Potential health-promoting effects of astaxanthin: a high-value carotenoid mostly from microalgae

Astaxanthin: a review of its chemistry and applications

Higuera-Ciapara, I., Félix-Valenzuela, L., & Goycoolea, F. M. (2006) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408690590957188 · Cited by 1,287

Commercial potential for Haematococcus microalgae as a natural source of astaxanthin

Lorenz, R. T., & Cysewski, G. R. (2000) · Trends in biotechnology · doi:10.1016/s0167-7799(00)01433-5 · Cited by 1,190

Antioxidant Activities of Astaxanthin and Related Carotenoids

Naguib, Y. M. A. (2000) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf991106k · Cited by 975

Carotenoid Action on the Immune Response

Chew, B. P., & Park, J. S. (2004) · Journal of Nutrition · doi:10.1093/jn/134.1.257s · Cited by 795

Astaxanthin, a Carotenoid with Potential in Human Health and Nutrition

Hussein, G. M. E., Sankawa, U., Goto, H., Matsumoto, K., & Watanabe, H. (2005) · Journal of Natural Products · doi:10.1021/np050354+ · Cited by 653

Carotenogenesis in the green alga Haematococcus pluvialis : Cellular physiology and stress response

Boussiba, S. (2000) · Physiologia Plantarum · doi:10.1034/j.1399-3054.2000.108002111.x · Cited by 591

Astaxanthin decreased oxidative stress and inflammation and enhanced immune response in humans

Park, J. S., Chyun, J. H., Kim, Y. K., Line, L. L., & Chew, B. P. (2010) · Nutrition & Metabolism · doi:10.1186/1743-7075-7-18 · Cited by 569

Astaxanthin from Microbial Sources

Johnson, E. A., & An, G.-H. (1991) · Critical Reviews in Biotechnology · doi:10.3109/07388559109040622 · Cited by 509

Astaxanthin: A Novel Potential Treatment for Oxidative Stress and Inflammation in Cardiovascular Disease

Pashkow, F. J., Watumull, D. G., & Campbell, C. L. (2008) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2008.02.010 · Cited by 455

Efficient radical trapping at the surface and inside the phospholipid membrane is responsible for highly potent antiperoxidative activity of the carotenoid astaxanthin

Goto, S., Kogure, K., Abe, K., Kimata, Y., Kitahama, K., Yamashita, E., & Terada, H. (2001) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/s0005-2736(01)00326-1 · Cited by 357

Algae for the production of bio-based products

Syrpas, M., & Venskutonis, P. R. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-818493-6.00006-3 · Cited by 25

Anti-Migration and Invasion Effects of Astaxanthin against A172 Human Glioblastoma Cell Line

Siangcham, T., Vivithanaporn, P., & Sangpairoj, K. (2020) · Asian Pacific Journal of Cancer Prevention · doi:10.31557/apjcp.2020.21.7.2029 · Cited by 25

Non-aqueous nanoemulsions as a new strategy for topical application of astaxanthin

Sun, R., Xia, N., & Xia, Q. (2019) · Journal of Dispersion Science and Technology · doi:10.1080/01932691.2019.1635027 · Cited by 24

Prevention of cardiovascular disease through modulation of endothelial cell function by dietary seaweed intake

Yamagata, K. (2021) · Phytomedicine Plus · doi:10.1016/j.phyplu.2021.100026 · Cited by 25

Microalgae: Classification, bioactives, medicinal properties, industrial applications, and future prospectives

Shaikh, R., Rizvi, A., Pandit, S., Desai, N., & Patil, R. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-823499-0.00004-3 · Cited by 26

Chlorella

Silva, J., Alves, C., Pintéus, S., Reboleira, J., Pedrosa, R., & Bernardino, S. M. S. A. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-812491-8.00026-6 · Cited by 24

Integrated pathway engineering and transcriptome analysis for improved astaxanthin biosynthesis in Yarrowia lipolytica

Wang, D., Feng, J., Yu, C., Zhang, X.-K., Chen, J., Wei, L., Liu, Z., Ouyang, L., Zhang, L., Hua, Q., et al. (2022) · Synthetic and Systems Biotechnology · doi:10.1016/j.synbio.2022.08.001 · Cited by 24

The potential modulation of gut microbiota and oxidative stress by dietary carotenoid pigments

Bernabeu, M., Gharibzahedi, S. M. T., Ganaie, A. A., Macha, M. A., Dar, B. N., Castagnini, J. M., García‐Bonillo, C., Meléndez‐Martínez, A. J., Altıntaş, Z., & Barba, F. J. (2023) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2023.2254383 · Cited by 30

Oncom: A Nutritive Functional Fermented Food Made from Food Process Solid Residue

Wijaya, C. H., Nuraida, L., Nuramalia, D. R., Hardanti, S., & Świąder, K. (2024) · Applied Sciences · doi:10.3390/app142210702 · Cited by 23

Effect of the oral intake of astaxanthin on semen parameters in patients with oligo-astheno-teratozoospermia: a randomized double-blind placebo-controlled trial

Kumalić, S. I., Virant‐Klun, I., Bokal, E. V., & Pinter, B. (2020) · Radiology and Oncology · doi:10.2478/raon-2020-0062 · Cited by 23

The Potential Role of Nutrition in Lung Cancer Establishment and Progression

Porro, C., Torre, M. E. L., Tartaglia, N., Benameur, T., Santini, M., Ambrosi, A., Messina, G., Cibelli, G., Fiorelli, A., Polito, R., et al. (2022) · Life · doi:10.3390/life12020270 · Cited by 26

Molecular approaches to enhance astaxanthin biosynthesis; future outlook: engineering of transcription factors in Haematococcus pluvialis

Kayani, S., Rahman, S.-U., Shen, Q., Cui, Y., Liu, W., Hu, X., Zhu, F., & Huo, S. (2023) · Critical Reviews in Biotechnology · doi:10.1080/07388551.2023.2208284 · Cited by 23

Prediction of ROA and ECD Related to Conformational Changes of Astaxanthin Enantiomers

Zając, G., Kaczor, A., Buda, S., Młynarski, J., Frelek, J., Dobrowolski, J. C., & Barańśka, M. (2015) · The Journal of Physical Chemistry B · doi:10.1021/acs.jpcb.5b07193 · Cited by 23

Biotechnological Production of Colorants

de Boer, L. (2013) · Advances in biochemical engineering, biotechnology · doi:10.1007/10_2013_241 · Cited by 23

In Vivo Antioxidant Activity of Fucoxanthin on Obese/Diabetes KK-Ay Mice

Iwasaki, S., Widjaja‐Adhi, M. A. K., Koide, A., Kaga, T., Nakano, S., Beppu, F., Hosokawa, M., & Miyashita, K. (2012) · Food and Nutrition Sciences · doi:10.4236/fns.2012.311194 · Cited by 23

The Potential Applications of Marine Bioactives Against Diabetes and Obesity

Wang, H., Fu, Z.-M., & Han, C. (2014) · doi:10.12691/marine-2-1-1 · Cited by 23

Biological characterization of a strain of Golenkinia (Chlorophyceae) with high oil and carotenoid content induced by increased salinity

Rearte, T. A., Vélez, C. G., Beligni, M. V., Figueroa, F. L., Gómez, P. I., Flaig, D., & de Iorio, A. F. (2018) · Algal Research · doi:10.1016/j.algal.2018.05.014 · Cited by 23

Astaxanthin provides neuroprotection in an experimental model of traumatic brain injury via the Nrf2/HO-1 pathway.

Gao, F., Wu, X., Mao, X., Niu, F., Zhang, B., Dong, J., & Liu, B. (2021) · PubMed Central · Cited by 23

An overview of various algal biomolecules and its applications

Agrawal, K., & Verma, P. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-823499-0.00006-7 · Cited by 22

Cytoprotective Effect of Astaxanthin in a Model of Normal Intraocular Pressure Glaucoma

Kikuchi, K., Dong, Z., Shinmei, Y., Murata, M., Kanda, A., Noda, K., Harada, T., & Ishida, S. (2020) · Journal of Ophthalmology · doi:10.1155/2020/9539681 · Cited by 22

A new approach on astaxanthin extraction via acid hydrolysis of wet Haematococcus pluvialis biomass

Vechio, H., Mariano, A. B., & Vieira, R. B. (2021) · Journal of Applied Phycology · doi:10.1007/s10811-021-02495-z · Cited by 22

Antihyperglycemic, antihyperlipidemic, and renoprotective effects ofChlorella pyrenoidosain diabetic rats exposed to cadmium

Thulasingam, S., Nagarajan, S., & Ashokkumar, N. (2012) · Toxicology Mechanisms and Methods · doi:10.3109/15376516.2012.714007 · Cited by 22

Evidence for decreased interaction and improved carotenoid bioavailability by sequential delivery of a supplement

Venzon, D. S., Kazlova, V., Izzy, S., Intra, J., Klosner, A. E., & Gellenbeck, K. W. (2016) · Food Science & Nutrition · doi:10.1002/fsn3.409 · Cited by 22

Astaxanthin Restrains Nitrative-Oxidative Peroxidation in Mitochondrial-Mimetic Liposomes: A Pre-Apoptosis Model

Mano, C. M., Guaratini, T., Cardozo, K. H. M., Colepicolo, P., Bechara, E. J. H., & Barros, M. P. (2018) · Marine Drugs · doi:10.3390/md16040126 · Cited by 22

Pathophysiology of Status Epilepticus Revisited

Alshehri, R. S., Alrawaili, M. S., Zawawi, B. M. H., Alzahrany, M., & Habib, A. H. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26157502 · Cited by 21

Extensive Bioactivity of Astaxanthin from Haematococcus pluvialis in Human

Yamashita, E. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-981-15-7360-6_23 · Cited by 21

Pulsed Electric Field–Assisted Cell Permeabilization of Microalgae (Haematococcus pluvialis) for Milking of Value-Added Compounds

Ahirwar, A., Khan, M. J., Sirotiya, V., Mourya, M., Rai, A., Schoefs, B., Marchand, J., Varjani, S., & Vinayak, V. (2022) · BioEnergy Research · doi:10.1007/s12155-022-10414-4 · Cited by 22

Loquat seed starch — Emerging source of non-conventional starch: Structure, properties, and novel applications

Tosif, M. M., Bains, A., Sadh, P. K., Sarangi, P. K., Kaushik, R., Burla, S. V. S., Chawla, P., & Sridhar, K. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.125230 · Cited by 21

The commercial potential of Aphanizomenon flos-aquae, a nitrogen-fixing edible cyanobacterium

Scoglio, G. D., Jackson, H. O., & Purton, S. (2024) · Journal of Applied Phycology · doi:10.1007/s10811-024-03214-0 · Cited by 23

Potential toxicity of carbonaceous nanomaterials on aquatic organisms and their alleviation strategies: A review

Chen, A., Wang, B., Feng, Q., & Wang, R. (2024) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2024.117019 · Cited by 21

Enhanced lipid accumulation of photoautotrophic microalgae by high-dose CO2 mimics a heterotrophic characterization

Sun, Z., Dou, X., Wu, J. W., He, B., Wang, Y., & Chen, Y. (2015) · World Journal of Microbiology and Biotechnology · doi:10.1007/s11274-015-1963-6 · Cited by 21

Integration of Waste Valorization for Sustainable Production of Chemicals and Materials via Algal Cultivation

Chen, Y., Sun, L.-P., Liu, Z., Martin, G. J. O., & Sun, Z. (2017) · Topics in Current Chemistry · doi:10.1007/s41061-017-0175-y · Cited by 21

Is the carotenoid production from Phaffia rhodozyma yeast genuinely sustainable? a comprehensive analysis of biocompatibility, environmental assessment, and techno-economic constraints

Mussagy, C. U., Dias, A. C., Santos‐Ebinuma, V. C., Sadek, M., Ahmad, M., de Andrade, C. R., Haddad, F. F., dos Santos, J. L., Scarim, C. B., Pereira, J. F. B., et al. (2024) · Bioresource Technology · doi:10.1016/j.biortech.2024.130456 · Cited by 20

Shrimp ferritin greatly improves the physical and chemical stability of astaxanthin

Zhang, C., Tan, X., Lv, C., Zang, J., & Zhao, G. (2021) · Journal of Food Science · doi:10.1111/1750-3841.15945 · Cited by 20

Label-free hyperspectral nonlinear optical microscopy of the biofuel micro-algae Haematococcus Pluvialis

Barlow, A. M., Slepkov, A. D., Ridsdale, A., McGinn, P. J., & Stolow, A. (2014) · Biomedical Optics Express · doi:10.1364/boe.5.003391 · Cited by 20

Effect of high-pressure compaction on supercritical CO2 extraction of astaxanthin from Haematococcus pluvialis

Reyes, F. A., Sielfeld, C., & del Valle, J. M. (2016) · Journal of Food Engineering · doi:10.1016/j.jfoodeng.2016.05.008 · Cited by 20

Health impact of marine carotenoids

Miyashita, K., & Hosokawa, M. (2018) · Journal of Food Bioactives · doi:10.31665/jfb.2018.1125 · Cited by 20

Astaxanthin protective barrier and its ability to improve the health in patients with COVID-19

Ahmadi, A.-R., & Ayazi‐Nasrabadi, R. (2021) · Iranian Journal of Microbiology · doi:10.18502/ijm.v13i4.6965 · Cited by 20

Effect of illumination intensities on astaxanthin synthesis by Xanthophyllomyces dendrorhous and its mutants

Stachowiak, B. (2013) · Food Science and Biotechnology · doi:10.1007/s10068-013-0180-z · Cited by 20

Well-Known Antioxidants and Newcomers in Sport Nutrition

Belviranlı, M., & Okudan, N. (2014) · CRC Press eBooks · doi:10.1201/b17442-5 · Cited by 20

Integrated algal and oil palm biorefinery as a model system for bioenergy co-generation with bioproducts and biopharmaceuticals

Abdullah, M. A., & Hussein, H. A. (2021) · Bioresources and Bioprocessing · doi:10.1186/s40643-021-00396-0 · Cited by 19

Astaxanthin: A Compound in the Prevention of Chronic Diseases and as a Potential Adjuvant Treatment Agent

Zhu, X., Chen, X., Wang, M.-X., & Hu, H. (2025) · Antioxidants · doi:10.3390/antiox14060715 · Cited by 19

Incorporation of Schizochytrium limacinum oil-based pickering emulsion in chitosan active composite films for strawberry preservation

Zou, X., Zhao, S., Xu, K., Liu, K., Li, L., Zhang, M., Yan, C. L., Zhang, X., & Fang, C. (2025) · Food Research International · doi:10.1016/j.foodres.2025.117235 · Cited by 19

Coloured Compounds in Fruits and Vegetables and Health

Deis, L., Quiroga, A. M., & Rosas, M. I. D. (2021) · Springer eBooks · doi:10.1007/978-3-030-61721-9_25 · Cited by 19

Enhancement of astaxanthin production in Schizochytrium limacinum B4D1 under ethanol induction

Zhu, X., Meng, C., Du, H., Chen, L., Sun, F., Chen, W., Wei, Z., Ren, J., Gao, Z., & Li, D. (2021) · Algal Research · doi:10.1016/j.algal.2021.102537 · Cited by 19

Advances, applications, challenges and prospects of alternative proteins

Li, X., Cao, Q., & Liu, G. (2024) · Journal of Food Composition and Analysis · doi:10.1016/j.jfca.2024.106900 · Cited by 19

Under low irradiation, the light regime modifies growth and metabolite production in various species of microalgae

Guermazi, W., Masmoudi, S., Boukhris, S., Ayadi, H., & Morant-Manceau, A. (2014) · Journal of Applied Phycology · doi:10.1007/s10811-014-0260-3 · Cited by 20

Bioactive Compounds and Pharmaceutical Excipients Derived from Animals, Marine Organisms, Microorganisms, Minerals, Synthesized Compounds, and Pharmaceutical Drugs

Alamgir, A. N. M. (2018) · Progress in drug research · doi:10.1007/978-3-319-92387-1_4 · Cited by 19

Microalgae-Based Processes for Pigments Production

Maroneze, M. M., Dias, R. R., Severo, I. A., & Queiroz, M. I. (2020) · Springer eBooks · doi:10.1007/978-3-030-50971-2_11 · Cited by 20

Maternal allocation of carotenoids increases tolerance to bacterial infection in brown trout

Wilkins, L. G. E., da Cunha, L. M., Menin, L., Ortiz, D., Vocat-Mottier, V., Hobil, M., Nusbaumer, D., & Wedekind, C. (2017) · Oecologia · doi:10.1007/s00442-017-3952-y · Cited by 19

Pharmacology of bioactive compounds from plant extracts for improving non-alcoholic fatty liver disease through endoplasmic reticulum stress modulation: A comprehensive review

Huang, L., Tan, L., Lv, Z., Chen, W., & Wu, J. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e25053 · Cited by 18

Molecular characterization of totiviruses in Xanthophyllomyces dendrorhous

Baeza, M., Bravo, N., Sanhueza, M., Flores, O., Villarreal, P. D., & Cifuentes, V. (2012) · Virology Journal · doi:10.1186/1743-422x-9-140 · Cited by 18

The Effect of Astaxanthin on Random Pattern Skin Flaps

Gürsoy, K., Teymur, H., Koca, G., Tanas, Ö., Demircan, F. B. G., Kankaya, Y., & Koçer, U. (2019) · Annals of Plastic Surgery · doi:10.1097/sap.0000000000002013 · Cited by 18

Quantification and Improvement of the Dynamics of Human Serum Albumin and Glycated Human Serum Albumin with Astaxanthin/Astaxanthin-Metal Ion Complexes: Physico-Chemical and Computational Approaches

Wibowo, S., Costa, J., Baratto, M. C., Pogni, R., Widyarti, S., Sabarudin, A., Matsuo, K., & Sumitro, S. B. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23094771 · Cited by 17

The Effects of Astaxanthin on Cognitive Function and Neurodegeneration in Humans: A Critical Review

Queen, C. J. J., Sparks, S. A., Marchant, D., & McNaughton, L. R. (2024) · Nutrients · doi:10.3390/nu16060826 · Cited by 18

Astaxanthin-loaded polylactic acid-glycolic acid nanoparticles alleviates atherosclerosis by suppressing macrophage ferroptosis via the NRF2/SLC7A11/GPX4 pathway

Jin, M., Chen, X., Zheng, L., Peng, Y., Lin, M., Liang, K., Liu, X., Xu, Z., Yang, Y., Wei, B., et al. (2025) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2025.110316 · Cited by 18

A Blinded Placebo-Controlled Randomized Trial on the Use of Astaxanthin as an Adjunct to Splinting in the Treatment of Carpal Tunnel Syndrome

MacDermid, J. C., Vincent, J. I., Gan, B. S., & Grewal, R. S. (2011) · Hand · doi:10.1007/s11552-011-9381-1 · Cited by 17

The Rise of Nutraceuticals: Overview and Future

Kapoor, N., Jamwal, V. L., Shukla, M. R., & Gandhi, S. G. (2020) · Ecoproduction · doi:10.1007/978-3-030-36130-3_4 · Cited by 18

The effect of astaxanthin on resistance of juvenile prawns Macrobrachium nipponense (Decapoda: Palaemonidae) to physical and chemical stress

Tizkar, B., Seidavi, A., Ponce‐Palafox, J. T., & Pourashouri, P. (2014) · Revista de Biología Tropical · doi:10.15517/rbt.v62i4.13057 · Cited by 17

Selected Powerful Natural Antioxidants: Structure, Food Sources, Antioxidant Activities, and Important Health Benefits

Nemzer, B. V., Yashin, A. Y., Vedenin, A. N., Yashin, Y. I., Yashunsky, D. V., Nifantiev, N. E., & Kalita, D. (2019) · Journal of Food Research · doi:10.5539/jfr.v8n1p60 · Cited by 18

Astaxanthin Production by Microalgae Haematococcus pluvialis Through Wastewater Treatment: Waste to Resource

Shah, M. M. R. (2019) · Springer eBooks · doi:10.1007/978-3-030-13909-4_2 · Cited by 17

Isolation of a Stable Astaxanthin-Hyperproducing Mutant of Xanthophyllomyces dendrorhous Through Random Mutagenesis

Ang, F. S., Khaw, S. Y., Few, L. L., Too, W. C. S., & Chew, A. L. (2019) · Applied Biochemistry and Microbiology · doi:10.1134/s0003683819030025 · Cited by 17

A Study on the Bioavailability of a Proprietary, Sustained-release Formulation of Astaxanthin.

Madhavi, D., Kagan, D., & Seshadri, S. (2018) · PubMed Central · Cited by 17

Cultivation of microalgae in food processing effluent for pollution attenuation and astaxanthin production: a review of technological innovation and downstream application

Zhang, X., & Lu, Q. (2024) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2024.1365514 · Cited by 16

Astaxanthin: a nature’s versatile compound utilized for diverse applications and its therapeutic effects

Bharti, A., Hooda, V., Jain, U., & Chauhan, N. (2025) · 3 Biotech · doi:10.1007/s13205-025-04241-5 · Cited by 17

In vitro inhibitory effect of crab shell extract on human umbilical vein endothelial cell

mirzapur, P., Rashidi, Z., Rezakhani, L., & Khazaei, M. (2014) · In Vitro Cellular & Developmental Biology - Animal · doi:10.1007/s11626-014-9810-x · Cited by 16

Effects of light and salinity on carotenoid biosynthesis in Ulva prolifera

He, Y., Ye, Y., & Shen, S. (2020) · Acta Oceanologica Sinica · doi:10.1007/s13131-020-1577-1 · Cited by 16

Carbohydrates derived from microalgae in the food industry

Ravindran, R., & Rajauria, G. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-821080-2.00007-1 · Cited by 16

Astaxanthin

Satoh, T. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802147-7.00038-3 · Cited by 16

A potential role for astaxanthin in the treatment of bone diseases (Review)

Valenti, M. T., Perduca, M., Romanelli, M. G., Mottes, M., & Carbonare, L. D. (2020) · Molecular Medicine Reports · doi:10.3892/mmr.2020.11284 · Cited by 16

Algal Carotenoids

Jain, A., & Vavilala, S. L. (2020) · Wiley eBooks · doi:10.1002/9781119143802.ch2 · Cited by 16

Vitamins

Mai, K., Waagbø, R., Zhou, X., Ai, Q., & Feng, L. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-819587-1.00014-8 · Cited by 15

Astaxanthin Exerts Immunomodulatory Effect by Regulating SDH-HIF-1α Axis and Reprogramming Mitochondrial Metabolism in LPS-Stimulated RAW264.7 Cells

Sun, L., Kim, S. E., Mori, R., Miyaji, N., Nikawa, T., & Hirasaka, K. (2022) · Marine Drugs · doi:10.3390/md20110660 · Cited by 15

Haematococcus lacustris genome assembly and annotation reveal diploid genetic traits and stress-induced gene expression patterns

Marcolungo, L., Bellamoli, F., Cecchin, M., Lopatriello, G., Rossato, M., Cosentino, E., Rombauts, S., Delledonne, M., & Ballottari, M. (2024) · Algal Research · doi:10.1016/j.algal.2024.103567 · Cited by 15

The effect of astaxanthin supplementation on inflammatory markers, oxidative stress indices, lipid profile, uric acid level, blood pressure, endothelial function, quality of life, and disease symptoms in heart failure subjects

Mohammadi, S. G., Feizi, A., Bagherniya, M., Shafie, D., Ahmadi, A.-R., & Kafeshani, M. (2024) · Trials · doi:10.1186/s13063-024-08339-8 · Cited by 15

Astaxanthin synthesis by Xanthophyllomyces dendrorhous DSM 5626 and its astaxanthin overproducing mutants on xylose media under diferent illumination

Stachowiak, B. (2014) · Acta Scientiarum Polonorum Technologia Alimentaria · doi:10.17306/j.afs.2014.3.6 · Cited by 15

Algae as Source of Pharmaceuticals

Dmytryk, A., Tuhy, Ł., & Chojnacka, K. (2017) · Springer eBooks · doi:10.1007/978-981-10-1950-0_11 · Cited by 15

Network Pharmacology Combined with Transcriptional Analysis to Unveil the Biological Basis of Astaxanthin in Reducing the Oxidative Stress Induced by Diabetes Mellitus

Sun, X., Ji, Y., Tahir, A., & Kang, J. G. (2020) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s274315 · Cited by 15

Chemical Features and Biological Effects of Astaxanthin Extracted from Haematococcus pluvialis Flotow: Focus on Gastrointestinal System

Budriesi, R., Micucci, M., Daglia, M., Corazza, I., Biotti, G., & Mattioli, L. (2022) · International Electronic Conference on Nutrients (IECN) · doi:10.3390/iecn2022-12376 · Cited by 15

Effects of Z-Isomerization on the Bioavailability and Functionality of Carotenoids: A Review

Honda, M., Maeda, H., Fukaya, T., & Goto, M. (2018) · InTech eBooks · doi:10.5772/intechopen.78309 · Cited by 15

The Delta 5, 7‐Sterols and Astaxanthin in the Marine Microheterotroph Schizochytrium sp. S31

Jiang, Y., Zhu, Q., Liao, Y., Wang, Q., Li, Y., Dong, X., Peng, J., Yuan, J., & Wang, J. (2020) · Journal of the American Oil Chemists Society · doi:10.1002/aocs.12364 · Cited by 15

Microencapsulation of astaxanthin based on emulsion solvent evaporation and subsequent spray drying

Fang, R., Liang, H., Li, J., Chen, Y., Luo, X., Li, Y., Li, B., & Liu, S. (2022) · Journal of Food Science · doi:10.1111/1750-3841.16063 · Cited by 14

Green and sustainable technologies for extraction of carotenoids from natural sources: a comprehensive review

Sharma, S., Dedha, A., Gupta, M. M., Singh, N., Gautam, A., & Kumari, A. (2024) · Preparative Biochemistry & Biotechnology · doi:10.1080/10826068.2024.2402905 · Cited by 14

Unveiling astaxanthin: biotechnological advances, delivery systems and versatile applications in nutraceuticals and cosmetics

Polamraju, S. M., Manochkumar, J., Ganeshbabu, M., & Ramamoorthy, S. (2025) · Archives of Microbiology · doi:10.1007/s00203-025-04241-2 · Cited by 14

Assessment of Expression Cassettes and Culture Media for Different Escherichia coli Strains to Produce Astaxanthin

Li, S., & Huang, J. (2018) · Natural Products and Bioprospecting · doi:10.1007/s13659-018-0172-z · Cited by 14

Purification and Identification of Astaxanthin and Its Novel Derivative Produced by Radio-tolerant Sphingomonas astaxanthinifaciens

Asker, D., Awad, T. S., Beppu, T., & Uéda, K. (2018) · Methods in molecular biology · doi:10.1007/978-1-4939-8742-9_10 · Cited by 14

Cognitive Effects of Astaxanthin Pretreatment on Recovery From Traumatic Brain Injury

Fleischmann, C., Shohami, E., Trembovler, V., Heled, Y., & Horowitz, M. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.00999 · Cited by 15

An overview on the role of microalgal metabolites and pigments in apoptosis induction against copious diseases

Razack, S. A., Surendhiran, D., Kozani, P. S., Kozani, P. S., Hamidi, M., Cabrera‐Barjas, G., & Delattre, C. (2021) · Algal Research · doi:10.1016/j.algal.2021.102556 · Cited by 14

Astaxanthin modulates osteopontin and transforming growth factor β1 expression levels in a rat model of nephrolithiasis: a comparison with citrate administration

Alex, M., Paul, M. V. S., Abhilash, M., Varghese, M. V., Anilkumar, T. V., & Nair, R. H. (2013) · British Journal of Urology · doi:10.1111/bju.12537 · Cited by 14

The Evaluation of Astaxanthin Effects on Differentiation of Human Adipose Derived Stem Cells into Oligodendrocyte Precursor Cells.

Ghasemi, N. (2018) · Europe PMC (PubMed Central) · Cited by 14

Rapid and Selective Screening Method for Isolation and Identification of Carotenoid-Producing Bacteria

Asker, D., Awad, T. S., Beppu, T., & Uéda, K. (2018) · Methods in molecular biology · doi:10.1007/978-1-4939-8742-9_9 · Cited by 14

Ultrafast Simultaneous Raman-Fluorescence Spectroscopy

Lindley, M., Hiramatsu, K., Nomoto, H., Shibata, F., Takeshita, T., Kawano, S., & Goda, K. (2019) · Analytical Chemistry · doi:10.1021/acs.analchem.9b03563 · Cited by 14

Astaxanthin supplementation impacts the cellular HSP expression profile during passive heating

Fleischmann, C., Bar-Ilan, N., Horowitz, M., Bruchim, Y., Deuster, P. A., & Heled, Y. (2020) · Cell Stress and Chaperones · doi:10.1007/s12192-019-01061-4 · Cited by 14

A clinical evaluation of the efficacy and tolerability of a novel topical antioxidant formulation featuring vitamin C, astaxanthin, and fermented turmeric

Konisky, H., Bowe, W. P., Yang, P., & Kobets, K. (2023) · Journal of Cosmetic Dermatology · doi:10.1111/jocd.15967 · Cited by 15

Astaxanthin slows down skeletal muscle atrophy in H22 tumor-bearing mice during sorafenib treatment by modulating the gut microbiota

Ren, P., Yue, H., Tang, Q., Wang, Y., & Xue, C. (2023) · Food & Function · doi:10.1039/d3fo04633h · Cited by 13

Astaxanthin induces plant tolerance against cadmium by reducing cadmium uptake and enhancing carotenoid metabolism for antioxidant defense in wheat (Triticum aestivum L.)

Ozavize, S. F., Qiu, C., & Wu, F. (2024) · Plant Physiology and Biochemistry · doi:10.1016/j.plaphy.2024.108622 · Cited by 13

The Role of Oral Supplementation for the Management of Age-Related Macular Degeneration: A Narrative Review

D’Angelo, A., Vitiello, L., Gagliardi, V., Salerno, G., Pascale, I. D., Coppola, A., Abbinante, G., Pellegrino, A., & Giannaccare, G. (2024) · Journal of Personalized Medicine · doi:10.3390/jpm14060653 · Cited by 13

Astaxanthin inhibits the reduction of glycolysis during the activation of hepatic stellate cells

Bae, M., Lee, Y., Pham, T. X., Hu, S., Park, Y., & Lee, J. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.117926 · Cited by 13

A developmental toxicity study of 3S, 3′S-Astaxanthin in New Zealand white rabbits

Schneider, S., Mellert, W., Schulte, S., & van Ravenzwaay, B. (2016) · Food and Chemical Toxicology · doi:10.1016/j.fct.2016.02.001 · Cited by 13

Development of nutraceuticals containing marine algae oils

Ansorena, D., & Astiasarán, I. (2013) · Elsevier eBooks · doi:10.1533/9780857098689.4.634 · Cited by 13

Astaxanthin: An algae-based natural compound with a potential role in human health-promoting effect: An updated comprehensive review

Jinu, M., & Chandra, K. M. (2021) · Journal of Applied Biology & Biotechnology · doi:10.7324/jabb.2021.9115 · Cited by 16

Bioactive Properties of the Pigment Astaxanthin from Haematococcus pluvialis in Human Health

Galarza, J. I., Pillacela, B., & Arredondo-Vega, B. O. (2023) · Physiology · doi:10.5772/intechopen.112085

Extensive Bioactivity of Astaxanthin from Haematococcus pluvialis in Human

Yamashita, E. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-981-15-7360-6_23 · Cited by 21

Haematococcus astaxanthin: applications for human health and nutrition

Guerin, M., Huntley, M. E., & Olaizola, M. (2003) · Trends in Biotechnology · doi:10.1016/s0167-7799(03)00078-7 · Cited by 1,495

Factors Affecting the Production of Astaxanthin in the Microalgae Haematococcus pluvialis: A Review

Soni, M., Aligita, W., Tina, R., & Levita, J. (2022) · International Journal of Current Research and Review · doi:10.31782/ijcrr.2022.141104 · Cited by 1