Efficacy of bioactive compounds from extra virgin olive oil to modulate atherosclerosis development

Lou‐Bonafonte, José M.; Arnal, Carmen; Navarro, María A.; Osada, Jesús

doi:10.1002/mnfr.201100668

Cited by 99Edible Oils Quality and AnalysisCholesterol and Lipid MetabolismNuts composition and effects

Efficacy of bioactive compounds from extra virgin olive oil to modulate atherosclerosis development

Open access

Lou‐Bonafonte, José M., Arnal, Carmen, Navarro, María A., Osada, Jesús·2012·Molecular Nutrition & Food Research

DOI 10.1002/mnfr.201100668

Open this paper in CoChat — free account Open PDF

Abstract

As olive oil is the main source of calories in the Mediterranean diet, a great deal of research has been devoted to characterizing its role in atherosclerosis. Virgin olive oil is an oily matrix that contains hydrocarbons, mainly squalene; triterpenes such as uvaol, erythrodiol, oleanolic, and maslinic acid; phytosterols; and a wide range of phenolic compounds comprising simple phenols, flavonoids, secoiridoids, and lignans. In this review, we analyze the studies dealing with atherosclerosis and olive oil in several species. A protective role of virgin olive oil against atherosclerosis has been shown in ApoE‐deficient mice and hamsters. In the former animal, sex, dose, and dietary cholesterol are modulators of the outcome. Contradictory findings have been reported for rabbits, a circumstance that could be due to the profusion of experimental designs, differing in terms of doses and animal strains, as well as sources of olive oils. This role has yet to be fully validated in humans. Minor components of olive oil have been shown to be involved in atherosclerosis protection. Nevertheless, evidence of the potential of isolated compounds or the right combination of them to achieve the antiatherosclerotic effect of virgin olive oil is inconclusive and will undoubtedly require further experimental support.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1002/mnfr.201100668

Cites

155 of 155 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Pentacyclic triterpenes, secondary metabolites abundant in the unsaponifiable fraction of OPO, may have contributed to the reduction in plasma lipids observed in the present study, since they have been suggested to play a role in the treatment and management of CVD.
“Indeed, pentacyclic triterpenes, secondary metabolites abundant in the unsaponifiable fraction of OPO, may have contributed to the reduction in plasma lipids observed in the present study, since they have been suggested to play a role in the treatment and management of CVD [25].”
From Olive pomace oil can improve blood lipid profile: a randomized, blind, crossover, controlled clinical trial in healthy and at-risk volunteers (2022) · cites this paper as [25]
Trials in several animal models have reported reductions in serum TC, TG, LDL-C or VLDL-C and/or increased HDL-C concentrations following oral administration of different doses of MA, OA or high but not low doses of ursolic acid.
“Trials in several animal models have also reported reductions in serum TC, TG, LDL-C or VLDL-C and/or increased HDL-C concentrations following oral administration of different doses (15–100 mg/kg/d) of MA [reviewed in 26], OA (5–25 mg/kg/d) [25–29] or high (200 mg/kg/d) but not low (50 mg/kg/d) doses of ursolic acid (UA) [30].”
From Olive pomace oil can improve blood lipid profile: a randomized, blind, crossover, controlled clinical trial in healthy and at-risk volunteers (2022) · cites this paper as [25]
The citation to this review is attached specifically to the maslinic acid (MA) claim. Section 6.2 reports MA effects on LDL peroxidation and hepatic gene expression, but our copy does not report reductions in serum lipids, increased HDL-C, or the stated 15–100 mg/kg/day dose range for MA. Searches for MA lipid-profile outcomes and that dose range found no supporting passage; page numbers were unavailable. (LLM, conf=0.72)
Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Preferred Reporting Items for Systematic Reviews and Meta-Analyses: the PRISMA statement
Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., & for the PRISMA Group (2009) · BMJ · doi:10.1136/bmj.b2535 · Cited by 83,823 · see citing works
Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement
Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., & The PRISMA Group (2009) · PLoS Medicine · doi:10.1371/journal.pmed.1000097 · Cited by 64,042 · see citing works
Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement
Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., & the PRISMA Group* (2009) · Annals of Internal Medicine · doi:10.7326/0003-4819-151-4-200908180-00135 · Cited by 37,554 · see citing works
Inflammation in atherosclerosis
Libby, P. (2002) · Nature · doi:10.1038/nature01323 · Cited by 8,315 · see citing works
Progress and challenges in translating the biology of atherosclerosis
Libby, P., Ridker, P. M., & Hansson, G. K. (2011) · Nature · doi:10.1038/nature10146 · Cited by 4,010 · see citing works
Oleuropein in Olive and its Pharmacological Effects
Omar, S. H. (2010) · Scientia Pharmaceutica · doi:10.3797/scipharm.0912-18 · Cited by 648 · see citing works
Olive Oil and Red Wine Antioxidant Polyphenols Inhibit Endothelial Activation: Antiatherogenic Properties of Mediterranean Diet Phytochemicals
Carluccio, M. A., Siculella, L., Ancora, M. A., Massaro, M., Scoditti, E., Storelli, C., Visioli, F., Distante, A., & De Caterina, R. (2003) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000062884.69432.a0 · Cited by 640 · see citing works
The phenolic compounds of olive oil: structure, biological activity and beneficial effects on human health
Tripoli, E., Giammanco, M., Tabacchi, G., Majo, D. D., Giammanco, S., & Guardia, M. L. (2005) · Nutrition Research Reviews · doi:10.1079/nrr200495 · Cited by 631 · see citing works
Olive oil: chemistry and technology.
Boskou, D. G. (2006) · Cited by 618 · see citing works
Phenolic compounds and squalene in olive oils: the concentration and antioxidant potential of total phenols, simple phenols, secoiridoids, lignansand squalene
Owen, R. W., Mier, W., Giacosa, A., Hull, W. E., Spiegelhalder, B., & Bartsch, H. (2000) · Food and Chemical Toxicology · doi:10.1016/s0278-6915(00)00061-2 · Cited by 577 · see citing works
Extremely potent triterpenoid inducers of the phase 2 response: Correlations of protection against oxidant and inflammatory stress
Dinkova‐Kostova, A. T., Liby, K. T., Stephenson, K. K., Holtzclaw, W. D., Gao, X., Suh, N., Williams, C. R., Risingsong, R., Honda, T., Gribble, G. W., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0500815102 · Cited by 575 · see citing works
Mediterranean diet and public health: personal reflections
Keys, A. (1995) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/61.6.1321s · Cited by 528 · see citing works
Olive oil and health: Summary of the II international conference on olive oil and health consensus report, Jaén and Córdoba (Spain) 2008
López-Miranda, J., Pérez-Jiménez, F., Ros, E., De Caterina, R., Badimón, L., Covas, M. I., Escrich, E., Ordovás, J. M., Soriguer, F., Abiá, R., et al. (2010) · Nutrition, Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2009.12.007 · Cited by 520 · see citing works
Self-citation
Biological Activities of Phenolic Compounds Present in Virgin Olive Oil
Cicerale, S., Lucas, L., & Keast, R. (2010) · International Journal of Molecular Sciences · doi:10.3390/ijms11020458 · Cited by 449 · see citing works
Phenolic compounds in olive oil: Antioxidant, health and organoleptic activities according to their chemical structure
Servili, M., Esposto, S., Fabiani, R., Urbani, S., Taticchi, A., Mariucci, F., Selvaggini, R., & Montedoro, G. F. (2009) · Inflammopharmacology · doi:10.1007/s10787-008-8014-y · Cited by 414 · see citing works
Olive oil and the cardiovascular system
Covas, M. I. (2007) · Pharmacological Research · doi:10.1016/j.phrs.2007.01.010 · Cited by 401 · see citing works
Antihypertensive, antiatherosclerotic and antioxidant activity of triterpenoids isolated from Olea europaea, subspecies africana leaves
Somova, L. I., Shode, F. O., Ramnanan, P., & Nadar, A. (2003) · Journal of Ethnopharmacology · doi:10.1016/s0378-8741(02)00332-x · Cited by 383 · see citing works
Cardiovascular, antihyperlipidemic and antioxidant effects of oleanolic and ursolic acids in experimental hypertension
Somova, L. O., Nadar, A., Rammanan, P., & Shode, F. O. (2003) · Phytomedicine · doi:10.1078/094471103321659807 · Cited by 356 · see citing works
Hydroxytyrosol: from laboratory investigations to future clinical trials
Granados-Principal, S. M., Quiles, J. L., Ramírez-Tortosa, C. L., Sánchez‐Rovira, P., & Ramírez-Tortosa, M. C. (2010) · Nutrition Reviews · doi:10.1111/j.1753-4887.2010.00278.x · Cited by 293 · see citing works
The role of virgin olive oil components in the modulation of endothelial function
Perona, J. S., Cabello-Moruno, R., & Ruíz-Gutiérrez, V. (2005) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2005.11.007 · Cited by 278 · see citing works
Effect of squalene on tissue defense system in isoproterenol-induced myocardial infarction in rats
SABEENAFARVIN, K., Anandan, R., SENTHILKUMAR, S., Shiny, K. S., Sankar, T. V., & Thankappan, T. K. (2004) · Pharmacological Research · doi:10.1016/j.phrs.2004.03.004 · Cited by 269 · see citing works
The influence of olive oil on human health: not a question of fat alone
Pérez‐Jiménez, F., Ruano, J., Pérez‐Martínez, P., Lopez‐Segura, F., & López‐Miranda, J. (2007) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200600273 · Cited by 257 · see citing works
Antioxidant activities of oleanolic acid in vitro: Possible role of Nrf2 and MAP kinases
Wang, X., Ye, X.-L., Liu, R., Chen, H., Bai, H., Liang, X., Zhang, X., Wang, Z., Li, W., & Hai, C. (2010) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2010.01.034 · Cited by 248 · see citing works
Controlled trial of fish oil for regression of human coronary atherosclerosis. HARP Research Group.
Sacks, F. M., Stone, P. H., Gibson, C., Silverman, D., Rosner, B., & Pasternak, R. C. (1995) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(95)00095-l · Cited by 239 · see citing works
Molecular Mechanisms of Inflammation. Anti-Inflammatory Benefits of Virgin Olive Oil and the Phenolic Compound Oleocanthal
Lucas, L., Russell, A. P., & Keast, R. (2011) · Current Pharmaceutical Design · doi:10.2174/138161211795428911 · Cited by 224 · see citing works
Extra Virgin Olive Oil's Polyphenols: Biological Activities
Visioli, F., & Bernardini, E. (2011) · Current Pharmaceutical Design · doi:10.2174/138161211795428885 · Cited by 213 · see citing works
A Re-Examination
Rogalski, R. J., & Tiniç, S. M. (1978) · Financial Management · doi:10.2307/3664909 · Cited by 189 · see citing works
Mediterranean Diet Rich in Olive Oil and Obesity, Metabolic Syndrome and Diabetes Mellitus
Pérez‐Martínez, P., García‐Ríos, A., Delgado‐Lista, J., Pérez‐Jiménez, F., & López‐Miranda, J. (2011) · Current Pharmaceutical Design · doi:10.2174/138161211795428948 · Cited by 187 · see citing works
One-month administration of hydroxytyrosol, a phenolic antioxidant present in olive oil, to hyperlipemic rabbits improves blood lipid profile, antioxidant status and reduces atherosclerosis development
González-Santiago, M., Martín-Bautista, E., Carrero, J. J., Fonollá, J., Baró, L., Bartolomé, M. V., Gil-Loyzaga, P. E., & López‐Huertas, E. (2005) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2005.10.022 · Cited by 183 · see citing works
Olive Oil, the Mediterranean Diet, and Cardiovascular Health
Huang, C. L., & Sumpio, B. E. (2008) · Journal of the American College of Surgeons · doi:10.1016/j.jamcollsurg.2008.02.018 · Cited by 171 · see citing works
Antioxidant, Antiproliferative, and Pro-apoptotic Capacities of Pentacyclic Triterpenes Found in the Skin of Olives on MCF-7 Human Breast Cancer Cells and Their Effects on DNA Damage
Allouche, Y., Warleta, F., Campos, M., Sánchez‐Quesada, C., Uceda, M., Beltrán, G., & Gaforio, J. J. (2010) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf102319y · Cited by 170 · see citing works
Olive oil and walnut breakfasts reduce the postprandial inflammatory response in mononuclear cells compared with a butter breakfast in healthy men
Jiménez, Y., López‐Miranda, J., Blanco‐Colio, L. M., Marı́n, C., Pérez‐Martínez, P., Ruano, J., Paniagua, J. A., Rodríguez, F., Egido, J., & Pérez‐Jiménez, F. (2008) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2008.09.011 · Cited by 168 · see citing works
Independent association of serum squalene and noncholesterol sterols with coronary artery disease in postmenopausal women
RAJARATNAM, R. A., Gylling, H. K., & Miettinen, T. A. (2000) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(00)00527-1 · Cited by 168 · see citing works
Experimental atherosclerosis in rabbits fed cholesterol-free diets
Kritchevsky, D. (1964) · Journal of Atherosclerosis Research · doi:10.1016/s0368-1319(64)80019-3 · Cited by 164 · see citing works
The effect of the Mediterranean diet on plasma brain-derived neurotrophic factor (BDNF) levels: The PREDIMED-NAVARRA randomized trial
Sánchez‐Villegas, A., Galbete, C., Martínez‐González, M. Á., Martínez, J. A., Razquín, C., Salas‐Salvadó, J., Estruch, R., Buil‐Cosiales, P., & Martí, A. (2011) · Nutritional Neuroscience · doi:10.1179/1476830511y.0000000011 · Cited by 163 · see citing works
Olive oil and cardiovascular health
Covas, M.-I., Konstantinidou, V., & Fitó, M. (2009) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0b013e3181c5e7fd · Cited by 158 · see citing works
Oleanolic acid, a natural triterpenoid improves blood glucose tolerance in normal mice and ameliorates visceral obesity in mice fed a high-fat diet
de Melo, C. L., de Queiroz, M. G. R., Fonseca, S. G. C., Bizerra, A. M. C., Lemos, T. L. G., de Melo, T. S., Santos, F. A., & Rao, V. S. N. (2010) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2010.02.028 · Cited by 151 · see citing works
Extra-Virgin Olive Oil Increases the Resistance of LDL to Oxidation More than Refined Olive Oil in Free-Living Men with Peripheral Vascular Disease
Ramírez-Tortosa, M. C., Urbano, G., López-Jurado, M., Nestares, T., Gómez, M. C., MIR, A., Ros, E., Mataix, J., & Gil, Á. (1999) · Journal of Nutrition · doi:10.1093/jn/129.12.2177 · Cited by 151 · see citing works
Cholesterol vehicle in experimental atherosclerosis
Kritchevsky, D., & Tepper, S. A. (1967) · Journal of Atherosclerosis Research · doi:10.1016/s0368-1319(67)80041-3 · Cited by 147 · see citing works
Mediterranean Diet, Lifestyle Factors, and 10-Year Mortality in Elderly European Men and Women: The HALE Project
Knoops, K. T. B., de Groot, L. C. P. G. M., Kromhout, D., Perrin, A.-E., Moreiras-Varela, O., Menotti, A., & van Staveren, W. A. (2004) · JAMA · doi:10.1001/jama.292.12.1433 · Cited by 146 · see citing works
Expression of proinflammatory, proatherogenic genes is reduced by the Mediterranean diet in elderly people
Camargo, A., Delgado‐Lista, J., García‐Ríos, A., Cruz‐Teno, C., Yubero‐Serrano, E. M., Pérez‐Martínez, P., Gutierrez-Mariscal, F. M., Lora-Aguilar, P., Rodríguez-Cantalejo, F., Fuentes, F. J., et al. (2011) · British Journal Of Nutrition · doi:10.1017/s0007114511005812 · Cited by 143 · see citing works
Protective effect of oleanolic acid and ursolic acid against lipid peroxidation.
Balanehru, S., & Nagarajan, B. (1991) · PubMed · Cited by 142 · see citing works
Cardiotonic and antidysrhythmic effects of oleanolic and ursolic acids, methyl maslinate and uvaol
Somova, L. I., Shode, F. O., & Mipando, M. (2004) · Phytomedicine · doi:10.1078/0944-7113-00329 · Cited by 132 · see citing works
Cytoprotective effects of DL-alpha-lipoic acid or squalene on cyclophosphamide-induced oxidative injury: An experimental study on rat myocardium, testicles and urinary bladder
Motawi, T. K., Sadik, N. A. H., & Refaat, A. (2010) · Food and Chemical Toxicology · doi:10.1016/j.fct.2010.05.067 · Cited by 129 · see citing works
The year in atherothrombosis
Moreno, P., & Fuster, V. (2004) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2004.06.077 · Cited by 128 · see citing works
Effect of Minor Components of Virgin Olive Oil on Topical Antiinflammatory Assays
de la Puerta, R., Martínez-Domínguez, E., & Ruíz-Gutiérrez, V. (2000) · Zeitschrift für Naturforschung C · doi:10.1515/znc-2000-9-1023 · Cited by 127 · see citing works
Supressive effect of maslinic acid from pomace olive oil on oxidative stress and cytokine production in stimulated murine macrophages
Márquez-Martín, A., la Puerta, R. D., Fernández, Á., & Ruíz-Gutiérrez, V. (2006) · Free Radical Research · doi:10.1080/10715760500467935 · Cited by 127 · see citing works
Antioxidant Activity of Olive Polyphenols in Humans: a Review
Raederstorff, D. (2009) · International Journal for Vitamin and Nutrition Research · doi:10.1024/0300-9831.79.3.152 · Cited by 122 · see citing works
Isolation and identification of radical scavengers in olive tree (Olea europaea) wood
Pérez‐Bonilla, M., Salido, S., van Beek, T. A., Linares‐Palomino, P. J., Altarejos, J., Nogueras, M., & Sánchez, A. (2006) · Journal of Chromatography A · doi:10.1016/j.chroma.2005.12.055 · Cited by 119 · see citing works
Modulation of cytokine secretion by pentacyclic triterpenes from olive pomace oil in human mononuclear cells
Márquez-Martín, A., la Puerta, R. D., Fernández, Á., Ruíz-Gutiérrez, V., & Yaqoob, P. (2006) · Cytokine · doi:10.1016/j.cyto.2006.12.007 · Cited by 119 · see citing works
Hydroxytyrosol reduces intracellular reactive oxygen species levels in vascular endothelial cells by upregulating catalase expression through the AMPK–FOXO3a pathway
Zrelli, H., Matsuoka, M., Kitazaki, S., Zarrouk, M., & Miyazaki, H. (2011) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2011.03.045 · Cited by 115 · see citing works
Metabolic variables of cholesterol during squalene feeding in humans: comparison with cholestyramine treatment
Strandberg, T., Tilvis, R., & Miettinen, T. (1990) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)42347-8 · Cited by 115 · see citing works
Vasculoprotective potential of olive oil components
Carluccio, M. A., Massaro, M., Scoditti, E., & Caterina, R. D. (2007) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200600305 · Cited by 114 · see citing works
Antioxidant and antiatherogenic activities of pentacyclic triterpenic diols and acids
Allouche, Y., Beltrán, G., Gaforio, J. J., Uceda, M., & Mesa, M. D. (2010) · Food and Chemical Toxicology · doi:10.1016/j.fct.2010.07.022 · Cited by 114 · see citing works
Potential vasorelaxant effects of oleanolic acid and erythrodiol, two triterpenoids contained in ‘orujo’ olive oil, on rat aorta
Rodríguez‐Rodríguez, R., Herrera, M. D., Perona, J. S., & Ruíz-Gutiérrez, V. (2004) · British Journal Of Nutrition · doi:10.1079/bjn20041231 · Cited by 113 · see citing works
Bioavailability and antioxidant effects of olive oil phenolic compounds in humans: a review.
Fitó, M., de la Torre, R., Farré, M., Khymenetz, O., Marrugat, J., & Covas, M. (2007) · PubMed · Cited by 112 · see citing works
The chronic intake of a Mediterranean diet enriched in virgin olive oil, decreases nuclear transcription factor κB activation in peripheral blood mononuclear cells from healthy men
Pérez‐Martínez, P., López‐Miranda, J., Blanco‐Colio, L. M., Bellido, C., Jiménez, Y., Moreno, J. A., Delgado‐Lista, J., Egido, J., & Pérez‐Jiménez, F. (2007) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2006.11.033 · Cited by 106 · see citing works
Maslinic Acid Reduces Blood Glucose in KK-Ay Mice
Liu, J., Sun, H., Duan, W., Mu, D., & Zhang, L. (2007) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.30.2075 · Cited by 105 · see citing works
Squalene, 26-hydroxycholesterol and 7-ketocholesterol in human atheromatous plaques
Brooks, C. J. W., HARLAND, W. A., & Steel, G. (1966) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(66)90055-5 · Cited by 100 · see citing works
Evidence of postprandial absorption of olive oil phenols in humans.
Bonanome, A., Pagnan, A., Caruso, D., Toia, A., Xamin, A., Fedeli, E., Berra, B., Zamburlini, A., Ursini, F., & Galli, G. (2000) · PubMed · Cited by 100 · see citing works
Mediterranean diet reduces senescence-associated stress in endothelial cells
Marin, C., Delgado-Lista, J., Ramirez, R., Carracedo, J., Caballero, J., Perez-Martinez, P., Gutierrez-Mariscal, F. M., Garcia-Rios, A., Delgado-Casado, N., Cruz-Teno, C., et al. (2012) · AGE · doi:10.1007/s11357-011-9305-6 · Cited by 96 · see citing works
Cardioprotective Effect of Oleanolic Acid on Isoproterenol-Induced Myocardial Ischemia in Rats
Selvaraj, S., Sridevi, M., & Pugalendi, K. V. (2007) · Toxicologic Pathology · doi:10.1080/01926230701230312 · Cited by 95 · see citing works
Low-Cholesterol and High-Fat Diets Reduce Atherosclerotic Lesion Development in ApoE-Knockout Mice
Calleja, L., París, M. A., Paul, A., Vilella, E., Joven, J., Jiménez, A., Beltrán, G., Uceda, M., Maeda, N., & Osada, J. (1999) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.19.10.2368 · Cited by 94 · see citing works
Self-citation
Antidiabetic Effect of Oleanolic Acid: A Promising Use of a Traditional Pharmacological Agent
Wang, X., Li, Y., Wu, H., Liu, J., Hu, J., Liao, N., Peng, J., Cao, P., Liang, X., & Hai, C. (2011) · Phytotherapy Research · doi:10.1002/ptr.3385 · Cited by 93 · see citing works
In vivo antiatherogenic properties of olive oil and its constituent lipid classes in hyperlipidemic rabbits
Karantonis, H. C., Antonopoulou, S., Perrea, D. N., Sokolis, D. P., Theocharis, S. E., Kavantzas, N., Iliopoulos, D., & Demopoulos, C. A. (2005) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2005.07.003 · Cited by 92 · see citing works
Carotid intima-media thickness changes with Mediterranean diet: A randomized trial (PREDIMED-Navarra)
Murie-Fernández, M., Irimia, P., Toledo, E., Martínez‐Vila, E., Buil‐Cosiales, P., Serrano-Martínez, M., Ruíz-Gutiérrez, V., Ros, E., Estruch, R., & Martínez‐González, M. Á. (2011) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2011.06.050 · Cited by 92 · see citing works
Phytosterols and vascular disease
John, S., Sorokin, A. V., & Thompson, P. D. (2007) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e328011e9e3 · Cited by 91 · see citing works
Triterpenic Compounds from “Orujo” Olive Oil Elicit Vasorelaxation in Aorta from Spontaneously Hypertensive Rats
Rodríguez‐Rodríguez, R., Perona, J. S., Herrera, M. D., & Ruíz-Gutiérrez, V. (2006) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0528512 · Cited by 91 · see citing works
Olive oil in the primary prevention of cardiovascular disease
Ruiz‐Canela, M., & Martínez‐González, M. Á. (2011) · Maturitas · doi:10.1016/j.maturitas.2010.12.002 · Cited by 91 · see citing works
Sunflower, virgin-olive and fish oils differentially affect the progression of aortic lesions in rabbits with experimental atherosclerosis
Aguilera, C. M., Ramírez-Tortosa, M. C., Mesa, M. D., Ramírez-Tortosa, C. L., & Gil, Á. (2002) · Atherosclerosis · doi:10.1016/s0021-9150(01)00737-7 · Cited by 89 · see citing works
The SUN cohort study (Seguimiento University of Navarra)
Martínez‐González, M. Á. (2006) · Public Health Nutrition · doi:10.1079/phn2005935 · Cited by 89 · see citing works
New insights into generalized hepatoprotective effects of oleanolic acid: Key roles of metallothionein and Nrf2 induction
Liu, J., Wu, Q., Lu, Y., & Pi, J. (2008) · Biochemical Pharmacology · doi:10.1016/j.bcp.2008.07.021 · Cited by 87 · see citing works
Cardioprotective Effect of Squalene on Lipid Profile in Isoprenaline-Induced Myocardial Infarction in Rats
Farvin, K. H. S., Anandan, R., Kumar, S. H. S., Shiny, K. S., Mathew, S., Sankar, T. V., & Nair, P. (2006) · Journal of Medicinal Food · doi:10.1089/jmf.2006.9.531 · Cited by 85 · see citing works
Atherosclerosis
Kok, F. J., & Kromhout, D. (2004) · European Journal of Nutrition · doi:10.1007/s00394-004-1102-x · Cited by 84 · see citing works
Handbook of Olive Oil
(2000) · Springer eBooks · doi:10.1007/978-1-4757-5371-4 · Cited by 84 · see citing works
Effects of Trace Components of Dietary Fat on Cholesterol Metabolism: Phytosterols, Oxysterols, and Squalene
Ostlund, R. E., Racette, S. B., & Stenson, W. F. (2002) · Nutrition Reviews · doi:10.1301/00296640260385793 · Cited by 83 · see citing works
Hydroxytyrosol Administration Enhances Atherosclerotic Lesion Development in Apo E Deficient Mice
Acı́n, S., Navarro, M. Á., Arbonés-Mainar, J. M., Guillén, N., Sarría, A. J., Carnicer, R., Surra, J. C., Orman, I., Segovia, J. C., de la Torre, R., et al. (2006) · The Journal of Biochemistry · doi:10.1093/jb/mvj166 · Cited by 82 · see citing works
Self-citation
Anti-Inflammatory Activity of Oleanolic Acid by Inhibition of Secretory Phospholipase A2
Dharmappa, K. K., Kumar, R. S., Angaswamy, N., Mohamed, R., Shivaprasad, H. V., & Vishwanath, B. S. (2008) · Planta Medica · doi:10.1055/s-0028-1088374 · Cited by 81 · see citing works
Antithrombotic Lipid Minor Constituents from Vegetable Oils. Comparison between Olive Oils and Others
Karantonis, H. C., Antonopoulou, S., & Demopoulos, C. A. (2002) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf010923t · Cited by 80 · see citing works
Triterpenic Content and Chemometric Analysis of Virgin Olive Oils from Forty Olive Cultivars
Allouche, Y., Jiménez, A., Uceda, M., Aguilera, M. P., Gaforio, J. J., & Beltrán, G. (2009) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf803237z · Cited by 79 · see citing works
Antithrombotic and Antiatherosclerotic Properties of Olive Oil and Olive Pomace Polar Extracts in Rabbits
Tsantila, N., Karantonis, H. C., Perrea, D. N., Theocharis, S. E., Iliopoulos, D., Antonopoulou, S., & Demopoulos, C. A. (2007) · Mediators of Inflammation · doi:10.1155/2007/36204 · Cited by 78 · see citing works
PI3K and ERK/Nrf2 pathways are involved in oleanolic acid‐induced heme oxygenase‐1 expression in rat vascular smooth muscle cells
Feng, J., Zhang, P., Chen, X., & He, G. (2011) · Journal of Cellular Biochemistry · doi:10.1002/jcb.23065 · Cited by 76 · see citing works
Dietary monounsaturated fatty acids appear not to provide cardioprotection.
Degirolamo, C., & Rudel, L. L. (2010) · Current Atherosclerosis Reports · doi:10.1007/s11883-010-0133-4 · Cited by 72 · see citing works
Pomace Olive Oil Improves Endothelial Function in Spontaneously Hypertensive Rats by Increasing Endothelial Nitric Oxide Synthase Expression
Rodríguez‐Rodríguez, R., Herrera, M. D., de Sotomayor, M. Á., & RUIZGUTIERREZ, V. (2007) · American Journal of Hypertension · doi:10.1016/j.amjhyper.2007.01.012 · Cited by 71 · see citing works
Olive Oil Phenols Modulate the Expression of Metalloproteinase 9 in THP-1 Cells by Acting on Nuclear Factor-κB Signaling
Dell’Agli, M., Fagnani, R., Galli, G. V., Maschi, O., Gilardi, F., Bellosta, S., Crestani, M., Bosisio, E., Fabiani, E. D., & Caruso, D. (2010) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf9042503 · Cited by 71 · see citing works
Antiatherogenicity of extra virgin olive oil and its enrichment with green tea polyphenols in the atherosclerotic apolipoprotein-E-deficient mice: enhanced macrophage cholesterol efflux
Rosenblat, M., Volkova, N., Coleman, R., Almagor, Y., & Aviram, M. (2007) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2007.06.007 · Cited by 68 · see citing works
Squalene in a sex-dependent manner modulates atherosclerotic lesion which correlates with hepatic fat content in apoE-knockout male mice
Guillén, N., Acı́n, S., Navarro, M. Á., Perona, J. S., Arbonés-Mainar, J. M., Arnal, C., Sarría, A. J., Surra, J. C., Carnicer, R., Orman, I., et al. (2007) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2007.08.008 · Cited by 68 · see citing works
Self-citation
Oleanolic acid induces relaxation and calcium‐independent release of endothelium‐derived nitric oxide
Rodríguez‐Rodríguez, R., Stankevıčıus, E., Herrera, M. D., Østergaard, L., Andersen, M. R., Ruíz-Gutiérrez, V., & Simonsen, U. (2008) · British Journal of Pharmacology · doi:10.1038/bjp.2008.289 · Cited by 67 · see citing works
Oleanolic Acid Induces Prostacyclin Release in Human Vascular Smooth Muscle Cells through a Cyclooxygenase-2-Dependent Mechanism
Martínez‐González, J., Rodríguez‐Rodríguez, R., González-Díez, M., Rodrı́guez, C., Herrera, M. D., Ruíz-Gutiérrez, V., & Badimón, L. (2008) · Journal of Nutrition · doi:10.1093/jn/138.3.443 · Cited by 66 · see citing works
Plant pentacyclic triterpenic acids as modulators of lipid membrane physical properties
Prades, J., Vögler, O., Alemany, R., Gómez‐Florit, M., Funari, S. S., Ruíz-Gutiérrez, V., & Barceló, F. (2010) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2010.12.007 · Cited by 65 · see citing works
Antithrombotic Potential of Olive Oil Administration in Rabbits with Elevated Cholesterol
Cruz, J. P. D. L., Villalobos, M. A., Carmona, J. A. L., Martı́n-Romero, M., Smith-Agreda, J., & de la Cuesta, F. S. (2000) · Thrombosis Research · doi:10.1016/s0049-3848(00)00321-2 · Cited by 65 · see citing works
Effect of Dietary High-Oleic-Acid Oils that are Rich in Antioxidants on Microsomal Lipid Peroxidation in Rats
Perona, J. S., Arcemis, C., Ruíz-Gutiérrez, V., & Catalá, Á. (2004) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf048374p · Cited by 60 · see citing works
Novel approaches to improving endothelium-dependent nitric oxide-mediated vasodilatation
Simonsen, U., Rodríguez‐Rodríguez, R., Dalsgaard, T., Buus, N. H., & Stankevıčıus, E. (2009) · Pharmacological Reports · doi:10.1016/s1734-1140(09)70012-x · Cited by 59 · see citing works
Nitric Oxide and Tumor Necrosis Factor-α Production by Oleanolic Acid via Nuclear Factor-κB Activation in Macrophages
Choi, C. Y., You, H. J., & Jeong, H. G. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.5727 · Cited by 59 · see citing works
Olive oil- and fish oil-enriched diets modify plasma lipids and susceptibility of LDL to oxidative modification in free-living male patients with peripheral vascular disease: the Spanish Nutrition Study
Ramírez-Tortosa, C., López-Pedrosa, J. M., Suárez, A., Ros, E., Mataix, J., & Gil, Á. (1999) · British Journal Of Nutrition · doi:10.1017/s0007114599001099 · Cited by 59 · see citing works
Effects of dietary oleic-rich oils (virgin olive and high-oleic-acid sunflower) on vascular reactivity in Wistar-Kyoto and spontaneously hypertensive rats
Herrera, M. D., Pérez‐Guerrero, C., Marhuenda, E., & Ruiz-Gutiéerrez, V. (2001) · British Journal Of Nutrition · doi:10.1079/bjn2001397 · Cited by 58 · see citing works
Accumulation of cholesterol precursors and plant sterols in human stenotic aortic valves
Helske, S., Miettinen, T. A., Gylling, H., Mäyränpää, M. I., Lommi, J., Turto, H., Werkkala, K., Kupari, M. M., & Kovanen, P. T. (2008) · Journal of Lipid Research · doi:10.1194/jlr.m800058-jlr200 · Cited by 58 · see citing works
Olive oil and the haemostatic system
López‐Miranda, J., Delgado‐Lista, J., Pérez‐Martínez, P., Jiménez, Y., Fuentes, F. J., Ruano, J., & Marı́n, C. (2007) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200600307 · Cited by 56 · see citing works
Effect of Dietary Wine Pomace Extract and Oleanolic Acid on Plasma Lipids in Rats Fed High-Fat Diet and Its DNA Microarray Analysis
Yunoki, K., Sasaki, G., Tokuji, Y., Kinoshita, M., Naito, A., Aida, K., & Ohnishi, M. (2008) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf8026217 · Cited by 56 · see citing works
Review Article: Effects of Plant Sterols and Stanols Beyond Low-Density Lipoprotein Cholesterol Lowering
Derdemezis, C. S., Filippatos, T. D., Mikhailidis, D. P., & Elisaf, M. (2010) · Journal of Cardiovascular Pharmacology and Therapeutics · doi:10.1177/1074248409357921 · Cited by 53 · see citing works
Olive Oil and Haemostasis: Platelet Function, Thrombogenesis and Fibrinolysis
Delgado‐Lista, J., García‐Ríos, A., Pérez‐Martínez, P., López‐Miranda, J., & Pérez‐Jiménez, F. (2011) · Current Pharmaceutical Design · doi:10.2174/138161211795428876 · Cited by 52 · see citing works
Fatty acids in serum phospholipids and carotid intima-media thickness in Spanish subjects with primary dyslipidemia
Sala‐Vila, A., Cofán, M., Pérez-Heras, A., Núñez, I., Gilabert, R., Junyent, M., Mateo‐Gállego, R., Cenarro, A., Civeira, F., & Ros, E. (2010) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.28807 · Cited by 52 · see citing works
Decreased aortic early atherosclerosis and associated risk factors in hypercholesterolemic hamsters fed a high- or mid-oleic acid oil compared to a high-linoleic acid oil
Nicolosi, R. J., Woolfrey, B., Wilson, T. A., Scollin, P., Handelman, G. J., & Fisher, R. A. (2004) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2004.04.001 · Cited by 51 · see citing works
Dietary cholesterol suppresses the ability of olive oil to delay the development of atherosclerotic lesions in apolipoprotein E knockout mice
Acı́n, S., Navarro, M. Á., Carnicer, R., Arbonés-Mainar, J. M., Guzmán, M., Arnal, C., Beltrán, G., Uceda, M., Maeda, N., & Osada, J. (2005) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2005.01.050 · Cited by 49 · see citing works
Self-citation
Antiatherogenic effects of oleanolic acid in apolipoprotein E knockout mice
Buus, N. H., Hansson, N. C., Rodríguez‐Rodríguez, R., Stankevıčıus, E., Andersen, M. R., & Simonsen, U. (2011) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2011.09.037 · Cited by 49 · see citing works
Olive oil preparation determines the atherosclerotic protection in apolipoprotein E knockout mice
Acı́n, S., Navarro, M. Á., Perona, J. S., Arbonés-Mainar, J. M., Surra, J. C., Guzmán, M., Carnicer, R., Arnal, C., Orman, I., Segovia, J. C., et al. (2006) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2006.08.005 · Cited by 49 · see citing works
Self-citation
Protective effects of oleanolic acid on cerebral ischemic damagein vivoand H2O2-induced injuryin vitro
Rong, Z.-T., Gong, X., Sun, H., Li, Y., & Ji, H. (2010) · Pharmaceutical Biology · doi:10.3109/13880209.2010.499130 · Cited by 47 · see citing works
Oleanolic Acid Protects against Myocardial Ischemia-Reperfusion Injury by Enhancing Mitochondrial Antioxidant Mechanism Mediated by Glutathione and α-Tocopherol in Rats
Du, Y., & Ko, K. M. (2006) · Planta Medica · doi:10.1055/s-2005-916197 · Cited by 46 · see citing works
The impact of olive oil consumption pattern on the risk of acute coronary syndromes: the cardio2000 case–control study
Kontogianni, M. D., Panagiotakos, D. B., Chrysohoou, C. A., Pitsavos, C. S., Zampelas, A., & Stefanadis, C. (2007) · Clinical Cardiology · doi:10.1002/clc.20043 · Cited by 45 · see citing works
Influence of dietary fats on atherosclerosis, coagulation and platelet phospholipids in rabbits
Renaud, S., & Gautheron, P. (1975) · Atherosclerosis · doi:10.1016/0021-9150(75)90098-2 · Cited by 43 · see citing works
Carotid intima-media thickness is inversely associated with olive oil consumption
Buil‐Cosiales, P., Irimia, P., Berrade, N., García‐Arellano, A., Riverol, M., Murie-Fernández, M., Martínez‐Vila, E., Martínez‐González, M. Á., & Serrano-Martínez, M. (2007) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2006.12.028 · Cited by 43 · see citing works
Accelerated atherosclerosis in apolipoprotein E-deficient mice fed Western diets containing palm oil compared with extra virgin olive oils: A role for small, dense high-density lipoproteins
Arbonés-Mainar, J. M., Navarro, M. Á., Carnicer, R., Guillén, N., Surra, J. C., Acı́n, S., Guzmán, M., Sarría, A. J., Arnal, C., Aguilera, M. P., et al. (2006) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2006.11.010 · Cited by 42 · see citing works
Self-citation
Cholesterol Vehicle in Experimental Atherosclerosis 24: Avocado Oil
Kritchevsky, D., Tepper, S. A., Wright, S., Czarnecki, S. K., Wilson, T. A., & Nicolosi, R. J. (2003) · Journal of the American College of Nutrition · doi:10.1080/07315724.2003.10719275 · Cited by 39 · see citing works
Antiatherogenic effect of olive and corn oils in cholesterol-fed rabbits with the same plasma cholesterol levels.
Leth-Espensen, P., Stender, S., Ravn, H., & Kjeldsen, K. (1988) · Arteriosclerosis An Official Journal of the American Heart Association Inc · doi:10.1161/01.atv.8.3.281 · Cited by 38 · see citing works
Modulation of the regression of atherosclerosis in the hamster by dietary lipids: comparison of coconut oil and olive oil
Mangiapane, E. H., McAteer, M. A., Benson, G. M., White, D. A., & Salter, A. M. (1999) · British Journal Of Nutrition · doi:10.1017/s0007114599001646 · Cited by 36 · see citing works
Gingival vascular damage in atherosclerotic rabbits: Hydroxytyrosol and squalene benefits
Bullón, P., Quiles, J. L., Morillo, J. M., Rubini, C., Goteri, G., Granados-Principal, S. M., Battino, M. A., & Ramírez-Tortosa, M. C. (2009) · Food and Chemical Toxicology · doi:10.1016/j.fct.2009.06.026 · Cited by 36 · see citing works
Effects of pomace olive oil-enriched diets on endothelial function of small mesenteric arteries from spontaneously hypertensive rats
Rodríguez‐Rodríguez, R., Herrera, M. D., de Sotomayor, M. Á., & Ruíz-Gutiérrez, V. (2009) · British Journal Of Nutrition · doi:10.1017/s0007114509990754 · Cited by 36 · see citing works
Virgin olive and fish oils enhance the hepatic antioxidant defence system in atherosclerotic rabbits
Aguilera, C. M., Mesa, M. D., Ramírez-Tortosa, M. C., Quiles, J. L., & Gil, Á. (2003) · Clinical Nutrition · doi:10.1016/s0261-5614(03)00038-4 · Cited by 36 · see citing works
Cholesterol metabolism in normal and heterozygous familial hypercholesterolemic newborns
Vuorio, A. F., Miettinen, T. A., Turtola, H., Oksanen, H. M., & Gylling, H. (2002) · Journal of Laboratory and Clinical Medicine · doi:10.1067/mlc.2002.125214 · Cited by 35 · see citing works
Olive Oil
Boskou, D. (2000) · KARGER eBooks · doi:10.1159/000059722 · Cited by 35 · see citing works
Untitled work
(2009) · PubMed · Cited by 33 · see citing works
Comparison of the effects of fish oil and olive oil on blood lipids and aortic atherosclerosis in Watanabe heritable hyperlipidaemic rabbits
Mortensen, A., Hansen, B. F., Hansen, J. F., Frandsen, H. L., Bartnikowska, E., Andersen, P. S., & Bertelsen, L. S. (1998) · British Journal Of Nutrition · doi:10.1017/s0007114598001664 · Cited by 32 · see citing works
POSTPRANDIAL EFFECTS OF THE MEDITERRANEAN DIET ON OXIDANT AND ANTIOXIDANT STATUS IN ELDERLY MEN AND WOMEN
Yubero‐Serrano, E. M., García‐Ríos, A., Delgado‐Lista, J., Delgado‐Casado, N., Pérez‐Martínez, P., Rodríguez-Cantalejo, F., Fuentes, F. J., Cruz‐Teno, C., Túnez, I., Tasset-Cuevas, I., et al. (2011) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2011.03381.x · Cited by 31 · see citing works
Effect of squalene and shark liver oil on serum cholesterol level in hamsters
Zhang, Z., Yeung, W. K., Huang, Y., & Chen, Z. (2002) · International Journal of Food Sciences and Nutrition · doi:10.1080/0963748021000044750 · Cited by 31 · see citing works
The influence of dietary olive oil and margarine on aortic cholesterol accumulation in cholesterol-fed rabbits maintained at similar plasma cholesterol level
Mortensen, A., ESPENSEN, P., HANSEN, B., & Ibsen, P. H. (1992) · Atherosclerosis · doi:10.1016/0021-9150(92)90062-l · Cited by 31 · see citing works
A monounsaturated fatty acid-rich diet reduces macrophage uptake of plasma oxidised low-density lipoprotein in healthy young men
Moreno, J. A., López‐Miranda, J., Pérez‐Martínez, P., Marı́n, C., Moreno‐Luna, R., Gómez, P., Paniagua, J. A., & Pérez‐Jiménez, F. (2008) · British Journal Of Nutrition · doi:10.1017/s0007114508911508 · Cited by 31 · see citing works
Experimental atherosclerosis in rabbits fed cholesterol-free diets
Kritchevsky, D., Tepper, S. A., Klurfeld, D. M., Vesselinovitch, D., & Wissler, R. W. (1984) · Atherosclerosis · doi:10.1016/0021-9150(84)90073-x · Cited by 30 · see citing works
Effect of dietary olive and sunflower oils on the lipid composition of the aorta and platelets and on blood eicosanoids in rats.
Navarro, M. D. L. C., Hortelano, P., Periago, J. L., & Pita, M. L. (1992) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.12.7.830 · Cited by 30 · see citing works
Self-citation
Understanding the role of dietary components on atherosclerosis using genetic engineered mouse models
Alfonso, J. S. (2006) · Frontiers in bioscience · doi:10.2741/1852 · Cited by 29 · see citing works
Squalene Feeding in Experimental Atherosclerosis
Kritchevsky, D., Moyer, A. W., Tesar, W. C., Logan, J. B., Brown, R. A., & Richmond, G. (1954) · Circulation Research · doi:10.1161/01.res.2.4.340 · Cited by 29 · see citing works
Di-oleoyl phosphatidylcholine (PC-18:1) stimulates paraoxonase 1 (PON1) enzymatic and biological activities: In vitro and in vivo studies
Efrat, M., Rosenblat, M., Mahmood, S., Vaya, J., & Aviram, M. (2008) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2008.05.016 · Cited by 28 · see citing works
Dietary enrichment of apolipoprotein E-deficient mice with extra virgin olive oil in combination with seal oil inhibits atherogenesis
Eilertsen, K., Mæhre, H. K., Cludts, K., Olsen, J. O., & Hoylaerts, M. (2011) · Lipids in Health and Disease · doi:10.1186/1476-511x-10-41 · Cited by 24 · see citing works
Evidence for an inverse relation between plasma triglyceride and aortic cholesterol in the coconut oil/cholesterol-fed rabbit
van Heek, M., & Zilversmit, D. B. (1988) · Atherosclerosis · doi:10.1016/0021-9150(88)90142-6 · Cited by 24 · see citing works
Effects of dietary fat amount and saturation on the regulation of hepatic mRNA and plasma apolipoprotein A-I in rats
Calleja, L., Trallero, M. C., Carrizosa, C., Méndez, M. T., Palacios−Alaiz, E., & Osada, J. (2000) · Atherosclerosis · doi:10.1016/s0021-9150(99)00451-7 · Cited by 22 · see citing works
Self-citation
Lowering cholesterol - a review on the role of plant sterols.
Clifton, P. M. (2009) · PubMed · Cited by 21 · see citing works
Serum squalene in postmenopausal women without and with coronary artery disease
Rajaratnam, R., Gylling, H. K., & Miettinen, T. A. (1999) · Atherosclerosis · doi:10.1016/s0021-9150(99)00129-x · Cited by 21 · see citing works
Squalene Does Not Exhibit a Chemopreventive Activity and Increases Plasma Cholesterol in a Wistar Rat Hepatocarcinogenesis Model
Scolastici, C., Ong, T. P., & Moreno, F. S. (2004) · Nutrition and Cancer · doi:10.1207/s15327914nc5001_13 · Cited by 21 · see citing works
Increased plasma levels of plant sterols and atherosclerosis: A controversial issue
Calpe‐Berdiel, L., Méndez‐González, J., Blanco‐Vaca, F., & Escolá‐Gil, J. C. (2009) · Current Atherosclerosis Reports · doi:10.1007/s11883-009-0059-x · Cited by 21 · see citing works
Replacement of dietary saturated fat with monounsaturated fat: effect on atherogenesis in cholesterol-fed rabbits clamped at the same plasma cholesterol level
Nielsen, L. B., Leth-Espensen, P., Nordestgaard, B. G., Forged, E., Kjeldsen, K., & Stender, S. (1995) · British Journal Of Nutrition · doi:10.1079/bjn19950154 · Cited by 20 · see citing works
Participating in peer review is both a privilege and a professional duty
Calder, P. C. (2009) · British Journal Of Nutrition · doi:10.1017/s0007114509289070 · Cited by 19 · see citing works
An olive oil-rich diet reduces scavenger receptor mRNA in murine macrophages
Miles, E. A., WALLACE, F. A., & Calder, P. C. (2001) · British Journal Of Nutrition · doi:10.1079/bjn2000244 · Cited by 19 · see citing works
Triacylglycerol-rich lipoproteins derived from healthy donors fed different olive oils modulate cytokine secretion and cyclooxygenase-2 expression in macrophages: the potential role of oleanolic acid
Graham, V., Lawson, C., Wheeler-Jones, C. P. D., Perona, J. S., Ruíz-Gutiérrez, V., & Botham, K. M. (2011) · European Journal of Nutrition · doi:10.1007/s00394-011-0215-2 · Cited by 18 · see citing works
Apolipoprotein E determines the hepatic transcriptional profile of dietary maslinic acid in mice
Guillén, N., Acı́n, S., Surra, J. C., Arnal, C., Godino, J., García‐Granados, A., Muniesa, P., Ruíz-Gutiérrez, V., & Osada, J. (2008) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2008.08.003 · Cited by 16 · see citing works
Self-citation
Dietary fatty acid unsaturation levels, lipoprotein oxidation and circulating chemokine in experimentally induced atherosclerotic rats
Elseweidy, M. M., El-Swefy, S. E., Abdallah, F. R., & Hashem, R. M. (2005) · Journal of Pharmacy and Pharmacology · doi:10.1211/jpp.57.11.0013 · Cited by 15 · see citing works
Comparison of the Effects of Dietary Saturated, Mono-, and n–6 Polyunsaturated Fatty Acids on Blood Lipid Profile, Oxidant Stress, Prostanoid Synthesis and Aortic Histology in Rabbits
Bayındır, O., Özmen, D., MUTAF, I., Turgan, N., Habif, S., Gülter, C., Parıldar, Z., & Uysal, A. (2002) · Annals of Nutrition and Metabolism · doi:10.1159/000065411 · Cited by 13 · see citing works
Phytostérols et athérosclérose
Hansel, B., Courie, R., Bayet, Y., Delestre, F., & Bruckert, É. (2010) · La Revue de Médecine Interne · doi:10.1016/j.revmed.2010.06.007 · Cited by 12 · see citing works
The Year in Atherothrombosis
Sanz, J., Moreno, P., & Fuster, V. (2010) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.12.027 · Cited by 12 · see citing works
Antioxidants in virgin olive oil
Montedoro, G. F., Taticchi, A., Esposto, S., Selvaggini, R., Urbani, S., & Servili, M. (2007) · Cited by 10 · see citing works
Squalene and cholestanol in normal rabbit aorta
Stefanovich, V., & Kajiyama, G. (1970) · Atherosclerosis · doi:10.1016/0021-9150(70)90019-5 · Cited by 8 · see citing works
Effects of long term 2% fish oil supplements on tissue fatty acids, phospholipids, cholesterol, and arterial histology in Japanese quail (Coturnix coturnix japonica).
Chamberlain, J. G., Dittmann, L. E., Hunt, S., Olson, H., & Cashman, J. R. (1991) · PubMed · Cited by 7 · see citing works
The squalene content of atheromatous plaques A re-examination
Lewis, R. W. (1975) · Atherosclerosis · doi:10.1016/0021-9150(75)90039-8 · Cited by 6 · see citing works
Distribution of alkanes in normal and atherosclerotic rabbit aortas
Ramsey, R. B., Aexel, R. T., JAIN, S., & NICHOLAS, H. (1972) · Atherosclerosis · doi:10.1016/0021-9150(72)90020-2 · Cited by 6 · see citing works
Is oleic acid or squalene the important preventive agent?
Newmark, H. L. (2000) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/72.2.502 · Cited by 5 · see citing works
Presence of squalene in human aorta.
Garbuzov, A. G., Nn, P., & Ak, P. (1966) · PubMed · Cited by 5 · see citing works
[The presence of squalene in the human aorta].
Garbuzov, A. G., Nn, P., & Ak, P. (1965) · PubMed · Cited by 4 · see citing works

Flagged first, then by citations

2 of the 157 references couldn’t be matched to a known paper.

Research works printed but not linked: 12

Wahrburg, U., Kratz, M., Cullen, P., Mediterranean diet, olive oil and health. Eur. J. Lipid Sci. Technol. 2002, 104, 698-705.
Uceda, M., Hermoso, M., in: Barranco, D., Fern ández- Escobar, R., Rallo, L. (Eds.), El cultivo del olivo. 3rd ed. Ediciones Mundi-Prensa, Madrid, 1999, pp. 572-596.
Jim énez, J., Rond ón, D., Martínez, L., Mataix, J., in: Mataix, J. (Ed.), Aceite de Oliva Virgen: nuestro patrimo- nio alimentario: Universidad de Granada, Puleva Food, Granada, 2001, pp. 115-136.
Calapaj, R., Chiricosta, S., Saija, G., Binova, V., Evaluation of gas chromatographic and spectrophotometric analyti- cal results to check the presence of seed oils in olive sam- ples. Riv. Ital. Sostanze Grasse. 1993, 70, 585-594.
Arbon és-Mainar, J. M., Navarro, M. A., Lou-Bonafonte, J. M., Martínez-Gracia, M. V. et al., in: Vasallo, N. (Ed.), Olive Oil Phenolic Compounds as Potential Therapeutical Agents, Nova, La Veletta, 2008.
Boskou, D., Olive oil. World Rev. Nutr. Diet 2000, 87, 56- 77.
Sanz, J., Moreno, P. R., Fuster, V., The year in atherothrom- bosis. J. Am. Coll Cardiol. 2010, 55, 1487-1498.
Ignatowski, A. C., Influence of animal food on the organ- ism of rabbits. Izv. Imp. Voyenno-Med. Akad. Peter. 1908, 16, 154-173.
Somova, L. I., Shode, F. O., Ramnanan, P., Nadar, A., An- tihypertensive, antiatherosclerotic and antioxidant activ- ity of triterpenoids isolated from Olea europaea, sub- species Africana leaves. J. Ethnopharmacol. 2003, 84, 299- 305.
Rong, Z. T., Gong, X. J., Sun, H. B., Li, Y. M. et al., Protec- tive effects of oleanolic acid on cerebral ischemic damage in vivo and H(2)O(2)-induced injury in vitro. Pharm. Biol. 2011, 49, 78-85.
Hansel, B., Courie, R., Bayet, Y., Delestre, F. et al., Phy- tosterols and atherosclerosis. Rev. Med. Interne. 2011, 32, 124-129.
Civantos, L., In: Contreras, R., Grana, R., Civantos, L., Con- treras, R., Grana, R. (Eds.), Agrícola Espa ñola Publishers 2 Edn., Madrid 1999, pp. 1-359.

Sorted by citations

Hydroxytyrosol, Tyrosol and Derivatives and Their Potential Effects on Human Health
Marković, A. K., Torić, J., Barbarić, M., & Brala, C. J. (2019) · Molecules · doi:10.3390/molecules24102001 · Cited by 541 · see citing works
Nutrition and Atherosclerosis
Torres, N., Guevara‐Cruz, M., Velázquez‐Villegas, L. A., & Tovar, A. R. (2015) · Archives of Medical Research · doi:10.1016/j.arcmed.2015.05.010 · Cited by 273 · see citing works
Oleuropein, a Bioactive Compound from Olea europaea L., as a Potential Preventive and Therapeutic Agent in Non-Communicable Diseases
Nediani, C., Ruzzolini, J., Romani, A., & Calorini, L. (2019) · Antioxidants · doi:10.3390/antiox8120578 · Cited by 232 · see citing works
Hemp (Cannabis sativa L.) Seed Oil: Analytical and Phytochemical Characterization of the Unsaponifiable Fraction
la Paz, S. M., Marín‐Aguilar, F., García, M. D., & Fernández, Á. (2014) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf404278q · Cited by 209 · see citing works
Virgin Olive Oil and Health: Summary of the III International Conference on Virgin Olive Oil and Health Consensus Report, JAEN (Spain) 2018
Gaforio, J. J., Visioli, F., Alarcón-de-la-Lastra, C., Castañer, O., Delgado-Rodríguez, M., Fitó, M., Hernández, A. F., Huertas, J. R., Martínez-González, M. A., Menendez, J. A., et al. (2019) · Nutrients · doi:10.3390/nu11092039 · Cited by 187 · see citing works
Self-citation
Current Insights into the Biological Action of Squalene
Lou-Bonafonte, J. M., Martínez‐Beamonte, R., Sanclemente, T., Surra, J. C., Herrera-Marcos, L. V., Sánchez-Marco, J., Arnal, C., & Osada, J. (2018) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201800136 · Cited by 187 · see citing works
Self-citation
Membrane composition and dynamics: A target of bioactive virgin olive oil constituents
López, S., Bermúdez, B., la Paz, S. M., Jaramillo, S., Varela, L. M., Ortega‐Gómez, A., Abia, R., & Muriana, F. J. G. (2014) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2014.01.007 · Cited by 166 · see citing works
Bioactive Properties of the Main Triterpenes Found in Olives, Virgin Olive Oil, and Leaves of Olea europaea
Sánchez‐Quesada, C., López-Biedma, A., Warleta, F., Campos, M., Beltrán, G., & Gaforio, J. J. (2013) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf403154e · Cited by 147 · see citing works
Squalene targets pro- and anti-inflammatory mediators and pathways to modulate over-activation of neutrophils, monocytes and macrophages
Cárdeno, A., Aparicio‐Soto, M., la Paz, S. M., Bermúdez, B., Muriana, F. J. G., & Alarcón‐de‐la‐Lastra, C. (2015) · Journal of Functional Foods · doi:10.1016/j.jff.2015.03.009 · Cited by 141 · see citing works
Modern vision of the Mediterranean diet
Kiani, A. K., Medori, M. C., Bonetti, G., Aquilanti, B., Velluti, V., Matera, G., Iaconelli, A., Stuppia, L., Connelly, S., Herbst, K. L., et al. (2022) · Journal of preventive medicine and hygiene · doi:10.15167/2421-4248/jpmh2022.63.2s3.2745 · Cited by 107 · see citing works
Vascular effects of the Mediterranean diet—Part II: Role of omega-3 fatty acids and olive oil polyphenols
Scoditti, E., Capurso, C. A., Capurso, A., & Massaro, M. (2014) · Vascular Pharmacology · doi:10.1016/j.vph.2014.07.001 · Cited by 87 · see citing works
Biologically Active Triterpenoids and Their Cardioprotective and Anti- Inflammatory Effects
Bakovic, N. H. M. (2015) · Journal of Bioanalysis & Biomedicine · doi:10.4172/1948-593x.s12-005 · Cited by 75 · see citing works
Influence of Olive Oil and Its Components on Breast Cancer: Molecular Mechanisms
Moral, R., & Escrich, E. (2022) · Molecules · doi:10.3390/molecules27020477 · Cited by 74 · see citing works
Dietary Squalene Increases High Density Lipoprotein-Cholesterol and Paraoxonase 1 and Decreases Oxidative Stress in Mice
Gabás‐Rivera, C., Barranquero, C., Martínez‐Beamonte, R., Navarro, M. Á., Surra, J. C., & Osada, J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0104224 · Cited by 74 · see citing works
Self-citation
Effects of Virgin Olive Oils Differing in Their Bioactive Compound Contents on Biomarkers of Oxidative Stress and Inflammation in Healthy Adults: A Randomized Double-Blind Controlled Trial
Sánchez-Rodríguez, E., Biel-Glesson, S., Fernandez-Navarro, J. R., Calleja, M. Á., Espejo-Calvo, J. A., Extremera, B. G., de la Torre, R., Fitó, M., Covas, M., Vílchez, P., et al. (2019) · Nutrients · doi:10.3390/nu11030561 · Cited by 67 · see citing works
Squalene: a multi-task link in the crossroads of cancer and aging
Ronco, Á. L., & Stéfani, E. D. (2013) · Functional Foods in Health and Disease · doi:10.31989/ffhd.v3i12.30 · Cited by 65 · see citing works
Assessment of the safety of maslinic acid, a bioactive compound from O lea europaea L .
Sánchez‐González, M., Lozano‐Mena, G., Juan, M. E., García‐Granados, A., & Planas, J. M. (2012) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201200481 · Cited by 64 · see citing works
PON1 and Mediterranean Diet
Lou-Bonafonte, J., Gabás-Rivera, C., Navarro, M., & Osada, J. (2015) · Nutrients · doi:10.3390/nu7064068 · Cited by 64 · see citing works
Self-citation
Vasculoprotective Role of Olive Oil Compounds via Modulation of Oxidative Stress in Atherosclerosis
Summerhill, V. I., Karagodin, V. P., Grechko, A. V., Myasoedova, V. A., & Orekhov, A. N. (2018) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2018.00188 · Cited by 61 · see citing works
Hydroxytyrosol attenuates tunicamycin‐induced endoplasmic reticulum stress in human hepatocarcinoma cells
Giordano, E., Dávalos, A., Nicod, N. M., & Visioli, F. (2013) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201300465 · Cited by 58 · see citing works
A review on management of cardiovascular diseases by olive polyphenols
Mehmood, A., Usman, M. A., Patil, P. J., Zhao, L., & Wang, C. (2020) · Food Science & Nutrition · doi:10.1002/fsn3.1668 · Cited by 58 · see citing works
Applications of recovered bioactive compounds in food products
Veneziani, G., Novelli, E., Esposto, S., Taticchi, A., & Servili, M. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-805314-0.00011-x · Cited by 51 · see citing works
Semi-synthesis of acylated triterpenes from olive-oil industry wastes for the development of anticancer and anti-HIV agents
Parra, A., Martin-Fonseca, S., Rivas, F., Reyes‐Zurita, F. J., Medina‐O’Donnell, M., Martı́nez, A., García‐Granados, A., Lupiáñez, J. A., & Alberício, F. (2014) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2013.12.049 · Cited by 48 · see citing works
Transcriptomics and the Mediterranean Diet: A Systematic Review
Herrera-Marcos, L. V., Lou-Bonafonte, J. M., Arnal, C., Navarro, M. Á., & Osada, J. (2017) · Nutrients · doi:10.3390/nu9050472 · Cited by 47 · see citing works
Self-citation
Screening of the Antioxidant and Enzyme Inhibition Potentials of Portuguese Pimpinella anisum L. Seeds by GC-MS
Farzaneh, V., Gominho, J., Pereira, H., & Carvalho, I. S. (2018) · Food Analytical Methods · doi:10.1007/s12161-018-1250-x · Cited by 42 · see citing works
Extra‐Virgin Olive Oil with Natural Phenolic Content Exerts an Anti‐Inflammatory Effect in Adipose Tissue and Attenuates the Severity of Atherosclerotic Lesions in Ldlr−/−.Leiden Mice
Luque‐Sierra, A., Álvarez‐Amor, L., Kleemann, R., Martı́n, F., & Varela, L. M. (2018) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201800295 · Cited by 40 · see citing works
Chronic administration of the soluble, nonbacterial fraction of kefir attenuates lipid deposition in LDLr −/− mice
Santanna, A. F., Filete, P. F., de Lima, E. M., Porto, M. L., Meyrelles, S. S., Vasquez, E. C., Endringer, D. C., Lenz, D., Abdalla, D. S. P., Pereira, T. D. M. C., et al. (2016) · Nutrition · doi:10.1016/j.nut.2016.11.001 · Cited by 39 · see citing works
Protective effects of functional foods against Parkinson's disease: A narrative review on pharmacology, phytochemistry, and molecular mechanisms
Iranshahy, M., Javadi, B., & Sahebkar, A. (2022) · Phytotherapy Research · doi:10.1002/ptr.7425 · Cited by 37 · see citing works
Pentacyclic triterpene in Olea europaea L: A simultaneous determination by high-performance liquid chromatography coupled to mass spectrometry
Giménez, E., Juan, M. E., Calvo-Melià, S., Barbosa, J., Sanz‐Nebot, V., & Planas, J. M. (2015) · Journal of Chromatography A · doi:10.1016/j.chroma.2015.07.064 · Cited by 36 · see citing works
The Risk of Breast Cancer between Western and Mediterranean Dietary Patterns
Tsai, H.-H., Yu, J., Hsu, H.-M., Chu, C.-H., Chang, T.-M., Hong, Z., Feng, A., Fu, C., Hsu, K., Dai, M., et al. (2023) · Nutrients · doi:10.3390/nu15092057 · Cited by 38 · see citing works
Protective Effect of Olive Oil Microconstituents in Atherosclerosis: Emphasis on PAF Implicated Atherosclerosis Theory
Antonopoulou, S., & Demopoulos, C. A. (2023) · Biomolecules · doi:10.3390/biom13040700 · Cited by 35 · see citing works
Effect of Dietary Intake of Avocado Oil and Olive Oil on Biochemical Markers of Liver Function in Sucrose-Fed Rats
Carvajal‐Zarrabal, O., Nolasco-Hipólito, C., Aguilar‐Uscanga, M. G., Santiesteban, G. M., Hayward‐Jones, P. M., & Barradas-Dermitz, D. M. (2014) · BioMed Research International · doi:10.1155/2014/595479 · Cited by 35 · see citing works
An Overview on Indications and Chemical Composition of Aromatic Waters (Hydrosols) as Functional Beverages in Persian Nutrition Culture and Folk Medicine for Hyperlipidemia and Cardiovascular Conditions
Hamedi, A., Moheimani, S. M., Sakhteman, A., Etemadfard, H., & Moein, M. (2017) · Journal of Evidence-Based Complementary & Alternative Medicine · doi:10.1177/2156587216686460 · Cited by 34 · see citing works
Olive Fruit and Olive Oil
Seçmeler, Ö., & Galanakis, C. M. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-814887-7.00008-3 · Cited by 32 · see citing works
Proteomics and gene expression analyses of squalene-supplemented mice identify microsomal thioredoxin domain-containing protein 5 changes associated with hepatic steatosis
Ramírez‐Torres, A., Barceló-Batllori, S., Martínez‐Beamonte, R., Navarro, M. Á., Surra, J. C., Arnal, C., Guillén, N., Acı́n, S., & Osada, J. (2012) · Journal of Proteomics · doi:10.1016/j.jprot.2012.07.001 · Cited by 32 · see citing works
Self-citation
Evaluating the potential of LC coupled to three alternative detection systems (ESI-IT, APCI-TOF and DAD) for the targeted determination of triterpenic acids and dialcohols in olive tissues
Olmo‐García, L., Bajoub, A., Fernández‐Gutiérrez, A., & Carrasco‐Pancorbo, A. (2015) · Talanta · doi:10.1016/j.talanta.2015.12.042 · Cited by 29 · see citing works
Erythrodiol, an Olive Oil Constituent, Increases the Half-Life of ABCA1 and Enhances Cholesterol Efflux from THP-1-Derived Macrophages
Wang, L., Wesemann, S., Krenn, L., Ladurner, A., Heiß, E. H., Dirsch, V. M., & Atanasov, A. G. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00375 · Cited by 29 · see citing works
Can rapeseed oil replace olive oil as part of a Mediterranean-style diet?
Hoffman, R., & Gerber, M. (2014) · British Journal Of Nutrition · doi:10.1017/s0007114514002888 · Cited by 29 · see citing works
The differential localization of a methyl group confers a different anti-breast cancer activity to two triterpenes present in olives
Sánchez‐Quesada, C., López-Biedma, A., & Gaforio, J. J. (2014) · Food & Function · doi:10.1039/c4fo00675e · Cited by 27 · see citing works
Hydroxytyrosyl alkyl ether derivatives inhibit platelet activation after oral administration to rats
Muñoz-Marín, J., Cruz, J. P. D. L., Reyes, J. J., López-Villodres, J. A., Guerrero, A., López‐Leiva, I., Espartero, J. L., Manzanares, M. T. L., & Correa, J. A. G. (2013) · Food and Chemical Toxicology · doi:10.1016/j.fct.2013.04.045 · Cited by 26 · see citing works
High Tyrosol and Hydroxytyrosol Intake Reduces Arterial Inflammation and Atherosclerotic Lesion Microcalcification in Healthy Older Populations
Zoubdane, N., Abdo, R.-A., Nguyen, M. T., Bentourkia, M., Turcotte, É. E., Berrougui, H., Fülöp, T., & Khalil, A. (2024) · Antioxidants · doi:10.3390/antiox13010130 · Cited by 25 · see citing works
Olive pomace oil can improve blood lipid profile: a randomized, blind, crossover, controlled clinical trial in healthy and at-risk volunteers
González-Rámila, S., Sarriá, B., Seguido, M. A., García-Cordero, J., Mateos, R., & Bravo, L. (2022) · European Journal of Nutrition · doi:10.1007/s00394-022-03001-y · Cited by 24 · see citing works
“It is known that a healthy diet and physical exercise can modulate the risk of CVD [1, 2].”
BackgroundInfluential
Molecular Aspects of Squalene and Implications for Olive Oil and the Mediterranean Diet
Gaforio, J. J., Sánchez‐Quesada, C., López-Biedma, A., Ramírez-Tortose, M. D. C., & Warleta, F. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-407849-9.00026-9 · Cited by 23 · see citing works
A Functional Virgin Olive Oil Enriched with Olive Oil and Thyme Phenolic Compounds Improves the Expression of Cholesterol Efflux-Related Genes: A Randomized, Crossover, Controlled Trial
Farràs, M., Arranz, S., Carrión, S., Subirana, I., Muñoz‐Aguayo, D., Blanchart, G., Kool, M., Solà, R., Motilva, M., Escolá‐Gil, J. C., et al. (2019) · Nutrients · doi:10.3390/nu11081732 · Cited by 23 · see citing works
Olea europaea as Potential Source of Bioactive Compounds for Diseases Prevention
Talhaoui, N., Trabelsi, N., Taamalli, A., Verardo, V., Gómez‐Caravaca, A. M., Fernández‐Gutiérrez, A., & Arraéz-Román, D. (2018) · Studies in natural products chemistry · doi:10.1016/b978-0-444-64057-4.00012-0 · Cited by 21 · see citing works
Pulsed electric field increases the extraction yield of extra virgin olive oil without loss of its biological properties
Martínez‐Beamonte, R., Ripalda, M., Herrero‐Continente, T., Barranquero, C., Dávalos, A., Hazas, M. L. D. L., Álvarez, I., Sánchez‐Gimeno, A. C., Raso, J., Arnal, C., et al. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.1065543 · Cited by 20 · see citing works
Self-citation
From Drupes to Olive Oil: An Exploration of Olive Key Metabolites
Termentzi, A., Halabalaki, M., & Skaltsounis, A. (2015) · Elsevier eBooks · doi:10.1016/b978-1-63067-041-2.50012-4 · Cited by 20 · see citing works
Behavior of lipophilic bioactives during olive oil processing
Seçmeler, Ö., & Üstündağ, Ö. G. (2017) · European Journal of Lipid Science and Technology · doi:10.1002/ejlt.201600404 · Cited by 19 · see citing works
Olive Oil Phenols
Papanikolaοu, C., Melliou, E., & Magiatis, P. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.81394 · Cited by 19 · see citing works
Nutlets of Tilia cordata Mill. and Tilia platyphyllos Scop. – Source of bioactive compounds
Siger, A., Antkowiak, W., Dwiecki, K., Rokosik, E., & Rudzińska, M. (2020) · Food Chemistry · doi:10.1016/j.foodchem.2020.128888 · Cited by 19 · see citing works
Physico-chemical and sensory evaluation of virgin olive oils from several Algerian olive-growing regions
Douzane, M., Daas, M. S., Meribai, A., Guezil, A.-H., Abdi, A., & Tamendjari, A. (2021) · OCL · doi:10.1051/ocl/2021044 · Cited by 18 · see citing works
Nutraceuticals and coronary heart disease
García‐Ríos, A., Delgado‐Lista, J., Alcala-Diaz, J. F., López‐Miranda, J., & Pérez‐Martínez, P. (2013) · Current Opinion in Cardiology · doi:10.1097/hco.0b013e32836081a5 · Cited by 18 · see citing works
Lycium intricatum Boiss.: An unexploited and rich source of unsaturated fatty acids, 4-desmethylsterols and other valuable phytochemicals
Boulila, A., & Béjaoui, A. (2015) · Lipids in Health and Disease · doi:10.1186/s12944-015-0055-9 · Cited by 18 · see citing works
Effect of Erythrodiol, A Natural Pentacyclic Triterpene from Olive Oil, on the Lipid Membrane Properties
Habib, L., Jraij, A., Khreich, N., Charcosset, C., & Greige‐Gerges, H. (2015) · The Journal of Membrane Biology · doi:10.1007/s00232-015-9821-x · Cited by 17 · see citing works
Hypolipidemic Activity of Olive Oil (Olea europaea) against High Fat Diet-Induced Nonalcoholic Fatty Liver Disease (NAFLD) in Mice
Wani, F. A., Albahrawy, A. Z., & Rahiman, S. (2015) · Open Journal of Pathology · doi:10.4236/ojpathology.2015.53011 · Cited by 17 · see citing works
Addition of fish oil to atherogenic high fat diet inhibited atherogenesis while olive oil did not, in LDL receptor KO mice
Harari, A., Leikin-Frenkel, A. I., Barshack, I., Sagee, A., Cohen, H., Kamari, Y., Harats, D., Kandel-Kfir, M., & Shaish, A. (2019) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2019.12.007 · Cited by 16 · see citing works
Dietary squalene modifies plasma lipoproteins and hepatic cholesterol metabolism in rabbits
Martínez‐Beamonte, R., Sánchez-Marco, J., Felices, M. J., Barranquero, C., Gascón, S., Arnal, C., Burillo, J. C., Lasheras, R., Busto, R., Lasunción, M. A., et al. (2021) · Food & Function · doi:10.1039/d0fo01836h · Cited by 15 · see citing works
Self-citation
The Use of Transcriptomics to Unveil the Role of Nutrients in Mammalian Liver
Osada, J. (2013) · ISRN Nutrition · doi:10.5402/2013/403792 · Cited by 15 · see citing works
Self-citation
Therapeutic importance of chemical compounds in extra virgin olive oil and their relationship to biological indicators: A narrative review and literature update
Farhan, N., Al‐Maleki, A. R., Sarih, N. M., Yahya, R. B., & Shebl, M. (2023) · Food Bioscience · doi:10.1016/j.fbio.2023.102372 · Cited by 14 · see citing works
Squalene through Its Post-Squalene Metabolites Is a Modulator of Hepatic Transcriptome in Rabbits
Abuobeid, R., Sánchez-Marco, J., Felices, M. J., Arnal, C., Burillo, J. C., Lasheras, R., Busto, R., Lasunción, M. A., Rodriguez‐Yoldi, M. J., Martínez‐Beamonte, R., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23084172 · Cited by 13 · see citing works
Self-citation
Modulation of KCa3.1 Channels by Eicosanoids, Omega-3 Fatty Acids, and Molecular Determinants
Kacik, M., Oliván‐Viguera, A., & Köhler, R. (2014) · PLoS ONE · doi:10.1371/journal.pone.0112081 · Cited by 13 · see citing works
Dietary intake of table olives exerts antihypertensive effects in association with changes in gut microbiota in spontaneously hypertensive rats
Gómez-Contreras, A., Franco‐Ávila, T., Miró, L., Juan, M. E., Moretó, M., & Planas, J. M. (2023) · Food & Function · doi:10.1039/d2fo02928f · Cited by 12 · see citing works
Phenolic content of extra virgin olive oil is essential to restore endothelial dysfunction but not to prevent vascular inflammation in atherosclerotic lesions of Apo E deficient mice
Claro, C., Ogalla, E., Rodríguez‐Rodríguez, R., Herrera, M. D., & de Sotomayor, M. Á. (2015) · Journal of Functional Foods · doi:10.1016/j.jff.2015.03.008 · Cited by 12 · see citing works
Structural, mechanical and myogenic properties of small mesenteric arteries from ApoE KO mice: Characterization and effects of virgin olive oil diets
Ogalla, E., Claro, C., de Sotomayor, M. Á., Herrera, M. D., & Rodríguez‐Rodríguez, R. (2014) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2014.11.022 · Cited by 12 · see citing works
Effect of 1-y oral supplementation with vitaminized olive oil on platelets from healthy postmenopausal women
Vignini, A., Nanetti, L., Raffaelli, F., Sabbatinelli, J., Salvolini, E., Quagliarini, V., Cester, N., & Mazzanti, L. (2017) · Nutrition · doi:10.1016/j.nut.2017.06.013 · Cited by 11 · see citing works
Anti-atherosclerotic and cardiovascular protective benefits of Brazilian nuts
Ferrari, C. K. B. (2019) · Frontiers in Bioscience-Scholar · doi:10.2741/s539 · Cited by 10 · see citing works
Dietary Squalene Induces Cytochromes Cyp2b10 and Cyp2c55 Independently of Sex, Dose, and Diet in Several Mouse Models
Gabás‐Rivera, C., Jurado‐Ruiz, E., Sánchez‐Ortíz, A., Romanos, E., Martínez‐Beamonte, R., Navarro, M. Á., Surra, J. C., Arnal, C., Rodriguez‐Yoldi, M. J., Andrés‐Lacueva, C., et al. (2020) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202000354 · Cited by 10 · see citing works
Self-citation
Dietary Erythrodiol Modifies Hepatic Transcriptome in Mice in a Sex and Dose-Dependent Way
Abuobeid, R., Herrera-Marcos, L. V., Navarro, M. Á., Arnal, C., Martínez‐Beamonte, R., Surra, J. C., & Osada, J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21197331 · Cited by 10 · see citing works
Self-citation
Relationship between olive oil consumption and ankle-brachial pressure index in a population at high cardiovascular risk
Sánchez‐Quesada, C., Toledo, E., González-Mata, G., Ramos-Ballesta, M.-I., Peis, J. I., Martínez‐González, M. Á., Salas‐Salvadó, J., Corella, D., Fitó, M., Romaguera, D., et al. (2020) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2020.10.008 · Cited by 9 · see citing works
Optimization of White Pan Bread Preparation by Addition of Black Barley Flour and Olive Oil using Response Surface Methodology
Kim, J. K., Kim, Y.-H., Oh, J. C., & Yu, H. (2013) · Korean Journal of Food Science and Technology · doi:10.9721/kjfst.2013.45.2.180 · Cited by 9 · see citing works
Therapeutic roles of plants for 15 hypothesised causal bases of Alzheimer’s disease
Tyler, S. E. B., & Tyler, L. D. K. (2022) · Natural Products and Bioprospecting · doi:10.1007/s13659-022-00354-z · Cited by 10 · see citing works
Thioredoxin domain containing 5 is involved in the hepatic storage of squalene into lipid droplets in a sex-specific way
Sánchez-Marco, J., Bidooki, S. H., Abuobeid, R., Barranquero, C., Herrero‐Continente, T., Arnal, C., Martínez‐Beamonte, R., Lasheras, R., Surra, J. C., Navarro, M. Á., et al. (2023) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2023.109503 · Cited by 8 · see citing works
Self-citation
Breadsticks Flavoured with Olives and Onions: One-Year Shelf Life
Giuffrè, A. M., Caracciolo, M., Zappia, C., Capocasale, M., & Poiana, M. (2023) · Foods · doi:10.3390/foods12091798 · Cited by 7 · see citing works
Effect of virgin olive oil as spreadable preparation on atherosclerosis compared to dairy butter in Apoe-deficient mice
Martínez‐Beamonte, R., Barranquero, C., Gascón, S., Mariño, J., Arnal, C., Estopañán, G., Rodriguez‐Yoldi, M. J., Surra, J. C., Martín‐Belloso, O., Odriozola‐Serrano, I., et al. (2024) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-024-01029-8 · Cited by 6 · see citing works
Self-citation
Shark liver and flaxseed oils as alternatives to soybean oil in the lipid quality of Japanese quail eggs
Meireles, B. R. L. D. A., da Fonseca, S. B., Grisi, C. V. B., Madruga, M. S., Filho, J. J., Pascoal, L. A. F., Soledade, L. E. B., & da Silva, J. H. V. (2022) · British Food Journal · doi:10.1108/bfj-11-2021-1236 · Cited by 5 · see citing works
Cardiovascular and Renal Calcification and Bone: A comparison of the effect of Dietary Fatty Acids
Nicoll, R. (2015) · International Cardiovascular Forum Journal · doi:10.17987/icfj.v1i3.37 · Cited by 4 · see citing works
Effect of Extra Virgin Olive Oil High in Bioactive Compounds on Atherosclerosis in Apoe‐Deficient Mice
Martínez‐Beamonte, R., Barranquero, C., Soler, L., Herrero‐Continente, T., Rondón, A. C., Arnal, C., Estopañán, G., Lasheras, R., Rodriguez‐Yoldi, M. J., Surra, J. C., et al. (2025) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.70223 · Cited by 3 · see citing works
Self-citation
Squalene activates Wnt/β-Catenin signaling pathway to mediate NF-κB pathway to regulate inflammatory response and disease resistance in hybrid grouper (♀ Epinephelus fuscoguttatus × ♂ E. lanceolatu)
Yan, X., Pan, S., Li, T., Huang, W., Zhou, M., Zhang, S., Yang, Y., Tan, B., & Dong, X. (2023) · Aquaculture Reports · doi:10.1016/j.aqrep.2023.101784 · Cited by 3 · see citing works
Improvements in markers of inflammation and coagulation potential following a 5-day high-fat diet rich in cottonseed oil vs. Olive oil in healthy males
Prater, M. C., Polley, K. R., & Cooper, J. A. (2024) · Cytokine · doi:10.1016/j.cyto.2023.156494 · Cited by 3 · see citing works
Oxidation of olive oil fortified with quercetin, caffeic acid, tyrosol and hydroxytyrosol
Etherton, A. K., & Omaye, S. T. (2015) · Nutrition & Food Science · doi:10.1108/nfs-09-2014-0083 · Cited by 3 · see citing works
Optimization of White Pan Bread Preparation via Addition of Purple Barley Flour and Olive Oil by Response Surface Methodology
Kim, J. K., Kim, Y.-H., Oh, J. C., & Yu, H. (2012) · Journal of the Korean Society of Food Science and Nutrition · doi:10.3746/jkfn.2012.41.12.1813 · Cited by 3 · see citing works
Integrative transcriptomic and metabolomic reveals squalene alleviating the inflammatory response and enhancing immunity of hybrid grouper (♀ Epinephelus fuscoguttatus × ♂ E. lanceolatu)
Yan, X., Pan, S., Suo, X., Huang, W., Li, T., Zhang, S., Yang, Y., Tan, B., & Dong, X. (2024) · Aquaculture Reports · doi:10.1016/j.aqrep.2024.102524 · Cited by 2 · see citing works
Dietary Effect of Squalene on Lipid Metabolism of Obese/Diabetes KK-Ay Mice and Wild-Type C57BL/6J Mice
Liu, S., Hosokawa, M., & Miyashita, K. (2018) · Food and Nutrition Sciences · doi:10.4236/fns.2018.912108 · Cited by 2 · see citing works
Plant extracts affect dose-dependently the hatching rate of Drosophila melanogaster but do not induce chromosome loss and/or aneuploidy.
Endre, M., Mos, L. P., Szőke-Kovás, Z., Szőke-Kovás, R., Vígh, S., Pribac, C., Czapar, M., & Oláh, C. (2012) · University of Debrecen Electronic Archive (University of Debrecen)
Efectos inmunomoduladores de las dietas lipídicas y papel determinante en los estados de inmunosupresión
Cerón-Rodríguez, J.-M. (2016) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)
Síntesis endógena de ácidos grasos en la glándula mamaria y síndrome de baja grasa en la leche en ovejas
Bichi, E. (2016)
Avaliação do consumo de lipídios oxidados na indução do estresse oxidativo associado à aterosclerose em modelo animal
Nogueira, M. S. (2016) · doi:10.11606/d.9.2016.tde-22122015-091244
A Mediterranean Diet in Relation to Subclinical Vascular Conditions
Gardener, H. E., & Wright, C. B. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-407849-9.00032-4
Modificação de uma refeição brasileira com componentes mediterrâneos induz benefícios cardiometabólicos
Pires, M. M. (2016) · doi:10.11606/t.6.2016.tde-22122015-121128
Síntesis endógena de ácidos grasos en la glándula mamaria y síndrome de baja grasa en la leche en ovejas = Endogenous synthesis of fatty acids in the mammary gland and milk fat depression in dairy ewes = Sintesi endogena di acidi grassi nella ghiandola mammaria e sindrome di scarso grasso nel latte di pecora
Forteguerri, E. B. R. (2015) · doi:10.18002/10612/5576
Mediterranean Lifestyle and Nutritional Education
del Balzo, V., & Vitiello, V. (2018) · Elsevier eBooks · doi:10.1016/b978-0-08-100596-5.22544-4
Oil chemical traits of kernels of different almond cultivars from China
Wang, Q., Liu, F., Meng, J., Jinmei, M. A. O., Zhang, L., & Jianyou, W. (2021) · Food Science and Technology · doi:10.1590/fst.27621
Hypolipidemic Effects Of Red Radish (Raphanus Sativus) Seed Oil In Rat Fed High-Fat Diet: Its Phytochemical Characterization
Bashandy, S. A. E., & Abdelhameed, M. F. (2022) · Egyptian Journal of Chemistry · doi:10.21608/ejchem.2022.111758.5074
Effects of Combined Garcinia kola and Kigelia africana on Insulin and Paraoxonase 1 (PON1) Levels in Type 2 Diabetic Rats
Omoaghe, A. O., Oyesola, O., Ezike, T., Omizu, B., & Boone, K. (2022) · Current Drug Discovery Technologies · doi:10.2174/1570163819666220408100011
Virgin Olive Oil, A Rich Source of Functional Bioactive Compounds in the Promotion of Human Health: An Overview
Maazoun, A. M., Aounallah, M. K., Damergi, C., & Hammami, S. B. M. (2021) · European Journal of Nutrition & Food Safety · doi:10.9734/ejnfs/2021/v13i1230469
Caracterización de las acciones protectoras del ácido oleanólico en modelos experimentales de patologías con base inflamatoria
Córdova, C. (2015) · doi:10.35376/10324/16185
A Comprehensive Nutrient and Chemical Composition Analysis of the Main Cooking Oils Consumed in Australia
de Alzaa, F., Guillaume, C., & Ravetti, L. M. (2025) · ACS Food Science & Technology · doi:10.1021/acsfoodscitech.1c00333
Extraction and evaluation of bioactive compounds from the leaf extracts of Echinodorus cordifolius
Kathirvel, M. (2025) · Natural Resources for Human Health · doi:10.53365/nrfhh/204977
BindingDB Entry 50006030: Semi-synthesis of acylated triterpenes from olive-oil industry wastes for the development of anticancer and anti-HIV agents.
BindingDB (2020) · UC San Diego · doi:10.7270/q2t43x2n

Aceite de oliva virgen, el alimento con propiedades farmacológicas preventivas de la aterosclerosis
Surra Muñoz, J. C., Navarro, M. Á., Martínez Gracia, M. V., & García, J. D. L. O. (2015) · Dialnet (Universidad de la Rioja)
Self-citation
Olive Oil Cultivars and Atherosclerotic Protection in Apolipoprotein E-knockout Mice
Arbonés-Mainar, J. M., & Osada, J. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-374420-3.00090-5
Self-citation
Effects of Hydroxytyrosol on Atherosclerotic Lesions in apoE-Deficient Mice
Martínez-Gracia, M. V., Ruíz-Gutiérrez, V., & Osada, J. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-374420-3.00140-6
Self-citation
Use of Olives-derived Phytochemicals for Prevention and Treatment of Atherosclerosis: An Update
Dabravolski, S. A., Pleshko, E., Sukhorukov, V. N., Glanz, V. Y., Sobenin, I. A., & Orekhov, A. N. (2024) · Current Topics in Medicinal Chemistry · doi:10.2174/0115680266314560240806101445 · Cited by 9 · see citing works
Effect of Extra Virgin Olive Oil High in Bioactive Compounds on Atherosclerosis in Apoe‐Deficient Mice
Martínez‐Beamonte, R., Barranquero, C., Soler, L., Herrero‐Continente, T., Rondón, A. C., Arnal, C., Estopañán, G., Lasheras, R., Rodriguez‐Yoldi, M. J., Surra, J. C., et al. (2025) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.70223 · Cited by 3 · see citing works
Self-citation

Authors: Lou‐Bonafonte, J. M., Arnal, C., Navarro, M. A., & Osada, J.
Affiliations: Departamento de Farmacología y Fisiología Facultad de Ciencias de la Salud y del Deporte Instituto de Investigación Sanitaria de Aragón‐ Universidad de Zaragoza Zaragoza Spain
Universidad de Zaragoza (ES)
CIBER de Fisiopatología de la Obesidad y Nutrición Instituto de Salud Carlos III Zaragoza Spain
Corresponding author: Osada, Jesús
ORCID: Arnal, Carmen
Osada, Jesús
Venue: Molecular Nutrition & Food Research
Publisher: Wiley
Published: 2012-07
Volume: 56
Issue: 7
Pages: 1043-1057
ISSN: 1613-4125 (ISSN-L)
1613-4133
DOI: 10.1002/mnfr.201100668
OpenAlex: W1980563083
Cited by: 98
References: 157
Citations by year: 2025: 3 · 2024: 4 · 2023: 7 · 2022: 10 · 2021: 4 · 2020: 5 · 2019: 9 · 2018: 7 · 2017: 6 · 2016: 5 · 2015: 15 · 2014: 12 · 2013: 7 · 2012: 4
FWCI: 0.58
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 3 d)
Locations: Molecular Nutrition & Food Research (publishedVersion)
PubMed (publishedVersion)
Zaguan (University of Zaragoza Repository) (acceptedVersion, other-oa)
Topics: Physical Sciences › Chemistry › Organic Chemistry › Edible Oils Quality and Analysis
Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
Health Sciences › Nursing › Nutrition and Dietetics › Nuts composition and effects
Keywords: extra virgin olive oil, atherosclerosis, bioactive compounds, phenolic compounds, secoiridoids, flavonoids, triterpenoids, phytosterols, ApoE-deficient mice, hamster, rabbits, dietary cholesterol, sex differences, anti-atherosclerotic effects
MeSH terms: Olive Oil, Animals, Anticholesteremic Agents, Antioxidants, Apolipoproteins E, Disease Models, Animal, Fruit, Humans, Phenols, Phytosterols, Plant Oils, Triterpenes, Olea, Diet, Mediterranean, Atherosclerosis, Functional Food

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Efficacy of bioactive compounds from extra virgin olive oil to modulate atherosclerosis development

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks