Cited by 91Gut microbiota and healthProbiotics and Fermented FoodsNeuroinflammation and Neurodegeneration Mechanisms

Roseburia hominis Alleviates Neuroinflammation via Short‐Chain Fatty Acids through Histone Deacetylase Inhibition

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Song, Lijin, Sun, Qinghua, Zheng, Haonan, Zhang, Yiming, Wang, Yujing, Liu, Shuangjiang, Duan, Liping·2022·Molecular Nutrition & Food Research

Abstract

Scope: The gut microbiota plays a prominent role in gut–brain interactions and gut dysbiosis is involved in neuroinflammation. However, specific probiotics targeting neuroinflammation need to be explored. In this study, the antineuroinflammatory effect of the potential probiotic Roseburia hominis (R. hominis) and its underlying mechanisms is investigated. Methods and results: First, germ‐free (GF) rats are orally treated with R. hominis. Microglial activation, proinflammatory cytokines, levels of short‐chain fatty acids, depressive behaviors, and visceral sensitivity are assessed. Second, GF rats are treated with propionate or butyrate, and microglial activation, proinflammatory cytokines, histone deacetylase 1 (HDAC1), and histone H3 acetyl K9 (Ac‐H3K9) are analyzed. The results show that R. hominis administration inhibits microglial activation, reduces the levels of IL‐1α, INF‐γ, and MCP‐1 in the brain, and alleviates depressive behaviors and visceral hypersensitivity in GF rats. Moreover, the serum levels of propionate and butyrate are increased significantly in the R. hominis‐treated group. Propionate or butyrate treatment reduces microglial activation, the levels of proinflammatory cytokines and HDAC1, and promotes the expression of Ac‐H3K9 in the brain. Conclusion: These findings suggest that R. hominis alleviates neuroinflammation by producing propionate and butyrate, which serve as HDAC inhibitors. This study provides a potential psychoprobiotic to reduce neuroinflammation.

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  • Inhibition of microglial HDAC1 expression by propionate and butyrate alleviates microglial activation and reduces levels of pro-inflammatory factors in GF mice.

    “Furthermore, the inhibition of microglial HDAC1 expression by propionate and butyrate has been shown to alleviate microglial activation and reduce the levels of pro-inflammatory factors in GF mice.290”

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Authors
Song, L., Sun, Q., Zheng, H., Zhang, Y., Wang, Y., Liu, S., & Duan, L.
Affiliations
  • Peking University Third Hospital (CN)
  • Chinese Academy of Sciences (CN)
  • State Key Laboratory of Microbial Resources Institute of Microbiology Chinese Academy of Sciences Beijing 100101 China
Corresponding author
Duan, Liping
Venue
Molecular Nutrition & Food Research
Publisher
Wiley
Published
2022-07-21
Volume
66
Issue
18
Pages
e2200164-e2200164
ISSN
  • 1613-4125 (ISSN-L)
  • 1613-4133
OpenAlex
W4285028377
Cited by
91
References
38
Citations by year
2026: 20 · 2025: 29 · 2024: 19 · 2023: 20 · 2022: 3
FWCI
5.80
Type
journal article
Language
en
Open access
Locations
  • Molecular Nutrition & Food Research (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
Funders
National Natural Science Foundation of China (82170557)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
Roseburia hominis, neuroinflammation, short-chain fatty acids, HDAC1, histone H3 acetylation, propionate, butyrate, microglial activation, inflammatory cytokines, depression-like behavior, visceral hypersensitivity, gut-brain axis, psychobiotics, germ-free rats, gut dysbiosis
MeSH terms
Clostridiales, Eubacteriales, Brain-Gut Axis, Neuroinflammatory Diseases, Animals, Butyrates, Fatty Acids, Volatile, Germ-Free Life, Histones, Propionates, Cytokines, Probiotics, Rats, Histone Deacetylase 1

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