The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Nutritional therapy improves function and complements corticosteroid intervention in mdx mice
Abstract
Corticosteroid therapy for Duchenne muscular dystrophy is effective but associated with long‐term side effects. To determine the potential therapeutic benefit from four nutritional compounds (creatine monohydrate, conjugated linoleic acid, α‐lipoic acid, and β‐hydroxy‐β‐methylbutyrate) alone, in combination, and with corticosteroids (prednisolone), we evaluated the effects on several variables in exercising mdx mice. Outcome measures included grip strength, rotarod performance, serum creatine kinase levels, muscle metabolites, internalized myonuclei, and retroperitoneal fat pad weight. In isolation, each nutritional treatment showed some benefit, with the combination therapy showing the most consistent benefits. Prednisolone and the combination therapy together provided the most consistent evidence of efficacy; increased peak grip strength (P < 0.05), decreased grip strength fatigue (P < 0.05), decreased number of internalized myonuclei (P < 0.01), and smaller retroperitoneal fat pad stores (P < 0.001). This study provided evidence for therapeutic benefit from a four‐compound combination therapy alone, and in conjunction with corticosteroids in the mdx model of DMD. Muscle Nerve, 2005
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“Pre-clinical studies have shown pathological and functional benefits from CrM supplementation in murine models of DMD [196–199], and also in a murine model of fascio-scapulo-humeral dystrophy (FSHD) [200].”
From Creatine monohydrate supplementation for older adults and clinical populations (2025) · cites this paper as [196]
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Dystrophin: the protein product of the Duchenne muscular dystrophy locus
Hoffman, E. P., Brown, R. H., & Kunkel, L. M. (1987) · Cell · doi:10.1016/0092-8674(87)90579-4 · Cited by 4,693
X chromosome-linked muscular dystrophy (mdx) in the mouse
Bulfield, G., Siller, W. G., Wight, P. A., & Moore, K. J. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.4.1189 · Cited by 1,765
Effect of conjugated linoleic acid on body composition in mice
Park, Y., Albright, K. J., Liu, W., Storkson, J. M., Cook, M. E., & Pariza, M. W. (1997) · Lipids · doi:10.1007/s11745-997-0109-x · Cited by 1,163
Park, Y., Storkson, J. M., Albright, K. J., Liu, W., & Pariza, M. W. (1999) · Lipids · doi:10.1007/s11745-999-0358-8 · Cited by 815
Neuroprotective Effects of Creatine in a Transgenic Mouse Model of Huntington's Disease
Ferrante, R. J., Andreassen, O. A., Jenkins, B. G., Dedeoglu, A., Kuemmerle, S., Kubilus, J. K., Kaddurah-Daouk, R., Hersch, S. M., & Beal, M. F. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-12-04389.2000 · Cited by 522
Nissen, S., Sharp, R., Ray, M., Rathmacher, J. A., Rice, D., Fuller, J. C., Connelly, A. S., & Abumrad, N. (1996) · Journal of Applied Physiology · doi:10.1152/jappl.1996.81.5.2095 · Cited by 393
Vukovich, M. D., Stubbs, N. B., & Bohlken, R. M. (2001) · The Journal of Nutrition · doi:10.1093/jn/131.7.2049 · Cited by 222
Creatine monohydrate enhances strength and body composition in Duchenne muscular dystrophy
Tarnopolsky, M. A., Mahoney, D. J., Vajsar, J., Rodriguez, C., Doherty, T. J., Roy, B. D., & Biggar, D. (2004) · Neurology · doi:10.1212/01.wnl.0000125178.18862.9d · Cited by 216
Self-citationJówko, E., Ostaszewski, P., Jank, M., Sacharuk, J., Zieniewicz, A., Wilczak, J., & Nissen, S. (2001) · Nutrition · doi:10.1016/s0899-9007(01)00540-8 · Cited by 189
??-hydroxy-??-methylbutyrate ingestion, Part I: effects on strength and fat free mass
GALLAGHER, P. M., CARRITHERS, J. A., GODARD, M. P., SCHULZE, K. E., & TRAPPE, A. S. W. (2000) · Medicine and Science in Sports and Exercise · doi:10.1097/00005768-200012000-00022 · Cited by 171
Beneficial effects of creatine supplementation in dystrophic patients
Louis, M., Lebacq, J., Poortmans, J. R., Belpaire‐Dethiou, M., Devogelaer, J., Van Hecke, P., Goubel, F., & Francaux, M. (2003) · Muscle & Nerve · doi:10.1002/mus.10355 · Cited by 130
Research works printed but not linked: 44
- 10.1093/jn/130.12.2943 · DOI · Paper page
- 10.1002/1097-4598(200009)23:9<1344::AID-MUS4>3.0.CO;2-F · DOI
- 10.1093/ajcn/75.4.749 · DOI
- 10.1123/ijsnem.13.3.294 · DOI
- 10.1177/0148607100024003133 · DOI
- 10.1016/S0960-8966(01)00232-2 · DOI
- 10.1093/jn/131.10.3001 · DOI
- 10.1016/S0960-8966(02)00006-8 · DOI
- 10.1212/WNL.41.12.1874 · DOI · Paper page
- 10.1093/ajcn/79.6.1118 · DOI · Paper page
- 10.1023/A:1005545325254 · DOI
- 10.1016/S0960-8966(99)00126-1 · DOI
- 10.1212/WNL.43.3_Part_1.520 · DOI
- 10.1096/fasebj.13.2.411 · DOI · Paper page
- Hudecki M, 1993, Strength and endurance in the therapeutic evaluation of prednisolone‐treated mdx mice, Res Commun Chem Pathol Pharmacol, 79, 45
- 10.1207/S15327914NC431_6 · DOI
- 10.1016/0092-8674(88)90383-2 · DOI · Paper page
- 10.1126/science.288.5464.335 · DOI · Paper page
- 10.1359/jbmr.1999.14.7.1153 · DOI
- 10.1002/mus.20014 · DOI · Paper page
- 10.1016/S0891-5849(99)00155-0 · DOI
- 10.1016/S0892-0362(03)00073-4 · DOI
- 10.1016/S0002-9610(02)00823-1 · DOI · Paper page
- 10.1056/NEJM198906153202405 · DOI · Paper page
- 10.1016/S0955-2863(97)00048-X · DOI · Paper page
- 10.1016/S0899-9007(00)00376-2 · DOI · Paper page
- 10.1093/ajcn/79.6.1132S · DOI · Paper page
- 10.1016/S0960-8966(01)00273-5 · DOI · Paper page
- 10.1016/S0014-5793(98)01399-4 · DOI
- 10.1080/10715769900300721 · DOI · Paper page
- 10.1016/S0891-5849(03)00141-2 · DOI
- 10.1139/y02-129 · DOI · Paper page
- RudelR BrinkmeierH. 76th ENMC International Workshop: pathophysiology and therapy in the mdx mouse. 21–23 January 2000 Naarden The Netherlands.Neuromuscul Disord2002;12:415–420. · DOI
- 10.1126/science.2662404 · DOI · Paper page
- 10.1038/352536a0 · DOI · Paper page
- 10.1096/fj.00-0176com · DOI
- 10.1002/ana.1028 · DOI · Paper page
- 10.1002/mus.10527 · DOI · Paper page
- 10.1002/(SICI)1097-4598(199909)22:9<1228::AID-MUS9>3.0.CO;2-6 · DOI
- 10.1097/00005768-200003000-00024 · DOI · Paper page
- 10.1016/j.metabol.2003.09.008 · DOI
- 10.1212/WNL.54.9.1848 · DOI · Paper page
- 10.1093/ajcn/79.6.1153S · DOI
- 10.1021/jf020086a · DOI
Cited by
Wilson, G. J., Wilson, J. M., & Manninen, A. H. (2008) · Nutrition & Metabolism · doi:10.1186/1743-7075-5-1 · Cited by 306
Muscle wasting and aging: Experimental models, fatty infiltrations, and prevention
Brioche, T., Pagano, A. F., Py, G., & Chopard, A. (2016) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2016.04.006 · Cited by 129
Hao, Y., Jackson, J. R., Wang, Y., Edens, N., Pereira, S. L., & Alway, S. E. (2011) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00840.2010 · Cited by 124
Powerful signals for weak muscles
Saini, A., Faulkner, S., Al-Shanti, N., & Stewart, C. (2009) · Ageing Research Reviews · doi:10.1016/j.arr.2009.02.001 · Cited by 109
Efficacy of β-hydroxy-β-methylbutyrate supplementation in elderly and clinical populations
Fitschen, P. J., Wilson, G. J., Wilson, J. M., & Wilund, K. R. (2013) · Nutrition · doi:10.1016/j.nut.2012.05.005 · Cited by 97
Metadata
- Authors
- Payne, E. T., Yasuda, N., Bourgeois, J. M., Devries, M. C., Rodriguez, M. C., Yousuf, J., & Tarnopolsky, M. A.
- Venue
- Muscle & Nerve
- Publisher
- Wiley
- Published
- 2005-09-07
- Volume
- 33
- Issue
- 1
- Pages
- 66-77
- ISSN
- 0148-639X
- 1097-4598
- Cited by
- 71
- References
- 11
- Language
- en
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