Cited by 292Plant chemical constituents analysisPlant Toxicity and Pharmacological PropertiesCarcinogens and Genotoxicity Assessment

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Toxicology and risk assessment of coumarin: Focus on human data

Abraham, Klaus, Wöhrlin, Friederike, Lindtner, Oliver, Heinemeyer, Gerhard, Lampen, Alfonso·2010·Molecular Nutrition & Food Research

DOI 10.1002/mnfr.200900281

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Abstract

Coumarin is a secondary phytochemical with hepatotoxic and carcinogenic properties. For the carcinogenic effect, a genotoxic mechanism was considered possible, but was discounted by the European Food Safety Authority in 2004 based on new evidence. This allowed the derivation of a tolerable daily intake (TDI) for the first time, and a value of 0.1 mg/kg body weight was arrived at based on animal hepatotoxicity data. However, clinical data on hepatotoxicity from patients treated with coumarin as medicinal drug is also available. This data revealed a subgroup of the human population being more susceptible for the hepatotoxic effect than the animal species investigated. The cause of the high susceptibility is currently unknown; possible mechanisms are discussed. Using the human data, a TDI of 0.1 mg/kg body weight was derived, confirming that of the European Food Safety Authority. Nutritional exposure may be considerably, and is mainly due to use of cassia cinnamon, which is a popular spice especially, used for cookies and sweet dishes. To estimate exposure to coumarin during the Christmas season in Germany, a telephone survey was performed with more than 1000 randomly selected persons. Heavy consumers of cassia cinnamon may reach a daily coumarin intake corresponding to the TDI.

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Vandesompele, J., De Preter, K., Pattyn, F., Poppe, B., Van Roy, N., De Paepe, A., & Speleman, F. (2002) · Genome Biology · doi:10.1186/gb-2002-3-7-research0034 · Cited by 20,038
The MIQE guidelines: minimum information for publication of quantitative real-time PCR experiments
Bustin, S. A., Benes, V., Garson, J. A., Hellemans, J., Huggett, J., Kubista, M., Mueller, R., Nolan, T., Pfaffl, M. W., Shipley, G. L., et al. (2009) · Clinical Chemistry · doi:10.1373/clinchem.2008.112797 · Cited by 16,303
Why Most Published Research Findings Are False
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Initial sequencing and comparative analysis of the mouse genome
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Why Most Published Research Findings Are False
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The importance of selenium to human health
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A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants
Juliano, R. L., & Ling, V. W. T. (1976) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(76)90160-7 · Cited by 3,317
Effects of Selenium Supplementation for Cancer Prevention in Patients With Carcinoma of the Skin
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EFSA, 2004, Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contacts with Food (AFC) on a request from the Commission related to Coumarin; adopted on 6 October 2004, EFSA J, 104, 1
EU Food Law, 2006, Cinnamon flavoured cereal recalled over coumarin levels, EU Food Law, 10
WHO, 1995, Coumarin: a strong association with hepatotoxicity, WHO Drug Information, 9, 159
10.1002/(SICI)1099-1557(199808)7:1 <S45::AID-PDS353>3.0.CO;2-1 · DOI
Abraham K., 2007, Zimt und Cumarin: eine Klarstellung aus wissenschaftlich‐behördlicher Sicht, Dtsch. Lebensmittel‐Rundschau, 103, 480
EFSA, 2008, Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food on a request from the European Commission on Coumarin in flavourings and other food ingredients with flavouring properties, EFSA J., 793, 1
Sharifi S. Pharmakokinetische Untersuchungen von Cumarin und seinen Metaboliten nach oraler und intravenöser Applikation bei gesunden Probanden. PhD thesis University of Göttingen1990.
Sharifi S., 1993, Pharmacokinetics of coumarin and its metabolites. Preliminary results in three volunteers, J. Ir. Coll. Physicians Surg., 22, 29
WHO (World Health Organization)1999 Cortex Cinnamomi. WHO monographs on selected medicinal plants Volume 1 Geneva 1999 pp.96–104.
Weber G., 2007, Zimt–Warenkunde und Markt, Dtsch. Lebensmittel‐Rundschau, 103, 492
Floc'h F., 2002, Coumarin in plants and fruits: implication in perfumery, Perfumer Flavorist, 27, 332

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Authors: Abraham, K., Wöhrlin, F., Lindtner, O., Heinemeyer, G., & Lampen, A.
Affiliations: German Federal Institute for Risk Assessment (BfR) (DE)
Corresponding author: Abraham, Klaus
ORCID: Abraham, Klaus
Lindtner, Oliver
Heinemeyer, Gerhard
Venue: Molecular Nutrition & Food Research
Publisher: Wiley
Published: 2010-02
Volume: 54
Issue: 2
Pages: 228-239
ISSN: 1613-4125 (ISSN-L)
1613-4133
DOI: 10.1002/mnfr.200900281
OpenAlex: W1972248486
Cited by: 292
References: 264
Citations by year: 2026: 22 · 2025: 23 · 2024: 21 · 2023: 28 · 2022: 29 · 2021: 21 · 2020: 32 · 2019: 17 · 2018: 15 · 2017: 17 · 2016: 11 · 2015: 16 · 2014: 11 · 2013: 7 · 2012: 8
FWCI: 0.63
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Molecular Nutrition & Food Research (publishedVersion)
PubMed (publishedVersion)
OpenAgrar (submittedVersion)
Topics: Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant chemical constituents analysis
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Plant Toxicity and Pharmacological Properties
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
Keywords: coumarins, hepatotoxicity, carcinogenicity, genotoxicity, tolerable daily intake, risk assessment, telephone surveys
MeSH terms: Animals, Biotransformation, Coumarins, Edema, Flavoring Agents, Humans, Liver Neoplasms, Lymphedema, Plants, Medicinal, Species Specificity, Venous Insufficiency, Risk Assessment, Toxicity Tests, Chemical and Drug Induced Liver Injury

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Toxicology and risk assessment of coumarin: Focus on human data

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