Mangiferin protects against adverse skeletal muscle changes and enhances muscle oxidative capacity in obese rats
Open accessAbstract
Obesity-related skeletal muscle changes include muscle atrophy, slow-to-fast fiber-type transformation, and impaired mitochondrial oxidative capacity. These changes relate with increased risk of insulin resistance. Mangiferin, the major component of the plant Mangifera indica, is a well-known anti-inflammatory, anti-diabetic, and antihyperlipidemic agent. This study tested the hypothesis that mangiferin treatment counteracts obesity-induced fiber atrophy and slow-to-fast fiber transition, and favors an oxidative phenotype in skeletal muscle of obese rats. Obese Zucker rats were fed gelatin pellets with (15 mg/kg BW/day) or without (placebo group) mangiferin for 8 weeks. Lean Zucker rats received the same gelatin pellets without mangiferin and served as non-obese and non-diabetic controls. Lesser diameter, fiber composition, and histochemical succinic dehydrogenase activity (an oxidative marker) of myosin-based fiber-types were assessed in soleus and tibialis cranialis muscles. A multivariate discriminant analysis encompassing all fiber-type features indicated that obese rats treated with mangiferin displayed skeletal muscle phenotypes significantly different compared with both lean and obese control rats. Mangiferin significantly decreased inflammatory cytokines, preserved skeletal muscle mass, fiber cross-sectional size, and fiber-type composition, and enhanced muscle fiber oxidative capacity. These data demonstrate that mangiferin attenuated adverse skeletal muscle changes in obese rats.
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Anti-inflammatory interventions are capable of attenuating deleterious skeletal muscle changes in obese Zucker rats by inhibiting inflammatory signalling pathways in skeletal muscle.
“The observation that anti-inflammatory interventions are capable of attenuating these deleterious skeletal muscle changes in obese Zucker rats by inhibiting inflammatory signalling pathways in skeletal muscle [29]”
From Effect of Ecdysterone on the Hepatic Transcriptome and Lipid Metabolism in Lean and Obese Zucker Rats (2021) · cites this paper as [29]
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Cites
The heat of shortening and the dynamic constants of muscle
Hill, A. V. (1938) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.1938.0050 · Cited by 5,570 · see citing works
Inflammatory links between obesity and metabolic disease
Lumeng, C. N., & Saltiel, A. R. (2011) · Journal of Clinical Investigation · doi:10.1172/jci57132 · Cited by 2,319 · see citing works
PPARs and the complex journey to obesity
Evans, R. M., Barish, G. D., & Wang, Y.-X. (2004) · Nature Medicine · doi:10.1038/nm1025 · Cited by 1,621 · see citing works
Three myosin heavy chain isoforms in type 2 skeletal muscle fibres
Schiaffino, S., Gorza, L., Sartore, S., Saggin, L., Ausoni, S., Vianello, M., Gundersen, K., & Lømo, T. (1989) · Journal of Muscle Research and Cell Motility · doi:10.1007/bf01739810 · Cited by 960 · see citing works
Lillioja, S., Young, A. A., Culter, C. L., Ivy, J. L., Abbott, W. G., Zawadzki, J. K., Yki-Järvinen, H., Christin, L., Secomb, T. W., & Bogardus, C. (1987) · Journal of Clinical Investigation · doi:10.1172/jci113088 · Cited by 782 · see citing works
Delp, M. D., & Duan, C. (1996) · Journal of Applied Physiology · doi:10.1152/jappl.1996.80.1.261 · Cited by 704 · see citing works
Shah, K., Patel, M., Patel, R., & Parmar, P. (2010) · Pharmacognosy Reviews · doi:10.4103/0973-7847.65325 · Cited by 494 · see citing works
Bottinelli, R., Schiaffino, S., & Reggiani, C. (1991) · The Journal of Physiology · doi:10.1113/jphysiol.1991.sp018617 · Cited by 486 · see citing works
Effect of mangiferin on hyperglycemia and atherogenicity in streptozotocin diabetic rats
Muruganandan, S., Srinivasan, K., Gupta, S., Gupta, P. K., & Lal, J. (2005) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2004.12.010 · Cited by 426 · see citing works
The heat of activation and the heat of shortening in a muscle twitch
Hill, A. V. (1949) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.1949.0019 · Cited by 419 · see citing works
Oberbach, A., Bossenz, Y., Lehmann, S., Niebauer, J., Adams, V., Paschke, R., Schön, M. R., Blüher, M., & Punkt, K. (2006) · Diabetes Care · doi:10.2337/diacare.29.04.06.dc05-1854 · Cited by 384 · see citing works
Editorial (Thematic Issue: Mitochondrial Biogenesis: Pharmacological Approaches)
Valero, T. (2014) · Current Pharmaceutical Design · doi:10.2174/138161282035140911142118 · Cited by 370 · see citing works
Hickey, M. S., Carey, J. O., Azevedo, J. L., Houmard, J. A., Pories, W. J., Israel, R. G., & Dohm, G. L. (1995) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1995.268.3.e453 · Cited by 305 · see citing works
Martins, A. R., Nachbar, R. T., Gorjão, R., Vinolo, M. A. R., Festuccia, W. T., Lambertucci, R. H., Cury‐Boaventura, M. F., Silveira, L. R., Curi, R., & Hirabara, S. M. (2012) · Lipids in Health and Disease · doi:10.1186/1476-511x-11-30 · Cited by 288 · see citing works
Inverse associations between muscle mass, strength, and the metabolic syndrome
Atlantis, E. E., Martin, S., Haren, M. T., Taylor, A. W., & Wittert, G. (2009) · Metabolism · doi:10.1016/j.metabol.2009.02.027 · Cited by 259 · see citing works
Perry, B. D., Caldow, M. K., Brennan‐Speranza, T. C., Sbaraglia, M., Jerums, G., GARNHAM, A. P., Wong, C. Y., Levinger, P., Haq, M. A. U., Hare, D. L., et al. (2016) · PubMed · Cited by 239 · see citing works
Antidiabetic activity of a xanthone compound, mangiferin
Miura, T., Ichiki, H., Hashimoto, I., Iwamoto, N., Kao, M., Kubo, M., Ishihara, E., Komatsu, Y., Okada, M., Ishida, T., et al. (2001) · Phytomedicine · doi:10.1078/0944-7113-00009 · Cited by 206 · see citing works
Pal, P. B., Sinha, K., & Sil, P. C. (2014) · PLoS ONE · doi:10.1371/journal.pone.0107220 · Cited by 185 · see citing works
Antihyperglycaemic effect of Mangifera indica in rat
Aderibigbe, A., EMUDIANUGHE, T. S., & Lawal, B. A. (1999) · Phytotherapy Research · doi:10.1002/(sici)1099-1573(199909)13:6 · Cited by 148 · see citing works
PGC-1α regulates a HIF2α-dependent switch in skeletal muscle fiber types
Rasbach, K. A., Gupta, R. K., Ruas, J. L., Wu, J., Naseri, E., Estall, J. L., & Spiegelman, B. M. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1016089107 · Cited by 142 · see citing works
Regulation of skeletal muscle mitochondrial fatty acid metabolism in lean and obese individuals
Holloway, G. P., Bonen, A., & Spriet, L. L. (2008) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.26717b · Cited by 140 · see citing works
MIURA, T., ICHIKI, H., IWAMOTO, N., KATO, M., KUBO, M., SASAKI, H., OKADA, M., ISHIDA, T., SEINO, Y., & TANIGAWA, K. (2001) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.24.1009 · Cited by 137 · see citing works
Serrano, A. L., QUIROZ‐ROTHE, E., & Rivero, J. L. L. (2000) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s004240000408 · Cited by 124 · see citing works
Self-citationBeneficial effects of mangiferin on hyperlipidemia in high-fat-fed hamsters
Guo, F., Huang, C., Liao, X., Wang, Y., He, Y., Feng, R., Li, Y., & Sun, C. (2011) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201100392 · Cited by 118 · see citing works
Niu, Y., Li, S., Na, L., Feng, R., Liu, L., Li, Y., & Sun, C. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030782 · Cited by 116 · see citing works
HSUNWEIHUANG, T., PENG, G., QIANLI, G., YAMAHARA, J., Roufogalis, B. D., & Li, G. Q. (2005) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2005.05.003 · Cited by 115 · see citing works
Perspectives on medicinal properties of mangiferin
Vyas, A., Syeda, K., Ahmad, A., Padhye, S., & H. Sarkar, F. (2012) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/138955712800493870 · Cited by 104 · see citing works
Rivero, J. L. L., Talmadge, R. J., & Edgerton, V. R. (1999) · Histochemistry and Cell Biology · doi:10.1007/s004180050358 · Cited by 103 · see citing works
Self-citationSingle-fiber myosin heavy chain polymorphism: how many patterns and what proportions?
Caiozzo, V. J., Baker, M. J., Huang, K., Chou, H., Wu, Y. Z., & Baldwin, K. M. (2003) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00646.2002 · Cited by 95 · see citing works
Diet-induced obesity alters skeletal muscle fiber types of male but not female mice
DeNies, M. S., Johnson, J., Maliphol, A. B., Bruno, M., Kim, A., Rizvi, A., Rustici, K., & Medler, S. (2014) · Physiological Reports · doi:10.1002/phy2.204 · Cited by 94 · see citing works
Sellamuthu, P. S., Arulselvan, P., Kamalraj, S., Fakurazi, S., & Kandasamy, M. (2013) · ISRN Pharmacology · doi:10.1155/2013/750109 · Cited by 93 · see citing works
Girón, M. D., Sevillano, N., Salto, R., Haidour, A., Manzano, M., Jiménez, M. L., Rueda, R., & López-Pedrosa, J. M. (2009) · Clinical Nutrition · doi:10.1016/j.clnu.2009.04.018 · Cited by 82 · see citing works
Benard, O., & Chi, Y. (2015) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/1389557515666150401111410 · Cited by 82 · see citing works
The suppressive effect of mangiferin with exercise on blood lipids in type 2 diabetes
MIURA, T., IWAMOTO, N., KATO, M., ICHIKI, H., KUBO, M., KOMATSU, Y., ISHIDA, T., OKADA, M., & TANIGAWA, K. (2001) · Biological & Pharmaceutical Bulletin · doi:10.1248/bpb.24.1091 · Cited by 71 · see citing works
Apontes, P., Liu, Z., Su, K., Benard, O., Youn, D. Y., Li, X., Li, W., Mirza, R. H., Bastie, C. C., Jelicks, L. A., et al. (2014) · Diabetes · doi:10.2337/db14-0006 · Cited by 69 · see citing works
Acevedo, L. M., & Rivero, J. L. L. (2005) · Cell and Tissue Research · doi:10.1007/s00441-005-0057-4 · Cited by 67 · see citing works
Self-citationDual mode action of mangiferin in mouse liver under high fat diet
Lim, J., Liu, Z., Apontes, P., Feng, D., Pessin, J. E., Sauve, A. A., Angeletti, R. H., & Chi, Y. (2014) · PLoS ONE · doi:10.1371/journal.pone.0090137 · Cited by 64 · see citing works
Effect of Mangiferin and Mahanimbine on Glucose Utilization in 3T3-L1 cells
Kumar, B. G., Krishnakumar, K., Jaganathan, S., & Mandal, M. (2013) · Pharmacognosy Magazine · doi:10.4103/0973-1296.108145 · Cited by 57 · see citing works
Anti‐diabetic and Anti‐hyperlipidemic Effects and Safety of Salacia reticulata and Related Species
Stohs, S. J., & Ray, S. D. (2015) · Phytotherapy Research · doi:10.1002/ptr.5382 · Cited by 56 · see citing works
Tsubaki, M., Takeda, T., Kino, T., Itoh, T., Imano, M., Tanabe, G., Muraoka, O., Satou, T., & Nishida, S. (2015) · Europe PMC (PubMed Central) · Cited by 56 · see citing works
Han, J., Yi, J., Liang, F., Jiang, B., Xiao, Y., Gao, S., Yang, N., Hu, H., Xie, W.-F., & Chen, W. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.02.008 · Cited by 50 · see citing works
(2014) · PubMed · Cited by 46 · see citing works
Wang, F., Yan, J., Niu, Y., Li, Y., Lin, H., Liu, X., Liu, J., & Li, L. (2013) · Pharmaceutical Biology · doi:10.3109/13880209.2013.814691 · Cited by 42 · see citing works
Ringseis, R., Rosenbaum, S., Geßner, D. K., Herges, L., Kubens, J. F., Mooren, F., Krüger, K., & Eder, K. (2012) · Journal of Nutrition · doi:10.3945/jn.112.164038 · Cited by 40 · see citing works
Han, J., Yang, N., Zhang, F., Zhang, C., Liang, F., Xie, W., & Chen, W. (2015) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2015.05.016 · Cited by 39 · see citing works
Couturier, A., Ringseis, R., Mooren, F., Krüger, K., Most, E., & Eder, K. (2013) · Nutrition & Metabolism · doi:10.1186/1743-7075-10-48 · Cited by 38 · see citing works
Effects of the interval between removal and freezing of muscle biopsies on muscle fibre size
Larsson, L., & Skogsberg, C. (1988) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(88)90033-0 · Cited by 34 · see citing works
Mahali, S. K., Verma, N., & Manna, S. K. (2014) · Journal of Cellular Physiology · doi:10.1002/jcp.24647 · Cited by 30 · see citing works
Pioglitazone treatment restores in vivo muscle oxidative capacity in a rat model of diabetes
Wessels, B., Čiapaitė, J., van den Broek, N. M. A., Houten, S. M., Nicolay, K., & Prompers, J. J. (2014) · Diabetes Obesity and Metabolism · doi:10.1111/dom.12388 · Cited by 25 · see citing works
Subcellular lipid droplet distribution in red and white muscles in the obese Zucker rat
Lally, J., Snook, L. A., Han, X., Chabowski, A., Bonen, A., & Holloway, G. P. (2011) · Diabetologia · doi:10.1007/s00125-011-2367-2 · Cited by 22 · see citing works
Pompeani, N., Rybalka, E., Latchman, H. K., Murphy, R. M., Croft, K. D., & Hayes, A. (2014) · Journal of Negative Results in BioMedicine · doi:10.1186/s12952-014-0019-z · Cited by 17 · see citing works
Acevedo, L. M., López, I., Peralta-Ramírez, A., Pineda, C., Chamizo, V. E., Rodríguez, M., Aguilera‐Tejero, E., & Rivero, J. L. L. (2016) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00957.2015 · Cited by 17 · see citing works
Self-citationEffect of thyroid hormone on the myosin heavy chain isoforms in slow and fast muscles of the rat.
Jakubiec-Puka, A., Ciechomska, I. A., Mackiewicz, U., Langford, J. H., & Chomontowska, H. (1999) · Acta Biochimica Polonica · doi:10.18388/abp.1999_4154 · Cited by 13 · see citing works
Acevedo, L. M., Peralta-Ramírez, A., López, I., Chamizo, V. E., Pineda, C., Rodríguez-Ortiz, M. E., Rodríguez, M., Aguilera‐Tejero, E., & Rivero, J. L. L. (2015) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00195.2015 · Cited by 11 · see citing works
Self-citationCouturier, A., Ringseis, R., Mooren, F., Krüger, K., Most, E., & Eder, K. (2014) · Nutrition & Metabolism · doi:10.1186/1743-7075-11-16 · Cited by 6 · see citing works
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The multifaceted role of mangiferin in health and diseases: a review
Jangra, A., Arora, M. K., Kisku, A., & Sharma, S. (2020) · Oriental Pharmacy and Experimental Medicine · doi:10.1007/s13596-020-00471-5 · Cited by 37 · see citing works
Jack, B. U., Malherbe, C. J., Mamushi, M., Muller, C. J. F., Joubert, E., Louw, J., & Pheiffer, C. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.109439 · Cited by 35 · see citing works
Zhang, Y., Luo, C., Huang, P., Cheng, Y., Ma, Y., Gao, J., & Ding, H. (2024) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2024.109780 · Cited by 22 · see citing works
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Liu, Z., Apontes, P., Fomenko, E., Chi, N., Schuster, V. L., Kurland, I. J., Pessin, J. E., & Chi, Y. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19010201 · Cited by 21 · see citing works
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Guo, H., Chen, M., Li, M., Hu, M., Chen, B., & Zhou, C. (2019) · Journal of Chemistry · doi:10.1155/2019/9272710 · Cited by 19 · see citing works
Xiang, G., Guo, S., Xing, N., Du, Q., Qin, J., Gao, H., Zhang, Y., & Wang, S. (2024) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x24500150 · Cited by 18 · see citing works
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Bagchi, D. (2018) · Japan Journal of Medicine · doi:10.31488/jjm.1000109 · Cited by 17 · see citing works
Hu, M., Zheng, W., Cheng, M., Song, Z., Shaukat, H., Atta, M., & Qin, H. (2022) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.1c08036 · Cited by 16 · see citing works
Marschall, M. J. M., Ringseis, R., Gessner, D. K., Grundmann, S. M., Most, E., Wen, G., Maheshwari, G., Zorn, H., & Eder, K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22105241 · Cited by 13 · see citing works
Sj, S., Swaroop, A., Moriyama, H., Bagchi, M., Ahmad, T., & Bagchi, D. (2018) · Journal of Nutrition and Health Sciences · doi:10.15744/2393-9060.5.303 · Cited by 12 · see citing works
Nutritional Potency of Mangifera indica L. (Mango): Focus on Mango as Antioxidant
Shah, B. V., Chopra, H., Medithi, S., & Ungarala, R. (2024) · Current Functional Foods · doi:10.2174/0126668629288525240228182840 · Cited by 7 · see citing works
Kumar, S. N., Darvin, S. S., Toppo, E., Porchezhiyan, V., Pandikumar, P., Paulraj, M. G., & Savarimuthu Ignacimuthu, S. J. (2022) · Biocatalysis and Agricultural Biotechnology · doi:10.1016/j.bcab.2022.102312 · Cited by 6 · see citing works
Acevedo, L. M., Vidal, Á., Aguilera‐Tejero, E., & Rivero, J. L. L. (2022) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00306.2022 · Cited by 6 · see citing works
Self-citationXian, J., Huang, Y., Bai, J., Liao, Q., Chen, Q., Cheng, W., Su, Z., Li, S., Wu, Y., Li, J., et al. (2024) · Phytotherapy Research · doi:10.1002/ptr.8400 · Cited by 5 · see citing works
Identification of Bacterial Endophytes Isolated from Different Medicinal Plants
Muhtari, K., Sailaja, I., Shekhawat, B. K., Kaura, S., & Mehta, S. (2024) · International Journal of Biomedical and Clinical Analysis · doi:10.61797/ijbca.v4i1.331 · Cited by 4 · see citing works
Li, C.-J., Li, M.-T., Zhang, Y., Xu, S.-F., Li, H.-X., Chen, W.-Q., Cheng, J., Gu, D., Geng, X., Si, Y.-C., et al. (2024) · Journal of Food Biochemistry · doi:10.1155/2024/6662942 · Cited by 3 · see citing works
Salter, D., Swamy, S., Salis, K. M., Deep, D. K., & Nadig, P. D. (2024) · Frontiers in Nutrition · doi:10.3389/fnut.2024.1393917 · Cited by 3 · see citing works
Torre-Villalvazo, I., Tovar‐Palacio, C., Díaz‐Villaseñor, A., & Palacios‐González, B. (2026) · Receptors · doi:10.3390/receptors5020012 · Cited by 1 · see citing works
Mangiferin as a Multilevel Modulator of Metabolic Syndrome: Current Evidence and Future Perspectives
Ramos-Olvera, J. A., Torres-Valencia, J. M., Ortiz, M. I., Fernández‐Martínez, E., Gómez‐Aldapa, C. A., Muñoz‐Pérez, V. M., & Cariño‐Cortés, R. (2026) · Metabolites · doi:10.3390/metabo16070453 · Cited by 1 · see citing works
Mamushi, M. (2020) · SUNScholar (Stellenbosch University)
Patil, A., & Singh, S. P. (2023) · Journal of Scientific Research and Reports · doi:10.9734/jsrr/2023/v29i71761
The benefits of diet and exercise on delaying heart and brain aging in obesity
Thonusin, C., Chattipakorn, N., & Chattipakorn, S. C. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-30060-8.00019-4
Antiviral potential of mangiferin, a natural plant polyphenol compound
Li, Y., Yang, J., Xu, G., & Cao, Z. (2026) · Natural Product Research · doi:10.1080/14786419.2026.2748465
- Authors
- Acevedo, L. M., Raya, A. I., Martínez-Moreno, J. M., Aguilera–Tejero, E., & Rivero, J.-L. L.
- Affiliations
- University of Córdoba (ES)
- Instituto Maimónides de Investigación Biomédica de Córdoba (ES)
- Corresponding author
- Rivero, José-Luis L.
- Venue
- PLOS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2017-03-02
- Volume
- 12
- Issue
- 3
- Pages
- e0173028
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC5333851
- OpenAlex
- W2594726289
- Cited by
- 24
- References
- 55
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 6 · 2023: 3 · 2022: 3 · 2021: 1 · 2020: 2 · 2019: 2 · 2018: 3
- FWCI
- 2.84
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS ONE (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- RISalud Institutional Health Repository of Andalucía (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Instituto de Salud Carlos III (PI14/00467)
- Agencia de Innovación y Desarrollo de Andalucía (P10-AGR-5963)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Mangiferin and Mango Extracts
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Keywords
- mangiferin, obesity, skeletal muscle, muscle atrophy, mitochondrial oxidative capacity, succinate dehydrogenase, inflammatory cytokines, insulin resistance, mango, soleus muscle, tibialis cranialis, Zucker rats
- MeSH terms
- Animals, Blood Glucose, Cholesterol, Fibroblast Growth Factors, Obesity, Oxidation-Reduction, Rats, Zucker, Weight Gain, Muscle, Skeletal, Xanthones, Rats
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