Beneficial effects of mangiferin on hyperlipidemia in high-fat-fed hamsters
Abstract
Scope Mangiferin, a natural polyphenol, has been shown to have hypolipidemic effect in rat and mouse. However, the mechanism of action is not well understood. This study was conducted to determine the effect and mechanism of action of mangiferin on hyperlipidemia induced in hamsters by a high-fat diet. Methods and results Forty male hamsters were randomly assigned to normal control, high-fat control, and high fat with mangiferin (50 and 150 mg/kg BW) groups. Mangiferin treatment significantly decreased final body weight, liver weight and visceral fat-pad weight, serum triglyceride (TG) and total free fatty acid (FFA) concentrations, hepatic TG levels and hepatic and muscle total FFA contents. Mangiferin upregulated mRNA expression of peroxisome proliferator-activated receptor-α (PPAR-α), fatty acid translocase (CD36) and carnitine palmitoyltransferase 1 (CPT-1), but downregulated mRNA expression of sterol regulatory element-binding protein 1c (SREBP-1c), acetyl CoA carboxylase (ACC), acyl-CoA:diacylglycerol acyltransferase 2 (DGAT-2) and microsomal triglyceride transfer protein (MTP) in liver. Mangiferin also stimulated mRNA expression of PPAR-α, CD36, CPT-1 and lipoprotein lipase (LPL) in muscle. Conclusions The results suggest that mangiferin may ameliorate hypertriglyceridemia partly by modulating the expression levels of genes involved in lipid oxidation and lipogenesis.
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Body weight, liver weight, visceral fat-pad weight, serum TG, FFA concentration, hepatic TG levels, hepatic FFA and muscle FFA contents are immensely decreased following mangiferin treatment.
“Body weight, liver weight, visceral fat-pad weight, serum TG, FFA concentration, hepatic TG levels, hepatic FFA and muscle FFA contents are immensely decreased following mangiferin treatment (85).”
From Mangiferin: An effective therapeutic agent against several disorders (Review) (2018) · cites this paper as [85]
Mangiferin (50 and 150 mg/kg) ameliorates hypertriglyceridemia by modulating expression of genes involved in lipid oxidation and lipogenesis.
“Guo et al (85) discovered that mangiferin (50 and 150 mg/kg) ameliorates hypertriglyceridemia by modulating the expression of genes involved in lipid oxidation and lipogenesis.”
From Mangiferin: An effective therapeutic agent against several disorders (Review) (2018) · cites this paper as [85]
Cites
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Up-regulation of SREBP-1c and lipogenic genes in skeletal muscles after exercise training
Ikeda, S., Miyazaki, H., Nakatani, T., Kai, Y., Kamei, Y., Miura, S., Tsuboyama-Kasaoka, N., & Ezaki, O. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)00883-5 · Cited by 92 · see citing works
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Mangiferin: A natural miracle bioactive compound against lifestyle related disorders
Imran, M., Arshad, M. S., Butt, M. S., Kwon, J.-H., Arshad, M. U., & Sultan, M. T. (2017) · Lipids in Health and Disease · doi:10.1186/s12944-017-0449-y · Cited by 366 · see citing works
Mangiferin: A xanthonoid with multipotent anti‐inflammatory potential
Saha, S., Sadhukhan, P., & Sil, P. C. (2016) · BioFactors · doi:10.1002/biof.1292 · Cited by 159 · see citing works
Mangiferin: An effective therapeutic agent against several disorders (Review)
Du, S., Liu, H., Lei, T., Xie, X., Wang, H., He, X., Tong, R., & Wang, Y. (2018) · Molecular Medicine Reports · doi:10.3892/mmr.2018.9529 · Cited by 139 · see citing works
“Body weight, liver weight, visceral fat-pad weight, serum TG, FFA concentration, hepatic TG levels, hepatic FFA and muscle FFA contents are immensely decreased following mangiferin treatment (85).”
Self-citationImproving permeability and oral absorption of mangiferin by phospholipid complexation
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Alsaedi, A. Q., Nader, M. A., El-Kashef, D. H., & Abdelmageed, M. E. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1572758 · Cited by 5 · see citing works
- Authors
- Guo, F., Huang, C., Liao, X., Wang, Y., He, Y., Feng, R., Li, Y., & Sun, C.
- Affiliations
- Harbin Medical University (CN)
- Corresponding author
- Sun, Changhao
- Venue
- Molecular Nutrition & Food Research
- Publisher
- Wiley
- Published
- 2011-10-31
- Volume
- 55
- Issue
- 12
- Pages
- 1809-1818
- ISSN
- 1613-4125 (ISSN-L)
- 1613-4133
- OpenAlex
- W1987942381
- Cited by
- 118
- References
- 2
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 6 · 2023: 4 · 2022: 4 · 2021: 9 · 2020: 10 · 2019: 11 · 2018: 7 · 2017: 12 · 2016: 14 · 2015: 11 · 2014: 6 · 2013: 9 · 2012: 5
- FWCI
- 17.06
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular Nutrition & Food Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- NSFC-CIHR (30811120432)
- NSFC (81130049)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Mangiferin and Mango Extracts
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
- Keywords
- mangiferin, hyperlipidemia, hypertriglyceridemia, high-fat diet, hypolipidemic effect, PPARα, CD36, carnitine palmitoyltransferase 1, SREBP-1c, acetyl-CoA carboxylase, microsomal triglyceride transfer protein, lipoprotein lipase, lipid oxidation, lipogenesis, hepatic triglycerides, free fatty acids, polyphenols, hamster
- MeSH terms
- Acetyl-CoA Carboxylase, Adipose Tissue, Animals, Hypolipidemic Agents, Body Weight, Carnitine O-Palmitoyltransferase, Carrier Proteins, Dietary Fats, Fatty Acids, Nonesterified, Cricetinae, Hyperlipidemias, Lipoprotein Lipase, Liver, Male, Organ Size, RNA, Messenger, Triglycerides, Hypertriglyceridemia, Down-Regulation, Up-Regulation, CD36 Antigens, Xanthones, PPAR alpha, Lipogenesis, Lipid Metabolism, Diacylglycerol O-Acyltransferase, Sterol Regulatory Element Binding Protein 1, Diet, High-Fat
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