The JNK Are Important for Development and Survival of Macrophages

Himes, S Roy; Sester, David P; Ravasi, Timothy; Cronau, Stephen L; Sasmono, Tedjo; Hume, David A

doi:10.4049/jimmunol.176.4.2219

Cited by 117Cytokine Signaling Pathways and InteractionsImmune cells in cancerNF-κB Signaling Pathways

The JNK Are Important for Development and Survival of Macrophages

Himes, S Roy, Sester, David P, Ravasi, Timothy, Cronau, Stephen L, Sasmono, Tedjo, Hume, David A·2006·The Journal of Immunology

DOI 10.4049/jimmunol.176.4.2219

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Abstract

We report in this study that activation of the JNK by the growth factor, CSF-1 is critical for macrophage development, proliferation, and survival. Inhibition of JNK with two distinct classes of inhibitors, the pharmacological agent SP600125, or the peptide D-JNKI1 resulted in cell cycle inhibition with an arrest at the G2/M transition and subsequent apoptosis. JNK inhibition resulted in decreased expression of CSF-1R (c-fms) and Bcl-xL mRNA in mature macrophages and repressed CSF-1-dependent differentiation of bone marrow cells to macrophages. Macrophage sensitivity to JNK inhibitors may be linked to phosphorylation of the PU.1 transcription factor. Inhibition of JNK disrupted PU.1 binding to an element in the c-fms gene promoter and decreased promoter activity. Promoter activity could be restored by overexpression of PU.1. A comparison of expression profiles of macrophages with 22 other tissue types showed that genes that signal JNK activation downstream of tyrosine kinase receptors, such as focal adhesion kinase, Nck-interacting kinase, and Rac1 and scaffold proteins are highly expressed in macrophages relative to other tissues. This pattern of expression may underlie the novel role of JNK in macrophages.

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Kerneur, C., Cano, C. E., & Olive, D. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1026954 · Cited by 348 · see citing works
JNK signaling in cancer cell survival
Wu, Q., Wu, W., Fu, B., Shi, L., Wang, X., & Kuca, K. (2019) · Medicinal Research Reviews · doi:10.1002/med.21574 · Cited by 322 · see citing works
Regulation of the immune response by stress‐activated protein kinases
Rincón, M., & Davis, R. J. (2009) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00744.x · Cited by 266 · see citing works
“Although pharmacological inhibitors and peptide inhibitors of JNK have been shown to induce apoptosis of macrophages and inhibit colony-stimulating factor (CSF-1)dependent differentiation of bone marrow cells into macrophages (37), no defect in macrophage differentiation has been reported in JNK-deficient mice.”
Background
JNK Pathway Signaling: A Novel and Smarter Therapeutic Target for Various Biological Diseases
Kumar, A., Singh, U. K., Kini, S. G., Garg, V., Agrawal, S., Tomar, P. K., Pathak, P., Chaudhary, A., Gupta, P., & Malik, A. (2015) · Future Medicinal Chemistry · doi:10.4155/fmc.15.132 · Cited by 200 · see citing works
Targeting iron homeostasis induces cellular differentiation and synergizes with differentiating agents in acute myeloid leukemia
Callens, C., Coulon, S., Naudin, J., Radford-Weiss, I., Boissel, N., Raffoux, E., Wang, P. H. M., Agarwal, S., Tamouza, H., Paubelle, E., et al. (2010) · Journal of Experimental Medicine · doi:10.1084/jem.20091488 · Cited by 197 · see citing works
“Given the high similarities shared between VD and iron deprivation agents to induce cell differentiation, we investi gated whether iron deprivation of cells could induce VDR signaling (Wang et al., 2003; Himes et al., 2006).”
Background
MAP4K Family Kinases in Immunity and Inflammation
Chuang, H., Wang, X., & Tan, T. (2015) · Advances in immunology · doi:10.1016/bs.ai.2015.09.006 · Cited by 200 · see citing works
“GCK is also detected in macrophages where its expression level is further increased upon LPS stimulation (Himes et al., 2006).”
Background
Selective inhibitors for JNK signalling: a potential targeted therapy in cancer
Wu, Q., Wu, W., Jacevic, V. M., França, T. C. C., Wang, X., & Kuča, K. (2020) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.1080/14756366.2020.1720013 · Cited by 172 · see citing works
Functions of macrophage colony-stimulating factor (CSF1) in development, homeostasis, and tissue repair
Sehgal, A., Irvine, K. M., & Hume, D. A. (2021) · Seminars in Immunology · doi:10.1016/j.smim.2021.101509 · Cited by 155 · see citing works
Self-citation
Manipulation of host signalling pathways by anthrax toxins
Turk, B. E. (2007) · Biochemical Journal · doi:10.1042/bj20061891 · Cited by 149 · see citing works
TLR2 mediates phagocytosis and autophagy through JNK signaling pathway in Staphylococcus aureus-stimulated RAW264.7 cells
Fang, L., Wu, H., Ding, P., & Liu, R. (2014) · Cellular Signalling · doi:10.1016/j.cellsig.2013.12.016 · Cited by 146 · see citing works
Bi-allelic CSF1R Mutations Cause Skeletal Dysplasia of Dysosteosclerosis-Pyle Disease Spectrum and Degenerative Encephalopathy with Brain Malformation
Guo, L., Bertola, D. R., Takanohashi, A., Saito, A., Segawa, Y., Yokota, T., Ishibashi, S., Nishida, Y., Yamamoto, G. L., Franco, J. F. D. S., et al. (2019) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2019.03.004 · Cited by 133 · see citing works
“It has previously been shown that phosphorylation of CSF1R-tyrosine triggered by the ligand binding to the receptor activates multiple kinase pathways including PI3K, ERK1/2, and JNK.(19,20) To evaluate the functional impacts of three CSF1R variants (c.”
Background
Regulation of the intestinal tight junction by natural polyphenols: A mechanistic perspective
Yang, G., Bibi, S., Du, ‬., Suzuki, T., & Zhu, M. J. (2016) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2016.1152230 · Cited by 132 · see citing works
“Members of the JNK family also play crucial roles in inflammation (Himes et al., 2006).”
Background
G-protein-coupled receptor expression, function, and signaling in macrophages
Lattin, J. E., Zidar, D. A., Schroder, K., Kellie, S., Hume, D. A., & Sweet, M. J. (2007) · Journal of Leukocyte Biology · doi:10.1189/jlb.0107051 · Cited by 115 · see citing works
“[263].”
Self-citation
TLR4 signaling and macrophage inflammatory responses are dampened by GIV/Girdin
Swanson, L., Katkar, G. D., Tam, J. S., Pranadinata, R. F., Chareddy, Y. S., Coates, J., Anandachar, M. S., Castillo, V., Olson, J., Nizet, V., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2011667117 · Cited by 107 · see citing works
Antibody blockade of c-fms suppresses the progression of inflammation and injury in early diabetic nephropathy in obese db/db mice
Lim, A. K. H., Ma, F. Y., Nikolic‐Paterson, D. J., Thomas, M. C., Hurst, L., & Tesch, G. H. (2009) · Diabetologia · doi:10.1007/s00125-009-1399-3 · Cited by 103 · see citing works
“Other studies have indicated that the activation of JNK following c-fms signalling is critical for the development, proliferation and survival of macrophages [35].”
Background
M-CSF Signals through the MAPK/ERK Pathway via Sp1 to Induce VEGF Production and Induces Angiogenesis In Vivo
Curry, J. M., Eubank, T. D., Roberts, R. D., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003405 · Cited by 97 · see citing works
“Also, M-CSF activates the pro-survival mitogen-activated protein kinase (MAPK) pathway, including ERK, p38, and JNK [10–13].”
Background
T Cell Lineage Commitment: Identity and Renunciation
Rothenberg, E. V. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1003703 · Cited by 90 · see citing works
CSF-1, IGF-1, and the control of postnatal growth and development
Gow, D., Sester, D. P., & Hume, D. A. (2010) · Journal of Leukocyte Biology · doi:10.1189/jlb.0310158 · Cited by 90 · see citing works
“In the absence of CSF-1, mouse macrophages undergo programmed cell death [32].”
BackgroundSelf-citation
JNK Signaling in Stem Cell Self-Renewal and Differentiation
Semba, T., Sammons, R. M., Wang, X., Xie, X., Dalby, K. N., & Ueno, N. T. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21072613 · Cited by 84 · see citing works
Aloe emodin induces hepatotoxicity by activating NF-κB inflammatory pathway and P53 apoptosis pathway in zebrafish
Quan, Y., Gong, L., He, J., Zhou, Y., Liu, M., Cao, Z., Li, Y., & Peng, C. Y. (2019) · Toxicology Letters · doi:10.1016/j.toxlet.2019.02.007 · Cited by 77 · see citing works
Platelet Factor 4 (CXC Chemokine Ligand 4) Differentially Regulates Respiratory Burst, Survival, and Cytokine Expression of Human Monocytes by Using Distinct Signaling Pathways
Kasper, B., Brandt, E., Brandau, S., & Petersen, F. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.4.2584 · Cited by 76 · see citing works
“Although for development and survival of murine macrophages the activation of JNK was reported to be more relevant than Erk (32), our findings confirm previous reports from Monick et al.”
Result
ERK Signaling Is Essential for Macrophage Development
Richardson, E. T., Shukla, S., Nagy, N., Boom, W. H., Beck, R. C., Zhou, L., Landreth, G. E., & Harding, C. V. (2015) · PLoS ONE · doi:10.1371/journal.pone.0140064 · Cited by 73 · see citing works
CpG DNA Activates Survival in Murine Macrophages through TLR9 and the Phosphatidylinositol 3-Kinase-Akt Pathway
Sester, D. P., Brion, K., Trieu, A., Goodridge, H. S., Roberts, T. L., Dunn, J. A., Hume, D. A., Stacey, K. J., & Sweet, M. J. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.7.4473 · Cited by 71 · see citing works
“This is in agreement with previous studies showing no role for MEK-dependent ERK1/2 activation in BMM survival promoted by CSF-1 (64, 65), nor in the antiapoptotic action of CpG ODN and LPS on murine splenic DC (4).”
ResultSelf-citation
The transcriptional regulation of the Colony-Stimulating Factor 1 Receptor (csf1r) gene during hematopoiesis
Bonifer, C. (2007) · Frontiers in bioscience · doi:10.2741/2700 · Cited by 70 · see citing works
P38 and ERK mitogen-activated protein kinases mediate acrolein-induced apoptosis in Chinese hamster ovary cells
Tanel, A., & Averill‐Bates, D. A. (2006) · Cellular Signalling · doi:10.1016/j.cellsig.2006.10.014 · Cited by 65 · see citing works
Essential Roles for the Tec Family Kinases Tec and Btk in M-CSF Receptor Signaling Pathways That Regulate Macrophage Survival
Melcher, M., Unger, B., Schmidt, U., Rajantie, I., Alitalo, K. K., & Ellmeier, W. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.12.8048 · Cited by 63 · see citing works
“M-CSF starvation in macrophage cultures induces apoptosis (27).”
Background
Diallyl Disulfide and Diallyl Trisulfide Up-Regulate the Expression of the π Class of Glutathione S-Transferase via an AP-1-Dependent Pathway
Tsai, C.-W., Chen, H., Yang, J., Sheen, L., & Lii, C. (2007) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf061874t · Cited by 63 · see citing works
Regulation of monocyte differentiation by specific signaling modules and associated transcription factor networks
Huber, R., Pietsch, D., Günther, J., Welz, B., Vogt, N., & Brand, K. (2013) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-013-1322-4 · Cited by 59 · see citing works
“Inhibition of JNK leads to (i) decreased monocytic differentiation of 1,25(OH)2D3-treated HL-60 cells [144], (ii) a reduction of the protein tyrosine phosphatase (PTP) Shp2-induced increased monocytic precursor cell formation in Shp2-transduced murine hematopoietic progenitor cells [145], and (iii) to a markedly reduc…”
Background
The MacBlue Binary Transgene (csf1r-gal4VP16/UAS-ECFP) Provides a Novel Marker for Visualisation of Subsets of Monocytes, Macrophages and Dendritic Cells and Responsiveness to CSF1 Administration
Sauter, K. A. D., Pridans, C., Sehgal, A., Bain, C. C., Scott, C. L., Moffat, L., Rojo, R., Stutchfield, B. M., Davies, C. L., Donaldson, D. S., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0105429 · Cited by 59 · see citing works
“1 to promote macrophage differentiation and expression of other macrophage-specific genes ([46] and references therein) and jun kinase is required for CSF1-dependent macrophage survival [47].”
BackgroundSelf-citation
Transcriptional mechanisms that control expression of the macrophage colony-stimulating factor receptor locus
Rojo, R., Pridans, C., Langlais, D., & Hume, D. A. (2017) · Clinical Science · doi:10.1042/cs20170238 · Cited by 60 · see citing works
Self-citation
Survival of monocytes and macrophages and their role in health and disease
Hunter, M. G. (2009) · Frontiers in bioscience · doi:10.2741/3514 · Cited by 56 · see citing works
“JNK inhibition also downregulates M-CSF receptor (c-fms) and Bcl-xL mRNA expression in mature macrophages and represses M-CSF-dependent differentiation of bone marrow cells to macrophages (97).”
BackgroundResult
Activation of pH-Sensing Receptor OGR1 (GPR68) Induces ER Stress Via the IRE1α/JNK Pathway in an Intestinal Epithelial Cell Model
Maeyashiki, C., Melhem, H., Hering, L., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-57657-9 · Cited by 55 · see citing works
Active ERK Contributes to Protein Translation by Preventing JNK-Dependent Inhibition of Protein Phosphatase 1
Monick, M. M., Powers, L. S., Gross, T. J., Flaherty, D. M., Barrett, C. W., & Hunninghake, G. W. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.3.1636 · Cited by 51 · see citing works
“(59) study uses murine bone marrow-derived macrophages instead of human primary tissue macrophages (alveolar).”
BackgroundResultInfluential
Protein Tyrosine Phosphatase Non-Receptor Type 22 Modulates NOD2-Induced Cytokine Release and Autophagy
Spalinger, M. R., Lang, S., Vavricka, S. R., Fried, M., Rogler, G., & Scharl, M. M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0072384 · Cited by 50 · see citing works
CpG-ODN promotes phagocytosis and autophagy through JNK/P38 signal pathway in Staphylococcus aureus-stimulated macrophage
Wu, H., Wang, J., Zhang, B., et al. (2016) · Life Sciences · doi:10.1016/j.lfs.2016.07.016 · Cited by 49 · see citing works
Exogenous heat shock protein 27 uniquely blocks differentiation of monocytes to dendritic cells
Laudański, K., De, A. K., & Miller‐Graziano, C. L. (2007) · European Journal of Immunology · doi:10.1002/eji.200636993 · Cited by 48 · see citing works
A Peptide Inhibitor of c-Jun N-Terminal Kinase for the Treatment of Endotoxin-Induced Uveitis
Touchard, E., Omri, S., Naud, M.-C., Berdugo, M., Deloche, C., Abadie, C., Jonet, L., Jeanny, J.-C., Crisanti, P., de Kozak, Y., et al. (2010) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.09-4733 · Cited by 43 · see citing works
Regulatory Role of the JNK-STAT1/3 Signaling in Neuronal Differentiation of Cultured Mouse Embryonic Stem Cells
Wei, Z. Z., Yu, S. P., Lee, J. H., Chen, D., Taylor, T. M., Deveau, T. C., Yu, A. C., & Wei, L. (2014) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-014-0067-4 · Cited by 43 · see citing works
“JNK is a sub-family member of mitogen-activated protein kinase (MAPK) and a multifunctional kinase involved in cell survival (Himes et al. 2006; Fraser et al. 2013), apoptosis (Ouyang and Shen 2006), proinflammatory cytokine production (Chang et al. 2006), and osmotic imbalance (Fanger et al. 1997).”
Background
Infection with Leishmania major Induces a Cellular Stress Response in Macrophages
Filardy, A. A., Costa-da-Silva, A. C., Koeller, C. M., Pinto, K. G., Ribeiro-Gomes, F. L., Lopes, M. F., Heise, N., Freire-de-Lima, C. G., Nunes, M. P., & DosReis, G. A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0085715 · Cited by 45 · see citing works
“However, the JNK pathway is also involved in non-apoptotic responses such as macrophage differentiation [16] and proinflammatory cytokine and chemokine production [17,18].”
Background
Quantitative Proteomic Characterization of Ethanol-Responsive Pathways in Rat Microglial Cells
Bell‐Temin, H., Zhang, P., Chaput, D., King, M. A., You, M., Liu, B., & Stevens, S. M. (2013) · Journal of Proteome Research · doi:10.1021/pr301038f · Cited by 41 · see citing works
Glioblastoma Stem Cells at the Nexus of Tumor Heterogeneity, Immune Evasion, and Therapeutic Resistance
Tang, J., Amin, M. A., & Campian, J. L. (2025) · Cells · doi:10.3390/cells14080562 · Cited by 50 · see citing works
“GSCs modulate the phenotype and function of antigen-presenting cells (APCs) such as dendritic cells and macrophages, inducing immunosuppression and impairing the initiation of effective immune responses [80].”
Evaluation of JNK Blockade as an Early Intervention Treatment for Type 1 Diabetic Nephropathy in Hypertensive Rats
Lim, A. K. H., Ma, F. Y., Nikolic‐Paterson, D. J., Ozols, E., Young, M. J., Bennett, B. L., Friedman, G. C., & Tesch, G. H. (2011) · American Journal of Nephrology · doi:10.1159/000331058 · Cited by 38 · see citing works
JNK Signaling as a Key Modulator of Soft Connective Tissue Physiology, Pathology, and Healing
Nikoloudaki, G. E., Brooks, S., Peidl, A., Tinney, D., & Hamilton, D. W. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21031015 · Cited by 41 · see citing works
“In contrast to neutrophils, in monocyte and macrophage populations, which begin to infiltrate granulation tissue at 24 hours following injury, JNK signaling has been shown to regulate their survival [52,53].”
Background
Puerarin Increases Survival and Protects Against Organ Injury by Suppressing NF-κB/JNK Signaling in Experimental Sepsis
Wang, L., Liang, Q., Lin, A., Chen, X., Wu, Y., Zhang, B., Zhang, Y., Min, H., Wen, Y., Song, S., et al. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00560 · Cited by 35 · see citing works
Adenosine A2A receptor signaling attenuates LPS-induced pro-inflammatory cytokine formation of mouse macrophages by inducing the expression of DUSP1
Köröskényi, K., Kiss, B., & Szondy, Z. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2016.04.003 · Cited by 34 · see citing works
“Since macrophages express JNK1 and 2 [26], but the human phospho-MAPK array kit did not detect mouse JNK1, we tested its phosphorylation by Western blot analysis by using a mouse specific anti-JNK1 antibody.”
Method
Plenary Perspective: The complexity of constitutive and inducible gene expression in mononuclear phagocytes
Hume, D. A. (2012) · Journal of Leukocyte Biology · doi:10.1189/jlb.0312166 · Cited by 33 · see citing works
“required for macrophage viability [89].”
Self-citation
Lipopolysaccharide downregulates macrophage-derived IL-22 to modulate alcohol-induced hepatocyte cell death
Liu, Y., Verma, V. K., Malhi, H., Gores, G. J., Kamath, P. S., Sanyal, A. J., Chalasani, N., Gao, B., & Shah, V. H. (2017) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00005.2017 · Cited by 33 · see citing works
12-o-Tetradecanoylphorbol 13-acetate prevents baicalein-induced apoptosis via activation of protein kinase C and JNKs in human leukemia cells
Chow, J., Shen, S., Wu, C.-Y., et al. (2006) · APOPTOSIS · doi:10.1007/s10495-006-0085-x · Cited by 31 · see citing works
“In macrophages, suppression of JNKs results in cell cycle arrest at G2/M and apoptosis in response to CSF-1 treatment [38].”
Background
Macrophage differentiation of myeloid progenitor cells in response to M-CSF is regulated by the dual-specificity phosphatase DUSP5
Grasset, M.-F., Gobert, S., Mouchiroud, G., & Bourette, R. P. (2009) · Journal of Leukocyte Biology · doi:10.1189/jlb.0309151 · Cited by 28 · see citing works
“DUSP5 (also known as hVH-3 or B23) is a nuclear MKP that dephosphorylates ERK1/2, not ERK5, p38 MAPK, and JNK, through specific and direct interaction [23].”
BackgroundInfluential
Transcriptomic Analysis of Rat Macrophages
Pridans, C., Irvine, K. M., Davis, G. M., Lefèvre, L., Bush, S. J., & Hume, D. A. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.594594 · Cited by 29 · see citing works
Self-citation
Impact of polyphenols in phagocyte functions
da Cunha, L. R., Muniz‐Junqueira, M. I., & Borges, T. K. D. S. (2019) · Journal of Inflammation Research · doi:10.2147/jir.s193749 · Cited by 26 · see citing works
“phages have a selective requirement of JNK for their survival, proliferation and differentiation.(99,100) Polyphenols might influence such mechanisms, as”
Background
Effects of Baicalin on piglet monocytes involving PKC–MAPK signaling pathways induced by Haemophilus parasuis
Ye, C., Li, R., Xu, L., Qiu, Y., Fu, S., Liu, Y., Wu, Z., Hou, Y., & Hu, C. A. (2019) · BMC Veterinary Research · doi:10.1186/s12917-019-1840-x · Cited by 26 · see citing works
“JNK plays an important role in regulating cell viability, and targeted disruption of JNK results in defects in apoptosis [26].”
Background
Lipopolysaccharide-dependent interaction between PU.1 and cJun determines production of lipocalin-type prostaglandin D synthase and prostaglandin D2 in macrophages
Joo, M., Kwon, M., Cho, Y.-J., Hu, N., Pedchenko, T. V., Sadikot, R. T., Blackwell, T. S., & Christman, J. W. (2009) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.90320.2008 · Cited by 25 · see citing works
Non-thermal plasma treatment induces MAPK signaling in human monocytes
Bundscherer, L., Nagel, S., Hasse, S., Tresp, H., Wende, K., Walther, R., Reuter, S., Weltmann, K., Masur, K., & Lindequist, U. (2014) · Open Chemistry · doi:10.1515/chem-2015-0071 · Cited by 24 · see citing works
“The mitogen-activated protein kinases (MAPK) extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and p38 MAPK are implicated in monocyte differentiation to macrophages [15-17].”
Background
The Mononuclear Phagocyte System of the Rat
Hume, D. A., Caruso, M., Keshvari, S., Patkar, O. L., Sehgal, A., Bush, S. J., SUMMERS, K. M., Pridans, C., & Irvine, K. M. (2021) · The Journal of Immunology · doi:10.4049/jimmunol.2100136 · Cited by 21 · see citing works
Self-citation
AXL-initiated paracrine activation of pSTAT3 enhances mesenchymal and vasculogenic supportive features of tumor-associated macrophages
Hung, C., Chen, M., DeArmond, D. T., Chiu, C. H.-L., Limboy, C. A., Tan, X., Kusi, M., Chou, C., Lin, L., Zhang, Z., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.113067 · Cited by 26 · see citing works
Analyzing M-CSF dependent monocyte/macrophage differentiation: Expression modes and meta-modes derived from an independent component analysis
Lutter, D., Ugocsai, P., Grandl, M., Orsó, E., Theis, F. J., Lang, E. W., & Schmitz, G. (2008) · BMC Bioinformatics · doi:10.1186/1471-2105-9-100 · Cited by 24 · see citing works
“The transcription factor JUN also known as c-Jun belongs to the family of c-Jun N-terminal kinases (JNKs) which are important for development and survival of macrophages [46].”
Background
Targeting Myeloid-Derived Cells: New Frontiers in the Treatment of Non-alcoholic and Alcoholic Liver Disease
Vonghia, L., Herck, M. A. V., Weyler, J., & Francque, S. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00563 · Cited by 23 · see citing works
A Functional Polymorphism in CSF1R Gene Is a Novel Susceptibility Marker for Lung Cancer among Never-Smoking Females
Kang, H., Lee, S. Y., Jeon, H.-S., Choi, Y. Y., Kim, S., Lee, W. K., Lee, H. C., Choi, J. E., Bae, E. Y., Yoo, S. S., et al. (2014) · Journal of Thoracic Oncology · doi:10.1097/jto.0000000000000310 · Cited by 23 · see citing works
“In addition, this SNP was found to increase the phosphorylation of a mitogen-activated protein kinase, JNK. Conclusions: Our results suggest that the three SNPs, particularly CSF1R rs10079250, may contribute to lung cancer susceptibility in never-smoking females.”
Background
Inhibitory effects of Saururus chinensis and its components on stomach cancer cells
Jeong, H. J., Koo, B., Kang, T., et al. (2014) · Phytomedicine · doi:10.1016/j.phymed.2014.12.003 · Cited by 23 · see citing works
Anthocyanins and intestinal barrier function: a review
Valdez, J. C., & Bolling, B. W. (2019) · Journal of Food Bioactives · doi:10.31665/jfb.2019.5175 · Cited by 24 · see citing works
Beta-arrestin 2 is required for complement C1q expression in macrophages and constrains factor-independent survival
Lattin, J. E., Greenwood, K. P., Daly, N. L., et al. (2009) · Molecular Immunology · doi:10.1016/j.molimm.2009.09.012 · Cited by 22 · see citing works
Self-citation
Deletion of JNK2 prevents vitamin-D-deficiency-induced hypertension and atherosclerosis in mice
Oh, J., Riek, A. E., Zhang, R. M., Williams, S. A. S., Darwech, I., & Bernal‐Mizrachi, C. (2017) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2017.09.014 · Cited by 22 · see citing works
Fibrillar Amyloid-β Accumulation Triggers an Inflammatory Mechanism Leading to Hyperphosphorylation of the Carboxyl-Terminal End of Tau Polypeptide in the Hippocampal Formation of the 3×Tg-AD Transgenic Mouse
Ontiveros‐Torres, M. Á., Labra‐Barrios, M. L., Díaz-Cintra, S. Y., Aguilar-Vázquez, A. R., Moreno-Campuzano, S., Flores-Rodríguez, P., Luna-Herrera, C., Mena, R., Perry, G. L., Florán, B., et al. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-150837 · Cited by 21 · see citing works
Serum granulocyte macrophage-colony stimulating factor: a tumor marker in colorectal carcinoma?
Demırcı, U., Çoşkun, U., Sancak, B., et al. (2009) · PubMed · Cited by 21 · see citing works
TNF-α renders macrophages resistant to a range of cancer chemotherapeutic agents through NF-κB-mediated antagonism of apoptosis signalling
Lo, S. Z. Y., Steer, J. H., & Joyce, D. A. (2011) · Cancer Letters · doi:10.1016/j.canlet.2011.03.020 · Cited by 19 · see citing works
c-Jun N-Terminal Kinase as a Therapeutic Target in Experimental Autoimmune Encephalomyelitis
Bagnoud, M., Briner, M., Remlinger, J., Meli, I., Schuetz, S., Pistor, M., Salmen, A., Chan, A., & Hoepner, R. (2020) · Cells · doi:10.3390/cells9102154 · Cited by 18 · see citing works
“In addition, it has been demonstrated that activation of the JNK pathway was essential for the development and the survival of macrophages [50].”
Background
Gene-selective transcription promotes the inhibition of tissue reparative macrophages by TNF
Dichtl, S., Sanin, D. E., Koss, C. K., Willenborg, S., Petzold, A., Tanzer, M. C., Dahl, A., Kabat, A. M., Lindenthal, L., Zeitler, L., et al. (2022) · Life Science Alliance · doi:10.26508/lsa.202101315 · Cited by 16 · see citing works
“This was an identical observation to Himes et al (2006) who used different modes of JNK inhibition and concluded that JNK signaling was required for CSF1R activity and thus the normal development of BMDMs (Himes et al, 2006).”
Result
Sinner or Saint?: Nck Adaptor Proteins in Vascular Biology
Alfaidi, M., Scott, M. L., & Orr, A. W. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.688388 · Cited by 16 · see citing works
Δ8-Tetrahydrocannabinol induces cytotoxicity in macrophage J774-1 cells: Involvement of cannabinoid receptor 2 and p38 MAPK
Yamaori, S., Ishii, H., Chiba, K., Yamamoto, I., & Watanabe, K. (2013) · Toxicology · doi:10.1016/j.tox.2013.10.007 · Cited by 17 · see citing works
JNK1, but Not JNK2, Is Required in Two Mechanistically Distinct Models of Inflammatory Arthritis
Denninger, K., Rasmussen, S. B., Larsen, J. M., Ørskov, C., Poulsen, S. S., Sørensen, P., Christensen, J. P., Illges, H., Ødum, N., & Labuda, T. (2011) · American Journal Of Pathology · doi:10.1016/j.ajpath.2011.06.019 · Cited by 17 · see citing works
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Authors: Himes, S. R., Sester, D. P., Ravasi, T., Cronau, S. L., Sasmono, T., & Hume, D. A.
Affiliations: The University of Queensland (AU)
Cooperative Research Centre for Chronic Inflammatory Disease, Institute for Molecular Biosciences, University of Queensland , Brisbane ,
ORCID: Sester, David P
Ravasi, Timothy
Hume, David A
Venue: The Journal of Immunology
Publisher: Oxford University Press (OUP)
Published: 2006-02
Volume: 176
Issue: 4
Pages: 2219-2228
ISSN: 0022-1767 (ISSN-L)
1550-6606
DOI: 10.4049/jimmunol.176.4.2219
OpenAlex: W1582648966
Cited by: 117
References: 69
Citations by year: 2026: 1 · 2025: 3 · 2024: 4 · 2023: 3 · 2022: 6 · 2021: 4 · 2020: 7 · 2019: 10 · 2018: 1 · 2017: 5 · 2016: 6 · 2015: 6 · 2014: 10 · 2013: 9 · 2012: 4
FWCI: 4.19
Type: journal article
Language: en
Open access: closed
Licence: academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations: The Journal of Immunology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Keywords: JNK, macrophage development, macrophage survival, CSF-1, CSF-1 receptor, c-fms, Bcl-xL, apoptosis
MeSH terms: Proto-Oncogene Protein Spi-1, Animals, Bone Marrow Cells, Cell Differentiation, Cell Survival, Cells, Cultured, DNA

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The JNK Are Important for Development and Survival of Macrophages

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