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Cited by 521

The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.

Theoretical Model for Water Diffusion in Tissues

Szafer, Aaron, Zhong, Jianhui, Gore, John C.·1995·Magnetic Resonance in Medicine
DOI 10.1002/mrm.1910330516
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Abstract

Water diffusion in a tissue model is studied both analytically and numerically. Tissue is regarded as a periodic array of boxes surrounded by partially permeable membranes (cells), embedded in an extracellular medium, intracellular and extracellular diffusion coefficients may differ. Expressions for the apparent diffusion coefficients (ADC) in isotropic and noniso‐tropic tissues are derived and compared with Monte Carlo simulations. Calculated ADCs disagree with values obtained from the widely used “fast exchange” formula. Effects of differences between intracellular and extracellular T2 relaxation times on measured values of ADC and T2 are discussed. The general analysis is specifically applied to the changes occurring in ADC following ischemic insults to brain tissue. It is found that although membranes affect ADC significantly, the observed changes in diffusion cannot be due to reduced membrane permeabilities. They may result from the combined effect of changes in cellular volume fraction, extracellular and intracellular diffusion.

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Metadata

Authors
Szafer, A., Zhong, J., & Gore, J. C.
Venue
Magnetic Resonance in Medicine
Publisher
Wiley
Published
1995-05
Volume
33
Issue
5
Pages
697-712
ISSN
  • 0740-3194 (ISSN-L)
  • 1522-2594
DOI
10.1002/mrm.1910330516
OpenAlex
W2021939133
Cited by
521
References
31
FWCI
15.62
Type
journal article
Language
en
Open access
closed

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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