PPARα L162V polymorphism alters the potential of n‐3 fatty acids to increase lipoprotein lipase activity

Rudkowska, Iwona; Caron‐Dorval, Dominique; Verreault, Mélanie; Couture, Patrick; Deshaies, Yves; Barbier, Olivier; Vohl, Marie‐Claude

doi:10.1002/mnfr.200900085

Cited by 36Fatty Acid Research and HealthLipid metabolism and disordersPeroxisome Proliferator-Activated Receptors

PPARα L162V polymorphism alters the potential of n‐3 fatty acids to increase lipoprotein lipase activity

Rudkowska, Iwona, Caron‐Dorval, Dominique, Verreault, Mélanie, Couture, Patrick, Deshaies, Yves, Barbier, Olivier, Vohl, Marie‐Claude·2010·Molecular Nutrition & Food Research

DOI 10.1002/mnfr.200900085

Open this paper in CoChat — free account

Abstract

Omega‐3 fatty acids (FAs) may accelerate plasma triglyceride (TG) clearance by altering lipoprotein lipase (LPL) activity. Yet, the ability of n‐3 FAs to increase LPL activity is dependent on transcription factors such as peroxisome proliferator‐activated receptor alpha (PPARα). The objective was to examine the effects of n‐3 FAs on LPL activity considering the occurrence of PPAR α L162V polymorphism. First, 14 pairs of men either L162 homozygotes or carriers of the V162 allele were supplemented with n‐3 FAs. Second, transient transfections in HepG2 cells, for the L162‐ and V162‐PPARα variants with the peroxisome proliferator‐response element from the human LPL gene, were transactivated with n‐3 FAs. In vivo results demonstrate that the LPL activity increased non‐significantly by 14.4% in L162 homozygotes compared with 6.6% in carriers of the PPAR α‐V162 allele, after n‐3 FA supplementation. Additionally, the L162 homozygotes tended towards an inverse correlation between LPL activities and plasma TG levels. Conversely, carriers of the V162 allele showed no such relationship. In vitro data demonstrates that transcription rates of LPL tended to be higher for the L162‐PPARα than V162‐PPARα after n‐3 FAs activation. Overall, these results indicate that n‐3 FA supplementation increases the transcription rate of LPL to a greater extent in L162‐PPARα than V162‐PPARα.

Integrity signals

Registry

Crossref · 10.1002/mnfr.200900085

Cites

45 of 45 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Increased activation of the peroxisome proliferator-activated receptor response element of the LPL gene is a potential mechanism for increased LPL mRNA expression.
“A potential mechanism for increased LPL mRNA expression is increased activation of the peroxisome proliferator-activated receptor response element of the LPL gene, which has been demonstrated using a transfection assay [42].”
From Omega-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid and their mechanisms of action on apolipoprotein B-containing lipoproteins in humans: a review (2017) · cites this paper as [42]

Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge
Friedewald, W. T., Levy, R. I., & Fredrickson, D. S. (1972) · Clinical Chemistry · doi:10.1093/clinchem/18.6.499 · Cited by 32,423 · see citing works
Summary of the second report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel II)
Grundy, S. M., Bilheimer, D. W., Chait, A., Clark, L. T., Denke, M. A., Havel, R. J., Hazzard, W. R., Hulley, S. B., Hunninghake, D. B., Kreisberg, R. A., et al. (1993) · JAMA · doi:10.1001/jama.269.23.3015 · Cited by 27,944 · see citing works
Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)
Expert Panel on Detection, E. (2001) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.285.19.2486 · Cited by 26,011 · see citing works
n-3 fatty acids and serum lipoproteins: human studies
Harris, W. (1997) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/65.5.1645s · Cited by 1,243 · see citing works
PPARalpha and PPARgamma activators direct a distinct tissue‐specific transcriptional response via a PPRE in the lipoprotein lipase gene.
Schoonjans, K., Peinado‐Onsurbe, J., Lefebvre, A. M., Heyman, R. A., Briggs, M., Deeb, S., Staels, B., & Auwerx, J. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00918.x · Cited by 1,173 · see citing works
Effects of omega-3 fatty acids on serum markers of cardiovascular disease risk: a systematic review
Balk, E. M., Lichtenstein, A. H., Chung, M., Kupelnick, B., Chew, P., & Lau, J. (2006) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2006.02.012 · Cited by 732 · see citing works
Sur un dosage rapide du cholesterol lié aux α-et aux β-lipoprotéines du sérum
Burstein, M., & Samaille, J. (1960) · Clinica Chimica Acta · doi:10.1016/0009-8981(60)90075-9 · Cited by 620 · see citing works
POLYUNSATURATED FATTY ACID REGULATION OF GENES OF LIPID METABOLISM
Sampath, H., & Ntambi, J. M. (2005) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.25.051804.101917 · Cited by 556 · see citing works
Automated enzymatic standardized lipid analyses for plasma and lipoprotein fractions
McNamara, J. R., & Schaefer, E. J. (1987) · Clinica Chimica Acta · doi:10.1016/0009-8981(87)90188-4 · Cited by 524 · see citing works
Why do omega-3 fatty acids lower serum triglycerides?
Harris, W. S., & Bulchandani, D. (2006) · Current Opinion in Lipidology · doi:10.1097/01.mol.0000236363.63840.16 · Cited by 398 · see citing works
Omega-3 fatty acid supplementation accelerates chylomicron triglyceride clearance
Park, Y., & Harris, W. S. (2003) · Journal of Lipid Research · doi:10.1194/jlr.m200282-jlr200 · Cited by 348 · see citing works
Dietary polyunsaturated fats of the W-6 and W-3 series reduce postprandial lipoprotein levels. Chronic and acute effects of fat saturation on postprandial lipoprotein metabolism.
Weintraub, M. S., Zechner, R., Brown, A., Eisenberg, S., & Breslow, J. L. (1988) · Journal of Clinical Investigation · doi:10.1172/jci113806 · Cited by 331 · see citing works
Reduction of postprandial triglyceridemia in humans by dietary n-3 fatty acids
Harris, W. S., Connor, W. E., Alam, N., & Illingworth, D. R. (1988) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)38424-8 · Cited by 321 · see citing works
Highly purified eicosapentaenoic acid and docosahexaenoic acid in humans have similar triacylglycerol-lowering effects but divergent effects on serum fatty acids
Grimsgaard, S., Bonaa, K., Hansen, J., & Nordøy, A. (1997) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/66.3.649 · Cited by 300 · see citing works
Postprandial lipemia, fenofibrate and coronary artery disease
Simpson, H., Williamson, C., Olivecrona, T., Pringle, S., MacLean, J. A., Lorimer, A. R., Bonnefous, F., Bogaievsky, Y., Packard, C. J., & Shepherd, J. (1990) · Atherosclerosis · doi:10.1016/0021-9150(90)90111-u · Cited by 229 · see citing works
PPARα and dyslipidemia
DUVAL, C., MULLER, M., & KERSTEN, S. (2007) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2007.05.003 · Cited by 199 · see citing works
Multi-laboratory comparison of three heparin-Mn2+ precipitation procedures for estimating cholesterol in high-density lipoprotein.
Albers, J. J., Warnick, G. R., Wiebe, D. A., King, P. J., Steiner, P. M., Smith, L., Breckenridge, C., Chow, A., Kuba, K., Weidman, S. W., et al. (1978) · Clinical Chemistry · doi:10.1093/clinchem/24.6.853 · Cited by 196 · see citing works
Molecular scanning of the human PPARα gene: association of the L162V mutation with hyperapobetalipoproteinemia
Vohl, M., Lepage, P., Gaudet, D., Brewer, C. G., Bétard, C., Perron, P., Houde, G., Cellier, C., Faith, J., Després, J., et al. (2000) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)32037-x · Cited by 175 · see citing works
Self-citation
Variation in the PPARα gene is associated with altered function in vitro and plasma lipid concentrations in Type II diabetic subjects
Flavell, D. M., Pineda‐Torra, I., Jamshidi, Y., Evans, D., Diamond, J. R., Elkeles, R. S., Bujac, S. R., Miller, G. J., Talmud, P. J., Staels, B., et al. (2000) · Diabetologia · doi:10.1007/s001250051357 · Cited by 171 · see citing works
Transcriptional control of triglyceride metabolism: fibrates and fatty acids change the expression of the LPL and apo C-III genes by activating the nuclear receptor PPAR
Auwerx, J. H., Schoonjans, K., Fruchart, J., & Staels, B. (1996) · Atherosclerosis · doi:10.1016/0021-9150(96)05854-6 · Cited by 158 · see citing works
Polyunsaturated Fatty Acids Interact with the PPARA-L162V Polymorphism to Affect Plasma Triglyceride and Apolipoprotein C-III Concentrations in the Framingham Heart Study
Tai, E. S., Corella, D., Demissie, S., Cupples, L. A., Coltell, Ó., Schaefer, E. J., Tucker, K. L., & Ordovás, J. M. (2005) · Journal of Nutrition · doi:10.1093/jn/135.3.397 · Cited by 146 · see citing works
Dietary long-chain n-3 PUFAs increase LPL gene expression in adipose tissue of subjects with an atherogenic lipoprotein phenotype
Khan, S., Minihane, A.-M., Talmud, P. J., Wright, J. W., Murphy, M. C., Williams, C. M., & Griffin, B. A. (2002) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)30473-9 · Cited by 145 · see citing works
Association Between the PPARA L162V Polymorphism and Plasma Lipid Levels
Tai, E. S., Demissie, S., Cupples, L. A., Corella, D., Wilson, P. W. F., Schaefer, E. J., & Ordovás, J. M. (2002) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000012302.11991.42 · Cited by 136 · see citing works
Influence of n-3 fatty acid supplementation on the endogenous activities of plasma lipases
Harris, W., Lu, G., Rambjør, G., Wõlen, A., Ontko, J., Cheng, Q., & Windsor, S. (1997) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/66.2.254 · Cited by 135 · see citing works
The human peroxisome proliferator-activated receptor ?? gene: identification and functional characterization of two natural allelic variants
Sapone, A., Peters, J. M., Sakai, S., Tomita, S., Papiha, S. S., Dai, R., Friedman, F. K., & Gonzalez, F. J. (2000) · Pharmacogenetics · doi:10.1097/00008571-200006000-00006 · Cited by 130 · see citing works
Association between the PPARα-L162V polymorphism and components of the metabolic syndrome
Robitaille, J., Brouillette, C., Houde, A., Lemieux, S., Përusse, L., Tchernof, A., Gaudet, D., & Vohl, M. (2004) · Journal of Human Genetics · doi:10.1007/s10038-004-0177-9 · Cited by 103 · see citing works
Self-citation
Polyunsaturated fatty acids stimulate hepatic UCP-2 expression via a PPARα-mediated pathway
Armstrong, M. B., & Towle, H. C. (2001) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2001.281.6.e1197 · Cited by 78 · see citing works
The effects of fibrates and thiazolidinediones on plasma triglyceride metabolism are mediated by distinct peroxisome proliferator activated receptors (PPARs)
Staels, B., Schoonjans, K., Fruchart, J., & Auwerx, J. H. (1997) · Biochimie · doi:10.1016/s0300-9084(97)81497-6 · Cited by 77 · see citing works
Postheparin lipolytic activity and plasma lipoprotein response to ω-3 polyunsaturated fatty acids in patients with primary hypertriglyceridemia
Nozaki, S., Garg, A., Vega, G., & Grundy, S. M. (1991) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/53.3.638 · Cited by 67 · see citing works
Retinoids Increase Human Apolipoprotein A-II Expression through Activation of the Retinoid X Receptor but Not the Retinoic Acid Receptor
Vu‐Dac, N., Schoonjans, K., Kosykh, V., Dallongeville, J., Heyman, R. A., Staels, B., & Auwerx, J. H. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.7.3350 · Cited by 59 · see citing works
The peroxisome proliferator-activated receptor α Leu162Val polymorphism influences the metabolic response to a dietary intervention altering fatty acid proportions in healthy men
Paradis, A.-M., Fontaine‐Bisson, B., Bossé, Y., Robitaille, J., Lemieux, S., Jacques, H., Lamarche, B., Tchernof, A., Couture, P., & Vohl, M. (2005) · American Journal of Clinical Nutrition · doi:10.1093/ajcn.81.2.523 · Cited by 57 · see citing works
Self-citation
Pharmacodynamic activity of lipoprotein lipase and hepatic lipase, and pharmacokinetic parameters measured in normolipidaemic subjects receiving ciprofibrate (100 or 200 mg/day) or micronised fenofibrate (200 mg/day) therapy for 23 days
Desager, J., Horsmans, Y., Vandenplas, C., & Harvengt, C. (1996) · Atherosclerosis · doi:10.1016/0021-9150(96)05859-5 · Cited by 54 · see citing works
PPARα L162V underlies variation in serum triglycerides and subcutaneous fat volume in young males
Uthurralt, J., Gordish‐Dressman, H., Bradbury, M., Rocha, C. T., Devaney, J. M., Harmon, B. T., Reeves, E. K. M., Brandoli, C., HANSEN, B. C., Seip, R. L., et al. (2007) · BMC Medical Genetics · doi:10.1186/1471-2350-8-55 · Cited by 49 · see citing works
Effect of gemfibrozil and lovastatin on postprandial lipoprotein clearance in the hypoalphalipoproteinemia and hypertriglyceridemia syndrome
Sitno, I. E., Yakichuk, J. A., & Ooi, T. C. (1993) · Atherosclerosis · doi:10.1016/0021-9150(93)90067-5 · Cited by 41 · see citing works
A one-vial method for routine extraction and quantification of free fatty acids in blood and tissue by HPLC
Jüngling, E., & Kammermeier, H. (1988) · Analytical Biochemistry · doi:10.1016/0003-2697(88)90136-4 · Cited by 39 · see citing works
Effects of omega-3 fatty acids on intravascular lipolysis of very-low-density lipoproteins in humans
Kasim-Karakas, S. E., Herrmann, R., & Almario, R. U. (1995) · Metabolism · doi:10.1016/0026-0495(95)90020-9 · Cited by 38 · see citing works
Effects of ω-3 Fish Oils on Plasma Lipids, Lipoprotein Composition, and Postheparin Lipoprotein Lipase in Women With IDDM
Bagdade, J. D., Buchanan, W., Levy, R. A., et al. (1990) · Diabetes · doi:10.2337/diab.39.4.426 · Cited by 37 · see citing works
Peroxisome proliferator-activated receptor α polymorphisms and postprandial lipemia in healthy men
Tanaka, T., Ordovás, J. M., Delgado‐Lista, J., Pérez‐Jiménez, F., Marı́n, C., Pérez‐Martínez, P., Gómez, P., & López‐Miranda, J. (2007) · Journal of Lipid Research · doi:10.1194/jlr.m700066-jlr200 · Cited by 33 · see citing works
Cod Protein Lowers the Hepatic Triglyceride Secretion Rate in Rats
Demonty, I., Deshaies, Y., Lamarche, B., & Jacques, H. (2003) · Journal of Nutrition · doi:10.1093/jn/133.5.1398 · Cited by 32 · see citing works
Self-citation
Measurement and physiological significance of lipoprotein and hepatic lipase activities in preheparin plasma
Watson, T. D. G., Tan, C., McConnell, M., Clegg, S. K., Squires, L. F., & Packard, C. J. (1995) · Clinical Chemistry · doi:10.1093/clinchem/41.3.405 · Cited by 32 · see citing works
Effect of the PPAR-Alpha L162V Polymorphism on the Cardiovascular Disease Risk Factor in Response to n–3 Polyunsaturated Fatty Acids
Caron‐Dorval, D., Paquet, P., Paradis, A.-M., Rudkowska, I., Lemieux, S., Couture, P., & Vohl, M. (2008) · Lifestyle Genomics · doi:10.1159/000137555 · Cited by 24 · see citing works
Self-citation
Ligand- and Species-Dependent Activation of PPARα
Akbıyık, F., Ray, D. M., Bozkaya, H., et al. (2004) · Cellular Physiology and Biochemistry · doi:10.1159/000080336 · Cited by 22 · see citing works
Postprandial lipoprotein (a) response to a single meal containing either saturated or ω-3 polyunsaturated fatty acids in subjects with hypoalphalipoproteinemia
Scanu, A. M., Edelstein, C., Fless, G. M., Eisenbart, J. D., Sitrin, M. D., Kasawa, B., & Hinman, J. (1992) · Metabolism · doi:10.1016/0026-0495(92)90108-m · Cited by 19 · see citing works
Hypotriglyceridemic action of omega-3 fatty acids in healthy subjects does not occur by enhanced lipoprotein lipase and hepatic lipase activities.
Desager, J. P., Dricot, J., & Harvengt, C. (1989) · PubMed · Cited by 18 · see citing works
Effects of omega-3 fish oils on plasma lipids, lipoprotein composition, and postheparin lipoprotein lipase in women with IDDM
Bagdade, J. D., Buchanan, W., Levy, R. A., Subbaiah, P. V., & Ritter, M. C. (1990) · Diabetes · doi:10.2337/diabetes.39.4.426 · Cited by 18 · see citing works

Flagged first, then by citations

Sorted by citations

Omega-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid and their mechanisms of action on apolipoprotein B-containing lipoproteins in humans: a review
Oscarsson, J., & Hurt-Camejo, E. (2017) · Lipids in Health and Disease · doi:10.1186/s12944-017-0541-3 · Cited by 158 · see citing works
Addition of omega-3 fatty acid and coenzyme Q10 to statin therapy in patients with combined dyslipidemia
Tóth, Š., Šajty, M., Pekárová, T., Mughees, A., Štefanič, P., Katz, M., Spišáková, K., Pella, J., & Pella, D. (2017) · Journal of Basic and Clinical Physiology and Pharmacology · doi:10.1515/jbcpp-2016-0149 · Cited by 40 · see citing works
Effects of ω-3 Polyunsaturated Fatty Acids on Coronary Atherosclerosis and Inflammation: A Systematic Review and Meta-Analysis
Gao, Z., Zhang, D., Yan, X., Shi, H., & Xian, X. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.904250 · Cited by 22 · see citing works
Controversies in the Use of Omega-3 Fatty Acids to Prevent Atherosclerosis
Quispe, R., Alfaddagh, A., Kazzi, B., Zghyer, F., Marvel, F. A., Blumenthal, R. S., Sharma, G., & Martin, S. S. (2022) · Current Atherosclerosis Reports · doi:10.1007/s11883-022-01031-9 · Cited by 17 · see citing works

Post-Heparin Lipolytic Enzymes in Patients on CAPD
Chan, M. K., Persaud, J. W., Varghese, Z., Baillod, R. A., & Moorhead, J. F. (1986) · Springer eBooks · doi:10.1007/978-3-662-11784-2_83 · Cited by 9 · see citing works
Distribution of lipoprotein lipase and hepatic lipase between plasma and tissues: effect of hypertriglyceridemia
Peterson, J., Olivecrona, T., & Bengtsson-Olivecrona, G. (1985) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(85)90049-9 · Cited by 115 · see citing works
The association of lipoprotein and hepatic lipase activities with high density lipoprotein subclass levels in men with myocardial infarction at a young age
Johansson, J., Nilsson‐Ehle, P., Carlson, L. A., & Hamsten, A. (1991) · Atherosclerosis · doi:10.1016/0021-9150(91)90207-j · Cited by 33 · see citing works
[The colorimetric method for measuring activities of lipoprotein lipase and hepatic lipase in plasma].
Zhang, R., Liu, Y., & Liu, B. (1996) · PubMed · Cited by 5 · see citing works
Postheparin Plasma Lipase Activities and Plasma Lipoproteins in Newborn Infants
Rovamo, L. M., Taskinen, M., Kuusi, T., et al. (1984) · Pediatric Research · doi:10.1203/00006450-198407000-00015 · Cited by 16 · see citing works

Authors: Rudkowska, I., Caron‐Dorval, D., Verreault, M., Couture, P., Deshaies, Y., Barbier, O., & Vohl, M.
Affiliations: Centre hospitalier de l'Université Laval (CA)
Institut sur la nutrition et les aliments fonctionnels (INAF) (CA)
Corresponding author: Vohl, Marie‐Claude
ORCID: Rudkowska, Iwona
Couture, Patrick
Deshaies, Yves
Barbier, Olivier
Vohl, Marie‐Claude
Venue: Molecular Nutrition & Food Research
Publisher: Wiley
Published: 2010-04
Volume: 54
Issue: 4
Pages: 543-550
ISSN: 1613-4125 (ISSN-L)
1613-4133
DOI: 10.1002/mnfr.200900085
OpenAlex: W2062737918
Cited by: 36
References: 45
Citations by year: 2026: 1 · 2025: 2 · 2024: 1 · 2023: 2 · 2022: 5 · 2021: 2 · 2020: 2 · 2018: 2 · 2017: 5 · 2016: 1 · 2015: 3 · 2014: 1 · 2013: 2 · 2012: 4
FWCI: 2.25
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Molecular Nutrition & Food Research (publishedVersion)
PubMed (publishedVersion)
Corpus Université Laval (Université Laval) (submittedVersion)
Funders: Canadian Institutes of Health Research (MOP-200609)
CIHR Bisby Fellowship
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
Keywords: PPARα, omega-3 fatty acids, lipoprotein lipase, plasma triglycerides, triglyceride clearance, peroxisome proliferator response element, dietary supplementation, genetic polymorphism
MeSH terms: Adolescent, Adult, Diet, Docosahexaenoic Acids, Erythrocytes, Fatty Acids, Genotype, Carcinoma, Hepatocellular, Humans, Lipids, Lipoprotein Lipase, Liver Neoplasms, Male, Middle Aged, Polymorphism, Genetic, Transfection, Eicosapentaenoic Acid, Fatty Acids, Omega-3, Gene Expression, Cell Line, Tumor, PPAR alpha

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

PPARα L162V polymorphism alters the potential of n‐3 fatty acids to increase lipoprotein lipase activity

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks