Cited by 24Mangiferin and Mango ExtractsMuscle Physiology and DisordersExercise and Physiological Responses

Mangiferin protects against adverse skeletal muscle changes and enhances muscle oxidative capacity in obese rats

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Acevedo, Luz M., Raya, Ana I., Martínez-Moreno, Julio M., Aguilera–Tejero, Escolástico, Rivero, José-Luis L.·2017·PLOS ONE

Abstract

Obesity-related skeletal muscle changes include muscle atrophy, slow-to-fast fiber-type transformation, and impaired mitochondrial oxidative capacity. These changes relate with increased risk of insulin resistance. Mangiferin, the major component of the plant Mangifera indica, is a well-known anti-inflammatory, anti-diabetic, and antihyperlipidemic agent. This study tested the hypothesis that mangiferin treatment counteracts obesity-induced fiber atrophy and slow-to-fast fiber transition, and favors an oxidative phenotype in skeletal muscle of obese rats. Obese Zucker rats were fed gelatin pellets with (15 mg/kg BW/day) or without (placebo group) mangiferin for 8 weeks. Lean Zucker rats received the same gelatin pellets without mangiferin and served as non-obese and non-diabetic controls. Lesser diameter, fiber composition, and histochemical succinic dehydrogenase activity (an oxidative marker) of myosin-based fiber-types were assessed in soleus and tibialis cranialis muscles. A multivariate discriminant analysis encompassing all fiber-type features indicated that obese rats treated with mangiferin displayed skeletal muscle phenotypes significantly different compared with both lean and obese control rats. Mangiferin significantly decreased inflammatory cytokines, preserved skeletal muscle mass, fiber cross-sectional size, and fiber-type composition, and enhanced muscle fiber oxidative capacity. These data demonstrate that mangiferin attenuated adverse skeletal muscle changes in obese rats.

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  • Anti-inflammatory interventions are capable of attenuating deleterious skeletal muscle changes in obese Zucker rats by inhibiting inflammatory signalling pathways in skeletal muscle.

    “The observation that anti-inflammatory interventions are capable of attenuating these deleterious skeletal muscle changes in obese Zucker rats by inhibiting inflammatory signalling pathways in skeletal muscle [29]”

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Authors
Acevedo, L. M., Raya, A. I., Martínez-Moreno, J. M., Aguilera–Tejero, E., & Rivero, J.-L. L.
Affiliations
  • University of Córdoba (ES)
  • Instituto Maimónides de Investigación Biomédica de Córdoba (ES)
Corresponding author
Rivero, José-Luis L.
Venue
PLOS ONE
Published
2017-03-02
Volume
12
Issue
3
Pages
e0173028
ISSN
1932-6203 (ISSN-L)
OpenAlex
W2594726289
Cited by
24
References
55
Citations by year
2026: 3 · 2025: 1 · 2024: 6 · 2023: 3 · 2022: 3 · 2021: 1 · 2020: 2 · 2019: 2 · 2018: 3
FWCI
2.84
Type
journal article
Language
en
Open access
Locations
  • PLoS ONE (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • RISalud Institutional Health Repository of Andalucía (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Instituto de Salud Carlos III (PI14/00467)
  • Agencia de Innovación y Desarrollo de Andalucía (P10-AGR-5963)
Topics
  • Health Sciences › Medicine › Complementary and alternative medicine › Mangiferin and Mango Extracts
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
  • Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
Keywords
mangiferin, obesity, skeletal muscle, muscle atrophy, mitochondrial oxidative capacity, succinate dehydrogenase, inflammatory cytokines, insulin resistance, mango, soleus muscle, tibialis cranialis, Zucker rats
MeSH terms
Animals, Blood Glucose, Cholesterol, Fibroblast Growth Factors, Obesity, Oxidation-Reduction, Rats, Zucker, Weight Gain, Muscle, Skeletal, Xanthones, Rats

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