Cited by 328NF-κB Signaling PathwaysProtein Kinase Regulation and GTPase SignalingMelanoma and MAPK Pathways

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JNK signaling in cancer cell survival

Wu, Qinghua, Wu, Wenda, Fu, Bishi, Shi, Lei, Wang, Xu, Kuca, Kamil·2019·Medicinal Research Reviews

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Abstract

c‐Jun N‐terminal kinase (JNK) is involved in cancer cell apoptosis; however, emerging evidence indicates that this Janus signaling promotes cancer cell survival. JNK acts synergistically with NF‐κB, JAK/STAT, and other signaling molecules to exert a survival function. JNK positively regulates autophagy to counteract apoptosis, and its effect on autophagy is related to the development of chemotherapeutic resistance. The prosurvival effect of JNK may involve an immune evasion mechanism mediated by transforming growth factor‐β, toll‐like receptors, interferon‐γ, and autophagy, as well as compensatory JNK‐dependent cell proliferation. The present review focuses on recent advances in understanding the prosurvival function of JNK and its role in tumor development and chemoresistance, including a comprehensive analysis of the molecular mechanisms underlying JNK‐mediated cancer cell survival. There is a focus on the specific “Yin and Yang” functions of JNK1 and JNK2 in the regulation of cancer cell survival. We highlight recent advances in our knowledge of the roles of JNK in cancer cell survival, which may provide insight into the distinct functions of JNK in cancer and its potential for cancer therapy.

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Authors: Wu, Q., Wu, W., Fu, B., Shi, L., Wang, X., & Kuca, K.
Affiliations: Nanjing Agricultural University (CN)
Harvard University (US)
University of Manchester (GB)
Huazhong Agricultural University (CN)
Department of Chemistry Faculty of Science, University of Hradec Kralove Hradec Kralove Czech Republic
Corresponding author: Wang, Xu
ORCID: Wu, Qinghua
Wu, Wenda
Fu, Bishi
Wang, Xu
Kuca, Kamil
Venue: Medicinal Research Reviews
Publisher: Wiley
Published: 2019-03-25
Volume: 39
Issue: 6
Pages: 2082-2104
ISSN: 0198-6325 (ISSN-L)
1098-1128
DOI: 10.1002/med.21574
OpenAlex: W2923315793
Cited by: 322
References: 146
Citations by year: 2026: 22 · 2025: 51 · 2024: 68 · 2023: 42 · 2022: 56 · 2021: 43 · 2020: 29 · 2019: 11
FWCI: 3.40
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Medicinal Research Reviews (publishedVersion)
PubMed (publishedVersion)
Funders: National Natural Science Foundation of China (31572575, 31602114)
China Postdoctoral Science Foundation (2016T90477)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Melanoma and MAPK Pathways
Keywords: JNK signaling, c-Jun N-terminal kinase, tumor cell survival, apoptosis, NF-κB, JAK/STAT signaling, autophagy, chemoresistance, immune evasion, TGF-beta, Toll-like receptors, interferon-gamma, JNK1, JNK2, carcinogenesis, cell proliferation
MeSH terms: Animals, Autophagy, Cell Survival, Humans, Neoplasms, Drug Resistance, Neoplasm, MAP Kinase Signaling System, JNK Mitogen-Activated Protein Kinases

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