Dietary monounsaturated fatty acids appear not to provide cardioprotection.
Open accessAbstract
Dietary interventions have been consistently proposed as a part of a comprehensive strategy to lower the incidence and severity of coronary heart disease (CHD), in the process providing long-term cardioprotection. Replacement of dietary saturated fatty acids (SFA) with higher intakes of monounsaturated fatty acids (MUFA) and polyunsaturated fatty acids (PUFA) has been reported to be inversely associated with risk of CHD. The observed lower incidence of CHD among populations consuming a Mediterranean-type diet, mainly enriched in MUFA from olive oil, has long supported the belief that MUFA are an optimal substitution for SFA. However, both epidemiologic and interventional studies suggest that although substituting MUFA-rich foods for SFA-rich foods in the diet can potentially lower total plasma cholesterol concentrations, this substitution does not lower the extent of coronary artery atherosclerosis. In addition, although recent evidence suggests that the source of MUFA (animal fat vs vegetable oils) may differentially influence the correlation between MUFA intake and CHD mortality, animal studies suggest that neither source is cardioprotective.
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Corn oil was selected because it was considered an inert comparator without effects on biochemical parameters associated with cardiovascular risk.
“Corn oil was selected because it was considered an inert comparator without effects on biochemical parametersassociatedwithcardiovascularrisk. 17,18”
From Effect of High-Dose Omega-3 Fatty Acids vs Corn Oil on Major Adverse Cardiovascular Events in Patients at High Cardiovascular Risk (2020) · cites this paper as [17]
The Introduction discusses oleic acid’s proposed neutral effect on serum cholesterol, and the section on olive oil versus other MUFA-enriched oils discusses how oils can affect cholesterol measures. Neither passage addresses corn oil, its selection as a comparator, or whether it was considered inert for cardiovascular-risk biomarkers (searched: corn oil, inert comparator). (LLM, conf=0.72)
Experimental — accuracy not yet measuredThe decision was made with the design of this trial to administer corn oil because it was considered to be a neutral comparator with the least effects on a range of biochemical parameters associated with cardiovascular risk.
“The decision was made with the design of this trial to administer corn oil because it was considered to be a neutral comparator with the least effects on a range of biochemical parameters associated with cardiovascular risk. 17,18”
From Effect of High-Dose Omega-3 Fatty Acids vs Corn Oil on Major Adverse Cardiovascular Events in Patients at High Cardiovascular Risk (2020) · cites this paper as [17]
The Introduction describes oleic acid in olive oil as neutral with respect to serum cholesterol, but that is not a claim about corn oil. A search for corn oil and neutral comparators found no passage explaining this trial’s choice of comparator or its expected effects on cardiovascular-risk biomarkers. (LLM, conf=0.77)
Experimental — accuracy not yet measured
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- Authors
- Degirolamo, C., & Rudel, L. L.
- Affiliations
- Mario Negri Sud Foundation (IT)
- Atrium Health Wake Forest Baptist (US)
- Corresponding author
- Rudel, Lawrence L.
- Venue
- Current Atherosclerosis Reports
- Published
- 2010-08-20
- Volume
- 12
- Issue
- 6
- Pages
- 391-396
- ISSN
- 1523-3804 (ISSN-L)
- 1534-6242
- PMC
- PMC2995267
- OpenAlex
- W2113328467
- Cited by
- 72
- References
- 56
- Citations by year
- 2025: 4 · 2024: 4 · 2023: 1 · 2022: 5 · 2021: 6 · 2020: 4 · 2019: 6 · 2018: 10 · 2017: 3 · 2016: 7 · 2015: 7 · 2014: 4 · 2013: 5 · 2012: 4
- FWCI
- 0.36
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Current Atherosclerosis Reports (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute (P01HL049373)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Nursing › Nutrition and Dietetics › Nuts composition and effects
- Keywords
- monounsaturated fatty acids, cardioprotection, coronary artery disease, saturated fatty acids, polyunsaturated fatty acids, olive oil, Mediterranean diet, fat replacement, serum cholesterol, coronary artery atherosclerosis, dietary intervention
- MeSH terms
- Animals, Coronary Disease, Fatty Acids, Monounsaturated, Humans
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