Cited by 649Antioxidant Activity and Oxidative StressSeaweed-derived Bioactive CompoundsFatty Acid Research and Health

The DOI matches its Crossref record; 129 of the 129 references it cites were found in a registry or an index.

Potential health-promoting effects of astaxanthin: a high-value carotenoid mostly from microalgae

Yuan, Jian‐Ping, Peng, Juan, Yin, Kai, Wang, Jiang‐Hai·2011·Molecular Nutrition & Food Research

DOI 10.1002/mnfr.201000414

Open this paper in CoChat — free account

Abstract

The ketocarotenoid astaxanthin can be found in the microalgae Haematococcus pluvialis, Chlorella zofingiensis, and Chlorococcum sp., and the red yeast Phaffia rhodozyma. The microalga H. pluvialis has the highest capacity to accumulate astaxanthin up to 4-5% of cell dry weight. Astaxanthin has been attributed with extraordinary potential for protecting the organism against a wide range of diseases, and has considerable potential and promising applications in human health. Numerous studies have shown that astaxanthin has potential health-promoting effects in the prevention and treatment of various diseases, such as cancers, chronic inflammatory diseases, metabolic syndrome, diabetes, diabetic nephropathy, cardiovascular diseases, gastrointestinal diseases, liver diseases, neurodegenerative diseases, eye diseases, skin diseases, exercise-induced fatigue, male infertility, and HgCl₂-induced acute renal failure. In this article, the currently available scientific literature regarding the most significant activities of astaxanthin is reviewed.

Integrity signals

Registry

Crossref · 10.1002/mnfr.201000414

Cites

129 of 129 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Astaxanthin: a review of its chemistry and applications
Higuera-Ciapara, I., Félix-Valenzuela, L., & Goycoolea, F. M. (2006) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408690590957188 · Cited by 1,287
Commercial potential for Haematococcus microalgae as a natural source of astaxanthin
Lorenz, R. T., & Cysewski, G. R. (2000) · Trends in biotechnology · doi:10.1016/s0167-7799(00)01433-5 · Cited by 1,190
Antioxidant Activities of Astaxanthin and Related Carotenoids
Naguib, Y. M. A. (2000) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf991106k · Cited by 975
Carotenoid Action on the Immune Response
Chew, B. P., & Park, J. S. (2004) · Journal of Nutrition · doi:10.1093/jn/134.1.257s · Cited by 795
Astaxanthin, a Carotenoid with Potential in Human Health and Nutrition
Hussein, G. M. E., Sankawa, U., Goto, H., Matsumoto, K., & Watanabe, H. (2005) · Journal of Natural Products · doi:10.1021/np050354+ · Cited by 653
Carotenogenesis in the green alga Haematococcus pluvialis : Cellular physiology and stress response
Boussiba, S. (2000) · Physiologia Plantarum · doi:10.1034/j.1399-3054.2000.108002111.x · Cited by 591
Astaxanthin decreased oxidative stress and inflammation and enhanced immune response in humans
Park, J. S., Chyun, J. H., Kim, Y. K., Line, L. L., & Chew, B. P. (2010) · Nutrition & Metabolism · doi:10.1186/1743-7075-7-18 · Cited by 569
Astaxanthin from Microbial Sources
Johnson, E. A., & An, G.-H. (1991) · Critical Reviews in Biotechnology · doi:10.3109/07388559109040622 · Cited by 509
Astaxanthin: A Novel Potential Treatment for Oxidative Stress and Inflammation in Cardiovascular Disease
Pashkow, F. J., Watumull, D. G., & Campbell, C. L. (2008) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2008.02.010 · Cited by 455
Efficient radical trapping at the surface and inside the phospholipid membrane is responsible for highly potent antiperoxidative activity of the carotenoid astaxanthin
Goto, S., Kogure, K., Abe, K., Kimata, Y., Kitahama, K., Yamashita, E., & Terada, H. (2001) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/s0005-2736(01)00326-1 · Cited by 357

Show all 129 references

Research works printed but not linked: 3

10.1021/np050354 · DOI
10.1002/(SICI)1097-4644(1997)27 <35::AID-JCB8>3.0.CO;2-2 · DOI
Nakamura A., 2004, Changes in visual function following peroral astaxanthin, Jpn. J. Clin. Opthamol., 58, 1051

Sorted by citations

Items 601–648 of 648

Possible Effect of Astaxanthin on Obesity-related Increased COVID-19 Infection Morbidity and Mortality
Demet, E. D. Ö., Alkan, Ş. B., & Öksüz, A. (2021) · Current Nutrition & Food Science · doi:10.2174/1573401317666211011105732
AVALIAÇÃO DA SEGURANÇA MICROBIOLÓGICA E DO PERFIL DE BACTÉRIAS PRODUTORAS DE HISTAMINA EM CAVALA (SCOMBEROMORUS CAVALLA) E DOURADO (SALMINUS BRASILIENSIS) COMERCIALIZADOS EM MACEIÓ, ALAGOAS, BRASIL
Moreira, J. D. O. V., da Silva, M. T., Costa, C. A. C. B., da Silva, J. E., Júnior, E. G. D. S., de Oliveira, J. V. L., Pimentel, A. L., Silva, F. G. C., de Moura, M. A. B. F., de Almeida, L. M., et al. (2022) · Amplla Editora eBooks · doi:10.51859/amplla.des1788-7
TAILÂNDIA: TERRA DOS SABERES E AROMAS QUE SEDUZEM A CULINÁRIA MUNDIAL
Burgos, T. H. R., & Shinohara, N. K. S. (2022) · Amplla Editora eBooks · doi:10.51859/amplla.des1788-24
QUEIJO MUÇARELA: AVALIAÇÃO DO PERFIL MICROBIOLÓGICO
Coelho, K. G. D. S., de Sousa, T. S., da Costa, L. C. S., da Silva, C. R., Carvalho, F. I. M., & Silva, P. A. (2022) · Amplla Editora eBooks · doi:10.51859/amplla.des1788-4
AVALIAÇÃO MICROBIOLÓGICA DE CHARQUES COMERCIALIZADOS EM SUPERMERCADOS E FEIRA LIVRE NO MUNICÍPIO DE VITÓRIA DE SANTO ANTÃO (PERNAMBUCO, BRASIL)
Tavares, F. R. P. S., & de Oliveira, F. H. P. C. (2022) · Amplla Editora eBooks · doi:10.51859/amplla.des1788-1
A GARANTIA DO DIREITO HUMANO À ALIMENTAÇÃO ADEQUADA E SAUDÁVEL EM TEMPOS PANDÊMICOS DE COVID-19: ALGUMAS QUESTÕES ESSENCIAIS
Cavalcante, R. M. S. (2022) · Amplla Editora eBooks · doi:10.51859/amplla.des1788-20
Desafios e estratégias para segurança alimentar mundial
Shinohara, N. K. S., & de Oliveira, F. H. P. C. (2022) · Amplla Editora eBooks · doi:10.51859/amplla.des1788-0
COMPORTAMENTO E ALIMENTAÇÃO DA POPULAÇÃO DE PARAUAPEBAS (PA) DURANTE O ISOLAMENTO SOCIAL EM DECORRÊNCIA DA PANDEMIA DA COVID-19
de Sousa, V. C. S., Froz, E. O. S., Silva, K. A. R., da Cunha, S. C., Silva, P. A., & Oliveira, M. L. (2022) · Amplla Editora eBooks · doi:10.51859/amplla.des1788-19
Analysis of relationship between key genes and astaxanthin biosynthesis in Phaffia rhodozyma by transcript level and gene knock-outPreprint
Li, Z., Chen, L., Li, T., Du, X., He, N., Jiang, Z., Li, L., & Ni, H. (2019) · doi:10.21203/rs.2.19181/v1
Isolation and characterisation of omega-3 fatty acids producing marine microbes
Gupta, A. (2014)
Astaxanthin Attenuates Nonalcoholic Steatohepatitis with Downregulation of Osteoprotegerin in Ovariectomized Mice Fed Choline-Deficient High-Fat Diet
Zhao, M., Ma, L., Honda, T., Kato, A., Ohshiro, T., Yokoyama, S., Yamamoto, K., Ito, T., Imai, N., Ishizu, Y., et al. (2022) · Digestive Diseases and Sciences · doi:10.1007/s10620-022-07489-6
Curing of liver cancer: an update on the efficacy of bioactive compounds
Moola, A. K., Renuka, S. G., Seenivasan, H. K., Manickam, N., Peela, S., & Kumari, B. D. R. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-99283-1.00009-4
Availability of Macronutrients and their Relationship with some Soil Properties in Molisols of Udham Singh Nagar District of Uttarakhand, India
Kumar, V., Srivastava, A., Meena, S. S., & Kumar, S. (2017) · International Journal of Current Microbiology and Applied Sciences · doi:10.20546/ijcmas.2017.606.028
Protective Role of Astaxanthin on Radiation-Related Intestinal Toxicity in Rats
Özkan, E. E. (2022) · Turkish Journal of Oncology · doi:10.5505/tjo.2022.3614
Analysis of the New Progress in the Treatment of Parkinson’s Disease from the Perspective of Antioxidant
Liu, Y., & Yan, Y. (2022) · Journal of Innovations in Medical Research · doi:10.56397/jimr/2022.10.02
Micro-Algae as a Source of Food and Bioactive Compounds for Human Health
Mishra, S., Kumari, N., & Sinha, R. P. (2022) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/9789815051872122010015
Bioactive Properties of the Pigment Astaxanthin from Haematococcus pluvialis in Human Health
Galarza, J. I., Pillacela, B., & Arredondo-Vega, B. O. (2023) · Physiology · doi:10.5772/intechopen.112085
ASTAXANTHIN TỪ VI TẢO: ỨNG DỤNG VÀ THÁCH THỨC TRONG QUÁ TRÌNH SẢN XUẤT VÀ THƯƠNG MẠI
Nguyễn, P. T., & Nguyễn, H. T. (2023) · Tạp chí Dinh dưỡng và Thực phẩm · doi:10.56283/1859-0381/557
Study on the processing of instant spiced tiny shrimp (Acetes Chinensis)
Anh, N. T. N., Phat, D. T., Truong, L. D., Long, H. B., Anh, P. D., & Nhi, T. T. Y. (2023) · AIP conference proceedings · doi:10.1063/5.0173468
Liposomes Containing Esters of the Natural Antioxidant Astaxanthin Modified with Pluronic F68 or DSPE-PEG 2000
Marchenkova, N., Баркарь, К. Е., Kulikov, E. A., Plokhikh, K. S., Lotosh, N. Y., & Селищева, А. А. (2023) · Nanobiotechnology Reports · doi:10.1134/s2635167623601511
New Perspectives and Sustainability Against Climate Change: Microalgae As Feed Sources
Sucu, M. C., & Şanlı, N. Ö. (2024) · doi:10.69860/nobel.9786053359258.4
Microalgal in the Production of Various High-End Value-Added Products Using Zero-Waste Biorefinery Approach
Jeya, K. R., Sankaranarayanan, A., & Veerapagu, M. (2024) · Interdisciplinary biotechnological advances · doi:10.1007/978-981-97-5544-8_7
Gene Array Technology and the Search for Cosmeceutical Actives
Sultan, N., Mehmood, F., Haider, M. Z., Ali, Q., Sami, A., Javed, S., Adeel, S., Irum, Shaheen, A., Afzaal, M., et al. (2025) · Springer eBooks · doi:10.1007/978-3-031-86087-4_14
Microalgae-derived bioactive compounds - A natural ally in cancer immunotherapy
Mittal, D., Thakur, R., Singh, S., Chauhan, A., & Devi, R. (2025) · The Applied Biology & Chemistry Journal · doi:10.52679/tabcj.2025.62002
Clinical Implications of Seawater in Reducing MMP-9 Levels in Eye Disorders: A Clinical Trial in Allergic Conjunctivitis
Díaz-Llopis, M., Pinazo-Duran, M. D., Loreto, D.-G., Rahhal-Ortuño, M., Gallego‐Pinazo, R., Dolz‐Marco, R., Diaz-Guiñon, T., Diaz, M., Romero, F. J., & Brotons-Canto, A. (2025) · Open Journal of Ophthalmology · doi:10.4236/ojoph.2025.154023
Pharmaceutical and Nutraceutical Applications of Marine Microalgae
John, N., Raj, P., Jose, J., Swathy, T., Haneef, F. F., Gokuljith, S., & Sunil, R. L. (2025) · Marine Biotechnology · doi:10.1002/9781394301324.ch3
The Potential Role of Microalgal Antioxidant Molecules on the Microbiota–Gut Axis in Inflammatory Bowel Diseases
Radice, R. P., Iannelli, V., Padula, F., Fabrizio, V. D., Δρόσος, Μ., Scopa, A., & Martelli, G. (2025) · Biomolecules · doi:10.3390/biom15111535
Additional file 1 of Integrated algal and oil palm biorefinery as a model system for bioenergy co-generation with bioproducts and biopharmaceuticals
Abdullah, M. A. B., & Hussein, H. A. (2021) · Figshare · doi:10.6084/m9.figshare.14633792
Algal Pigments and Diabetes
Gallege, J., Uduwana, S., Menaka, U., & Wickramasinghe, I. (2025) · Springer eBooks · doi:10.1007/978-981-95-0571-5_12
Microalgae-Based Pigments as Food Freshness Indicators in Smart Packaging
Abedini, A., Rastegarpour, M., Hasanvand, S., Sina, M., Mohamadi, B., Sani, M. A., & Mortazavian, A. M. (2026) · Springer eBooks · doi:10.1007/978-3-032-05253-7_6
Extraction biocompatible par les champs électriques pulsés des molécules d'intérêt de la microalgue verte Haematococcus pluvialis (Flotow 1844)
Gâteau, H. (2017) · theses.fr (ABES) · doi:10.70675/073227e9z7260z4fbaz9f9az505c5272526f
Multiscale NMR analysis of the microalgae metabolism
Bouillaud, D. (2020) · theses.fr (ABES) · doi:10.70675/dd3fd7fez7135z4ce9z97c6zd9c3cfa1a91a
Evaluation des microalgues sélectionnées en Nouvelle-Calédonie comme source potentielle d'anti-oxydants naturels : identification des molécules anti-radicalaires et stimulation de leur biosynthèse par orientation métabolique
Coulombier, N. (2020) · theses.fr (ABES) · doi:10.70675/1fc6442az8116z418dza169z7fa855798c1c
Environmental impact extrapolation of environmental processes at low Technology Readiness Level (TRL) : application to microalgae-based processes
Penaranda, D. (2024) · theses.fr (ABES) · doi:10.70675/1bec41dez4f30z44cbz8686zeeb3f0b83834
Prospective, Randomized, Double‐Blind, Placebo‐Controlled Study of an Oral Antioxidant‐Rich Synbiotic Supplement on Skin Health and Photoaging
Afzal, L., Nguyen, N., Afzal, N., Adnan, S., Khan, Z., Dulai, A. S., Nayak, S., Trivedi, R. R., Min, A., & Sivamani, R. K. (2026) · Journal of Cosmetic Dermatology · doi:10.1111/jocd.70836
Direct recovery of free astaxanthin from Haematococcus pluvialis: Bifunctional deep eutectic solvent-mediated extraction and conversion in a single-step
Chen, S., Shen, Z., Wen, L., Han, Y., & Cao, X. (2026) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2026.04.022
Potential applications of lipid droplets from marine plants and microalgae in food and health
Pasaribu, B., Atsaraak, A. M., Dewanti, L. P., Yuniarti, M. S., Harahap, S. A., Putra, P. K., SRIWIJAYANTI, L. A., Kusuma, A. S. W., Abdulah, R., Putri, A. K., et al. (2026) · Food Chemistry Advances · doi:10.1016/j.focha.2026.101340
The role of astaxanthin in the prevention of socially significant diseases
Baburina, Y. L., Sotnikov, R., & Krestinin, R. R. (2025) · Biological Communications · doi:10.21638/spbu03.2025.407
Astaxanthin in Food Systems: From Natural Sources and Stability Challenges to Emerging Functional Applications
Šolto, T. J., Čagalj, M., & Šimat, V. (2026) · Sustainability · doi:10.3390/su18147433
The Antioxidant and Antibacterial Properties of Honeycomb-Structured Polylactic Acid/Astaxanthin@ZIF-8 Bio-Composite Film Applied in Beef Preservation
Liu, S., Xing, S., Wang, F., Zhu, H., Fu, X., Yu, Y., & Wang, L. (2026) · Biomolecules · doi:10.3390/biom16081184
Protective Effect of Astaxanthin on Cardiac Telomere Length in Cigarette Smoke-Exposed Rats (Rattus norvegicus)
Ratnata, P. A., Santoso, A., Hamid, F., Aminuddin, A., & Cangara, M. H. (2026) · Natural Resources for Human Health · doi:10.53365/nrfhh/224625
Pigments Isolated from Microalgae and Food Applications
Rayo-Mendez, L. M., & Llanos, J. H. R. (2026) · Wiley eBooks · doi:10.1002/9781394360307.ch04
Astaxanthin alleviates dibutyl phthalate-induced cardiotoxicity in zebrafish larvae by regulating mitophagy
Gao, J., Wu, J., Hu, J., Li, C., & Ji, H. (2026) · Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology · doi:10.1016/j.cbpc.2026.110665
Astaxanthin attenuates proinflammatory signaling and promotes adipogenesis in human adipose stem cells
Toncan, F., Yamamoto, Y., Raj, R. R., Bharti, M., & Lee, M. (2026) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2026.159769
Comparative evaluation of ST-PBR and airlift photobioreactors for astaxanthin production from Haematococcus pluvialis with potential nutraceutical applications
Rudnicki, P., Borowiak, D., Haczkiewicz, M., & Kaleta, J. (2026) · Chemical Engineering Journal Advances · doi:10.1016/j.ceja.2026.101476
Neuroprotective Potential of Crustacean-Derived Astaxanthin: A Review on Monoamine Oxidase Inhibition
Dikel, Ç., & Dikel, S. (2026) · Journal of Agricultural Production · doi:10.56430/japro.1989556
Eutectic solvent platform for the selective isolation and one-year stabilisation of astaxanthin from crustacean shell waste
Urbančič, V., Urbancic, N., Lavrič, Ž., Vaz, B. M. C., Ventura, S. P. M., Likozar, B., & Vicente, F. A. (2026) · Separation and Purification Technology · doi:10.1016/j.seppur.2026.140547
Natural products in the management of Parkinson's disease in animal models
Desouky, M. A., Abdelhamid, A. H., Gamal, N. K., Naeem, A. G., Sabry, N. C., Fahmy, S. M., Hanna, D. M. F., & Michel, H. E. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-54032-5.00010-3

Authors: Yuan, J., Peng, J., Yin, K., & Wang, J.
Affiliations: Sun Yat-sen University (CN)
Corresponding author: Yuan, Jian‐Ping
ORCID: Yuan, Jian‐Ping
Peng, Juan
Venue: Molecular Nutrition & Food Research
Publisher: Wiley
Published: 2010-11-18
Volume: 55
Issue: 1
Pages: 150-165
ISSN: 1613-4125 (ISSN-L)
1613-4133
DOI: 10.1002/mnfr.201000414
OpenAlex: W1988895856
Cited by: 649
References: 129
Citations by year: 2026: 23 · 2025: 44 · 2024: 45 · 2023: 44 · 2022: 55 · 2021: 70 · 2020: 70 · 2019: 47 · 2018: 44 · 2017: 37 · 2016: 34 · 2015: 39 · 2014: 34 · 2013: 25 · 2012: 27
FWCI: 1.77
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Molecular Nutrition & Food Research (publishedVersion)
PubMed (publishedVersion)
Funders: Science and Technology Planning Project of Guangdong Province, China (2007B020708003)
Topics: Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Keywords: astaxanthin, ketocarotenoids, microalgae, Haematococcus pluvialis, Chlorella zofingiensis, Chlorococcum, Phaffia rhodozyma, health-promoting properties, anticancer activity, anti-inflammatory activity, metabolic syndrome, diabetes mellitus, diabetic nephropathy, cardiovascular disease, neurodegenerative diseases, eye diseases, skin diseases, exercise fatigue, male infertility
MeSH terms: Chlorophyta, Anti-Inflammatory Agents, Antineoplastic Agents, Antioxidants, Cardiovascular Agents, Chronic Disease, Humans, Hypoglycemic Agents, Neuroprotective Agents, Xanthophylls, Microalgae

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Potential health-promoting effects of astaxanthin: a high-value carotenoid mostly from microalgae

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks