by 1,329

Inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity

Kortylewski, M., Kujawski, M., Wang, T., Sheng, W., Zhang, S., Pilon‐Thomas, S., Niu, G., Kay, H. D., Mulé, J. J., Kerr, W. G., et al. (2005) · Nature Medicine · doi:10.1038/nm1325 · Cited by 1,026

Apoptotic Cells Can Induce Compensatory Cell Proliferation through the JNK and the Wingless Signaling Pathways

Ryoo, H. D., Gorenc, T., & Steller, H. (2004) · Developmental Cell · doi:10.1016/j.devcel.2004.08.019 · Cited by 624

JNK Signaling: Regulation and Functions Based on Complex Protein-Protein Partnerships

Zeke, A., Misheva, M., Reményi, A., & Bogoyevitch, M. A. (2016) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00043-14 · Cited by 552

Targeting the RAF–MEK–ERK pathway in cancer therapy

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Evasion of the p53 tumour surveillance network by tumour-derived MYC mutants

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MAPK/JNK signalling: a potential autophagy regulation pathway

Zhou, Y.-Y., Li, Y., Jiang, W.-Q., & Zhou, L.-F. (2015) · Bioscience Reports · doi:10.1042/bsr20140141 · Cited by 444

JNK at the crossroad of obesity, insulin resistance, and cell stress response

Solinas, G., & Becattini, B. (2016) · Molecular Metabolism · doi:10.1016/j.molmet.2016.12.001 · Cited by 444

Activation of the JNK signaling pathway: Breaking the brake on apoptosis

Lin, A. (2002) · BioEssays · doi:10.1002/bies.10204 · Cited by 432

Dual Role of JNK1-mediated phosphorylation of Bcl-2 in autophagy and apoptosis regulation

Wei, Y., Sinha, S. C., & Levine, B. (2008) · Autophagy · doi:10.4161/auto.6788 · Cited by 424

Distinct Roles for JNK1 and JNK2 in Regulating JNK Activity and c-Jun-Dependent Cell Proliferation

Sabapathy, K., Hochedlinger, K., Nam, S. Y., Bauer, A., Karin, M., & Wagner, E. F. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.08.028 · Cited by 397

JNK-signaling: A multiplexing hub in programmed cell death

Dhanasekaran, D. N., & Reddy, E. P. (2017) · Genes & Cancer · doi:10.18632/genesandcancer.155 · Cited by 369

Matrix Survival Signaling

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JNK signalling in cancer: in need of new, smarter therapeutic targets

Bubici, C., & Papa, S. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12432 · Cited by 355

Chemical Genetic Analysis of the Time Course of Signal Transduction by JNK

Ventura, J., Hübner, A., Zhang, C., Flavell, R. A., Shokat, K. M., & Davis, R. J. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.01.018 · Cited by 329

Insulin‐like growth factor‐1 and TNF‐α regulate autophagy through c‐jun N‐terminal kinase and Akt pathways in human atherosclerotic vascular smooth cells

Jia, G., Cheng, G., Gangahar, D. M., & Agrawal, D. K. (2006) · Immunology and Cell Biology · doi:10.1111/j.1440-1711.2006.01454.x · Cited by 306

The functional contrariety of JNK

Bode, A. M., & Dong, Z. (2007) · Molecular Carcinogenesis · doi:10.1002/mc.20348 · Cited by 304

Sustained production of ROS triggers compensatory proliferation and is required for regeneration to proceed

Gauron, C., Rampon, C., Bouzaffour, M., Ipendey, E., Teillon, J., Volovitch, M., & Vriz, S. (2013) · Scientific Reports · doi:10.1038/srep02084 · Cited by 296

Role of JNK1-dependent Bcl-2 Phosphorylation in Ceramide-induced Macroautophagy

Pattingre, S., Bauvy, C., Carpentier, S., Levade, T., Levine, B., & Codogno, P. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m805920200 · Cited by 290

Disruption of TAK1 in hepatocytes causes hepatic injury, inflammation, fibrosis, and carcinogenesis

Inokuchi, S., Aoyama, T., Miura, K., Österreicher, C. H., Kodama, Y., Miyai, K. N., Akira, S., Brenner, D. A., & Seki, E. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909781107 · Cited by 283

Linking JNK signaling to NF-κB: a key to survival

Papa, S., Zazzeroni, F., Pham, C. G., Bubici, C., & Franzoso, G. (2004) · Journal of Cell Science · doi:10.1242/jcs.01483 · Cited by 277

JunD Mediates Survival Signaling by the JNK Signal Transduction Pathway

Lamb, J. A., Ventura, J., Hess, P., Flavell, R. A., & Davis, R. J. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00203-x · Cited by 261

The Role of Apoptosis-Induced Proliferation for Regeneration and CancerPreprint

Ryoo, H. D., & Bergmann, A. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a008797 · Cited by 243

Cisplatin induces a persistent activation of JNK that is related to cell death

Sánchez‐Pérez, I., Murguía, J. R., & Perona, R. (1998) · Oncogene · doi:10.1038/sj.onc.1201578 · Cited by 236

Evading tumor evasion: Current concepts and perspectives of anti-angiogenic cancer therapy

Abdollahi, A., & Folkman, J. (2010) · Drug Resistance Updates · doi:10.1016/j.drup.2009.12.001 · Cited by 236

Differential effects of JNK1 and JNK2 inhibition on murine steatohepatitis and insulin resistance†

Singh, R., Wang, Y., Xiang, Y., Tanaka, K. E., Gaarde, W. A., & Czaja, M. J. (2008) · Hepatology · doi:10.1002/hep.22578 · Cited by 228

The JNK Signaling Pathway in Renal Fibrosis

Grynberg, K., Ma, F. Y., & Nikolic‐Paterson, D. J. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00829 · Cited by 226

Regulation of Hippo signaling by Jun kinase signaling during compensatory cell proliferation and regeneration, and in neoplastic tumors

Sun, G., & Irvine, K. D. (2011) · Developmental Biology · doi:10.1016/j.ydbio.2010.11.036 · Cited by 219

JNK-Induced Apoptosis, Compensatory Growth, and Cancer Stem Cells

Chen, F. (2012) · Cancer Research · doi:10.1158/0008-5472.can-11-1982 · Cited by 205

c-Jun N-Terminal Protein Kinase 1 (JNK1), but Not JNK2, Is Essential for Tumor Necrosis Factor Alpha-Induced c-Jun Kinase Activation and Apoptosis

Liu, J., Minemoto, Y., & Lin, A. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.24.10844-10856.2004 · Cited by 201

JNK Pathway Signaling: A Novel and Smarter Therapeutic Target for Various Biological Diseases

Kumar, A., Singh, U. K., Kini, S. G., Garg, V., Agrawal, S., Tomar, P. K., Pathak, P., Chaudhary, A., Gupta, P., & Malik, A. (2015) · Future Medicinal Chemistry · doi:10.4155/fmc.15.132 · Cited by 200

Tumor Evasion from T Cell Surveillance

Töpfer, K., Kempe, S., Müller, N., Schmitz, M., Bachmann, M. P., Cartellieri, M., Schackert, G., & Temme, A. (2011) · BioMed Research International · doi:10.1155/2011/918471 · Cited by 178

Yorkie: the final destination of Hippo signaling

Oh, H., & Irvine, K. D. (2010) · Trends in Cell Biology · doi:10.1016/j.tcb.2010.04.005 · Cited by 169

The Activation of c-Jun NH2-terminal Kinase (JNK) by DNA-damaging Agents Serves to Promote Drug Resistance via Activating Transcription Factor 2 (ATF2)-dependent Enhanced DNA Repair

Hayakawa, J., Depatie, C., Ohmichi, M., & Mercola, D. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210992200 · Cited by 158

c-Jun N-terminal kinase (JNK) is required for survival and proliferation of B-lymphoma cells

Gururajan, M., Chui, R., Karuppannan, A. K., Ke, J., JENNINGS, C. D., & Bondada, S. (2005) · Blood · doi:10.1182/blood-2004-10-3819 · Cited by 156

The Absence of NF-κB-Mediated Inhibition of c-Jun N-Terminal Kinase Activation Contributes to Tumor Necrosis Factor Alpha-Induced Apoptosis

Tang, F., Tang, G., Xiang, J., Dai, Q., Rosner, M. R., & Lin, A. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.24.8571-8579.2002 · Cited by 145

c-Jun NH2-Terminal Kinase (JNK)1 and JNK2 Have Distinct Roles in CD8+ T Cell Activation

Conze, D. B., Krahl, T., Kennedy, N. J., Weiss, L., Lumsden, J. M., Hess, P., Flavell, R. A., Gros, G. S. L., Davis, R. J., & Rincón, M. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20011508 · Cited by 145

The true face of JNK activation in apoptosis

Lin, A., & Dibling, B. C. (2002) · Aging Cell · doi:10.1046/j.1474-9728.2002.00014.x · Cited by 144

Linking tumor glycolysis and immune evasion in cancer: Emerging concepts and therapeutic opportunities

Ganapathy‐Kanniappan, S. (2017) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2017.04.002 · Cited by 144

JAK/STAT Pathway Plays a Critical Role in the Proinflammatory Gene Expression and Apoptosis of RAW264.7 Cells Induced by Trichothecenes as DON and T-2 Toxin

Wang, X., Liu, Q., Ihsan, A., Huang, L., Dai, M., Hao, H., Cheng, G., Liu, Z., Wang, Y., & Yuan, Z. (2012) · Toxicological Sciences · doi:10.1093/toxsci/kfs106 · Cited by 131

JNK/c-Jun Signaling Mediates an Anti-Apoptotic Effect of RANKL in Osteoclasts

Ikeda, F., Matsubara, T., Tsurukai, T., Hata, K., Nishimura, R., & Yoneda, T. (2008) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.080211 · Cited by 130

RIP3 Inhibits Inflammatory Hepatocarcinogenesis but Promotes Cholestasis by Controlling Caspase-8- and JNK-Dependent Compensatory Cell Proliferation

Vucur, M., Reisinger, F., Gautheron, J., Janssen, J., Roderburg, C., Cardenas, D. V., Kreggenwinkel, K., Koppe, C., Hammerich, L., Hakem, R., et al. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.07.035 · Cited by 127

TRPM2 channel–mediated regulation of autophagy maintains mitochondrial function and promotes gastric cancer cell survival via the JNK-signaling pathway

Almasi, S., Kennedy, B. E., Elaghil, M., Sterea, A. M., Gujar, S. A., Partida‐Sánchez, S., & Hiani, Y. E. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.817635 · Cited by 126

JNK-Bcl-2/Bcl-xL-Bax/Bak Pathway Mediates the Crosstalk between Matrine-Induced Autophagy and Apoptosis via Interplay with Beclin 1

Yang, J., & Yao, S. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms161025744 · Cited by 118

The JNK Are Important for Development and Survival of Macrophages

Himes, S. R., Sester, D. P., Ravasi, T., Cronau, S. L., Sasmono, T., & Hume, D. A. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.4.2219 · Cited by 117

Trichothecenes: immunomodulatory effects, mechanisms, and anti-cancer potential

Wu, Q., Wang, X., Nepovimová, E., Miron, A., Liu, Q., Wang, Y., Su, D., Yang, H., Li, L., & Kuča, K. (2017) · Archives of Toxicology · doi:10.1007/s00204-017-2118-3 · Cited by 115

c-Jun NH2-Terminal Kinase Activation Contributes to Hypoxia-Inducible Factor 1α–Dependent P-Glycoprotein Expression in Hypoxia

Comerford, K. M., Cummins, E. P., & Taylor, C. T. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-1919 · Cited by 108

Differential effects of JNK1 and JNK2 on signal specific induction of apoptosis

Hochedlinger, K., Wagner, E. F., & Sabapathy, K. (2002) · Oncogene · doi:10.1038/sj.onc.1205348 · Cited by 105

Crosstalk between CCL7 and CCR3 promotes metastasis of colon cancer cells via ERK-JNK signaling pathways

Lee, Y. S., Kim, S.-Y., Hong, H. K., Hong, H. K., Lee, Y., Oh, B. Y., Lee, W. Y., & Cho, Y. B. (2016) · Oncotarget · doi:10.18632/oncotarget.9209 · Cited by 105

A Wingless and Notch double‐repression mechanism regulates G1–S transition in the Drosophila wing

Herranz, H., Pérez, L., Martín, F. A., & Milán, M. (2008) · The EMBO Journal · doi:10.1038/emboj.2008.84 · Cited by 105

Annexin A2 contributes to cisplatin resistance by activation of JNK-p53 pathway in non-small cell lung cancer cells

Feng, X., Liu, H., Zhang, Z., Gu, Y., Qiu, H., & He, Z. (2017) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-017-0594-1 · Cited by 100

JNK suppression of chemotherapeutic agents-induced ROS confers chemoresistance on pancreatic cancer stem cells

Suzuki, S., Okada, M., Shibuya, K., Seino, M., Satō, A., Takeda, H., Seino, S., Yoshioka, T., & Kitanaka, C. (2014) · Oncotarget · doi:10.18632/oncotarget.2693 · Cited by 94

ROS activates JNK-mediated autophagy to counteract apoptosis in mouse mesenchymal stem cells in vitro

Liu, G.-Y., Jiang, X., Zhu, X., He, W., Kuang, Y., Ren, K., Lin, Y., & Gou, X. (2015) · Acta Pharmacologica Sinica · doi:10.1038/aps.2015.101 · Cited by 93

Autophagy stimulation as a promising approach in treatment of neurodegenerative diseases

Pierzynowska, K., Gaffke, L., Cyske, Z., Puchalski, M., Rintz, E., Bartkowski, M., Osiadły, M., Pierzynowski, M., Mantej, J., Piotrowska, E., et al. (2018) · Metabolic Brain Disease · doi:10.1007/s11011-018-0214-6 · Cited by 93

JNK2: A Negative Regulator of Cellular Proliferation

Sabapathy, K., & Wagner, E. F. (2004) · Cell Cycle · doi:10.4161/cc.3.12.1315 · Cited by 91

Balance between NF-κB and JNK/AP-1 activity controls dendritic cell life and death

Kriehuber, E., Bauer, W. M., Charbonnier, A.-S., Winter, D., Amatschek, S., Tamandl, D., Schweifer, N., Stingl, G., & Maurer, D. (2005) · Blood · doi:10.1182/blood-2004-08-3072 · Cited by 90

JAK/STAT signalling mediates cell survival in response to tissue stress

Fortezza, M. L., Schenk, M., Cosolo, A., Kolybaba, A. M., Grass, I., & Classen, A.-K. (2016) · Development · doi:10.1242/dev.132340 · Cited by 89

Role of JNK signaling in oral cancer: A mini review

Gkouveris, I., & Nikitakis, N. G. (2017) · Tumor Biology · doi:10.1177/1010428317711659 · Cited by 87

Ciclopirox induces autophagy through reactive oxygen species-mediated activation of JNK signaling pathway

Zhou, H., Shen, T., Shang, C., Luo, Y., Liu, L., Yan, J., Li, Y., & Huang, S. (2014) · Oncotarget · doi:10.18632/oncotarget.2471 · Cited by 86

c-Jun NH2-Terminal Kinase (JNK)1 and JNK2 Signaling Pathways Have Divergent Roles in CD8+ T Cell–mediated Antiviral Immunity

Arbour, N., Naniche, D., Homann, D., Davis, R. J., Flavell, R. A., & Oldstone, M. B. A. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20011481 · Cited by 83

JNK Signaling Mediates EPHA2-Dependent Tumor Cell Proliferation, Motility, and Cancer Stem Cell–like Properties in Non–Small Cell Lung Cancer

Song, W., Ma, Y., Wang, J., Brantley‐Sieders, D. M., & Chen, J. (2014) · Cancer Research · doi:10.1158/0008-5472.can-13-2136 · Cited by 82

Activation of JNK/c-Jun is required for the proliferation, survival, and angiogenesis induced by EET in pulmonary artery endothelial cells

Ma, J., Zhang, L., Han, W., Shen, T., Ma, C., Liu, Y., Nie, X., Liu, M., Ran, Y., & Zhu, D. (2012) · Journal of Lipid Research · doi:10.1194/jlr.m024398 · Cited by 77

HMGB1-mediated autophagy attenuates gemcitabine-induced apoptosis in bladder cancer cells involving JNK and ERK activation

Yin, H., Yang, X., Gu, W., Liu, Y., Li, X., Huang, X., Zhu, X., Tao, Y., Gou, X., & He, W. (2017) · Oncotarget · doi:10.18632/oncotarget.17796 · Cited by 74

Antioxidant agents against trichothecenes: new hints for oxidative stress treatment

Wu, Q., Wang, X., Nepovimová, E., Wang, Y., Yang, H., Li, L., Zhang, X., & Kuča, K. (2017) · Oncotarget · doi:10.18632/oncotarget.22800 · Cited by 73

Acentrosomal Drosophila Epithelial Cells Exhibit Abnormal Cell Division, Leading to Cell Death and Compensatory Proliferation

Poulton, J. S., Cuningham, J. C., & Peifer, M. A. (2014) · Developmental Cell · doi:10.1016/j.devcel.2014.08.007 · Cited by 72

JNK1 and JNK2 Oppositely Regulate p53 in Signaling Linked to Apoptosis Triggered by an Altered Fibronectin Matrix

Tafolla, E., Wang, S., Wong, B., Leong, J., & Kapila, Y. L. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m500331200 · Cited by 72

Jnk signaling pathway-mediated regulation of Stat3 activation is linked to the development of doxorubicin resistance in cancer cell lines

Kim, J.-H., Lee, S. C., Ro, J., Kang, H. S., Kim, H. S., & Yoon, S. (2009) · Biochemical Pharmacology · doi:10.1016/j.bcp.2009.09.008 · Cited by 71

A role for JNK/SAPK in proliferation, but not apoptosis, of IL-3-dependent cells

Smith, A., Ramos‐Morales, F., Ashworth, A., & Collins, M. K. (1997) · Current Biology · doi:10.1016/s0960-9822(06)00380-0 · Cited by 71

The Cdc42/Par6/aPKC Polarity Complex Regulates Apoptosis-Induced Compensatory Proliferation in Epithelia

Warner, S. J., Yashiro, H., & Longmore, G. D. (2010) · Current Biology · doi:10.1016/j.cub.2010.03.025 · Cited by 70

DUSP4 deficiency caused by promoter hypermethylation drives JNK signaling and tumor cell survival in diffuse large B cell lymphoma

Schmid, C. A., Robinson, M. D., Scheifinger, N. A., Müller, S., Cogliatti, S., Tzankov, A., & Mueller, A. (2015) · The Journal of Experimental Medicine · doi:10.1084/jem.20141957 · Cited by 64

Apoptosis and Compensatory Proliferation Signaling Are Coupled by CrkI-Containing Microvesicles

Gupta, K. H., Goldufsky, J. W., Wood, S. J., Tardi, N. J., Moorthy, G. S., Gilbert, D. Z., Zayas, J. P., Hahm, E., Altintas, M. M., Reiser, J., et al. (2017) · Developmental Cell · doi:10.1016/j.devcel.2017.05.014 · Cited by 62

Cardamonin induces autophagy and an antiproliferative effect through JNK activation in human colorectal carcinoma HCT116 cells

Kim, Y., Kang, K. S., Choi, K., & Ko, H. (2015) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2015.04.054 · Cited by 60

IL-33-induced JNK pathway activation confers gastric cancer chemotherapy resistance

YE, X.-L., Zhao, Y., Weng, G., Chen, Y., Wei, X., Shao, J., & Ji, H. (2015) · Oncology Reports · doi:10.3892/or.2015.3898 · Cited by 60

Increased JNK1 Signaling Pathway Is Responsible for ABCG2-Mediated Multidrug Resistance in Human Colon Cancer

Zhu, M., Tong, J. L., Xu, Q., Nie, F., Xi Tao, X. U., Shu Dong, X. I. A. O., & Ran, Z. H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041763 · Cited by 59

Galectin-7 Regulates Keratinocyte Proliferation and Differentiation through JNK-miR-203-p63 Signaling

Chen, H.-L., Chiang, P.-C., Lo, C.-H., Lo, Y., Hsu, D. K., Chen, H., & Liu, F. (2015) · Journal of Investigative Dermatology · doi:10.1038/jid.2015.366 · Cited by 58

Pro-survival effects of JNK and p38 MAPK pathways in LPS-induced activation of BV-2 cells

Svensson, C., Part, K., Künnis-Beres, K., Kaldmäe, M., Fernaeus, S. Z., & Land, T. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.02.083 · Cited by 56

JNK and Macroautophagy Activation by Bortezomib Has a Pro-Survival Effect in Primary Effusion Lymphoma Cells

Granato, M., Santarelli, R., Lotti, L. V., Renzo, L. D., Gonnella, R., Garufi, A., Trivedi, P., Frati, L., D’Orazi, G., Faggioni, A., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0075965 · Cited by 55

Tumor Immune Evasion

Zindl, C. L., & Chaplin, D. (2010) · Science · doi:10.1126/science.1190310 · Cited by 55

TGF-β1 enhances tumor-induced angiogenesis via JNK pathway and macrophage infiltration in an improved zebrafish embryo/xenograft glioma model

Yang, X., Chen, G.-L., Yu, S., Xu, C. S., Xin, Y.-H., Li, T., Shi, Y., Ai, G., Duan, J., Qian, C., et al. (2012) · International Immunopharmacology · doi:10.1016/j.intimp.2012.12.002 · Cited by 53

Overexpression of c-Jun contributes to sorafenib resistance in human hepatoma cell lines

Haga, Y., Kanda, T., Nakamura, M., Nakamoto, S., Sasaki, R., Takahashi, K., Wu, S., & Yokosuka, O. (2017) · PLoS ONE · doi:10.1371/journal.pone.0174153 · Cited by 52

TBP Is Differentially Regulated by c-Jun N-Terminal Kinase 1 (JNK1) and JNK2 through Elk-1, Controlling c-Jun Expression and Cell Proliferation

Zhong, S., Longo, J. F., & Johnson, D. L. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.01365-06 · Cited by 50

Heme oxygenase-1 suppresses the apoptosis of acute myeloid leukemia cells via the JNK/c-JUN signaling pathway

Lin, X., Fang, Q., Chen, S., Zhe, N., Chai, Q., Yu, M., Zhang, Y., Wang, Z., & Wang, J. (2015) · Leukemia Research · doi:10.1016/j.leukres.2015.02.009 · Cited by 47

Role of C-Jun N-terminal Kinase in Hepatocellular Carcinoma Development

Wang, J., & Tai, G. (2016) · Targeted Oncology · doi:10.1007/s11523-016-0446-5 · Cited by 46

Doxorubicin induces expression of multidrug resistance-associated protein 1 in human small cell lung cancer cell lines by the c-jun N-terminal kinase pathway

Shinoda, C., Maruyama, M., 藤下, 隆., Dohkan, J., Oda, H., Shinoda, K., Yamada, T., Miyabayashi, K., Hayashi, R., Kawagishi, Y., et al. (2005) · International Journal of Cancer · doi:10.1002/ijc.21094 · Cited by 46

Jun Kinase Delays Caspase-9 Activation by Interaction with the Apoptosome

Tran, T., Andreka, P. G., Rodrigues, C. O., Webster, K. A., & Bishopric, N. H. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m702210200 · Cited by 45

Drug resistance of bladder cancer cells through activation of ABCG2 by FOXM1

Roh, Y.-G., Mun, M.-H., Jeong, M.-S., Kim, W., Lee, S.-R., Chung, J.-W., Kim, S. I., Kim, T. N., Nam, J. K., & Leem, S. (2018) · BMB Reports · doi:10.5483/bmbrep.2018.51.2.222 · Cited by 45

Targeting STAT3 phosphorylation by neem leaf glycoprotein prevents immune evasion exerted by supraglottic laryngeal tumor induced M2 macrophages

Goswami, K. K., Barik, S., Sarkar, M., Bhowmick, A. K., Biswas, J. K., Bose, A., & Baral, R. (2014) · Molecular Immunology · doi:10.1016/j.molimm.2014.01.015 · Cited by 44

Functional p38 MAPK Identified by Biomarker Profiling of Pancreatic Cancer Restrains Growth through JNK Inhibition and Correlates with Improved Survival

Zhong, Y., Naito, Y., Cope, L., Naranjo‐Suarez, S., Saunders, T., Hong, S., Goggins, M., Herman, J. M., Wolfgang, C. L., & Iacobuzio–Donahue, C. A. (2014) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-13-2823 · Cited by 44

TLE4 promotes colorectal cancer progression through activation of JNK/c-Jun signaling pathway

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Toll-like receptor 4 signaling promotes invasion of hepatocellular carcinoma cells through MKK4/JNK pathway

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Crosstalk of JNK1-STAT3 is critical for RAW264.7 cell survival

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Crosstalk between JNK and NF-κB signaling pathways via HSP27 phosphorylation in HepG2 cells

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JNK1 Inhibition Attenuates Hypoxia-Induced Autophagy and Sensitizes to Chemotherapy

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Anti-proliferation of triple-negative breast cancer cells with physagulide P: ROS/JNK signaling pathway induces apoptosis and autophagic cell death

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mTORC1 pathway mediates beta cell compensatory proliferation in 60 % partial-pancreatectomy mice

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Activation of JNK by TPA promotes apoptosis via PKC pathway in gastric cancer cells

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Blocking autophagy enhances the apoptotic effect of 18β-glycyrrhetinic acid on human sarcoma cells via endoplasmic reticulum stress and JNK activation

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cJun N-terminal kinase (JNK) mediates cortico-striatal signaling in a model of Parkinson's disease

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Basal Cancer Cell Survival Involves JNK2 Suppression of a Novel JNK1/c-Jun/Bcl-3 Apoptotic Network

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Midazolam anesthesia protects neuronal cells from oxidative stress-induced death via activation of the JNK-ERK pathway

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Endothelin‐1 protects human melanocytes from UV ‐induced DNA damage by activating JNK and p38 signalling pathways

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Cancer associated fibroblasts tailored tumor microenvironment of therapy resistance in gastrointestinal cancers

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Role of mitogen-activated protein kinase signaling in the pathogenesis of dengue virus infection

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Tumour growth and immune evasion as targets for a new strategy in advanced cancer

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SP600125, an inhibitor of Jnk pathway, reduces viability of relatively resistant cancer cells to doxorubicin

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Contribution of persistent C-Jun N-terminal kinase activity to the survival of human vestibular schwannoma cells by suppression of accumulation of mitochondrial superoxides

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Autophagy activated by the c-Jun N-terminal kinase-mediated pathway protects human prostate cancer PC3 cells from celecoxib-induced apoptosis

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Involvement of the c-jun N-terminal kinases JNK1 and JNK2 in complement-mediated cell death

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Immune-mediated tumor evolution: Nanog links the emergence of a stem like cancer cell state and immune evasion

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Oppositional Regulation of Noxa by JNK1 and JNK2 during Apoptosis Induced by Proteasomal Inhibitors

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Autophagy-independent function of Atg1 for apoptosis-induced compensatory proliferation

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Activation of a c-Jun N-terminal kinase-mediated autophagy pathway attenuates the anticancer activity of gemcitabine in human bladder cancer cells

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Foxo1 Attenuates NaF-Induced Apoptosis of LS8 Cells through the JNK and Mitochondrial Pathways

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Autophagy blockade sensitizes the anticancer activity of CA-4 via JNK-Bcl-2 pathway

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CIP2A overexpression induces autoimmune response and enhances JNK signaling pathway in human lung cancer

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An In Vivo Functional Screen Identifies JNK Signaling As a Modulator of Chemotherapeutic Response in Breast Cancer

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Synthesis and SAR of novel isoxazoles as potent c-jun N-terminal kinase (JNK) inhibitors

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Signalling pathways involved in clinical responses to chemotherapy

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The NAB-Brk Signal Bifurcates at JNK to Independently Induce Apoptosis and Compensatory Proliferation

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TAK1–JNK Axis Mediates Survival Signal through Mcl1 Stabilization in Activated T Cells

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STAT3-enhancing germline mutations contribute to tumor-extrinsic immune evasion

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JNK and JAK/STAT signalling are required for inducing loss of cell fate specification during imaginal wing discs regeneration in Drosophila melanogaster

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The c-Jun N-terminal kinase inhibitor SP600125 inhibits human cytomegalovirus replication

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JNK activation is required for TNFα-induced apoptosis in human hepatocarcinoma cells

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Inhibition of JNK and prothymosin-alpha sensitizes hepatocellular carcinoma cells to cisplatin

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Attenuated JNK signaling in multidrug-resistant leukemic cells. Dual role of MAPK in cell survival

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Ligation of IFN-γ-induced HLA-DR molecules on fibroblasts induces RANTES expression via c-Jun N-terminal kinase (JNK) pathway

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TGF‐β Down‐regulates Apolipoprotein M Expression through the TAK‐1‐JNK‐c‐Jun Pathway in HepG2 Cells

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The Bone Marrow-Mediated Protection of Myeloproliferative Neoplastic Cells to Vorinostat and Ruxolitinib Relies on the Activation of JNK and PI3K Signalling Pathways

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Two different specific JNK activators are required to trigger apoptosis or compensatory proliferation in response to Rbf1 in Drosophila

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Tumor necrosis factor receptor‐associated factor 6 mediated the promotion of salivary adenoid cystic carcinoma progression through Smad‐p38‐ JNK signaling pathway induced by TGF ‐β

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Phosphorylation of Bcl-associated death protein (Bad) by erythropoietin-activated c-Jun N-terminal protein kinase 1 contributes to survival of erythropoietin-dependent cells

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Compensatory role of Neuroglobin in nervous and non-nervous cancer cells in response to the nutrient deprivation

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c-Jun N-terminal kinase 1 defective CD4+CD25+FoxP3+ cells prolong islet allograft survival in diabetic mice

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A Tumor Cell-Intrinsic Yin-Yang Determining Immune Evasion

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Regulation of compensatory β-cell proliferation by inter-organ networks from the liver to pancreatic β-cells

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37LRP induces invasion in hypoxic lung adenocarcinoma cancer cells A549 through the JNK/ERK/c-Jun signaling cascade

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The JAK/STAT signaling pathway: from bench to clinic

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Hypoxia-inducible factors: master regulators of hypoxic tumor immune escape

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Hypoxia inhibits ferritinophagy, increases mitochondrial ferritin, and protects from ferroptosis

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The JNK Signaling Pathway in Inflammatory Skin Disorders and Cancer

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Selective inhibitors for JNK signalling: a potential targeted therapy in cancer

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THE CELL SURVIVAL FUNCTION OF JNK

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JunD Mediates Survival Signaling by the JNK Signal Transduction Pathway

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JNK-signaling: A multiplexing hub in programmed cell death

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The Regulation of the JNK Cascade and Programmed Cell Death by NF-κB: Mechanisms and Functions

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