Methionine restriction effects on mitochondrial biogenesis and aerobic capacity in white adipose tissue, liver, and skeletal muscle of F344 rats

Perrone, Carmen E.; Mattocks, Dwight A.L.; Jarvis-Morar, Maureen; Plummer, Jason D.; Orentreich, Norman

doi:10.1016/j.metabol.2009.10.023

Cited by 138Adipose Tissue and MetabolismGenetics, Aging, and Longevity in Model OrganismsMitochondrial Function and Pathology

Methionine restriction effects on mitochondrial biogenesis and aerobic capacity in white adipose tissue, liver, and skeletal muscle of F344 rats

Perrone, Carmen E., Mattocks, Dwight A.L., Jarvis-Morar, Maureen, Plummer, Jason D., Orentreich, Norman·2010·Metabolism

DOI 10.1016/j.metabol.2009.10.023

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Abstract

Methionine restriction increases life span in rats and mice and reduces age-related accretion of adipose tissue in Fischer 344 rats. Recent reports have shown that adipose tissue mitochondrial content and function are associated with adiposity; therefore, the expression of genes involved in mitochondrial biogenesis and oxidative capacity was examined in white adipose tissue, liver, and skeletal muscle from Fischer 344 rats fed control (0.86% methionine) or methionine-restricted (0.17% methionine) diets for 3 months. Methionine restriction induced transcriptional changes of peroxisome proliferator-activated receptors, peroxisome proliferator-activated receptor coactivators 1alpha and 1beta, and some of their known target genes in all of these tissues. In addition, tissue-specific responses were elicited at the protein level. In inguinal adipose tissue, methionine restriction increased protein levels of peroxisome proliferator-activated receptor and peroxisome proliferator-activated receptor coactivator target genes. It also induced mitochondrial DNA copy number, suggesting mitochondrial biogenesis and corresponding with the up-regulation of citrate synthase activity. In contrast, methionine restriction induced changes in mitochondrial glycerol-3-phosphate dehydrogenase activity and stearoyl-coenzyme A desaturase 1 protein levels only in liver and uncoupling protein 3 and cytochrome c oxidase subunit IV protein levels only in skeletal muscle. No increase in mitochondrial DNA copy number was observed in liver and skeletal muscle despite an increase in mitochondrial citrate synthase activity. The results indicate that adiposity resistance in methionine-restricted rats is associated with mitochondrial biogenesis in inguinal adipose tissue and increased mitochondrial aerobic capacity in liver and skeletal muscle.

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Feeding low levels of methionine (methionine restriction) causes a strong inhibition of hepatic lipid synthesis and a lowering of blood lipid levels in laboratory animals.
“Noteworthily, studies in laboratory animals showed that feeding low levels of methionine (“methionine restriction”) causes a strong inhibition of hepatic lipid synthesis and a lowering of blood lipid levels [16,17,18]”
From Supplementation of Sulfur-Containing Amino Acids or Essential Amino Acids Does Not Reverse the Hepatic Lipid-Lowering Effect of a Protein-Rich Insect Meal in Obese Zucker Rats (2020) · cites this paper as [18]

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Authors: Perrone, C. E., Mattocks, D. A. L., Jarvis-Morar, M., Plummer, J. D., & Orentreich, N.
Affiliations: Orentreich Foundation for the Advancement of Science (US)
ORCID: Mattocks, Dwight A.L.
Venue: Metabolism
Publisher: Elsevier BV
Published: 2010-07
Volume: 59
Issue: 7
Pages: 1000-1011
ISSN: 0026-0495 (ISSN-L)
DOI: 10.1016/j.metabol.2009.10.023
OpenAlex: W1981999383
Cited by: 136
References: 74
Citations by year: 2026: 6 · 2025: 4 · 2024: 7 · 2023: 7 · 2022: 9 · 2021: 12 · 2020: 24 · 2019: 12 · 2018: 2 · 2017: 7 · 2016: 9 · 2015: 6 · 2014: 9 · 2013: 11 · 2012: 5
FWCI: 4.54
Type: journal article
Language: en
Update notices: erratum (2010-11-01)
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Metabolism (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
Topics: Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Keywords: methionine restriction, mitochondrial biogenesis, cardiorespiratory fitness, white adipose tissue, liver, skeletal muscle, peroxisome proliferator-activated receptors, mitochondrial DNA copy number, citrate synthase, UCP3, stearoyl-CoA desaturase 1, glycerol-3-phosphate dehydrogenase, cytochrome c oxidase, adiposity, aging, F344 rats
MeSH terms: Aerobiosis, Animals, Body Weight, Citrate (si)-Synthase, DNA, Mitochondrial, Liver, Male, Methionine, Mitochondria, Mitochondria, Liver, Mitochondria, Muscle, Organ Size, Rats, Inbred F344, Stearoyl-CoA Desaturase, Blotting, Western, Gene Expression, Muscle, Skeletal, Reverse Transcriptase Polymerase Chain Reaction, Adiposity, Glycerol-3-Phosphate Dehydrogenase (NAD+), Rats, Adipose Tissue, White

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Methionine restriction effects on mitochondrial biogenesis and aerobic capacity in white adipose tissue, liver, and skeletal muscle of F344 rats

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