The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Positive contrast visualization of iron oxide‐labeled stem cells using inversion‐recovery with ON‐resonant water suppression (IRON)
Open accessAbstract
In proton magnetic resonance imaging (MRI) metallic substances lead to magnetic field distortions that often result in signal voids in the adjacent anatomic structures. Thus, metallic objects and superparamagnetic iron oxide (SPIO)‐labeled cells appear as hypointense artifacts that obscure the underlying anatomy. The ability to illuminate these structures with positive contrast would enhance noninvasive MR tracking of cellular therapeutics. Therefore, an MRI methodology that selectively highlights areas of metallic objects has been developed. Inversion‐recovery with ON‐resonant water suppression (IRON) employs inversion of the magnetization in conjunction with a spectrally‐selective on‐resonant saturation prepulse. If imaging is performed after these prepulses, positive signal is obtained from off‐resonant protons in close proximity to the metallic objects. The first successful use of IRON to produce positive contrast in areas of metallic spheres and SPIO‐labeled stem cells in vitro and in vivo is presented. Magn Reson Med 58:1072–1077, 2007. © 2007 Wiley‐Liss, Inc.
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de Vries, I. J. M., Lesterhuis, W. J., Barentsz, J. O., Verdijk, P., van Krieken, J. H., Boerman, O. C., Oyen, W. J. G., Bonenkamp, J. J., Boezeman, J. B., Adema, G. J., et al. (2005) · Nature Biotechnology · doi:10.1038/nbt1154 · Cited by 821
Self-citation
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Weinstein, J. S., Varallyay, C. G., Dosa, E., Gahramanov, S., Hamilton, B., Rooney, W. D., Muldoon, L. L., & Neuwelt, E. A. (2010) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2009.192 · Cited by 500
Liu, T., Spincemaille, P., de Rochefort, L., Kressler, B., & Wang, Y. (2009) · Magnetic Resonance in Medicine · doi:10.1002/mrm.21828 · Cited by 454
In vivo MRI cell tracking: clinical studies
Bulte, J. W. M. (2009) · American Journal of Roentgenology · doi:10.2214/ajr.09.3107 · Cited by 430
Self-citationWáng, Y. X. J., & Idée, J.-M. (2017) · Quantitative Imaging in Medicine and Surgery · doi:10.21037/qims.2017.02.09 · Cited by 247
Metadata
- Authors
- Stuber, M., Gilson, W. D., Schär, M., Kedziorek, D. A., Hofmann, L. V., Shah, S., Vonken, E., Bulte, J. W. M., & Kraitchman, D. L.
- Venue
- Magnetic Resonance in Medicine
- Publisher
- Wiley
- Published
- 2007-10-29
- Volume
- 58
- Issue
- 5
- Pages
- 1072-1077
- ISSN
- 0740-3194 (ISSN-L)
- 1522-2594
- OpenAlex
- W2088435744
- Cited by
- 215
- References
- 1
- FWCI
- 19.38
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Stuber, M., Gilson, W. D., Schär, M., Kedziorek, D. A., Hofmann, L. V., Shah, S., Vonken, E., Bulte, J. W. M., & Kraitchman, D. L. (2007). Positive contrast visualization of iron oxide‐labeled stem cells using inversion‐recovery with ON‐resonant water suppression (IRON). Magnetic Resonance in Medicine. https://doi.org/10.1002/mrm.21399
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