Ubiquinol-10 Supplementation Activates Mitochondria Functions to Decelerate Senescence in Senescence-Accelerated Mice
Open accessAbstract
Aim: The present study was conducted to define the relationship between the anti-aging effect of ubiquinol-10 supplementation and mitochondrial activation in senescence-accelerated mouse prone 1 (SAMP1) mice. Results: Here, we report that dietary supplementation with ubiquinol-10 prevents age-related decreases in the expression of sirtuin gene family members, which results in the activation of peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α), a major factor that controls mitochondrial biogenesis and respiration, as well as superoxide dismutase 2 (SOD2) and isocitrate dehydrogenase 2 (IDH2), which are major mitochondrial antioxidant enzymes. Ubiquinol-10 supplementation can also increase mitochondrial complex I activity and decrease levels of oxidative stress markers, including protein carbonyls, apurinic/apyrimidinic sites, malondialdehydes, and increase the reduced glutathione/oxidized glutathione ratio. Furthermore, ubiquinol-10 may activate Sirt1 and PGC-1α by increasing cyclic adenosine monophosphate (cAMP) levels that, in turn, activate cAMP response element-binding protein (CREB) and AMP-activated protein kinase (AMPK). Innovation and Conclusion: These results show that ubiquinol-10 may enhance mitochondrial activity by increasing levels of SIRT1, PGC-1α, and SIRT3 that slow the rate of age-related hearing loss and protect against the progression of aging and symptoms of age-related diseases. Antioxid. Redox Signal. 20, 2606–2620
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Upregulation of SIRT1, SIRT3, SOD2 and IDH2 enzymes, together with a higher GSH/GSSG ratio, are described upon dietary CoQ10H2 supplementation.
“Upregulation of sirtuins 1 and 3 (SIRT1 and SIRT3), SOD2 and isocitrate dehydrogenase 2 (IDH2) enzymes, together with a higher reduced to oxidized glutathione (GSH/GSSG) ratio are also described upon dietary CoQ10H2 supplementation in an independent study, thus confirming the role of ubiquinol in protecting against cellular senescence progression and aging [73].”
From The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence (2022) · cites this paper as [73]
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- Authors
- Tian, G., Sawashita, J., Kubo, H., Nishio, S.-Y., Hashimoto, S., Suzuki, N., Yoshimura, H., Tsuruoka, M., Wang, Y., Liu, Y., Luo, H., Xu, Z., Mori, M., Kitano, M., Hosoe, K., Takeda, T., Usami, S.-I., & Higuchi, K.
- Affiliations
- Shinshu University (JP)
- Kaneka (Japan) (JP)
- Council for SAM Research
- Corresponding author
- Higuchi, Keiichi
- ORCID
- Venue
- Antioxidants & Redox Signaling
- Publisher
- SAGE Publications
- Published
- 2014-06
- Volume
- 20
- Issue
- 16
- Pages
- 2606-2620
- ISSN
- 1523-0864 (ISSN-L)
- 1557-7716
- PMC
- PMC4025630
- OpenAlex
- W2164929924
- Cited by
- 123
- References
- 74
- Citations by year
- 2026: 8 · 2025: 11 · 2024: 5 · 2023: 10 · 2022: 10 · 2021: 19 · 2020: 19 · 2019: 14 · 2018: 9 · 2017: 4 · 2016: 6 · 2015: 6 · 2014: 2
- FWCI
- 2.08
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Antioxidants and Redox Signaling (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Institutional Repositories DataBase (IRDB) (submittedVersion)
- SOAR (Shinshu University) (submittedVersion, other-oa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Coenzyme Q10 studies and effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Keywords
- ubiquinol-10, coenzyme Q10 supplementation, aging, mitochondrial biogenesis, PGC-1α, sirtuins, SIRT1, SIRT3, oxidative stress, mitochondrial complex I, age-related hearing loss, AMPK, CREB, manganese superoxide dismutase, IDH2, dietary supplementation
- MeSH terms
- Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha, AMP-Activated Protein Kinase Kinases, Acetylation, Aging, Animals, Dose-Response Relationship, Drug, Humans, Membrane Proteins, Mitochondria, Nuclear Proteins, Phosphorylation, Protein Kinases, Structure-Activity Relationship, Transcription Factors, Tumor Cells, Cultured, Ubiquinone, Oxidative Stress, Dietary Supplements, Mice, Sirtuin 1, Hep G2 Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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