Similar Fecal Microbiota Signatures in Patients With Diarrhea-Predominant Irritable Bowel Syndrome and Patients With Depression
Abstract
Background & aims Patients with irritable bowel syndrome (IBS) often have psychiatric comorbidities. Alterations in the intestinal microbiota have been associated with IBS and depression, but it is not clear if there is a microbial relationship between these disorders. We studied the profiles of fecal microbiota samples from patients with IBS, depression, or comorbidities of IBS and depression; we determined the relationships among these profiles and clinical and pathophysiological features of these disorders.Methods We used 454 pyrosequencing to analyze fecal microbiota samples from 100 subjects (40 with diarrhea-predominant IBS [IBS-D], 15 with depression, 25 with comorbidities of IBS and depression, and 20 healthy individuals [controls]), recruited at Peking University. Abdominal and psychological symptoms were evaluated with validated questionnaires. Visceral sensitivity was evaluated using a barostat. Colonic mucosal inflammation was assayed by immunohistochemical analyses of sigmoid tissue biopsy specimens.Results Fecal microbiota signatures were similar between patients with IBS-D and depression in that they were less diverse than samples from controls and had similar abundances of alterations. They were characterized by high proportions of Bacteroides (type I), Prevotella (type II), or nondominant microbiota (type III). Most patients with IBS-D or depression had type I or type II profiles (IBS-D had 85% type I and type II profiles, depression had 80% type I and type II profiles). Colon tissues from patients with type I or type II profiles had higher levels of inflammatory markers than colon tissues from patients with type III profiles. The level of colon inflammation correlated with the severity of IBS symptoms.Conclusions Patients with IBS-D and depression have similar alterations in fecal microbiota; these might be related to the pathogenesis of these disorders. We identified 3 microbial profiles in patients that could indicate different subtypes of IBS and depression or be used as diagnostic biomarkers.
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Prevotella has been shown to be higher in patients with depression, insulin resistance, non-alcoholic fatty liver disease, hypertension, and colon cancer.
“Prevotella has been shown to be higher in patients with depression [214], insulin resistance [215], non-alcoholic fatty liver disease [216, 217], hypertension [217], and colon cancer [218].”
From The athletic gut microbiota (2020) · cites this paper as [214]
Prevotella has been noted to be associated with several disease states.
“Prevotella has been noted to be associated with several disease states.”
From The athletic gut microbiota (2020) · cites this paper as [214]
Individuals with psychiatric illness have a dissimilar microbiota composition compared to healthy individuals, due to decreased diversity and abundance of healthy gut microbes.
“In past studies, individuals with psychiatric illness have also been shown to have a dissimilar microbiota composition compared to healthy individuals, due to decreased diversity and abundance of the healthy gut microbes [9].”
From Effect of fecal microbiota transplant on symptoms of psychiatric disorders: a systematic review (2020) · cites this paper as [9]
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- Authors
- Liu, Y., Zhang, L., Wang, X., Wang, Z., Zhang, J., Jiang, R., Wang, X., Wang, K., Liu, Z., Xia, Z., Xu, Z., Nie, Y., Lv, X., Wu, X., Zhu, H., & Duan, L.
- Affiliations
- Peking University Third Hospital (CN)
- Peking University (CN)
- Corresponding author
- Zhu, Huaiqiu
- Duan, Liping
- ORCID
- Venue
- Clinical Gastroenterology and Hepatology
- Publisher
- Elsevier BV
- Published
- 2016-11
- Volume
- 14
- Issue
- 11
- Pages
- 1602-1611.e5
- ISSN
- 1542-3565 (ISSN-L)
- OpenAlex
- W2415407748
- Cited by
- 301
- References
- 36
- Citations by year
- 2026: 13 · 2025: 38 · 2024: 32 · 2023: 46 · 2022: 33 · 2021: 44 · 2020: 43 · 2019: 27 · 2018: 17 · 2017: 6 · 2016: 1
- FWCI
- 8.83
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Gastroenterology and Hepatology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Epidemiology › Microscopic Colitis
- Keywords
- diarrhea-predominant irritable bowel syndrome, depression, fecal microbiota, gut microbiota, psychiatric comorbidity, Bacteroides, Prevotella, microbiological profile, colonic mucosal inflammation, visceral sensitivity, biomarkers, IBS subtypes
- MeSH terms
- Adult, Biopsy, China, Colon, Depression, Diarrhea, Feces, Female, Histocytochemistry, Humans, Male, Middle Aged, Colon, Sigmoid, Irritable Bowel Syndrome, Young Adult, Metagenomics, Biota
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